公开(公告)号：US20050273701A1

公开(公告)日：2005-12-08

申请号：US10836327

申请日：2004-04-30

申请人： Daniel Emerson ,  David Ornstein ,  Greg Schechter ,  Jerry Dunietz ,  Joe King ,  Sriram Subramanian ,  Oliver Foehr ,  Wei Zhu ,  Michael Hillberg ,  David Brown ,  Mikhail Leonov ,  Joseph Ternasky

发明人： Daniel Emerson ,  David Ornstein ,  Greg Schechter ,  Jerry Dunietz ,  Joe King ,  Sriram Subramanian ,  Oliver Foehr ,  Wei Zhu ,  Michael Hillberg ,  David Brown ,  Mikhail Leonov ,  Joseph Ternasky

IPC分类号： B41B1/00 ,  G06F17/21 ,  G06F17/22 ,  G06F17/24 ,  G06F17/27

CPC分类号： G06F17/30908 ,  G06F17/218 ,  G06F17/2229 ,  G06F17/2247 ,  G06F17/2288 ,  G06F17/272 ,  Y10S707/99945 ,  Y10S707/99948

摘要： Modular content framework and document format methods and systems are described. The described framework and format define a set of building blocks for composing, packaging, distributing, and rendering document-centered content. These building blocks define a platform-independent framework for document formats that enable software and hardware systems to generate, exchange, and display documents reliably and consistently. The framework and format have been designed in a flexible and extensible fashion. In addition to this general framework and format, a particular format, known as the reach package format, is defined using the general framework. The reach package format is a format for storing paginated documents. The contents of a reach package can be displayed or printed with full fidelity among devices and applications in a wide range of environments and across a wide range of scenarios.

摘要翻译： 描述了模块化内容框架和文档格式方法和系统。 描述的框架和格式定义了一组构建块，用于组合，打包，分发和呈现以文档为中心的内容。 这些构建模块定义了一个独立于平台的文档格式框架，可以使软件和硬件系统可靠，可靠地生成，交换和显示文档。 框架和格式的设计灵活可扩展。 除了这个一般框架和格式之外，使用通用框架定义了一种称为覆盖包格式的特定格式。 覆盖包格式是用于存储分页文档的格式。 可以在广泛的环境和广泛的场景下，在设备和应用程序之间以完全保真的方式显示或打印覆盖包的内容。

公开(公告)号：US20060238787A1

公开(公告)日：2006-10-26

申请号：US11112845

申请日：2005-04-22

申请人： Oliver Foehr ,  Jerry Dunietz ,  Mikhail Leonov ,  David Brown ,  Simon Daniels

发明人： Oliver Foehr ,  Jerry Dunietz ,  Mikhail Leonov ,  David Brown ,  Simon Daniels

IPC分类号： G06K15/02

CPC分类号： G06F17/214

摘要： Methods and systems permit rendering a text element formatted using unavailable or restricted fonts. In one embodiment, when producing a document that contains a restricted font, text portions formatted with the restricted font are processed into an alternate representation. A textual representation for the text portions and the additional representation(s) are embedded in a document or container. A unique representation for the restricted font file allows a consuming computing system to attempt to find the restricted font locally. Each textual representation is rendered using its corresponding restricted font, if the restricted font file is found. Otherwise, the additional representation(s) are used.

公开(公告)号：US20060242166A1

公开(公告)日：2006-10-26

申请号：US11112601

申请日：2005-04-22

申请人： Jean-Marie Larcheveque ,  Andrey Shur ,  Young Kim ,  David Brown ,  Mikhail Leonov ,  Robert Relyea ,  Zhenbin Xu ,  Jerry Dunietz

发明人： Jean-Marie Larcheveque ,  Andrey Shur ,  Young Kim ,  David Brown ,  Mikhail Leonov ,  Robert Relyea ,  Zhenbin Xu ,  Jerry Dunietz

IPC分类号： G06F17/00

CPC分类号： G06F17/30911

摘要： Methods for filtering a file written in Extensible Application Markup Language (XAML) and incrementally returning the logical content contained therein to the environment, e.g., a search engine, are provided. Additionally provided are methods for extracting logical content contained in a XAML file to facilitate searching and/or indexing thereof. The methods provided permit the filtering of files containing only flow-format elements, files containing only elements representing fixed-format pages, and/or files containing both flow-format and elements representing fixed-format pages.

摘要翻译： 提供了用可扩展应用标记语言（XAML）进行过滤的文件，并将包含在其中的逻辑内容递增回环境的方法，例如搜索引擎。 另外提供了用于提取包含在XAML文件中的逻辑内容以便于其搜索和/或索引的方法。 所提供的方法允许过滤仅包含流格式元素的文件，仅包含表示固定格式页面的元素的文件，和/或包含流格式和表示固定格式页面的元素的文件。

公开(公告)号：US20060136670A1

公开(公告)日：2006-06-22

申请号：US11342216

申请日：2006-01-27

申请人： David Brown ,  Mikhail Leonov ,  Michael Byrd

发明人： David Brown ,  Mikhail Leonov ,  Michael Byrd

IPC分类号： G06F13/00

CPC分类号： G09G5/363 ,  G06F9/52 ,  G09G5/24 ,  G09G5/393 ,  G09G2360/121 ,  G09G2370/027

摘要： Disclosed is a central cache that is updated without the overhead of locking. Updates are “atomic” in that they cannot be interrupted part way through. Applications are always free to read data in the cache, accessing the data through a reference table. Applications do not directly update the cache, instead, they send update requests to a service routine. To update the cache, the service routine proceeds in two phases. In the first phase, the service routine prepares the new data and adds them to the cache, without updating the reference table. During the first phase, an application accessing the cache cannot “see” the new data because the reference table has not yet been updated. After the first phase is complete, the service routine performs the second phase of the update process: atomically updating the reference table. The two-phase update process leaves the cache, at all times, in a consistent state.

公开(公告)号：US20050251627A1

公开(公告)日：2005-11-10

申请号：US11184578

申请日：2005-07-19

申请人： David Brown ,  Mikhail Leonov ,  Michael Byrd

发明人： David Brown ,  Mikhail Leonov ,  Michael Byrd

IPC分类号： G06F12/00 ,  G06F9/46 ,  G06F12/08 ,  G06F17/30 ,  G09G5/24 ,  G09G5/36 ,  G09G5/393

CPC分类号： G09G5/363 ,  G06F9/52 ,  G09G5/24 ,  G09G5/393 ,  G09G2360/121 ,  G09G2370/027

摘要： Disclosed is a central cache that is updated without the overhead of locking. Updates are “atomic” in that they cannot be interrupted part way through. Applications are always free to read data in the cache, accessing the data through a reference table. Applications do not directly update the cache, instead, they send update requests to a service routine. To update the cache, the service routine proceeds in two phases. In the first phase, the service routine prepares the new data and adds them to the cache, without updating the reference table. During the first phase, an application accessing the cache cannot “see” the new data because the reference table has not yet been updated. After the first phase is complete, the service routine performs the second phase of the update process: atomically updating the reference table. The two-phase update process leaves the cache, at all times, in a consistent state.

摘要翻译： 公开了一种在没有锁定开销的情况下更新的中央缓存。 更新是“原子的”，因为它们不能被中断。 应用程序始终可以自由地读取缓存中的数据，通过参考表访问数据。 应用程序不直接更新缓存，而是将更新请求发送到服务程序。 为了更新缓存，服务程序分两步进行。 在第一阶段，服务程序准备新数据并将其添加到缓存中，而不更新参考表。 在第一阶段，访问高速缓存的应用程序不能“查看”新数据，因为参考表尚未更新。 第一阶段完成后，服务程序执行更新过程的第二阶段：以原子方式更新参考表。 两阶段更新过程始终保持高速缓存，始终处于一致状态。

公开(公告)号：US20070177215A1

公开(公告)日：2007-08-02

申请号：US11345016

申请日：2006-02-01

申请人： Mikhail Lyapunov ,  Christopher Han ,  David Brown ,  Jason Hartman ,  Michael Duggan ,  Mikhail Leonov

发明人： Mikhail Lyapunov ,  Christopher Han ,  David Brown ,  Jason Hartman ,  Michael Duggan ,  Mikhail Leonov

IPC分类号： G06F15/00

CPC分类号： G09G5/227

摘要： Various technologies and techniques are disclosed that improve text rendering contrast. The shape of one or more characters is converted from an original format, such as a vector format received from a font, to an overscaled bitmap format. The width of the shape of the character is adjusted based on a text contrast setting. For example, the width of the shape can be adjusted by extending a right or other edge of the shape by the number of pixels corresponding to the numerical value of the text contrast setting. The shape is made wider or thinner based on the text contrast setting. A filtering procedure is used to determine density values for how the shape corresponds to a set of screen pixels. The density values are blended with color values related to the display device to form a modified shape ready for output. The modified shape is then displayed.

摘要翻译： 公开了改善文本呈现对比度的各种技术和技术。 一个或多个字符的形状从原始格式（例如从字体接收的向量格式）转换为过大的位图格式。 基于文本对比度设置调整字符的形状宽度。 例如，可以通过将形状的右边缘或其他边缘延伸与对应于文本对比度设置的数值的像素数量来调节形状的宽度。 基于文本对比度设置，形状变得更宽或更薄。 滤波过程用于确定形状对应于一组屏幕像素的密度值。 将浓度值与与显示装置相关的颜色值混合以形成准备输出的修改形状。 然后显示修改后的形状。

公开(公告)号：US20070249615A1

公开(公告)日：2007-10-25

申请号：US11737966

申请日：2007-04-20

申请人： Robert Hughes ,  Andrew Bell ,  David Brown ,  Dafydd Owen ,  Michael Palmer ,  Christopher Phillips ,  David Brown ,  Yvette Fobian ,  John Freskos ,  Steven Heasley ,  E. Jacobsen ,  Todd Maddux ,  Brent Mischke ,  John Molyneaux ,  Joseph Moon ,  D. Rogier ,  Michael Tollefson ,  John Walker

发明人： Robert Hughes ,  Andrew Bell ,  David Brown ,  Dafydd Owen ,  Michael Palmer ,  Christopher Phillips ,  David Brown ,  Yvette Fobian ,  John Freskos ,  Steven Heasley ,  E. Jacobsen ,  Todd Maddux ,  Brent Mischke ,  John Molyneaux ,  Joseph Moon ,  D. Rogier ,  Michael Tollefson ,  John Walker

IPC分类号： A61K31/498 ,  C07D487/02

CPC分类号： C07D471/04

摘要： Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: wherein R2, R6A, R6B and R8 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, synthetic methods, and intermediates are also disclosed.

摘要翻译： 公开了化合物的化合物和药学上可接受的盐，其中所述化合物具有式I的结构：其中R 2，R 6A，R 6B， >和R＆gt; 8如说明书中所定义。 还公开了相应的药物组合物，治疗方法，合成方法和中间体。

公开(公告)号：US20240026317A1

公开(公告)日：2024-01-25

申请号：US18249023

申请日：2021-10-13

申请人： Dong SHEN ,  David BROWN ,  Renxiang CHEN ,  RNAimmune, Inc

发明人： Dong Shen ,  David Brown ,  Renxiang Chen

IPC分类号： C12N9/14 ,  C12P19/30 ,  A61K39/00 ,  A61K9/127 ,  A61K47/69 ,  A61P35/00 ,  A61K47/54

CPC分类号： C12N9/14 ,  C12Y306/05002 ,  C12P19/30 ,  A61K39/001164 ,  A61K9/1273 ,  A61K47/6911 ,  A61P35/00 ,  A61K47/54 ,  A61K2039/53 ,  A61K2039/585 ,  A61K2039/55555

摘要： Compositions and methods are provided for potent mRNA vaccines for treatment of cancers with a mutation in the ras gene family. The compositions include a pharmaceutical composition comprising, or consisting essentially of, or yet further comprising mRNA molecules encoding at least one of multiple peptides of a group of somatic mutants and a pharmaceutically acceptable carrier. Methods for stimulating system immune responses and treatment are provided, including intratumoral, intravenous, intramuscular, intradermal, or subcutaneous injection of the composition as disclosed herein.

公开(公告)号：US11345606B2

公开(公告)日：2022-05-31

申请号：US15435318

申请日：2017-02-17

申请人： David Brown

发明人： David Brown

IPC分类号： G02B6/02 ,  C01G23/053 ,  C01G49/06 ,  C01B33/18

摘要： Disclosed is a method for producing deposition particles or intermediate particles, characterized in that the method comprises: forming a solution comprising a solvent and one or more deposit sources, aerosolizing the formed solution to produce an aerosol of precursor particles comprising the deposit source, conditioning the precursor particles to produce deposition particles or intermediate particles from the deposit source and collecting said particles. The particles may be collected as a deposit or precursor deposit on a substrate. The particles may include a matrix material and a dopant. The conditioning may be quenched to produce a desired substructure. The matrix material may be essentially optically clear. The substrate may comprise an optical fiber or an optical fiber preform or mandrel.

公开(公告)号：USD819777S1

公开(公告)日：2018-06-05

申请号：US29581051

申请日：2016-10-14

申请人： David Brown

设计人： David Brown