公开(公告)号：US20060159696A1

公开(公告)日：2006-07-20

申请号：US11314397

申请日：2005-12-21

申请人： David Junker ,  Mark Cochran ,  Mark Smith ,  Kenneth Palmer ,  Gregory Pogue

发明人： David Junker ,  Mark Cochran ,  Mark Smith ,  Kenneth Palmer ,  Gregory Pogue

IPC分类号： A61K39/12 ,  C12N15/82 ,  C07K14/005

CPC分类号： C07K14/005 ,  A61K2039/5256 ,  C07K14/475 ,  C07K2319/00 ,  C12N15/8258 ,  C12N2770/00022 ,  C12N2770/00043

摘要： The invention provides a fusion protein comprising a plant virus coat protein and a GDF8 peptide domain, or antigenic fragment of the GDF8 peptide domain. Plant virus vectors expressing the fusion protein and methods of using these vectors are also provided.

摘要翻译： 本发明提供了包含植物病毒外壳蛋白和GDF8肽结构域或GDF8肽结构域的抗原性片段的融合蛋白。 还提供了表达融合蛋白的植物病毒载体和使用这些载体的方法。

公开(公告)号：US20060188991A1

公开(公告)日：2006-08-24

申请号：US11410572

申请日：2006-04-24

申请人： Alison McCormick ,  Mark Smith ,  Kenneth Palmer ,  John Lindbo ,  Long Nguyen ,  Gregory Pogue

发明人： Alison McCormick ,  Mark Smith ,  Kenneth Palmer ,  John Lindbo ,  Long Nguyen ,  Gregory Pogue

IPC分类号： C12N15/86 ,  C12N7/00 ,  A01H1/00

CPC分类号： C07K14/005 ,  A61K39/0011 ,  A61K39/12 ,  A61K39/385 ,  A61K2039/5258 ,  A61K2039/55516 ,  A61K2039/6075 ,  A61K2039/627 ,  A61K2039/64 ,  C07K14/4748 ,  C07K2319/00 ,  C12N7/00 ,  C12N2710/20022 ,  C12N2710/20034 ,  C12N2760/16122 ,  C12N2760/18022 ,  C12N2770/00022 ,  C12N2770/00023

摘要： Herein-described are various methods for making a vaccine that are made of re-assembled virus like particles (VLP). First, the VLPs are disassembled into encapsidation intermediate populations. Each encapsidation intermediate population undergoes, for instance, chemical conjugation of unique peptide or nucleic moieties to form separate populations. Thereafter, a predetermined amount of each of the several (one or more) different encapsidation intermediates from the different populations is mixed and joined, forming intact VLPs, surrounding a nucleic acid core, that are composed of different encapsidation intermediate such that the reassembled VLP displays more than one peptide or nucleic acid. The nucleic acid can function either as a scaffold alone or can be engineered for the expression of an immunomodulatory protein in a eukaryotic cell.

摘要翻译： 本文描述了制备由重组病毒颗粒（VLP）制成的疫苗的各种方法。 首先，将VLP分解成壳化中间种群。 每个壳化中间体经历例如独特的肽或核酸部分的化学共轭以形成分开的群体。 此后，将来自不同群体的几种（一种或多种）不同的壳化中间体中的每一种的预定量混合并连接，形成围绕核酸核心的完整的VLP，其由不同的包封中间体组成，使得重新组装的VLP显示 多于一种肽或核酸。 核酸可以作为单独的支架起作用，或者可以被工程化以在真核细胞中表达免疫调节蛋白。

公开(公告)号：US20060029612A1

公开(公告)日：2006-02-09

申请号：US11107575

申请日：2005-04-15

申请人： Kenneth Palmer ,  Daniel Tuse ,  Stephen Reinl ,  Mark Smith ,  Gregory Pogue

发明人： Kenneth Palmer ,  Daniel Tuse ,  Stephen Reinl ,  Mark Smith ,  Gregory Pogue

IPC分类号： A61K39/12

CPC分类号： C12N15/8258 ,  A61K39/12 ,  A61K2039/5258 ,  C12N2710/20034

摘要： Juvenile-onset recurrent respiratory papillomatosis is treated using active vaccination or passive immune therapy of neutralizing antibodies against HPV L2 neutralizing epitopes.

摘要翻译： 使用针对HPV L2中和表位的中和抗体的主动接种或被动免疫治疗来治疗少年复发性呼吸道乳头状瘤病。

公开(公告)号：US20060134604A1

公开(公告)日：2006-06-22

申请号：US11303548

申请日：2005-12-16

申请人： Mark Smith ,  Kenneth Palmer ,  Gregory Pogue ,  John Lindbo ,  Kathleen Hanley ,  David Mannion ,  Gershon Wolfe

发明人： Mark Smith ,  Kenneth Palmer ,  Gregory Pogue ,  John Lindbo ,  Kathleen Hanley ,  David Mannion ,  Gershon Wolfe

IPC分类号： C12Q1/00 ,  G01N33/50

CPC分类号： C07K5/06165 ,  A61K38/00 ,  B01D15/1885 ,  B01D15/3804 ,  C07K5/06139

摘要： A plurality of proteins of interest, or peptides of interest, or other genetically expressed materials, are screened and subsequently produced using any of a variety of expression systems. The plurality of proteins are extracted from a plurality of separate, processed green juices, each green juice containing one of the proteins of interest. A multi-channel apparatus processes the various green juices, one green juice per channel. The apparatus is computer controlled such that the various valves in each channel and pump are controlled in an automated manner to extract each protein of interest and deliver each protein of interest into its own storage vessel.

公开(公告)号：US20050282263A1

公开(公告)日：2005-12-22

申请号：US11090497

申请日：2005-03-25

申请人： Alison McCormick ,  Mark Smith ,  Kenneth Palmer ,  John Lindbo ,  Long Nguyen ,  Gregory Pogue

发明人： Alison McCormick ,  Mark Smith ,  Kenneth Palmer ,  John Lindbo ,  Long Nguyen ,  Gregory Pogue

IPC分类号： C12N7/00 ,  C12N7/04 ,  C12N15/86

CPC分类号： C12N7/00 ,  A61K2039/5258 ,  C12N2710/20022 ,  C12N2770/00023

摘要： Herein described are various methods for making a vaccine that are made of re-assembled virus like particles (VLP). First, the VLPs are disassembled into coat proteins or encapsidation intermediate populations. Each population undergoes, for instance, chemical conjugation of unique peptide or nucleic moieties to form separate populations. Thereafter, a predetermined amount of each of the several (one or more) different coat proteins or encapsidation intermediates from the different populations is mixed and joined, forming intact VLPs, surrounding a nucleic acid core, that are composed of different coat proteins such that the reassembled VLP displays more than one peptide or other molecule. The nucleic acid can function either as a scaffold alone or can be engineered for the expression of an immunomodulatory protein in a eukaryotic cell.

摘要翻译： 本文描述了制备由重新组装的病毒样颗粒（VLP）制成的疫苗的各种方法。 首先，将VLP分解成外壳蛋白或衣壳化中间种群。 每个群体经历例如独特的肽或核酸部分的化学共轭以形成分开的群体。 此后，将来自不同群体的几种（一种或多种）不同外壳蛋白或壳化中间体中的每一种的预定量混合并连接，形成围绕核酸核心的完整VLP，其由不同的外壳蛋白组成，使得 重组VLP显示多于一个肽或其他分子。 核酸可以作为单独的支架起作用，或者可以被工程化以在真核细胞中表达免疫调节蛋白。

公开(公告)号：US11951746B2

公开(公告)日：2024-04-09

申请号：US17429748

申请日：2020-03-06

申请人： James R. Pryde ,  Mark Smith ,  Robert Hargreaves

发明人： James R. Pryde ,  Mark Smith ,  Robert Hargreaves

IPC分类号： B41J2/175 ,  G03G15/08

CPC分类号： B41J2/17523 ,  G03G15/0877

摘要： A device (1) for controlling user access to at least one container (4) for dispensing printing material housed by a printing apparatus (5), the device (1) comprising an openable and closable barrier (2) corresponding to the container (4) and a lock for locking the barrier (2) in a closed position. The lock is overlapped by at least a portion of the barrier (2) both when the barrier (2) is in the closed position and when the barrier (2) is in an open position.

公开(公告)号：US20170206608A1

公开(公告)日：2017-07-20

申请号：US15403374

申请日：2017-01-11

申请人： Mark Smith

发明人： Mark Smith

IPC分类号： G06Q40/08 ,  G06Q40/00 ,  G06Q40/06

CPC分类号： G06Q40/08 ,  G06Q40/06 ,  G06Q40/10

摘要： A Horizontally-Linked Reinsurance Network (HLRN) formed of a plurality of small insurance companies (as defined by applicable law, e.g. U.S.C. §831(b)) that is established and managed by a network administrator presents a new approach to harnessing the benefits of small insurance companies while mitigating the drawbacks of small insurance companies. This system uses a rules-based approach and algorithm to select, allocate, optimize and manage the individual risk portfolio of independent small insurance companies so as to preserve their status as a small insurance company while diversifying risk. Further, network administrator will perform the management functions if the HLRN. This allows investors or persons who would not otherwise own an insurance company to invest in a new asset class which by its nature demonstrates a non-correlation to traditional investment markets and carries both unique return and tax properties.

公开(公告)号：USD729041S1

公开(公告)日：2015-05-12

申请号：US29433547

申请日：2012-10-01

申请人： Mark Smith

设计人： Mark Smith

公开(公告)号：US20150038409A1

公开(公告)日：2015-02-05

申请号：US14097818

申请日：2013-12-05

申请人： Nikolaos Tezapsidis ,  Steven Greco ,  Mark Smith

发明人： Nikolaos Tezapsidis ,  Steven Greco ,  Mark Smith

IPC分类号： A61K38/22 ,  A61K31/7056

CPC分类号： A61K38/22 ,  A61K31/7056 ,  A61K38/2264 ,  A61K45/06 ,  C12Q1/485 ,  G01N33/5058 ,  G01N2800/2821 ,  G01N2800/2828 ,  A61K2300/00

摘要： The present disclosure provides compositions containing a leptin product and methods of clinical therapy and diagnostic methods for progressive cognitive disorders. According to one aspect, the described invention provides a method for treating a progressive cognitive disorder. According to another aspect, the described invention provides a method for improving resilience of cognitive function in a subject in need thereof. According to another aspect, the described invention provides a method for identifying an effective therapeutic agent for treating a progressive cognitive dysfunction disease or disorder that results from at least one of accumulation of Aβ, hyperphosphorylation of tau, or accumulation of neurofibrillary tangles.

摘要翻译： 本公开提供了含有瘦素产物的组合物和用于进行性认知障碍的临床治疗和诊断方法的方法。 根据一个方面，所述发明提供了治疗进行性认知障碍的方法。 根据另一方面，本发明提供了一种用于提高有需要的受试者的认知功能的弹性的方法。 根据另一方面，所述发明提供了鉴定用于治疗进行性认知功能障碍疾病或病症的有效治疗剂的方法，所述有效治疗剂由A和BGR的累积，tau的高度磷酸化或神经原纤维缠结的积累中的至少一种引起。

公开(公告)号：US08795194B2

公开(公告)日：2014-08-05

申请号：US12058910

申请日：2008-03-31

申请人： Mark Howard ,  Mark Smith

发明人： Mark Howard ,  Mark Smith

IPC分类号： A61B10/02 ,  A61M1/00 ,  B01D25/00

CPC分类号： C12N5/0653 ,  A61B10/025 ,  A61B10/0283 ,  A61B17/1635 ,  A61B17/32002 ,  A61B17/3205 ,  A61B2017/00969 ,  A61B2217/005 ,  A61M1/00 ,  A61M1/0056 ,  A61M2202/0014 ,  A61M2202/08

摘要： The present disclosure relates to a tissue collection apparatus. The tissue collection apparatus comprises a housing defining an inlet and an outlet, a first filter disposed within the housing, a second filter disposed within the housing, the second filter configured to isolate tissue particles of a desired size that pass through the first filter under the application of an aspiration force applied through the housing. A method of harvesting tissue is also disclosed.

摘要翻译： 本公开涉及一种组织收集装置。 所述组织收集装置包括限定入口和出口的壳体，设置在所述壳体内的第一过滤器，设置在所述壳体内的第二过滤器，所述第二过滤器被配置为将通过所述第一过滤器的所需尺寸的组织颗粒隔开， 施加通过壳体施加的抽吸力。 还公开了收获组织的方法。