摘要:
Described are the crystal structure of the α-helical domain of the gp41 component of HIV-1 envelope glycoprotein which represents the core of fusion-active gp41, methods of identifying and designing drugs which inhibit gp41 function and drugs which do so.
摘要:
Five-Helix protein, which comprises the three N-helices and at least two, but not three, of the three C-helices of the trimer-of-hairpin structure of HIV gp41, separated by linkers, such as amino acid residue linkers, is disclosed. Six-Helix protein, which includes the three N-helices and the three C-helices of the trimer-of-hairpin structure of HIV gp41, separated by linkers, is also disclosed.
摘要:
Inhibitors of HIV membrane fusion and a method of identifying drugs or agents which inhibit binding of the N-helix coiled-coil and the C helix of HIV gp41 envelope protein.
摘要:
Herein is provided an anastomosis device which includes a cylindrical support housing having a tapered section being formed of a plurality of compliant fingers integrally formed around the circumference of an end of the cylindrical section which can flex at their connection point to the cylindrical section. Each compliant finger holds a suture needle. The device includes a push rod having a cam head at one end of the rod section. The cam head is located adjacent to the tapered portion. In operation the anastomosis device is aligned with the anatomical tubular structure undergoing an anastomosis process. When a back end of the push rod is pushed towards the tapered section of the support housing, the cam head section bears against an inner surface causing each compliant finger to flex radially outwards forcing the suture needles to simultaneously pierce the wall of the anatomical tubular structure.
摘要:
A folding endoscope with incorporated optical sensors and light sources includes a housing having first and second ends and a longitudinal axis and at least one channel extending between the first and second ends and associated ports at the first and second ends for inserting surgical instruments through the housing into a surgical site. The endoscope includes at least two elongate arms having proximal and distal ends and being pivotally connected at the distal ends thereof to the first end of the housing. A camera and light source are mounted on each of the elongate arms such that when the elongate arms are deployed the cameras have a field of view in a generally forward direction away from the housing. A linkage mechanism is connected to the elongate arms, and an actuator is connected to the linkage mechanism. The linkage mechanism, upon activation by the actuator, is configured to pivotally deploy the at least two elongate arms from a closed position in which the elongate arms are aligned along the longitudinal axis to an open position with the distal ends of the elongate arms radially spaced from the longitudinal axis.
摘要:
A game to be modified in accordance with the invention involves a first random outcome and a second random outcome that are combined according to game rules to produce a game outcome. The game is administered by receiving a player request for a specific entry, the specific entry replacing one of the random outcomes and being selected from a finite set of possibilities not determined by chance. The requested specific entry affects the probable outcome of the game. The specific entry is combined with the remaining one of the random outcomes according to the game rules to determine the game outcome. According to one embodiment, the specific entry may be a score such as 18 which replaces the player's hand in the game of blackjack.
摘要:
A game to be modified in accordance with the invention involves a first random outcome and a second random outcome that are combined according to game rules to produce a game outcome. The game is administered by receiving a player request for a specific entry, the specific entry replacing one of the random outcomes and being selected from a finite set of possibilities not determined by chance. The requested specific entry affects the probable outcome of the game. The specific entry is combined with the remaining one of the random outcomes according to the game rules to determine the game outcome. According to one embodiment, the specific entry may be a score such as 18 which replaces the player's hand in the game of blackjack.
摘要:
A method and apparatus of playing a game provides a player with at least one option for playing at least one round of the game in accordance with at least one advantage and/or disadvantage. For example, a player may agree to play a current round of play and/or at least one future round of play in accordance with a revised rule.