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1.发明授权Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells 有权使用产后衍生细胞治疗中风和其他急性神经变性疾病公开(公告)号：US07875272B2
公开(公告)日：2011-01-25
申请号：US11315898
申请日：2005-12-22
申请人： Darin J. Messina , Sanjay Mistry , L. S. Klaudyne Hong , Brian C. Kramer , Michael J. Romanko , Anna Gosiewska
发明人： Darin J. Messina , Sanjay Mistry , L. S. Klaudyne Hong , Brian C. Kramer , Michael J. Romanko , Anna Gosiewska
CPC分类号： A61K35/30 , A61K35/12 , A61K35/48 , C12N5/0605 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2533/50 , A61K2300/00
摘要： Cells derived from postpartum tissue such as the umbilical cord and placenta, and methods for their use to regenerate, repair, and improve neural tissue, and to improve behavior and neurological function in stroke patients are disclosed.
摘要翻译： 公开了衍生自产后组织如脐带和胎盘的细胞，以及用于再生，修复和改善神经组织以及改善中风患者的行为和神经功能的方法。
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2.发明授权Treatment of Parkinson's disease and related disorders using postpartum derived cells 有权使用产后衍生细胞治疗帕金森病和相关疾病公开(公告)号：US07875273B2
公开(公告)日：2011-01-25
申请号：US11315943
申请日：2005-12-22
CPC分类号： C12N5/0619 , A61K35/30 , A61K35/44 , C12N2501/11 , C12N2501/115 , C12N2501/119 , C12N2506/03 , A61K2300/00
摘要： Cells derived from postpartum tissue such as the umbilical cord and placenta, pharmaceutical compositions comprising such cells, and methods for using such cells and pharmaceutical compositions to treat patients having a neurodegenerative condition of the substantia nigra or striatum, such as Parkinson's disease, are provided.
摘要翻译： 提供衍生自产后组织如脐带和胎盘的细胞，包含这种细胞的药物组合物，以及使用这些细胞和药物组合物治疗患有黑质或纹状体如神经退行性疾病如帕金森病的患者的方法。
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公开(公告)号：US07618622B2
公开(公告)日：2009-11-17
申请号：US11315943
申请日：2005-12-22
摘要： Cells derived from postpartum tissue such as the umbilical cord and placenta, pharmaceutical compositions comprising such cells, and methods for using such cells and pharmaceutical compositions to treat patients having a neurodegenerative condition of the substantia nigra or striatum, such as Parkinson's disease, are provided.
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4.发明授权公开(公告)号：US09498501B2
公开(公告)日：2016-11-22
申请号：US12389305
申请日：2009-02-19
申请人： Sanjay Mistry , Anthony J. Kihm , Ian R. Harris , Alexander M. Harmon , Darin J. Messina , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
发明人： Sanjay Mistry , Anthony J. Kihm , Ian R. Harris , Alexander M. Harmon , Darin J. Messina , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
CPC分类号： A61K35/51 , A01N1/0226 , A61K35/12 , A61K35/50 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/204 , A61K38/2053 , A61K38/27 , A61K45/06 , C12N5/0605 , C12N5/0606 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2509/10 , C12N2533/50
摘要： Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.
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5.发明授权Postpartum cells derived from umbilical cord tissue, and methods of making and using the same 有权来自脐带组织的产后细胞，以及制造和使用它们的方法公开(公告)号：US08318483B2
公开(公告)日：2012-11-27
申请号：US11481456
申请日：2006-07-06
申请人： Sanjay Mistry , Anthony J. Kihm , Ian Ross Harris , Alexander M. Harmon , Darin J. Messina , Agnieszka Seyda , Anna Gosiewska
发明人： Sanjay Mistry , Anthony J. Kihm , Ian Ross Harris , Alexander M. Harmon , Darin J. Messina , Agnieszka Seyda , Anna Gosiewska
IPC分类号： C12N5/00
CPC分类号： A61K35/51 , A01N1/0226 , A61K35/12 , A61K35/50 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/204 , A61K38/2053 , A61K38/27 , A61K45/06 , C12N5/0605 , C12N5/0606 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2509/10 , C12N2533/50
摘要： Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.
摘要翻译： 公开了源自人脐带的细胞及其治疗用途的方法。 描述了相对于其细胞表面标志物的细胞的分离技术，培养方法和详细表征，基因表达及其营养因子的分泌。
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6.发明授权Postpartum cells derived from placental tissue, and methods of making and using the same 有权来自胎盘组织的产后细胞，以及制造和使用胎盘组织的方法公开(公告)号：US09579351B2
公开(公告)日：2017-02-28
申请号：US10877446
申请日：2004-06-25
申请人： Anthony J. Kihm , Ian Ross Harris , Sanjay Mistry , Alexander M. Harmon , Darin J. Messina , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
发明人： Anthony J. Kihm , Ian Ross Harris , Sanjay Mistry , Alexander M. Harmon , Darin J. Messina , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
CPC分类号： A61K35/51 , A01N1/0226 , A61K35/12 , A61K35/50 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/204 , A61K38/2053 , A61K38/27 , A61K45/06 , C12N5/0605 , C12N5/0606 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2509/10 , C12N2533/50
摘要： Cells derived from postpartum placenta and methods for their isolation are provided by the invention. The invention further provides cultures and compositions of the placenta-derived cells. The placenta-derived cells of the invention have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications.
摘要翻译： 由产后胎盘衍生的细胞及其分离方法由本发明提供。 本发明还提供了胎盘衍生细胞的培养物和组合物。 本发明的胎盘衍生细胞具有许多用途，包括但不限于研究，诊断和治疗应用。
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7.发明授权公开(公告)号：US08658152B2
公开(公告)日：2014-02-25
申请号：US13605716
申请日：2012-09-06
申请人： Darin J. Messina , Alexander M. Harmon , Ian R. Harris , Anthony J. Kihm , Sanjay Mistry , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
发明人： Darin J. Messina , Alexander M. Harmon , Ian R. Harris , Anthony J. Kihm , Sanjay Mistry , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
CPC分类号： A61K35/51 , A01N1/0226 , A61K35/12 , A61K35/50 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/204 , A61K38/2053 , A61K38/27 , A61K45/06 , C12N5/0605 , C12N5/0606 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2509/10 , C12N2533/50
摘要： Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of neural tissue using the postpartum-derived cells are also disclosed.
摘要翻译： 公开了产自产后脐带和胎盘的细胞。 还公开了使用产后来源细胞进行神经组织再生或修复的药物组合物，装置和方法。
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8.发明申请REGENERATION AND REPAIR OF NEURAL TISSUE USING POSTPARTUM-DERIVED CELLS 有权使用POSTPART-DERIVED细胞再生和修复神经组织公开(公告)号：US20100260843A1
公开(公告)日：2010-10-14
申请号：US12429849
申请日：2009-04-24
申请人： Darin J. Messina , Sanjay Mistry , Alexander M. Harmon , Ian Ross Harris , Anthony J. Kihm , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
发明人： Darin J. Messina , Sanjay Mistry , Alexander M. Harmon , Ian Ross Harris , Anthony J. Kihm , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
CPC分类号： A61K35/51 , A01N1/0226 , A61K35/12 , A61K35/50 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/204 , A61K38/2053 , A61K38/27 , A61K45/06 , C12N5/0605 , C12N5/0606 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2509/10 , C12N2533/50
摘要： Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of neural tissue using the postpartum-derived cells are also disclosed.
摘要翻译： 公开了产自产后脐带和胎盘的细胞。 还公开了使用产后来源细胞进行神经组织再生或修复的药物组合物，装置和方法。
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9.发明授权Postpartum cells isolated from umbilical cord tissue, and methods of making and using the same 有权从脐带组织分离的产后细胞，以及制造和使用它们的方法公开(公告)号：US07510873B2
公开(公告)日：2009-03-31
申请号：US10877012
申请日：2004-06-25
申请人： Sanjay Mistry , Anthony J. Kihm , Ian Ross Harris , Alexander M. Harmon , Darin J. Messina , Chin-Feng Yi , Anna Gosiewska
发明人： Sanjay Mistry , Anthony J. Kihm , Ian Ross Harris , Alexander M. Harmon , Darin J. Messina , Chin-Feng Yi , Anna Gosiewska
CPC分类号： A61K35/51 , A01N1/0226 , A61K35/12 , A61K35/50 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/204 , A61K38/2053 , A61K38/27 , A61K45/06 , C12N5/0605 , C12N5/0606 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2509/10 , C12N2533/50
摘要： Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.
摘要翻译： 公开了源自人脐带的细胞及其治疗用途的方法。 描述了相对于其细胞表面标志物的细胞的分离技术，培养方法和详细表征，基因表达及其营养因子的分泌。
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公开(公告)号：US07413734B2
公开(公告)日：2008-08-19
申请号：US10877541
申请日：2004-06-25
申请人： Sanjay Mistry , Darin J. Messina , Ian Ross Harris , Alexander M. Harmon , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
发明人： Sanjay Mistry , Darin J. Messina , Ian Ross Harris , Alexander M. Harmon , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
CPC分类号： A61K35/51 , A01N1/0226 , A61K35/12 , A61K35/50 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/204 , A61K38/2053 , A61K38/27 , A61K45/06 , C12N5/0605 , C12N5/0606 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2509/10 , C12N2533/50
摘要： Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of ocular tissue using the postpartum-derived cells are also disclosed.
摘要翻译： 公开了产自产后脐带和胎盘的细胞。 还公开了使用产后来源细胞再生或修复眼组织的药物组合物，装置和方法。
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