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    Human papillomavirus vaccine formulations
    1.
    发明授权
    Human papillomavirus vaccine formulations 有权
    人乳头瘤病毒疫苗制剂

    公开(公告)号：US06251678B1

    公开(公告)日：2001-06-26

    申请号：US09496812

    申请日：2000-02-02

    申请人： David B. Volkin ,  Li Shi ,  Henryk Mach

    发明人： David B. Volkin ,  Li Shi ,  Henryk Mach

    IPC分类号： G01N3100

    CPC分类号： A61K39/12 ,  A61K2039/5258 ,  A61K2039/55505 ,  C12N2710/20034 ,  Y10T436/10 ,  Y10T436/108331

    摘要： New human papilloma virus (HPV) vaccine formulations exhibit enhanced long-term stability. Formulation components can include: virus-like particles (VLPs) absorbed onto aluminum, a salt, non-ionic surfactant, and a buffer. Additional formulations also contain a polymeric polyanionic stabilizer and a salt either in the presence or absence buffering agents and nonionic detergent.

    摘要翻译： 新的人乳头状瘤病毒（HPV）疫苗制剂表现出增强的长期稳定性。 制剂组分可以包括：吸收在铝上的病毒样颗粒（VLP），盐，非离子表面活性剂和缓冲液。 在存在或不存在缓冲剂和非离子洗涤剂的情况下，附加配方还含有聚合聚阴离子稳定剂和盐。

    Assisted selective growth of highly dense and vertically aligned carbon nanotubes
    4.
    发明申请
    Assisted selective growth of highly dense and vertically aligned carbon nanotubes 审中-公开
    辅助选择生长高密度和垂直排列的碳纳米管

    公开(公告)号：US20100117764A1

    公开(公告)日：2010-05-13

    申请号：US11405657

    申请日：2006-04-17

    申请人： Yunyu Wang ,  Paul S. Ho ,  Li Shi ,  Zhen Yao

    发明人： Yunyu Wang ,  Paul S. Ho ,  Li Shi ,  Zhen Yao

    IPC分类号： H01P1/20 ,  C23C16/26 ,  C03C17/38

    CPC分类号： B82Y40/00 ,  B82Y30/00 ,  C01B32/162 ,  C01B2202/08 ,  Y10T428/12625

    摘要： The selective growth of vertically aligned, highly dense carbon nanotube (CNT) arrays using a thermal catalytic chemical vapor deposition (CCVD) method via selection of the supporting layer where the thin catalyst layer is deposited on. A thin iron (Fe) catalyst deposited on a supporting layer of tantalum (Ta) yielded CCVD growth of the vertical dense CNT arrays. Cross-sectional transmission electron microscopy revealed a Vollmer-Weber mode of Fe island growth on Ta, with a small contact angle of the islands controlled by the relative surface energies of the supporting layer, the catalyst and their interface. The as-formed Fe island morphology promoted surface diffusion of carbon atoms seeding the growth of the CNTs from the catalyst surface.

    摘要翻译： 通过选择沉积薄催化剂层的支撑层，使用热催化化学气相沉积（CCVD）方法选择性地生长垂直取向的高密度碳纳米管（CNT）阵列。 沉积在钽（Ta）的支撑层上的薄铁（Fe）催化剂产生垂直致密CNT阵列的CCVD生长。 横截面透射电子显微镜显示在Ta上的Fe岛生长的Vollmer-Weber模式，岛的小接触角由支撑层，催化剂及其界面的相对表面能控制。 形成的Fe岛形态促进碳原子的表面扩散，从催化剂表面接种CNT的生长。

    Method and apparatus for measuring dopant profile of a semiconductor
    5.
    发明授权
    Method and apparatus for measuring dopant profile of a semiconductor 失效
    用于测量半导体掺杂剂分布的方法和装置

    公开(公告)号：US06893884B2

    公开(公告)日：2005-05-17

    申请号：US10112482

    申请日：2002-03-28

    申请人： Li Shi ,  Uttam Shyamalindu Ghoshal

    发明人： Li Shi ,  Uttam Shyamalindu Ghoshal

    IPC分类号： G01Q10/06 ,  G01N27/00 ,  G01Q60/00 ,  H01L21/66

    CPC分类号： G01N27/002 ,  Y10S977/854

    摘要： A method and apparatus for measuring dopant profile of a semiconductor is disclosed. Initially, the temperature of a tip of a probe and the temperature of a semiconductor sample are ascertained. Then, a voltage at a location on a surface of the semiconductor sample is obtained via the tip of the probe. The dopant concentration at the location of the surface of the semiconductor sample is subsequently determined by combining the obtained voltage and the temperature difference between the probe tip and the semiconductor sample. The above-mentioned steps can be repeated in order to generate a dopant profile of the semiconductor.

    摘要翻译： 公开了一种用于测量半导体掺杂剂分布的方法和装置。 首先，确定探头的温度和半导体样品的温度。 然后，经由探针的尖端获得半导体样品表面上的位置处的电压。 随后通过组合获得的电压和探针尖端和半导体样品之间的温度差来确定半导体样品表面位置处的掺杂剂浓度。 可以重复上述步骤以便产生半导体的掺杂剂分布。

    Drug Delivery System, its Preparation Process and Use
    6.
    发明申请
    Drug Delivery System, its Preparation Process and Use 审中-公开
    药物输送系统，其制备过程和使用

    公开(公告)号：US20110064794A1

    公开(公告)日：2011-03-17

    申请号：US12863130

    申请日：2009-01-16

    申请人： Yihui Deng ,  Xiaohui Dong ,  Li Shi ,  Yi Lu

    发明人： Yihui Deng ,  Xiaohui Dong ,  Li Shi ,  Yi Lu

    IPC分类号： A61K9/127 ,  A61K9/10 ,  A61K47/42 ,  B82Y5/00

    CPC分类号： A61K9/19 ,  A61K9/1075 ,  A61K47/42 ,  A61K47/44

    摘要： A protein-phospholipid dispersion preparation in a drug delivery system is provided, in which the weight ratio of protein to phospholipid is 1:300-300:1 and the particle size is between 5 nm and 1000 nm. The preparation process of the said preparation contains the mixture of protein phase and phospholipid phase and the homogenization process. The said drug delivery system can be used in many different pharmaceutical agents.

    摘要翻译： 提供了药物递送系统中的蛋白质 - 磷脂分散体制剂，其中蛋白质与磷脂的重量比为1:300〜300:1，粒径为5nm〜1000nm。 所述制剂的制备过程包含蛋白质相和磷脂相的混合物和均化过程。 所述药物递送系统可用于许多不同的药剂。

    Papillomavirus vaccine compositions
    8.
    发明授权
    Papillomavirus vaccine compositions 有权
    乳头瘤病毒疫苗组合物

    公开(公告)号：US07709010B2

    公开(公告)日：2010-05-04

    申请号：US12074783

    申请日：2008-03-06

    申请人： Janine T. Bryan ,  Michelle K. Brownlow ,  Li Shi ,  Danilo Casimiro ,  William L. McClements ,  Brian K. Meyer ,  Binghua Hu

    发明人： Janine T. Bryan ,  Michelle K. Brownlow ,  Li Shi ,  Danilo Casimiro ,  William L. McClements ,  Brian K. Meyer ,  Binghua Hu

    IPC分类号： A61K45/00

    CPC分类号： A61K39/12 ,  A61K2039/5258 ,  A61K2039/55505 ,  A61K2039/55577 ,  A61K2039/70 ,  C12N7/00 ,  C12N2710/20023 ,  C12N2710/20034

    摘要： The present invention relates to pharmaceutical compositions comprising virus-like particles (VLPs) of HPV, said VLPs adsorbed to an aluminum adjuvant, and an ISCOM-type adjuvant comprising a saponin, cholesterol, and a phospholipid. In preferred embodiments, the aluminum adjuvant comprises amorphous aluminum hydroxyphosphate sulfate. Another aspect of the invention provides multi-dose HPV vaccine formulations comprising HPV VLPs and an antimicrobial preservative selected from the group consisting of: m-cresol, phenol and benzyl alcohol. Also provided are methods of using the disclosed pharmaceutical compositions and formulations to induce an immune response against HPV in a human patient and to prevent HPV infection.

    摘要翻译： 本发明涉及包含HPV病毒样颗粒（VLP），所述VLP吸附于铝佐剂的IS​​MA型佐剂和包含皂角苷，胆固醇和磷脂的ISCOM型佐剂的药物组合物。 在优选的实施方案中，铝佐剂包括无定形的羟基磷酸氢铝硫酸盐。 本发明的另一方面提供了包含HPV VLP和选自间甲酚，苯酚和苄醇的抗微生物防腐剂的多剂量HPV疫苗制剂。 还提供了使用所公开的药物组合物和制剂在人类患者中诱导针对HPV的免疫应答并防止HPV感染的方法。

    Methods for fabricating nano and microparticles for drug delivery
    9.
    发明申请
    Methods for fabricating nano and microparticles for drug delivery 有权
    用于制备用于药物递送的纳米和微粒的方法

    公开(公告)号：US20070031505A1

    公开(公告)日：2007-02-08

    申请号：US11418885

    申请日：2006-05-05

    申请人： Krishnendu Roy ,  Li Shi ,  Luz Glangchai

    发明人： Krishnendu Roy ,  Li Shi ,  Luz Glangchai

    IPC分类号： A61K9/50 ,  A61K9/16

    CPC分类号： A61K9/5146 ,  A61K41/0042 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y30/00 ,  B82Y40/00 ,  G03F7/0002

    摘要： The present invention generally relates to stimuli-responsive drug carriers and methods for making. More specifically, the present invention relates to stimuli-responsive lidded particles that respond to a physiological stimulus and dissolve at a target site inside the body thereby releasing therapeutic agents. The present invention further relates to solid, drug-loaded particles that are made from biodegradable polymers. The present invention further relates to methods for fabricating lidded particles and particles for drug delivery.

    摘要翻译： 本发明一般涉及刺激响应性药物载体和制备方法。 更具体地，本发明涉及响应于生理刺激并溶解在体内目标部位的刺激响应的带盖的颗粒，从而释放治疗剂。 本发明还涉及由可生物降解的聚合物制成的固体，药物负载的颗粒。 本发明还涉及用于制造用于药物递送的带盖颗粒和颗粒的方法。

    Circuitry having exclusive-OR and latch function, and method therefor
    10.
    发明授权
    Circuitry having exclusive-OR and latch function, and method therefor 失效
    具有异或和锁存功能的电路及其方法

    公开(公告)号：US06724221B2

    公开(公告)日：2004-04-20

    申请号：US10112513

    申请日：2002-03-28

    申请人： Juan-Antonio Carballo ,  David William Boerstler ,  Jeffrey L. Burns ,  Kevin John Nowka ,  Li Shi

    发明人： Juan-Antonio Carballo ,  David William Boerstler ,  Jeffrey L. Burns ,  Kevin John Nowka ,  Li Shi

    IPC分类号： H03K1921

    CPC分类号： H03K19/215

    摘要： In one form of the invention, circuitry having exclusive-OR and latch functionality includes timing circuitry and logic circuitry. The circuitry includes a memory, with first and second memory nodes, for storing a state and its complement, and first and second timing circuitry portions, each operable to receive at least one timing signal, coupled to the respective memory nodes. The logic circuitry includes first and second logic circuitry portions, each of which is operable to receive at least first and second data signals. Each of the logic circuitry portions is coupled in series with a conditionally conductive path of one of the respective first and second timing circuitry portions.

    摘要翻译： 在本发明的一种形式中，具有异或和锁存功能的电路包括定时电路和逻辑电路。 电路包括具有用于存储状态及其补码的第一和第二存储器节点的存储器，以及第一和第二定时电路部分，每个定时电路部分可操作以接收耦合到相应存储器节点的至少一个定时信号。 逻辑电路包括第一和第二逻辑电路部分，每个逻辑电路部分可操作以接收至少第一和第二数据信号。 每个逻辑电路部分与相应的第一和第二定时电路部分之一的条件导电路径串联耦合。