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公开(公告)号：US08895920B2
公开(公告)日：2014-11-25
申请号：US13702931
申请日：2011-06-07
申请人： Jeffery Mark Brown , Anthony James Gilbert , John Brian Hoyes , David J. Langridge , Jason Lee Wildgoose
发明人： Jeffery Mark Brown , Anthony James Gilbert , John Brian Hoyes , David J. Langridge , Jason Lee Wildgoose
CPC分类号： H01J49/401 , H01J49/0031 , H01J49/0095 , H01J49/062 , H01J49/067 , H01J49/405
摘要： A mass spectrometer is disclosed comprising a RF confinement device, a beam expander and a Time of Flight mass analyzer. The beam expander is arranged to expand an ion beam emerging from the RF confinement device so that the ion beam is expanded to a diameter of at least 3 mm in the orthogonal acceleration extraction region of the Time of Flight mass analyzer.
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公开(公告)号：US09214328B2
公开(公告)日：2015-12-15
申请号：US13996893
申请日：2011-12-22
IPC分类号： H01J49/40
CPC分类号： H01J49/403 , H01J49/0027 , H01J49/401
摘要： A Time of Flight mass spectrometer is disclosed wherein a fifth order spatial focusing device is provided. The device which may comprise an additional stage in the source region of the Time of Flight mass analyzer is arranged to introduce a non-zero fifth order spatial focusing term so that the combined effect of first, third and fifth order spatial focusing terms results in a reduction in the spread of ion arrival times ΔT of ions arriving at the ion detector.
摘要翻译： 公开了一种提供五阶空间聚焦装置的飞行时间质谱仪。 可以在飞行时间质量分析器的源区域中包括附加级的装置被布置成引入非零五阶空间聚焦项，使得第一，第三和第五阶空间聚焦项的组合效应导致 减少到达离子检测器的离子到达时间和离子浓度Dgr。
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3.发明授权Electrostatic gimbal for correction of errors in time of flight mass spectrometers 有权用于校正飞行时间质谱仪误差的静电万向架公开(公告)号：US08921775B2
公开(公告)日：2014-12-30
申请号：US14004946
申请日：2012-03-13
CPC分类号： H01J49/403 , H01J49/40
摘要： A Time of Flight mass analyser is disclosed comprising one or more devices arranged and adapted to correct for tilt in an isochronous plane of ions and to adjust the isochronous plane of the ions so as to be parallel with the plane of detection in an ion detector.
摘要翻译： 公开了一种飞行时间质量分析器，其包括一个或多个设备，其被配置并适于校正离子的等时平面中的倾斜，并且在离子检测器中调整离子的等时平面以与检测平面平行。
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公开(公告)号：US20140014830A1
公开(公告)日：2014-01-16
申请号：US13996893
申请日：2011-12-22
IPC分类号： H01J49/40
CPC分类号： H01J49/403 , H01J49/0027 , H01J49/401
摘要： A Time of Flight mass spectrometer is disclosed wherein a fifth order spatial focusing device is provided. The device which may comprise an additional stage in the source region of the Time of Flight mass analyser is arranged to introduce a non-zero fifth order spatial focusing term so that the combined effect of first, third and fifth order spatial focusing terms results in a reduction in the spread of ion arrival times ΔT of ions arriving at the ion detector.
摘要翻译： 公开了一种提供五阶空间聚焦装置的飞行时间质谱仪。 可以在飞行时间质量分析器的源区域中包括附加级的装置被布置成引入非零五阶空间聚焦项，使得第一，第三和第五阶空间聚焦项的组合效应导致 降低到达离子检测器的离子到达时间ΔT的离子扩散。
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公开(公告)号：US20130256524A1
公开(公告)日：2013-10-03
申请号：US13702931
申请日：2011-06-07
申请人： Jeffery Mark Brown , Anthony James Gilbert , John Brian Hoyes , David J. Langridge , Jason Lee Wildgoose
发明人： Jeffery Mark Brown , Anthony James Gilbert , John Brian Hoyes , David J. Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/40
CPC分类号： H01J49/401 , H01J49/0031 , H01J49/0095 , H01J49/062 , H01J49/067 , H01J49/405
摘要： A mass spectrometer is disclosed comprising a RF confinement device, a beam expander and a Time of Flight mass analyser. The beam expander is arranged to expand an ion beam emerging from the RF confinement device so that the ion beam is expanded to a diameter of at least 3 mm in the orthogonal acceleration extraction region of the Time of Flight mass analyser.
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公开(公告)号：US06992283B2
公开(公告)日：2006-01-31
申请号：US10739041
申请日：2003-12-19
IPC分类号： H01J49/00
CPC分类号： H01J49/40 , G01N27/622 , H01J49/0036 , H01J49/004
摘要： A mass spectrometer is disclosed wherein ions are passed through an ion mobility separator and are then mass analysed by a Time of Flight mass analyzer. Multiple sets of mass spectral data are obtained which are then post-processed so that mass spectral data relating to ions having undesired charge state(s) is filtered out. The resultant mass spectrum comprises ions having a desired charge state.
摘要翻译： 公开了一种质谱仪，其中离子通过离子迁移率分离器，然后通过飞行时间质量分析仪进行质量分析。 获得多组质谱数据，然后对其进行后处理，从而滤出与具有不期望的电荷状态的离子相关的质谱数据。 所得质谱包括具有所需电荷状态的离子。
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公开(公告)号：US07586088B2
公开(公告)日：2009-09-08
申请号：US10176072
申请日：2002-06-21
IPC分类号： H01J49/26
CPC分类号： H01J49/40 , G01N27/624 , H01J49/004 , H01J49/4215
摘要： A mass spectrometer is disclosed comprising an ion mobility spectrometer in combination with a quadrupole mass filter which is scanned in synchronization with the pulsing of ions into the ion mobility spectrometer thereby enabling ions having a particular charge state to be preferentially transmitted. Another embodiment replaces the quadrupole mass filter with an axial time of flight mass filter and an injection electrode.
摘要翻译： 公开了一种质谱仪，其包括与四极质量过滤器组合的离子迁移谱仪，其与离子脉冲离子扫描到离子迁移谱仪中，从而使具有特定电荷状态的离子能够被优先传输。 另一实施例用轴向飞行时间质量过滤器和注入电极取代四极质量过滤器。
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公开(公告)号：US06838662B2
公开(公告)日：2005-01-04
申请号：US10693874
申请日：2003-10-28
CPC分类号： H01J49/4235
摘要： A mass spectrometer is disclosed comprising a mass filter for separating ions according to their mass to charge ratio. The mass filter comprises a plurality of electrodes wherein ions are radially confined within the mass filter by the application of AC or RF voltages to the electrodes. One or more transient DC voltages or one or more transient DC voltage waveforms are progressively applied to the electrodes so that ions having a certain mass to charge ratio are separated from other ions having different mass to charge ratios which remain radially confined within the mass filter.
摘要翻译： 公开了一种质谱仪，其包括用于根据其质荷比分离离子的质量过滤器。 质量过滤器包括多个电极，其中通过向电极施加AC或RF电压，离子径向地限制在质量过滤器内。 一个或多个瞬态直流电压或一个或多个瞬态直流电压波形逐渐地施加到电极，使得具有一定质荷比的离子与具有不同质量与电荷比的其它离子分离，这些离子保持径向地限制在质量过滤器内。
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公开(公告)号：US06791078B2
公开(公告)日：2004-09-14
申请号：US10603824
申请日：2003-06-26
IPC分类号： H01J4940
CPC分类号： G01N27/622
摘要： A mass spectrometer comprising an ion mobility separator for separating ions according to their ion mobility is disclosed. The ion mobility separator comprises a plurality of electrodes and one or more transient DC voltages or one or more transient DC voltage waveforms are progressively applied to the electrodes so that ions having a certain ion mobility are separated from other ions having different ion mobilities.
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公开(公告)号：US07635841B2
公开(公告)日：2009-12-22
申请号：US10498046
申请日：2002-12-12
IPC分类号： H01J49/00
CPC分类号： H01J49/062 , Y10T436/24
摘要： A method of mass spectrometry is disclosed wherein ions are trapped for a period of time T within an AC or RF ion guide maintained at a pressure P wherein the product P×T is at least 1 mbar-ms. The effect of trapping the ions according to a preferred embodiment is that singly charged ions which may, for example, comprise unwanted background ions are substantially lost from the trap whereas multiply charged analyte ions are maintained within the ion trap and can then be released for subsequent mass analysis.
摘要翻译： 公开了一种质谱法，其中在产品PxT至少为1毫巴的压力下，在保持在压力P的AC或RF离子导向器内捕获离子一段时间T。 捕获根据优选实施方案的离子的效果是，可以例如包含不想要的背景离子的单电荷离子从捕获阱基本上丢失，而多电荷分析物离子保持在离子阱内，然后可以释放以用于随后的 质量分析。
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