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公开(公告)号：US20080058881A1
公开(公告)日：2008-03-06
申请号：US11469767
申请日：2006-09-01
申请人： Darrell O. Wagner , Haris J. Sih , Tamara Colette Baynham , Steven D. Girouard , Joseph M. Pastore , Mark Schwartz
发明人： Darrell O. Wagner , Haris J. Sih , Tamara Colette Baynham , Steven D. Girouard , Joseph M. Pastore , Mark Schwartz
IPC分类号： A61N1/05
CPC分类号： A61N5/0601 , A61N1/3627 , A61N1/36585 , A61N1/3962 , A61N5/062 , A61N2005/063
摘要： An implantable device for delivering phototherapy is described that enables the phototherapy to be delivered to internal locations in either a clinical or ambulatory setting for treatment of post-MI patients. Telemetry circuitry enables the device to deliver the phototherapy upon command or be programmed to delivery the phototherapy according to a specified schedule. The device may also incorporate one or more sensing modalities that can be used to trigger delivery of phototherapy upon occurrence of a sensed event or condition. In one particular embodiment, the phototherapy device is incorporated into a cardiac rhythm management device that also delivers pacing and/or defibrillation therapy.
摘要翻译： 描述了用于递送光疗法的可植入装置，其使得光疗能够在临床或动态设置中被输送到内部位置以用于治疗MI后患者。 遥测电路使得设备能够根据命令传送光疗，或者被编程为根据指定的时间表传送光疗。 该装置还可以包括一个或多个感测模式，其可以用于在感测的事件或状况发生时触发光疗的传送。 在一个特定实施例中，光疗装置被并入还可以进行起搏和/或除颤疗法的心律管理装置中。
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公开(公告)号：US20080281305A1
公开(公告)日：2008-11-13
申请号：US11746829
申请日：2007-05-10
CPC分类号： A61F2/82 , A61F2/915 , A61F2002/91575 , A61F2230/0054 , A61F2250/0002 , A61N1/3787 , A61N5/0601 , A61N2005/0602 , A61N2005/0652 , A61N2005/0653
摘要： An implantable medical device includes a light emitting circuit incorporated into an intravascular stent. The light emitting circuit emits a light to an ischemic region. The light has characteristics suitable for reliving the angina symptoms associated with ischemia.
摘要翻译： 可植入医疗装置包括并入血管内支架中的发光电路。 发光电路将光发射到缺血区域。 该光具有适合于重现与缺血相关的心绞痛症状的特征。
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3.发明申请METHOD AND APPARATUS FOR TISSUE PROTECTION AGAINST ISCHEMIA USING REMOTE CONDITIONING 有权使用远程调节对组织织物组织防护的方法和装置公开(公告)号：US20110077701A1
公开(公告)日：2011-03-31
申请号：US12963224
申请日：2010-12-08
CPC分类号： A61N1/3627
摘要： A stimulation system delivers stimulation to protect an ischemic region of a body from tissue damage caused by ischemia. The stimulation is delivered to one or more stimulation sites remote from the ischemic region to elicit a physiological effect that protects the ischemic region from the tissue damage caused by ischemia. In one embodiment, the stimulation system delivers cardioprotective stimulation to one or more stimulation sites remote from the heart to protect the heart from injuries associated with cardiac ischemic events. In another embodiment, the stimulation system delivers remote conditioning stimulation to one or more stimulation sites in or on the heart to protect a non-cardiac region from injuries associated with non-cardiac ischemic events.
摘要翻译： 刺激系统提供刺激以保护身体的缺血区域免于由局部缺血引起的组织损伤。 刺激被递送到远离缺血区域的一个或多个刺激部位，以产生保护缺血区域免受缺血引起的组织损伤的生理作用。 在一个实施例中，刺激系统将心脏保护刺激递送到远离心脏的一个或多个刺激部位，以保护心脏免于与心脏缺血事件相关的损伤。 在另一个实施例中，刺激系统将远程调节刺激递送到心脏中或心脏上的一个或多个刺激部位，以保护非心脏区域免于与非心脏缺血事件相关的损伤。
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4.发明授权Method and apparatus for tissue protection against ischemia using remote conditioning 有权使用远程调理的组织保护针对缺血的方法和装置公开(公告)号：US08874207B2
公开(公告)日：2014-10-28
申请号：US12963224
申请日：2010-12-08
CPC分类号： A61N1/3627
摘要： A stimulation system delivers stimulation to protect an ischemic region of a body from tissue damage caused by ischemia. The stimulation is delivered to one or more stimulation sites remote from the ischemic region to elicit a physiological effect that protects the ischemic region from the tissue damage caused by ischemia. In one embodiment, the stimulation system delivers cardioprotective stimulation to one or more stimulation sites remote from the heart to protect the heart from injuries associated with cardiac ischemic events. In another embodiment, the stimulation system delivers remote conditioning stimulation to one or more stimulation sites in or on the heart to protect a non-cardiac region from injuries associated with non-cardiac ischemic events.
摘要翻译： 刺激系统提供刺激以保护身体的缺血区域免于由局部缺血引起的组织损伤。 刺激被递送到远离缺血区域的一个或多个刺激部位，以产生保护缺血区域免受缺血引起的组织损伤的生理作用。 在一个实施例中，刺激系统将心脏保护刺激递送到远离心脏的一个或多个刺激部位，以保护心脏免于与心脏缺血事件相关的损伤。 在另一个实施例中，刺激系统将远程调节刺激递送到心脏中或心脏上的一个或多个刺激部位，以保护非心脏区域免于与非心脏缺血事件相关的损伤。
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公开(公告)号：US20110137385A1
公开(公告)日：2011-06-09
申请号：US13024975
申请日：2011-02-10
IPC分类号： A61N5/06
CPC分类号： A61F2/82 , A61F2/915 , A61F2002/91575 , A61F2230/0054 , A61F2250/0002 , A61N1/3787 , A61N5/0601 , A61N2005/0602 , A61N2005/0652 , A61N2005/0653
摘要： An implantable medical device includes a light emitting circuit incorporated into an intravascular stent. The light emitting circuit emits a light to an ischemic region. The light has characteristics suitable for reliving the angina symptoms associated with ischemia.
摘要翻译： 可植入医疗装置包括并入血管内支架中的发光电路。 发光电路将光发射到缺血区域。 该光具有适合于重现与缺血相关的心绞痛症状的特征。
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6.发明授权Method and apparatus for tissue protection against ischemia using remote conditioning 有权使用远程调理的组织保护针对缺血的方法和装置公开(公告)号：US07885710B2
公开(公告)日：2011-02-08
申请号：US11318263
申请日：2005-12-23
IPC分类号： A61N1/372
CPC分类号： A61N1/3627
摘要： A stimulation system delivers stimulation to protect an ischemic region of a body from tissue damage caused by ischemia. The stimulation is delivered to one or more stimulation sites remote from the ischemic region to elicit a physiological effect that protects the ischemic region from the tissue damage caused by ischemia. In one embodiment, the stimulation system delivers cardioprotective stimulation to one or more stimulation sites remote from the heart to protect the heart from injuries associated with cardiac ischemic events. In another embodiment, the stimulation system delivers remote conditioning stimulation to one or more stimulation sites in or on the heart to protect a non-cardiac region from injuries associated with non-cardiac ischemic events.
摘要翻译： 刺激系统提供刺激以保护身体的缺血区域免于由局部缺血引起的组织损伤。 刺激被递送到远离缺血区域的一个或多个刺激部位，以产生保护缺血区域免受缺血引起的组织损伤的生理作用。 在一个实施例中，刺激系统将心脏保护刺激递送到远离心脏的一个或多个刺激部位，以保护心脏免于与心脏缺血事件相关的损伤。 在另一个实施例中，刺激系统将远程调节刺激递送到心脏中或心脏上的一个或多个刺激部位，以保护非心脏区域免于与非心脏缺血事件相关的损伤。
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公开(公告)号：US20100130913A1
公开(公告)日：2010-05-27
申请号：US12694328
申请日：2010-01-27
CPC分类号： A61N1/05 , A61F2/958 , A61N1/0568 , A61N1/057 , A61N1/36514 , A61N1/37205 , A61N1/37235 , A61N2001/0585
摘要： Disclosed herein, among other things, is a system for providing pacing during revascularization. An embodiment of the system includes an angioplasty or stent delivery catheter system having a catheter, a balloon and an inflation device adapted to inflate and deflate the balloon for delivery of a stent. The embodiment also includes a programmable pulse generator and at least one electrode integrated with the angioplasty catheter system, where the pulse generator is connected to the electrode. In various embodiments, at least one integrated sensor is connected to the angioplasty catheter system. The sensor is adapted to sense a parameter indicative of flow restoration and trigger the pulse generator to begin pacing based on the parameter.
摘要翻译： 此处公开的是用于在血运重建期间提供起搏的系统。 该系统的一个实施例包括血管成形术或支架递送导管系统，其具有导管，气囊和适于使气囊膨胀和放气以便输送支架的充气装置。 该实施例还包括可编程脉冲发生器和与血管成形术导管系统集成的至少一个电极，其中脉冲发生器连接到电极。 在各种实施例中，至少一个集成传感器连接到血管成形术导管系统。 传感器适于感测指示流量恢复的参数，并且基于参数触发脉冲发生器开始起搏。
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公开(公告)号：US20080071315A1
公开(公告)日：2008-03-20
申请号：US11468875
申请日：2006-08-31
IPC分类号： A61N1/36
CPC分类号： A61N1/05 , A61F2/958 , A61N1/0568 , A61N1/057 , A61N1/36514 , A61N1/37205 , A61N1/37235 , A61N2001/0585
摘要： Disclosed herein, among other things, is a system for providing pacing during revascularization. An embodiment of the system includes an angioplasty or stent delivery catheter system having a catheter, a balloon and an inflation device adapted to inflate and deflate the balloon for delivery of a stent. The embodiment also includes a programmable pulse generator and at least one electrode integrated with the angioplasty catheter system, where the pulse generator is connected to the electrode. In various embodiments, at least one integrated sensor is connected to the angioplasty catheter system. The sensor is adapted to sense a parameter indicative of flow restoration and trigger the pulse generator to begin pacing based on the parameter.
摘要翻译： 此处公开的是用于在血运重建期间提供起搏的系统。 该系统的一个实施例包括血管成形术或支架递送导管系统，其具有导管，气囊和适于使气囊膨胀和放气以便输送支架的充气装置。 该实施例还包括可编程脉冲发生器和与血管成形术导管系统集成的至少一个电极，其中脉冲发生器连接到电极。 在各种实施例中，至少一个集成传感器连接到血管成形术导管系统。 传感器适于感测指示流量恢复的参数，并且基于参数触发脉冲发生器开始起搏。
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公开(公告)号：US20110230928A1
公开(公告)日：2011-09-22
申请号：US13113706
申请日：2011-05-23
申请人： Allan Shuros , Tamara Colette Baynham , Jihong Qu , Joseph M. Pastore , Andrew P. Kramer , Frits W. Prinzen , Ward Y. R. Vanagt , Richard N. Cornelussen
发明人： Allan Shuros , Tamara Colette Baynham , Jihong Qu , Joseph M. Pastore , Andrew P. Kramer , Frits W. Prinzen , Ward Y. R. Vanagt , Richard N. Cornelussen
CPC分类号： A61N1/362 , A61B17/22 , A61B18/1492 , A61B2017/22001 , A61B2018/00214 , A61B2018/0041 , A61B2018/00422 , A61N1/056 , A61N1/3625 , A61N5/1001 , A61N2001/0585
摘要： Cardiac protection pacing is applied to prevent or reduce cardiac injury and/or occurrences of arrhythmia associated with an ischemic event including the occlusion of a blood vessel during a revascularization procedure. Pacing pulses are generated from a pacemaker and delivered through one or more pacing electrodes incorporated onto a percutaneous transluminal vascular intervention (PTVI) device used in the revascularization procedure. The pacemaker generates the pacing pulses according to a predetermined cardiac protection pacing sequence before, during, and/or after the ischemic event.
摘要翻译： 应用心脏保护起搏来预防或减少与血管重建手术期间血管闭塞的缺血事件相关的心律失常和/或发生的心律不齐。 起搏脉冲从起搏器产生，并通过一个或多个起搏电极产生，并通过并入到血运重建术中使用的经皮腔内血管介入（PTVI）装置上。 起搏器根据在缺血事件之前，期间和/或之后的预定心脏保护起搏序列产生起搏脉冲。
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10.发明申请METHOD AND APPARATUS FOR DEVICE CONTROLLED GENE EXPRESSION FOR CARDIAC PROTECTION 失效用于设备控制的基因表达用于心脏保护的方法和装置公开(公告)号：US20100274306A1
公开(公告)日：2010-10-28
申请号：US12830534
申请日：2010-07-06
申请人： Joseph M. Pastore , Jeffrey Ross , Tamara Colette Baynham , Rodney W. Salo , Andrew P. Kramer , Julio C. Spinelli
发明人： Joseph M. Pastore , Jeffrey Ross , Tamara Colette Baynham , Rodney W. Salo , Andrew P. Kramer , Julio C. Spinelli
CPC分类号： A61N1/3627 , A61K48/0083 , A61N1/36514
摘要： A gene regulatory system detects ischemia events and is capable of delivering a biologic therapy in response to the detection of an ischemic event or the reception of a command. The biologic therapy protects the heart from ischemic damage by regulating the expression of an exogenously introduced gene product. In one embodiment, the gene regulatory system includes an implantable system that emits at least one gene regulatory signal in response to the detection of the ischemic event or the reception of the command. The gene regulatory signal directly or indirectly regulates gene expression of the gene product.
摘要翻译： 基因调控系统检测缺血事件，并且能够响应于缺血事件的检测或命令的接收而递送生物疗法。 生物治疗通过调节外源基因产物的表达来保护心脏免于缺血性损伤。 在一个实施方案中，基因调控系统包括可植入系统，其可以响应于缺血事件的检测或命令的接收而发射至少一个基因调节信号。 基因调控信号直接或间接调控基因产物的基因表达。
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