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公开(公告)号：US08491561B2
公开(公告)日：2013-07-23
申请号：US12857489
申请日：2010-08-16
申请人： Jeffrey T. Borenstein , Eli Weinberg , Brian K. Orrick , Eleanor M. Pritchard , Edward J. Barnard , Nicholas J. Krebs , Theodore Marentis , Joseph P. Vacanti , Mohammad Reza Kaazempur-Mofrad
发明人： Jeffrey T. Borenstein , Eli Weinberg , Brian K. Orrick , Eleanor M. Pritchard , Edward J. Barnard , Nicholas J. Krebs , Theodore Marentis , Joseph P. Vacanti , Mohammad Reza Kaazempur-Mofrad
IPC分类号： C12M3/06
CPC分类号： A61M1/1678 , Y10T436/25375 , Y10T436/255
摘要： Methods and materials for making an apparatus which duplicates the functionality of a physiological system is provided.
摘要翻译： 提供了用于制造复制生理系统的功能的装置的方法和材料。
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公开(公告)号：US20110056882A1
公开(公告)日：2011-03-10
申请号：US12857489
申请日：2010-08-16
申请人： Jeffrey T. Borenstein , Eli Weinberg , Brian K. Orrick , Eleanor M. Pritchard , Edward J. Barnard , Nicholas J. Krebs , Theodore Marentis , Joseph P. Vacanti , Mohammad Reza Kaazempur-Mofrad
发明人： Jeffrey T. Borenstein , Eli Weinberg , Brian K. Orrick , Eleanor M. Pritchard , Edward J. Barnard , Nicholas J. Krebs , Theodore Marentis , Joseph P. Vacanti , Mohammad Reza Kaazempur-Mofrad
CPC分类号： A61M1/1678 , Y10T436/25375 , Y10T436/255
摘要： Methods and materials for making an apparatus which duplicates the functionality of a physiological system is provided.
摘要翻译： 提供了用于制造复制生理系统的功能的装置的方法和材料。
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公开(公告)号：US07776021B2
公开(公告)日：2010-08-17
申请号：US10983213
申请日：2004-11-05
申请人： Jeffrey T. Borenstein , Eli Weinberg , Brian K. Orrick , Eleanor M. Pritchard , Edward J. Barnard , Nicholas J. Krebs , Theodore Marentis , Joseph P. Vacanti , Mohammad Reza Kaazempur-Mofrad
发明人： Jeffrey T. Borenstein , Eli Weinberg , Brian K. Orrick , Eleanor M. Pritchard , Edward J. Barnard , Nicholas J. Krebs , Theodore Marentis , Joseph P. Vacanti , Mohammad Reza Kaazempur-Mofrad
IPC分类号： C12M3/06
CPC分类号： A61M1/1678 , Y10T436/25375 , Y10T436/255
摘要： Methods and materials for making an apparatus which duplicates the functionality of a physiological system id provided.
摘要翻译： 用于制造复制所提供的生理系统标识的功能的装置的方法和材料。
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4.发明申请公开(公告)号：US20100267136A1
公开(公告)日：2010-10-21
申请号：US12785865
申请日：2010-05-24
申请人： Joseph P. Vacanti , Young-Moon Michael Shin , Jennifer Ogilvie , Alexander Sevy , Tomoyuki Maemura , Osamu Ishii , Mohammad Reza Kaazempur-Mofrad , Jeffrey T. Borenstein , Kevin R. King , Chiao-Chun Wang , Eli Weinberg
发明人： Joseph P. Vacanti , Young-Moon Michael Shin , Jennifer Ogilvie , Alexander Sevy , Tomoyuki Maemura , Osamu Ishii , Mohammad Reza Kaazempur-Mofrad , Jeffrey T. Borenstein , Kevin R. King , Chiao-Chun Wang , Eli Weinberg
CPC分类号： A61F2/062 , A61F2240/004 , A61F2240/005 , A61L27/3604 , A61L27/3804 , A61L27/3808 , A61L27/3891 , A61L27/3895 , A61L27/58 , A61L2300/64 , B33Y80/00 , C12M21/08 , C12M23/06 , C12M23/30 , C12M25/02 , C12N5/0062 , C12N5/0697 , C12N2533/12 , C12N2533/30 , Y10T29/49826
摘要： Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided.
摘要翻译： 提供了用于制造器官和组织置换的复杂的，活的，血管化的组织，特别是复杂和/或较厚的结构例如肝组织的方法和材料。 在包括具有（a）第一模具或聚合物支架，半透膜和第二模具或聚合物支架的装置的系统中制造组织层，其中半透膜设置在第一和第二模具之间或 聚合物支架，其中第一和第二模具或聚合物支架具有限定朝向半透膜的微通道的装置，其中第一和第二模具或聚合物支架紧固在一起; 和（b）动物细胞。 还提供了从组织层片制备复合的三维组织或器官的方法。
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公开(公告)号：US07759113B2
公开(公告)日：2010-07-20
申请号：US10187247
申请日：2002-06-28
申请人： Joseph P. Vacanti , Young-Moon Michael Shin , Jennifer Ogilvie , Alexander Sevy , Tomoyuki Maemura , Osamu Ishii , Mohammad Reza Kaazempur-Mofrad , Jeffrey T. Borenstein , Kevin R. King , Chiao-Chun Wang , Eli Weinberg
发明人： Joseph P. Vacanti , Young-Moon Michael Shin , Jennifer Ogilvie , Alexander Sevy , Tomoyuki Maemura , Osamu Ishii , Mohammad Reza Kaazempur-Mofrad , Jeffrey T. Borenstein , Kevin R. King , Chiao-Chun Wang , Eli Weinberg
IPC分类号： C12M1/14
CPC分类号： A61F2/062 , A61F2240/004 , A61F2240/005 , A61L27/3604 , A61L27/3804 , A61L27/3808 , A61L27/3891 , A61L27/3895 , A61L27/58 , A61L2300/64 , B33Y80/00 , C12M21/08 , C12M23/06 , C12M23/30 , C12M25/02 , C12N5/0062 , C12N5/0697 , C12N2533/12 , C12N2533/30 , Y10T29/49826
摘要： Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided.
摘要翻译： 提供了用于制造器官和组织置换的复杂的，活的，血管化的组织，特别是复杂和/或较厚的结构例如肝组织的方法和材料。 在包括具有（a）第一模具或聚合物支架，半透膜和第二模具或聚合物支架的装置的系统中制造组织层，其中半透膜设置在第一和第二模具之间或 聚合物支架，其中第一和第二模具或聚合物支架具有限定朝向半透膜的微通道的装置，其中第一和第二模具或聚合物支架紧固在一起; 和（b）动物细胞。 还提供了从组织层片制备复合的三维组织或器官的方法。
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6.发明授权公开(公告)号：US08642336B2
公开(公告)日：2014-02-04
申请号：US12785865
申请日：2010-05-24
申请人： Joseph P. Vacanti , Young-Moon Michael Shin , Jennifer Ogilvie , Alexander Sevy , Tomoyuki Maemura , Osamu Ishii , Mohammad Reza Kaazempur-Mofrad , Jeffrey T. Borenstein , Kevin R. King , Chiao-Chun Wang , Eli Weinberg
发明人： Joseph P. Vacanti , Young-Moon Michael Shin , Jennifer Ogilvie , Alexander Sevy , Tomoyuki Maemura , Osamu Ishii , Mohammad Reza Kaazempur-Mofrad , Jeffrey T. Borenstein , Kevin R. King , Chiao-Chun Wang , Eli Weinberg
IPC分类号： C12N5/02
CPC分类号： A61F2/062 , A61F2240/004 , A61F2240/005 , A61L27/3604 , A61L27/3804 , A61L27/3808 , A61L27/3891 , A61L27/3895 , A61L27/58 , A61L2300/64 , B33Y80/00 , C12M21/08 , C12M23/06 , C12M23/30 , C12M25/02 , C12N5/0062 , C12N5/0697 , C12N2533/12 , C12N2533/30 , Y10T29/49826
摘要： Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided.
摘要翻译： 提供了用于制造器官和组织置换的复杂的，活的，血管化的组织，特别是复杂和/或较厚的结构例如肝组织的方法和材料。 在包括具有（a）第一模具或聚合物支架，半透膜和第二模具或聚合物支架的装置的系统中制造组织层，其中半透膜设置在第一和第二模具之间或 聚合物支架，其中第一和第二模具或聚合物支架具有限定朝向半透膜的微通道的装置，其中第一和第二模具或聚合物支架紧固在一起; 和（b）动物细胞。 还提供了从组织层片制备复合的三维组织或器官的方法。
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公开(公告)号：US20100098742A1
公开(公告)日：2010-04-22
申请号：US10187247
申请日：2002-06-28
申请人： Joseph P. Vacanti , Young-Moon Michael Shin , Jennifer Ogilvie , Alexander Sevy , Tomoyuki Maemura , Osamu Ishii , Mohammad Reza Kaazempur-Mofrad , Jeffrey T. Borenstein , Kevin R. King , Chiao-Chun Wang , Eli Weinberg
发明人： Joseph P. Vacanti , Young-Moon Michael Shin , Jennifer Ogilvie , Alexander Sevy , Tomoyuki Maemura , Osamu Ishii , Mohammad Reza Kaazempur-Mofrad , Jeffrey T. Borenstein , Kevin R. King , Chiao-Chun Wang , Eli Weinberg
CPC分类号： A61F2/062 , A61F2240/004 , A61F2240/005 , A61L27/3604 , A61L27/3804 , A61L27/3808 , A61L27/3891 , A61L27/3895 , A61L27/58 , A61L2300/64 , B33Y80/00 , C12M21/08 , C12M23/06 , C12M23/30 , C12M25/02 , C12N5/0062 , C12N5/0697 , C12N2533/12 , C12N2533/30 , Y10T29/49826
摘要： Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided.
摘要翻译： 提供了用于制造器官和组织置换的复杂的，活的，血管化的组织，特别是复杂和/或较厚的结构例如肝组织的方法和材料。 在包括具有（a）第一模具或聚合物支架，半透膜和第二模具或聚合物支架的装置的系统中制造组织层，其中半透膜设置在第一和第二模具之间或 聚合物支架，其中第一和第二模具或聚合物支架具有限定朝向半透膜的微通道的装置，其中第一和第二模具或聚合物支架紧固在一起; 和（b）动物细胞。 还提供了从组织层片制备复合的三维组织或器官的方法。
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8.发明申请公开(公告)号：US20110256619A1
公开(公告)日：2011-10-20
申请号：US13156675
申请日：2011-06-09
IPC分类号： C12M3/00
CPC分类号： C12N5/0068 , B33Y80/00 , C12N5/0062 , C12N5/0697 , C12N2533/40
摘要： The present invention relates to a three-dimensional system, and compositions obtained therefrom, wherein individual layers of the system comprise channels divided longitudinally into two compartments by a centrally positioned membrane, and wherein each compartment can comprise a different cell type.
摘要翻译： 本发明涉及一种三维体系及其组合物，其中系统的各层包括通过中心定位的膜纵向分成两个隔室的通道，并且其中每个隔室可包括不同的细胞类型。
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9.发明授权Microfabricated compositions and processes for engineering tissues containing multiple cell types 有权包含多种细胞类型的工程组织的微型组合物和方法公开(公告)号：US07960166B2
公开(公告)日：2011-06-14
申请号：US10557081
申请日：2004-05-21
IPC分类号： C12M1/14
CPC分类号： C12N5/0068 , B33Y80/00 , C12N5/0062 , C12N5/0697 , C12N2533/40
摘要： The present invention relates to a three-dimensional system, and compositions obtained therefrom, wherein individual layers of the system comprise channels divided longitudinally into two compartments by a centrally positioned membrane, and wherein each compartment can comprise a different cell type.
摘要翻译： 本发明涉及一种三维体系及其组合物，其中系统的各层包括通过中心定位的膜纵向分成两个隔室的通道，并且其中每个隔室可包括不同的细胞类型。
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10.发明授权Microfabricated compositions and processes for engineering tissues containing multiple cell types 有权包含多种细胞类型的工程组织的微型组合物和方法公开(公告)号：US08357528B2
公开(公告)日：2013-01-22
申请号：US13156675
申请日：2011-06-09
IPC分类号： C12M1/14
CPC分类号： C12N5/0068 , B33Y80/00 , C12N5/0062 , C12N5/0697 , C12N2533/40
摘要： The present invention relates to a three-dimensional system, and compositions obtained therefrom, wherein individual layers of the system comprise channels divided longitudinally into two compartments by a centrally positioned membrane, and wherein each compartment can comprise a different cell type.
摘要翻译： 本发明涉及一种三维体系及其组合物，其中系统的各层包括通过中心定位的膜纵向分成两个隔室的通道，并且其中每个隔室可包括不同的细胞类型。
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