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公开(公告)号：US09592285B2
公开(公告)日：2017-03-14
申请号：US12269824
申请日：2008-11-12
IPC分类号： A61K39/12 , A61K9/00 , A61K38/20 , C07K14/005 , A61K47/34 , A61K39/145 , A61K39/00
CPC分类号： A61K39/145 , A61K9/0019 , A61K38/208 , A61K38/2086 , A61K39/12 , A61K47/34 , A61K2039/53 , A61K2039/54 , A61K2039/58 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2760/16034 , C12N2760/16122 , C12N2760/16134 , A61K2300/00
摘要： An aspect of the present invention is directed towards DNA plasmid vaccines capable of generating in a mammal an immune response against a plurality of influenza virus subtypes, comprising a DNA plasmid and a pharmaceutically acceptable excipient. The DNA plasmid is capable of expressing a consensus influenza antigen in a cell of the mammal in a quantity effective to elicit an immune response in the mammal, wherein the consensus influenza antigen comprises consensus hemagglutinin (HA), neuraminidase (NA), matrix protein, nucleoprotein, M2 ectodomain-nucleo-protein (M2e-NP), or a combination thereof. Preferably the consensus influenza antigen comprises HA, NA, M2e-NP, or a combination thereof. The DNA plasmid comprises a promoter operably linked to a coding sequence that encodes the consensus influenza antigen. Additionally, an aspect of the present invention includes methods of eliciting an immune response against a plurality of influenza virus subtypes in a mammal using the DNA plasmid vaccines provided.
摘要翻译： 本发明的一个方面涉及能够在哺乳动物中产生针对多种流感病毒亚型的免疫应答的DNA质粒疫苗，其包含DNA质粒和药学上可接受的赋形剂。 DNA质粒能够以有效引发哺乳动物免疫应答的量在哺乳动物细胞中表达共有流感抗原，其中共有流感抗原包含共有血凝素（HA），神经氨酸酶（NA），基质蛋白， 核蛋白，M2胞外结构域 - 核蛋白（M2e-NP）或其组合。 优选地，共有流感抗原包含HA，NA，M2e-NP或其组合。 DNA质粒包含与编码共有流感抗原的编码序列可操作地连接的启动子。 此外，本发明的一个方面包括使用提供的DNA质粒疫苗在哺乳动物中引发针对多种流感病毒亚型的免疫应答的方法。
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公开(公告)号：US20130004529A1
公开(公告)日：2013-01-03
申请号：US13458013
申请日：2012-04-27
申请人： David B. Weiner , Jian Yan , Dominick Laddy
发明人： David B. Weiner , Jian Yan , Dominick Laddy
IPC分类号： A61K39/00 , C07K14/155 , A61P37/04 , A61P31/18 , A61P31/20 , A61P31/14 , A61P31/16 , A61K39/21 , C07K2/00 , C07K14/025 , C07K14/08 , C12N9/12 , C07K14/11 , A61K39/29 , A61K39/145 , A61K39/12 , C12N15/54 , C12N15/37 , C12N15/44 , C12N15/40 , C12N15/63 , C12N7/04 , C12N5/09 , A61P35/00 , C12N15/49
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K39/0011 , A61K39/12 , A61K39/21 , A61K2039/523 , A61K2039/53 , A61K2039/54 , A61K2039/55538 , A61K2039/585 , C12N7/00 , C12N2710/20034 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2740/16322 , C12N2740/16334 , C12N2760/16134 , C12N2770/24234
摘要： Improved anti-HIV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus sequences for HIV Subtype A Envelope protein, those having consensus sequences for HIV Subtype B Envelope protein, those having consensus sequences for HIV Subtype C Envelope protein, those having consensus sequences for HIV Subtype D Envelope protein, those having consensus sequences for HIV Subtype B consensus Nef-Rev protein, and those having consensus sequences form HIV Gag protein subtypes A, B, C and D. Improved anti-HPV immunogens and nucleic acid molecules that encode them; improved anti-HCV immunogens and nucleic acid molecules that encode them; improved hTERT immunogens and nucleic acid molecules that encode them; and improved anti-Influenza immunogens and nucleic acid molecules that encode them are disclosed as well methods of inducing an immune response in an individual against HIV, HPV, HCV, hTERT and Influenza are disclosed.
摘要翻译： 公开了改进的抗HIV免疫原和编码它们的核酸分子。 所公开的免疫原包括具有HIV亚型A包膜蛋白的共有序列的那些，对于HIV亚型B包膜蛋白具有共有序列的那些，对于HIV亚型C包膜蛋白具有共有序列的那些，对于HIV亚型D包膜蛋白具有共有序列的那些 HIV亚型B共有序列Nef-Rev蛋白和具有共有序列的序列形成HIV Gag蛋白亚型A，B，C和D.改进的抗HPV免疫原和编码它们的核酸分子; 改进的抗HCV免疫原和编码它们的核酸分子; 改进的hTERT免疫原和编码它们的核酸分子; 公开了改进的抗流感免疫原和编码它们的核酸分子，以及在个体中针对HIV，HPV，HCV，hTERT和流感诱导免疫应答的方法。
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公开(公告)号：US20110305664A1
公开(公告)日：2011-12-15
申请号：US13158150
申请日：2011-06-10
IPC分类号： A61K39/145 , A61K38/20 , A61P31/16 , A61P37/04 , A61P31/12 , A61K39/395 , C12N15/63
CPC分类号： A61K39/145 , A61K9/0019 , A61K38/208 , A61K38/2086 , A61K39/12 , A61K47/34 , A61K2039/53 , A61K2039/54 , A61K2039/58 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2760/16034 , C12N2760/16122 , C12N2760/16134 , A61K2300/00
摘要： An aspect of the present invention is directed towards DNA plasmid vaccines capable of generating in a mammal an immune response against a plurality of influenza virus subtypes, comprising a DNA plasmid and a pharmaceutically acceptable excipient. The DNA plasmid is capable of expressing a consensus influenza antigen in a cell of the mammal in a quantity effective to elicit an immune response in the mammal, wherein the consensus influenza antigen comprises consensus hemagglutinin (HA), neuraminidase (NA), matrix protein, nucleoprotein, M2 ectodomain-nucleo-protein (M2e-NP), or a combination thereof. Preferably the consensus influenza antigen comprises HA, NA, M2e-NP, or a combination thereof. The DNA plasmid comprises a promoter operably linked to a coding sequence that encodes the consensus influenza antigen. Additionally, an aspect of the present invention includes methods of eliciting an immune response against a plurality of influenza virus subtypes in a mammal using the DNA plasmid vaccines provided.
摘要翻译： 本发明的一个方面涉及能够在哺乳动物中产生针对多种流感病毒亚型的免疫应答的DNA质粒疫苗，其包含DNA质粒和药学上可接受的赋形剂。 DNA质粒能够以有效引发哺乳动物免疫应答的量在哺乳动物细胞中表达共有流感抗原，其中共有流感抗原包含共有血凝素（HA），神经氨酸酶（NA），基质蛋白， 核蛋白，M2胞外域 - 核蛋白（M2e-NP）或其组合。 优选地，共有流感抗原包含HA，NA，M2e-NP或其组合。 DNA质粒包含与编码共有流感抗原的编码序列可操作地连接的启动子。 此外，本发明的一个方面包括使用提供的DNA质粒疫苗在哺乳动物中引发针对多种流感病毒亚型的免疫应答的方法。
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公开(公告)号：US08697084B2
公开(公告)日：2014-04-15
申请号：US13458013
申请日：2012-04-27
申请人： David B Weiner , Jian Yan , Dominick Laddy
发明人： David B Weiner , Jian Yan , Dominick Laddy
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K39/0011 , A61K39/12 , A61K39/21 , A61K2039/523 , A61K2039/53 , A61K2039/54 , A61K2039/55538 , A61K2039/585 , C12N7/00 , C12N2710/20034 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2740/16322 , C12N2740/16334 , C12N2760/16134 , C12N2770/24234
摘要： Improved anti-HIV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus sequences for HIV Subtype A Envelope protein, those having consensus sequences for HIV Subtype B Envelope protein, those having consensus sequences for HIV Subtype C Envelope protein, those having consensus sequences for HIV Subtype D Envelope protein, those having consensus sequences for HIV Subtype B consensus Nef-Rev protein, and those having consensus sequences form HIV Gag protein subtypes A, B, C and D. Improved anti-HPV immunogens and nucleic acid molecules that encode them; improved anti-HCV immunogens and nucleic acid molecules that encode them; improved hTERT immunogens and nucleic acid molecules that encode them; and improved anti-Influenza immunogens and nucleic acid molecules that encode them are disclosed as well methods of inducing an immune response in an individual against HIV, HPV, HCV, hTERT and Influenza are disclosed.
摘要翻译： 公开了改进的抗HIV免疫原和编码它们的核酸分子。 所公开的免疫原包括具有HIV亚型A包膜蛋白的共有序列的那些，对于HIV亚型B包膜蛋白具有共有序列的那些，对于HIV亚型C包膜蛋白具有共有序列的那些，对于HIV亚型D包膜蛋白具有共有序列的那些 HIV亚型B共有序列Nef-Rev蛋白和具有共有序列的序列形成HIV Gag蛋白亚型A，B，C和D.改进的抗HPV免疫原和编码它们的核酸分子; 改进的抗HCV免疫原和编码它们的核酸分子; 改进的hTERT免疫原和编码它们的核酸分子; 公开了改进的抗流感免疫原和编码它们的核酸分子，以及在个体中针对HIV，HPV，HCV，hTERT和流感诱导免疫应答的方法。
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公开(公告)号：US20100166787A1
公开(公告)日：2010-07-01
申请号：US12375518
申请日：2007-07-30
申请人： David B Weiner , Jian Yan , Dominick Laddy
发明人： David B Weiner , Jian Yan , Dominick Laddy
IPC分类号： A61K39/275 , C07H21/02 , A61K31/713 , A61K39/00 , C12N7/01 , C07K14/00 , A61K38/16 , A61P31/18 , A61P37/04 , C07H21/04
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K39/0011 , A61K39/12 , A61K39/21 , A61K2039/523 , A61K2039/53 , A61K2039/54 , A61K2039/55538 , A61K2039/585 , C12N7/00 , C12N2710/20034 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2740/16322 , C12N2740/16334 , C12N2760/16134 , C12N2770/24234
摘要： Improved anti-HIV immunogens and nucleic acid molecules that encode them are disclosed, Immunogens disclosed include those having consensus sequences for HIV Subtype A Envelope protein, those having consensus sequences for HIV Subtype B Envelope protein, those having consensus sequences for HIV Subtype C Envelope protein, those having consensus sequences for HIV Subtype D Envelope protein, those having consensus sequences for HIV Subtype B consensus Nef-Rev protein, and those having consensus sequences form HIV Gag protein subtypes A, B, C and D. Improved anti-HPV immunogens and nucleic acid molecules that encode them; improved anti-HCV immunogens and nucleic acid molecules that encode them; improved hTERT immunogens and nucleic acid molecules that encode them; and improved anti-Influenza immunogens and nucleic acid molecules that encode them are disclosed. Pharmaceutical composition, recombinant vaccines comprising and live attenuated pathogens are disclosed as well methods of inducing an immune response in an individual against HIV, HPV, HCV, hTERT and Influenza are disclosed.
摘要翻译： 公开了改进的抗HIV免疫原和编码它们的核酸分子，所公开的免疫原包括具有HIV亚型A包膜蛋白共有序列的那些，具有HIV亚型B包膜蛋白的共有序列的那些，具有HIV亚型C包膜蛋白的共有序列的那些 具有HIV亚型D包膜蛋白共有序列的那些，具有HIV亚型共有序列Nef-Rev蛋白的共有序列的那些，以及具有共有序列的那些序列形成HIV Gag蛋白亚型A，B，C和D.改进的抗HPV免疫原和 编码它们的核酸分子; 改进的抗HCV免疫原和编码它们的核酸分子; 改进的hTERT免疫原和编码它们的核酸分子; 并且公开了改进的抗流感免疫原和编码它们的核酸分子。 公开了药物组合物，包含和减毒病原体的重组疫苗，以及诱导个体对HIV，HPV，HCV，hTERT和流感的免疫应答的方法。
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公开(公告)号：US20090169505A1
公开(公告)日：2009-07-02
申请号：US12269824
申请日：2008-11-12
IPC分类号： A61K38/20 , A61K39/145 , C12N15/00
CPC分类号： A61K39/145 , A61K9/0019 , A61K38/208 , A61K38/2086 , A61K39/12 , A61K47/34 , A61K2039/53 , A61K2039/54 , A61K2039/58 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2760/16034 , C12N2760/16122 , C12N2760/16134 , A61K2300/00
摘要： An aspect of the present invention is directed towards DNA plasmid vaccines capable of generating in a mammal an immune response against a plurality of influenza virus subtypes, comprising a DNA plasmid and a pharmaceutically acceptable excipient. The DNA plasmid is capable of expressing a consensus influenza antigen in a cell of the mammal in a quantity effective to elicit an immune response in the mammal, wherein the consensus influenza antigen comprises consensus hemagglutinin (HA), neuraminidase (NA), matrix protein, nucleoprotein, M2 ectodomain-nucleo-protein (M2e-NP), or a combination thereof. Preferably the consensus influenza antigen comprises HA, NA, M2e-NP, or a combination thereof. The DNA plasmid comprises a promoter operably linked to a coding sequence that encodes the consensus influenza antigen. Additionally, an aspect of the present invention includes methods of eliciting an immune response against a plurality of influenza virus subtypes in a mammal using the DNA plasmid vaccines provided.
摘要翻译： 本发明的一个方面涉及能够在哺乳动物中产生针对多种流感病毒亚型的免疫应答的DNA质粒疫苗，其包含DNA质粒和药学上可接受的赋形剂。 DNA质粒能够以有效引发哺乳动物免疫应答的量在哺乳动物细胞中表达共有流感抗原，其中共有流感抗原包含共有血凝素（HA），神经氨酸酶（NA），基质蛋白， 核蛋白，M2胞外结构域 - 核蛋白（M2e-NP）或其组合。 优选地，共有流感抗原包含HA，NA，M2e-NP或其组合。 DNA质粒包含与编码共有流感抗原的编码序列可操作地连接的启动子。 此外，本发明的一个方面包括使用提供的DNA质粒疫苗在哺乳动物中引发针对多种流感病毒亚型的免疫应答的方法。
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公开(公告)号：US11419925B2
公开(公告)日：2022-08-23
申请号：US14775047
申请日：2014-03-14
申请人： David B. Weiner , Jian Yan , Karuppiah Muthumani , Jewell Walters
发明人： David B. Weiner , Jian Yan , Karuppiah Muthumani , Jewell Walters
IPC分类号： A61K39/00 , A61K39/395 , C12N9/02
摘要： Disclosed herein are compositions and methods for treating cancer and in particular vaccines that treat and provide protection against tumor growth.
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公开(公告)号：US10398769B2
公开(公告)日：2019-09-03
申请号：US14910136
申请日：2014-08-04
申请人： The Trustees of the University of Pennsylvania , Inovio Pharmaceuticals, Inc. , David B. Weiner , Jian Yan
发明人： David B. Weiner , Jian Yan
IPC分类号： A61K39/145 , A61K39/12 , C12N7/00 , C07K14/005 , A61K39/00
摘要： Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of HA Influenza A of serotype H7N9 alone and in combination with HA hemagglutinin and/or influenza B hemagglutinin, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an immune response against one or more influenza A serotypes and/or influenza B serotypes, or combinations thereof, using the vaccines that are provided.
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9.发明申请CONSENSUS ANTIGEN CONSTRUCTS AND VACCINES MADE THEREFROM, AND METHODS OF USING THE SAME TO TREAT MALARIA 审中-公开共同抗原构建物及其制备方法及其使用方法治疗疟疾公开(公告)号：US20130273112A1
公开(公告)日：2013-10-17
申请号：US13876148
申请日：2011-09-27
IPC分类号： A61K39/015 , A61K38/20
摘要： Provided herein is consensus amino acid sequences of P. falciparum (P.f.) proteins and their encoding sequences, as well as expression constructs expressing the sequences. Also provided herein are methods for generating an immune response against P. falciparum using the expression constructs provided herein.
摘要翻译： 本文提供恶性疟原虫（P.f.）蛋白及其编码序列的共有氨基酸序列以及表达序列的表达构建体。 本文还提供了使用本文提供的表达构建体来产生针对恶性疟原虫的免疫应答的方法。
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公开(公告)号：US08298820B2
公开(公告)日：2012-10-30
申请号：US12694238
申请日：2010-01-26
申请人： David B Weiner , Jian Yan , Matthew P Morrow
发明人： David B Weiner , Jian Yan , Matthew P Morrow
IPC分类号： C12N15/00 , A61K39/145 , C12P21/06 , C07H21/02
CPC分类号： A61K39/145 , A61K31/7088 , A61K39/12 , A61K45/06 , A61K2039/53 , A61K2039/54 , C12N2760/16134
摘要： Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of HA hemagglutinin, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an immune response against one or more Influenza A serotypes using the vaccines that are provided.
摘要翻译： 本文提供了编码HA血凝素的新的共有氨基酸序列以及表达序列的遗传构建体/载体和疫苗的核酸序列。 本文还提供了使用所提供的疫苗产生针对一种或多种流感A血清型的免疫应答的方法。
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