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公开(公告)号：US11879127B2
公开(公告)日：2024-01-23
申请号：US16640787
申请日：2018-08-21
申请人： DANISCO US INC
CPC分类号： C12N15/75 , C12N9/0006 , C12N9/88 , C12N15/902 , C12R2001/10 , C12Y101/01095 , C12Y401/0102 , C12Y401/01023
摘要： The instant disclosure is generally related to compositions and methods for obtaining and constructing Bacillus licheniformis host cells (e.g., protein production host cells, cell factories) having increased protein production capabilities. Certain embodiments of the disclosure are directed to efficient genetic modifications of B. licheniformis cells and the subsequent selection of such B. licheniformis cells having increased protein production capabilities. Certain other embodiments of the disclosure are generally related to methods and compositions for producing/obtaining auxotrophic B. licheniformis cells, wherein certain other embodiments of the disclosure are directed to methods and compositions for restoring prototrophy in auxotrophic B. licheniformis cells, and expressing genes of interest (GOIs) in such restored prototrophy B. licheniformis cells.
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公开(公告)号：US12077762B1
公开(公告)日：2024-09-03
申请号：US17818258
申请日：2022-08-08
申请人： DANISCO US INC.
发明人： Cristina Bongiorni , Marc Anton Bernhard Kolkman , Chris Leeflang , Virgil Arthur Rhodius , Anita Van Kimmenade
CPC分类号： C12N15/75 , C07K14/32 , C12N9/2417 , C12N9/54 , C12Y302/01001 , C12Y304/21062
摘要： The instant disclosure is generally related to novel engineered (hybrid) promoters. In certain embodiments, the instant disclosure is directed to one or more nucleic acid compositions comprising engineered promoters operably linked to nucleic acids encoding proteins of interest. Thus, the disclosure set forth herein described methods and compositions for the production of proteins of interest using one or more novel engineered (hybrid) promoters of the disclosure.
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公开(公告)号：US20200056193A1
公开(公告)日：2020-02-20
申请号：US16486892
申请日：2018-02-22
申请人： DANISCO US INC.
发明人： Marc Anton Bernhard Kolkman , Steven D. Doig , Ryan L. Frisch , Hongxian He , Frank Wouter , Chris Leeflang
摘要： The present disclosure is generally related to compositions and methods for obtaining Bacillus licheniformis cells/strains having increased protein production capabilities. Certain embodiments of the disclosure are related to genetically modified Bacillus licheniformis cells/strains derived from parental B. licheniformis cells/strains comprising a variant rghR2 gene.
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公开(公告)号：US11473075B2
公开(公告)日：2022-10-18
申请号：US16720106
申请日：2019-12-19
申请人： DANISCO US INC
发明人： David A. Estell , Frits Goedegebuur , Marc Anton Bernhard Kolkman , Rie Mejldal , Katherine Augustyn , Lilia Maria Babe , Richard R Bott , Jian Yao , Roopa Santosh Ghirnikar
摘要： The present disclosure provides AprL-clade protease enzymes, including variant AprL-clade protease enzymes, nucleic acids encoding same, and compositions and methods related to the production and use thereof, including an AprL-clade variant subtilisin enzyme that has improved stability and/or soil removal compared to a parent AprL-clade subtilisin enzyme.
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公开(公告)号：US20200002693A1
公开(公告)日：2020-01-02
申请号：US16572804
申请日：2019-09-17
申请人： DANISCO US INC.
摘要： Disclosed are compositions and methods relating to variant maltohexaose-forming alpha-amylases. The variant alpha-amylases are useful, for example, for starch liquefaction and saccharification, for cleaning starchy stains in laundry, dishwashing, and other applications, for textile processing (e.g., desizing), in animal feed for improving digestibility, and for baking and brewing.
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公开(公告)号：US20190264187A1
公开(公告)日：2019-08-29
申请号：US16404828
申请日：2019-05-07
申请人： DANISCO US INC
发明人： Lilia M Babe , Roopa Santosh Ghirnikar , Frits Goedegebuur , Xiaogang Gu , Marc Anton Bernhard Kolkman , Jian Yao , Shukun Yu
IPC分类号： C12N9/52 , A23K10/14 , C11D3/386 , A23K20/189
摘要： Aspects of the present compositions and methods relate to novel metalloproteases polynucleotides encoding the novel metalloprotease, compositions and methods for use thereof.
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公开(公告)号：US20240229001A1
公开(公告)日：2024-07-11
申请号：US18487157
申请日：2023-10-16
申请人： Danisco US Inc.
发明人： Lilia M Babe , Richard R. Bott , Roopa Santosh Ghirnikar , Frits Goedegebuur , Xiaogang Gu , Marc Anton Bernhard Kolkman , Jian Yao , Shukun Yu
CPC分类号： C12N9/54 , C11D3/386 , C12Y304/24 , C12Y304/24027
摘要： Aspects of the present compositions and methods relate to novel metalloproteases polynucleotides encoding the novel metalloprotease, compositions and methods for use thereof.
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公开(公告)号：US11898177B2
公开(公告)日：2024-02-13
申请号：US17373307
申请日：2021-07-12
申请人： DANISCO US INC.
CPC分类号： C12N9/2417 , A21D8/042 , C11D3/386 , C12Y302/01001 , D06L1/14 , D06L4/40
摘要： Disclosed are compositions and methods relating to variant maltohexaose-forming alpha-amylases. The variant alpha-amylases are useful, for example, for starch liquefaction and saccharification, for cleaning starchy stains in laundry, dishwashing, and other applications, for textile processing (e.g., desizing), in animal feed for improving digestibility, and for baking and brewing.
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公开(公告)号：US20230002749A1
公开(公告)日：2023-01-05
申请号：US16491078
申请日：2017-11-09
申请人： Danisco US Inc.
发明人： Jacob Flyvholm Cramer , Jing Ge , Marc Anton Bernhard Kolkman , Igor Nikolaev , Jayarama K. Shetty , Zhongmei Tang , Wilhelmus Antonius Van Der Kleij , Zhiyong Xie , Bo Zhang , Zhengzheng Zou
摘要： Described are polypeptides having glucoamylase activity, compositions comprising such polypeptides, and methods of using such polypeptides and compositions.
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公开(公告)号：US20240182914A1
公开(公告)日：2024-06-06
申请号：US18524856
申请日：2023-11-30
申请人： DANISCO US INC.
发明人： Marc Anton Bernhard Kolkman , Steven D. Doig , Ryan L. Frisch , Hongxian He , Frank Wouter Koopman , Chris Leeflang
摘要： The present disclosure is generally related to compositions and methods for obtaining Bacillus licheniformis cells/strains having increased protein production capabilities. Certain embodiments of the disclosure are related to genetically modified Bacillus licheniformis cells/strains derived from parental B. licheniformis cells/strains comprising a variant rghR2 gene.
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