专利检索 ap:("David L. Kaplan" OR "Bruce Panilaitis" OR "Eleanor M. Pritchard" OR "Fiorenzo Omenetto" OR "Jordan Axelrad") AND inv:"Eleanor M. Pritchard" 第 1 页

1.

发明申请
SILK FIBROIN SYSTEMS FOR ANTIBIOTIC DELIVERY 审中-公开
标题翻译： SILK FIBROIN系统用于抗生素递送

公开(公告)号：US20120052124A1

公开(公告)日：2012-03-01

申请号：US13254629

申请日：2010-03-04

申请人： David L. Kaplan , Bruce Panilaitis , Eleanor M. Pritchard , Fiorenzo Omenetto , Jordan Axelrad

发明人： David L. Kaplan , Bruce Panilaitis , Eleanor M. Pritchard , Fiorenzo Omenetto , Jordan Axelrad

IPC分类号： A61K9/14 , A61P31/04 , A61K31/546 , A61P31/00 , A61K31/7028 , A61K31/43

CPC分类号： A61L27/227 , A61K9/0019 , A61K9/1617 , A61K9/1664 , A61K9/7007 , A61K31/43 , A61K31/546 , A61K31/7036 , A61K45/06 , A61K47/42 , A61K47/46 , A61L15/40 , A61L15/44 , A61L27/3604 , A61L27/54 , A61L2300/406 , A61L2300/45 , A61L2300/622 , C07K14/43586 , Y02A50/473 , A61K2300/00

摘要： The present invention provides for silk fibroin-based compositions comprising one or more antibiotic agents for prevention or treatment of microbial contamination, methods of making antibiotic-containing silk scaffold, methods of stabilizing antibiotics in silk scaffolds, and methods for preventing or treating microbial contamination using the antibiotic-containing compositions. Various methods may be used to embed the antibiotic(s) into the silk fibroin-based compositions. The antibiotic-containing compositions of the invention are particular useful for stabilizing antibiotics, preventing bacterial infections, and for medical implants, tissue engineering, drug delivery systems, or other pharmaceutical or medical applications.

摘要翻译： 本发明提供了包含一种或多种用于预防或治疗微生物污染的抗生素的丝素蛋白基组合物，制备含抗生素的丝支架的方法，在丝支架中稳定抗生素的方法，以及用于预防或治疗微生物污染的方法含有抗生素的组合物。可以使用各种方法将抗生素包埋在基于丝素蛋白的组合物中。本发明的含抗生素的组合物特别可用于稳定抗生素，防止细菌感染，以及用于医疗植入物，组织工程，药物递送系统或其它药物或医疗应用。

2.

发明申请
SILK FIBROIN-BASED MICRONEEDLES AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：基于丝基纤维素的麦克风及其制备方法

公开(公告)号：US20130338632A1

公开(公告)日：2013-12-19

申请号：US13880592

申请日：2011-10-19

申请人： David L. Kaplan , Konstantinos Tsioris , Fiorenzo G. Omenetto , Eleanor M. Pritchard

发明人： David L. Kaplan , Konstantinos Tsioris , Fiorenzo G. Omenetto , Eleanor M. Pritchard

IPC分类号： A61L31/12 , A61M37/00

CPC分类号： A61L31/125 , A61B17/205 , A61K9/0021 , A61L31/047 , A61L31/16 , A61M5/158 , A61M37/0015 , A61M2037/0046 , A61M2037/0053

摘要： A microneedle or microneedle device includes a microneedle body extending from a base to a penetrating tip formed from a silk fibroin based material, which is easy to fabricate and highly biocompatible. The microneedle device can include one or more microneedles mounted to a substrate. The silk fibroin can include active agents to be transported into or across biological barriers such as skin, tissue and cell membranes. The silk fibroin microneedles can be fully or partially biodegradable and/or bioerodible. The silk fibroin is highly stable, affords room temperature storage and is implantable. The silk fibroin structure can be modulated to control the rate of active agent delivery.

摘要翻译： 微针或微针装置包括从基部延伸到由丝素蛋白基材料形成的穿透尖端的微针体，其易于制造和高度生物相容性。微针装置可以包括安装到基底的一个或多个微针。丝素蛋白可以包括被运送到生物屏障如皮肤，组织和细胞膜之中或之上的活性剂。丝素蛋白微针可以全部或部分生物降解和/或生物侵蚀。丝素蛋白高度稳定，提供室温储存并可植入。可以调节丝素蛋白结构以控制活性剂递送的速率。

3.

发明授权
Silk fibroin-based microneedles and methods of making the same 有权

公开(公告)号：US10933173B2

公开(公告)日：2021-03-02

申请号：US13880592

申请日：2011-10-19

申请人： David L. Kaplan , Konstantinos Tsioris , Fiorenzo G. Omenetto , Eleanor M. Pritchard

发明人： David L. Kaplan , Konstantinos Tsioris , Fiorenzo G. Omenetto , Eleanor M. Pritchard

IPC分类号： A61L31/12 , A61B17/20 , A61K9/00 , A61L31/04 , A61L31/16 , A61M5/158 , A61M37/00

摘要： A microneedle or microneedle device includes a microneedle body extending from a base to a penetrating tip formed from a silk fibroin based material, which is easy to fabricate and highly biocompatible. The microneedle device can include one or more microneedles mounted to a substrate. The silk fibroin can include active agents to be transported into or across biological barriers such as skin, tissue and cell membranes. The silk fibroin microneedles can be fully or partially biodegradable and/or bioerodible. The silk fibroin is highly stable, affords room temperature storage and is implantable. The silk fibroin structure can be modulated to control the rate of active agent delivery.

4.

发明申请
ENCAPSULATED OILS 审中-公开
标题翻译：封闭油

公开(公告)号：US20140023688A1

公开(公告)日：2014-01-23

申请号：US13940671

申请日：2013-07-12

申请人： Stephanie Budijono , David L. Kaplan , Valery Normand , Florenzo Omenetto , Lahoussine Quali , Eleanor M. Pritchard

发明人： Stephanie Budijono , David L. Kaplan , Valery Normand , Florenzo Omenetto , Lahoussine Quali , Eleanor M. Pritchard

IPC分类号： A61K47/14 , A23D7/00 , A61K9/113 , A61K9/14 , A61K8/04

CPC分类号： A61K47/14 , A23D7/003 , A23D7/005 , A23D7/0053 , A23L27/72 , A23L29/10 , A61K8/04 , A61K8/066 , A61K8/11 , A61K8/64 , A61K9/113 , A61K9/146 , A61K9/1658 , A61K9/5052 , A61K9/5063 , A61K2800/10 , A61K2800/412 , A61Q19/00 , B01F17/00 , B01J13/14

摘要： Provided herein is a silk material compositions and methods for encapsulating and/or stabilizing oil, lipid, hydrophobic or lipophilic compounds including active agents in a silk matrix.

摘要翻译： 本文提供丝素材料组合物和用于在丝基质中包封和/或稳定包含活性剂的油，脂质，疏水或亲油化合物的丝素组合物和方法。