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公开(公告)号:US06376534B1
公开(公告)日:2002-04-23
申请号:US09555579
申请日:2000-06-01
申请人: Daniel Delorme , Vlad Gregor , Edward Roberts , Eric Sun
发明人: Daniel Delorme , Vlad Gregor , Edward Roberts , Eric Sun
IPC分类号: A61K31155
CPC分类号: C07D333/58 , A61K51/0406 , C07C279/12 , C07C279/24 , C07C311/18
摘要: Compounds of general formula I are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain. Intermediates to the compounds of the formula I are also claimed.
摘要翻译: 在本申请中公开和要求保护的通式I的化合物及其药学上可接受的盐,包含新化合物的药物组合物及其在治疗中的用途,特别是在治疗疼痛中的用途。 还要求对式I化合物的中间体。
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公开(公告)号:US20050032789A1
公开(公告)日:2005-02-10
申请号:US10877967
申请日:2004-06-28
申请人: Daniel Delorme , Vlad Gregor , Edward Roberts , Eric Sun
发明人: Daniel Delorme , Vlad Gregor , Edward Roberts , Eric Sun
IPC分类号: A61K51/04 , C07C273/18 , C07C275/28 , A61K31/54 , A61K31/17 , A61K31/445 , A61K31/495 , A61K31/537
CPC分类号: A61K51/0406 , A61K51/0446 , C07C273/1854 , C07C275/28
摘要: Compounds of general formula I are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain.
摘要翻译: 通式I的化合物在本申请中公开和要求保护,以及它们的药学上可接受的盐,包含新化合物的药物组合物及其在治疗中的用途,特别是在疼痛的治疗中的用途。
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公开(公告)号:US06387949B1
公开(公告)日:2002-05-14
申请号:US09555580
申请日:2000-06-01
申请人: Daniel Delorme , Vlad Gregor , Niklas Plobeck , Edward Roberts , Eric Sun
发明人: Daniel Delorme , Vlad Gregor , Niklas Plobeck , Edward Roberts , Eric Sun
IPC分类号: A61K3117
CPC分类号: C07D213/89 , C07C211/27 , C07C273/1854 , C07C275/28 , C07C279/12 , C07C323/27 , C07C2601/12 , C07C2601/14 , C07D207/42 , C07D237/20 , C07D295/215
摘要: Compounds of general formula I are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain.
摘要翻译: 在本申请中公开和要求保护的通式I的化合物及其药学上可接受的盐,包含新化合物的药物组合物及其在治疗中的用途,特别是在治疗疼痛中的用途。
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公开(公告)号:US06777561B1
公开(公告)日:2004-08-17
申请号:US09555575
申请日:2000-06-01
申请人: Daniel Delorme , Vlad Gregor , Edward Roberts , Eric Sun
发明人: Daniel Delorme , Vlad Gregor , Edward Roberts , Eric Sun
IPC分类号: C07C29712
CPC分类号: A61K51/0406 , A61K51/0446 , C07C273/1854 , C07C275/28
摘要: Compounds of general formula I are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain.
摘要翻译: 在本申请中公开和要求保护的通式I的化合物及其药学上可接受的盐,包含新化合物的药物组合物及其在治疗中的用途,特别是在治疗疼痛中的用途。
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公开(公告)号:US06693117B2
公开(公告)日:2004-02-17
申请号:US10222990
申请日:2002-08-19
申请人: Daniel Delorme , Edward Roberts , Zhongyong Wei
发明人: Daniel Delorme , Edward Roberts , Zhongyong Wei
IPC分类号: A61K31445
CPC分类号: C07D401/06 , C07D211/46 , C07D211/70 , C07D405/06
摘要: Compounds of general formula (I) are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain.
摘要翻译: 通式(I)的化合物在本申请中公开和要求保护,以及它们的药学上可接受的盐,包含新化合物的药物组合物及其在治疗中的用途,特别是用于治疗疼痛。
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公开(公告)号:US06455545B2
公开(公告)日:2002-09-24
申请号:US09761833
申请日:2001-01-18
申请人: Daniel Delorme , Edward Roberts , Zhongyong Wei
发明人: Daniel Delorme , Edward Roberts , Zhongyong Wei
IPC分类号: A61K31445
CPC分类号: C07D401/06 , C07D211/46 , C07D211/70 , C07D405/06
摘要: Compounds of general formula (I) are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain.
摘要翻译: 通式(I)的化合物在本申请中公开和要求保护,以及它们的药学上可接受的盐,包含新化合物的药物组合物及其在治疗中的用途,特别是用于治疗疼痛。
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公开(公告)号:US20080176903A1
公开(公告)日:2008-07-24
申请号:US11951014
申请日:2007-12-05
申请人: Daniel Delorme , Edward Roberts , Zhongyong Wei
发明人: Daniel Delorme , Edward Roberts , Zhongyong Wei
IPC分类号: A61K31/445 , C07D211/34 , A61P25/00
CPC分类号: C07D401/06 , C07D211/46 , C07D211/70 , C07D405/06
摘要: Compounds of general formula (I) are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain.
摘要翻译: 通式(I)的化合物在本申请中公开和要求保护,以及它们的药学上可接受的盐,包含新化合物的药物组合物及其在治疗中的用途,特别是用于治疗疼痛。
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公开(公告)号:US07312336B2
公开(公告)日:2007-12-25
申请号:US10730265
申请日:2003-12-09
申请人: Daniel Delorme , Edward Roberts , Zhongyong Wei
发明人: Daniel Delorme , Edward Roberts , Zhongyong Wei
IPC分类号: C07D401/10 , C07D403/10 , C07D413/10 , A61K31/4465 , A61K31/454
CPC分类号: C07D401/06 , C07D211/46 , C07D211/70 , C07D405/06
摘要: Compounds of general formula (I) are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain.
摘要翻译: 通式(I)的化合物在本申请中公开和要求保护,以及它们的药学上可接受的盐,包含新化合物的药物组合物及其在治疗中的用途,特别是用于治疗疼痛。
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公开(公告)号:US06187792B1
公开(公告)日:2001-02-13
申请号:US09029633
申请日:1998-03-05
申请人: Daniel Delorme , Edward Roberts , Zhongyong Wei
发明人: Daniel Delorme , Edward Roberts , Zhongyong Wei
IPC分类号: A61K31445
CPC分类号: C07D401/06 , C07D211/46 , C07D211/70 , C07D405/06
摘要: Compounds of general formula (I) are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain.
摘要翻译: 通式(I)的化合物在本申请中公开和要求保护,以及它们的药学上可接受的盐,包含新化合物的药物组合物及其在治疗中的用途,特别是用于治疗疼痛。
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公开(公告)号:US08088805B2
公开(公告)日:2012-01-03
申请号:US11687398
申请日:2007-03-16
IPC分类号: A61K31/428 , C07D277/62 , C07D277/70 , C07D277/82
CPC分类号: C07C237/40 , C07C311/21 , C07C311/39 , C07D209/42 , C07D213/38 , C07D213/74 , C07D231/38 , C07D235/16 , C07D237/20 , C07D239/42 , C07D239/48 , C07D263/58 , C07D271/06 , C07D307/84 , C07D333/38 , C07D401/04 , C07D401/12 , C07D403/12 , C07D409/04 , C07D417/04 , C07D495/04
摘要: The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
摘要翻译: 本发明涉及抑制组蛋白脱乙酰酶。 本发明提供了抑制组蛋白脱乙酰酶酶活性的化合物和方法。 本发明还提供了治疗细胞增殖性疾病和病症的组合物和方法。
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