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公开(公告)号：US20130189780A1
公开(公告)日：2013-07-25
申请号：US13519558
申请日：2010-12-21
申请人： Daniel Shoemaker , Peter Flynn
发明人： Daniel Shoemaker , Peter Flynn
IPC分类号： C12N5/071
CPC分类号： C12N5/0696 , C12N2501/065 , C12N2501/60
摘要： The present invention provides compositions and methods of using the compositions to alter the developmental potency of a cell. The present invention provides in vivo and ex vivo cell reprogramming or dedifferentiation methods suitable for autologous cell therapy and regenerative medicine.
摘要翻译： 本发明提供使用该组合物来改变细胞的发育潜能的组合物和方法。 本发明提供适于自体细胞治疗和再生医学的体内和离体细胞重编程或去分化方法。
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2.发明申请Methods and compositions for identifying chemical or biological agents using multiplexed labeling and colocalization detection 审中-公开使用多重标记和共定位检测鉴定化学或生物制剂的方法和组合物公开(公告)号：US20070026391A1
公开(公告)日：2007-02-01
申请号：US11398998
申请日：2006-04-06
CPC分类号： G01N33/569 , B82Y5/00 , B82Y10/00 , B82Y15/00 , G01N33/54306 , G01N33/582 , G01N33/588 , Y02A50/52 , Y02A50/53 , Y02A50/55
摘要： The present invention provides methods for detecting a target pathogenic agent, e.g., a virus, a bacterium, and/or a toxic substance, using colocalization detection. The invention also provides methods for parallel detection of different target pathogenic agents in a sample using multiplexed labeling and colocalization detection. The invention also provides kits comprising sets of probes for detecting pathogenic agents. The invention further provides computer systems and computer program products for carrying out the method of determining degrees of colocalization.
摘要翻译： 本发明提供了使用共定位检测来检测靶病原体，例如病毒，细菌和/或有毒物质的方法。 本发明还提供了使用多重标记和共定位检测在样品中并行检测不同靶病原体的方法。 本发明还提供了包括用于检测病原体的探针组的试剂盒。 本发明还提供了用于执行确定共定位度的方法的计算机系统和计算机程序产品。
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3.发明申请DETERMINATION OF FETAL ANEUPLOIDY BY QUANTIFICATION OF GENOMIC DNA FROM MIXED SAMPLES 审中-公开通过从混合样品中定量鉴定基因组DNA来确定天然异构体公开(公告)号：US20120183963A1
公开(公告)日：2012-07-19
申请号：US13433232
申请日：2012-03-28
申请人： Roland Stoughton , Ravi Kapur , Mehmet Toner , Daniel Shoemaker , Ronald W. Davis , Barb Ariel Cohen
发明人： Roland Stoughton , Ravi Kapur , Mehmet Toner , Daniel Shoemaker , Ronald W. Davis , Barb Ariel Cohen
IPC分类号： C12Q1/68
CPC分类号： G01N1/30 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G16B20/00
摘要： The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, i.e. aneuploidy. In addition, the present invention provides methods to determine when there are insufficient fetal cells for a determination and report a non-informative case. The present invention involves quantifying regions of genomic DNA from a mixed sample. More particularly the invention involves quantifying DNA polymorphisms from the mixed sample.
摘要翻译： 本发明提供了当与样品中的母体细胞群混合时检测胎儿细胞的存在并测试胎儿异常（即非整倍体）的系统，装置和方法。 此外，本发明提供了确定何时胎儿细胞不足以确定并报告非信息性病例的方法。 本发明涉及量化来自混合样品的基因组DNA的区域。 更具体地，本发明涉及从混合样品中定量DNA多态性。
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公开(公告)号：US20100136529A1
公开(公告)日：2010-06-03
申请号：US12230628
申请日：2008-09-02
申请人： Daniel Shoemaker , Martin Fuchs , Neil X. Krueger , Mehmet Toner , Darren Gray , Ravi Kapur , Zihua Wang
发明人： Daniel Shoemaker , Martin Fuchs , Neil X. Krueger , Mehmet Toner , Darren Gray , Ravi Kapur , Zihua Wang
CPC分类号： C12Q1/6881 , B01L3/502761 , C12Q1/6809 , C12Q1/6869 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N2015/1006 , G01N2015/1087 , Y10T436/143333
摘要： The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the invention involves quantifying labeled DNA polymorphisms from each cell in the mixed sample.
摘要翻译： 本发明提供了当与样品中的母体细胞群混合时检测胎儿细胞的存在并测试胎儿异常的系统，装置和方法，例如， 非整倍体 本发明涉及用不同的标记标记所述混合样品中每个细胞中的基因组DNA的区域，其中每个标记对每个细胞是特异性的，并且定量混合样品中每个细胞的基因组DNA的标记区域。 更具体地，本发明涉及从混合样品中的每个细胞定量标记的DNA多态性。
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公开(公告)号：US20060105460A1
公开(公告)日：2006-05-18
申请号：US11158533
申请日：2005-06-22
申请人： John Danssaert , Robert Shopes , Daniel Shoemaker
发明人： John Danssaert , Robert Shopes , Daniel Shoemaker
IPC分类号： B01J19/00
CPC分类号： B01L7/52 , B01L7/525 , B01L7/5255 , B01L7/54 , B01L2200/147 , B01L2300/0829 , B01L2300/1822 , B01L2300/1827 , B01L2300/1838 , B01L2300/1844 , G01N35/0099 , G01N35/028 , G01N2035/042 , Y10S435/809 , Y10T436/25
摘要： A method in which a temperature gradient is generated across a “gradient” block, and an apparatus comprising a block across which a temperature gradient can be generated. By setting up such a gradient, multiple reaction mixtures held in wells on the gradient block can be simultaneously run at temperatures which differ only slightly, thereby permitting an optimum temperature for the reaction to be quickly identified. In a preferred embodiment the gradient block is integrated into a thermal cycler used for nucleic acid amplification reactions.
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公开(公告)号：US20130189688A1
公开(公告)日：2013-07-25
申请号：US13835926
申请日：2013-03-15
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , B01L3/502761 , C12Q1/6809 , C12Q1/6869 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N2015/1006 , G01N2015/1087 , Y10T436/143333
摘要： The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the invention involves quantifying labeled DNA polymorphisms from each cell in the mixed sample.
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公开(公告)号：US08372584B2
公开(公告)日：2013-02-12
申请号：US11763421
申请日：2007-06-14
申请人： Daniel Shoemaker , Mehmet Toner , Ravi Kapur , Roland Stoughton
发明人： Daniel Shoemaker , Mehmet Toner , Ravi Kapur , Roland Stoughton
CPC分类号： C12Q1/6881 , B01L3/502761 , C12Q1/6809 , C12Q1/6869 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N2015/1006 , G01N2015/1087 , Y10T436/143333
摘要： The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the invention involves quantifying labeled DNA polymorphisms from each cell in the mixed sample.
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公开(公告)号：US20120171666A1
公开(公告)日：2012-07-05
申请号：US13306640
申请日：2011-11-29
申请人： Daniel Shoemaker , Martin Fuchs , Neil X. Krueger , Mehmet Toner , Darren Gray , Ravl Kapur , Zihua Wang
发明人： Daniel Shoemaker , Martin Fuchs , Neil X. Krueger , Mehmet Toner , Darren Gray , Ravl Kapur , Zihua Wang
IPC分类号： G01N27/62
CPC分类号： C12Q1/6883 , B01L3/502761 , C12Q1/6809 , C12Q1/6869 , C12Q1/6881 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N2015/1006 , G01N2015/1087 , Y10T436/143333
摘要： The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the invention involves quantifying labeled DNA polymorphisms from each cell in the mixed sample.
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公开(公告)号：US20080220422A1
公开(公告)日：2008-09-11
申请号：US11763421
申请日：2007-06-14
申请人： Daniel Shoemaker , Martin Fuchs , Neil X. Krueger , Mehmet Toner , Darren Gray , Ravi Kapur , Zihua Wang
发明人： Daniel Shoemaker , Martin Fuchs , Neil X. Krueger , Mehmet Toner , Darren Gray , Ravi Kapur , Zihua Wang
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , B01L3/502761 , C12Q1/6809 , C12Q1/6869 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N2015/1006 , G01N2015/1087 , Y10T436/143333
摘要： The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the invention involves quantifying labeled DNA polymorphisms from each cell in the mixed sample.
摘要翻译： 本发明提供了当与样品中的母体细胞群混合时检测胎儿细胞的存在并测试胎儿异常的系统，装置和方法，例如， 非整倍体 本发明涉及用不同的标记标记所述混合样品中每个细胞中的基因组DNA的区域，其中每个标记对每个细胞是特异性的，并且定量混合样品中每个细胞的基因组DNA的标记区域。 更具体地，本发明涉及从混合样品中的每个细胞定量标记的DNA多态性。
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10.发明申请公开(公告)号：US20070009884A1
公开(公告)日：2007-01-11
申请号：US11399192
申请日：2006-04-06
CPC分类号： C12Q1/6813 , B82Y5/00 , B82Y10/00 , Y02A50/52 , Y02A50/53 , Y02A50/54 , Y02A50/55 , Y02A50/59 , Y02A50/60
摘要： The present invention provides methods and apparatuses for detection of pathogens or toxins in a sample. The invention also provides kits comprises reagents, including probes sets, and other consumables, such as surfaces, which can be used for detection of pathogens or toxins in a sample.
摘要翻译： 本发明提供了用于检测样品中病原体或毒素的方法和装置。 本发明还提供了包括试剂，包括探针组和其它可用于检测样品中的病原体或毒素的消耗品，例如表面的试剂盒。
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