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公开(公告)号：US06495558B1
公开(公告)日：2002-12-17
申请号：US09528976
申请日：2000-03-21
申请人： David M. Armistead , Jean E. Bemis , Daniel Elbaum , Gregory J. Habgood , Perry M. Novak , Joseph J. Nunes , Leticia M. Toledo-Sherman
发明人： David M. Armistead , Jean E. Bemis , Daniel Elbaum , Gregory J. Habgood , Perry M. Novak , Joseph J. Nunes , Leticia M. Toledo-Sherman
IPC分类号： C09D23936
CPC分类号： C07D239/47 , C07D239/56 , C07D239/70
摘要： The invention relates to inhibitors of kinases, compositions comprising the inhibitors, and methods of using the inhibitors and inhibitor compositions. The inhibitors and compositions comprising them are useful for treating disease or disease symptoms. The invention also provides for methods of making kinase inhibitor compounds, methods of inhibiting kinase activity, and methods for treating disease or disease symptoms.
摘要翻译： 本发明涉及激酶抑制剂，包含抑制剂的组合物，以及使用抑制剂和抑制剂组合物的方法。 包含它们的抑制剂和组合物可用于治疗疾病或疾病症状。 本发明还提供了制备激酶抑制剂化合物的方法，抑制激酶活性的方法，以及治疗疾病或疾病症状的方法。
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公开(公告)号：US07074789B2
公开(公告)日：2006-07-11
申请号：US10699518
申请日：2003-10-31
申请人： David M. Armistead , Jean E. Bemis , John L. Buchanan , Lucian V. DiPietro , Daniel Elbaum , Stephanie D. Geuns-Meyer , Gregory J. Habgood , Joseph L. Kim , Teresa L. Marshall , Perry M. Novak , Joseph J. Nunes , Vinod F. Patel , Leticia M. Toledo-Sherman , Xiaotian Zhu
发明人： David M. Armistead , Jean E. Bemis , John L. Buchanan , Lucian V. DiPietro , Daniel Elbaum , Stephanie D. Geuns-Meyer , Gregory J. Habgood , Joseph L. Kim , Teresa L. Marshall , Perry M. Novak , Joseph J. Nunes , Vinod F. Patel , Leticia M. Toledo-Sherman , Xiaotian Zhu
IPC分类号： C07D403/12 , C07D403/14 , A61K31/4155 , A61P35/04
CPC分类号： C07D401/04 , C07D251/18 , C07D251/22 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The invention relates to inhibitors of enzymes that bind to ATP or GTP and/or catalyze phosphoryl transfer, compositions comprising the inhibitors, and methods of using the inhibitors and inhibitor compositions. The inhibitors and compositions comprising them are useful for treating disease or disease symptoms. The invention also provides for methods of making phosphoryl transferase inhibitor compounds, methods of inhibiting phosphoryl transferase activity, and methods for treating disease or disease symptoms.
摘要翻译： 本发明涉及结合ATP或GTP和/或催化磷酸转移的酶抑制剂，包含抑制剂的组合物，以及使用抑制剂和抑制剂组合物的方法。 包含它们的抑制剂和组合物可用于治疗疾病或疾病症状。 本发明还提供了制备磷酸转移酶抑制剂化合物的方法，抑制磷酸转移酶活性的方法，以及治疗疾病或疾病症状的方法。
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公开(公告)号：US07282504B2
公开(公告)日：2007-10-16
申请号：US11125614
申请日：2005-05-09
申请人： David M. Armistead , Jean E Bemis , Lucian V DiPietro , Stephanie D. Geuns-Meyer , Gregory J. Habgood , Joseph L. Kim , Joseph J. Nunes , Vinod F. Patel , Leticia M. Toledo-Sherman
发明人： David M. Armistead , Jean E Bemis , Lucian V DiPietro , Stephanie D. Geuns-Meyer , Gregory J. Habgood , Joseph L. Kim , Joseph J. Nunes , Vinod F. Patel , Leticia M. Toledo-Sherman
IPC分类号： C07D403/04 , A61K31/404
CPC分类号： C07D401/14 , C07D403/04 , C07D403/12 , C07D413/04 , C07D413/14 , C07D417/14
摘要： The invention relates to inhibitors of kinases, compositions comprising the inhibitors, and methods of using the inhibitors and inhibitor compositions. The inhibitors and compositions comprising them are useful for treating disease or disease symptoms. The invention also provides for methods of making kinase inhibitor compounds, methods of inhibiting kinase activity, and methods for treating disease or disease symptoms.
摘要翻译： 本发明涉及激酶抑制剂，包含抑制剂的组合物，以及使用抑制剂和抑制剂组合物的方法。 包含它们的抑制剂和组合物可用于治疗疾病或疾病症状。 本发明还提供了制备激酶抑制剂化合物的方法，抑制激酶活性的方法，以及治疗疾病或疾病症状的方法。
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公开(公告)号：US06541496B1
公开(公告)日：2003-04-01
申请号：US09556253
申请日：2000-04-24
申请人： David M. Armistead , Michael C. Badia , Guy W. Bemis , Randy S. Bethiel , Catharine A. Frank , Perry M. Novak , Steven M. Ronkin , Jeffrey O. Saunders
发明人： David M. Armistead , Michael C. Badia , Guy W. Bemis , Randy S. Bethiel , Catharine A. Frank , Perry M. Novak , Steven M. Ronkin , Jeffrey O. Saunders
IPC分类号： A61K3142
CPC分类号： C07D413/12 , A61K31/404 , A61K31/42 , A61K31/422 , C07C275/42 , C07D263/32 , Y02P20/55
摘要： The present invention relates to a novel class of compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.
摘要翻译： 本发明涉及抑制IMPDH的新一类化合物。 本发明还涉及包含这些化合物的药物组合物。 本发明的化合物和药物组合物特别适用于抑制IMPDH酶活性，因此可有利地用作IMPDH介导的过程的治疗剂。 本发明还涉及使用本发明化合物和相关化合物抑制IMPDH活性的方法。
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公开(公告)号：US6054472A
公开(公告)日：2000-04-25
申请号：US832165
申请日：1997-04-02
申请人： David M. Armistead , Michael C. Badia , Guy W. Bemis , Randy S. Bethiel , Catharine A. Frank , Perry M. Novak , Steven M. Ronkin , Jeffrey O. Saunders
发明人： David M. Armistead , Michael C. Badia , Guy W. Bemis , Randy S. Bethiel , Catharine A. Frank , Perry M. Novak , Steven M. Ronkin , Jeffrey O. Saunders
IPC分类号： A61K31/404 , A61K31/42 , A61K31/422 , C07C275/42 , C07D263/32 , C07D413/12 , A01N43/76 , C07D263/02 , C07D263/34
CPC分类号： C07D413/12 , A61K31/404 , A61K31/42 , A61K31/422 , C07C275/42 , C07D263/32
摘要： The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.
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公开(公告)号：US5807876A
公开(公告)日：1998-09-15
申请号：US636361
申请日：1996-04-23
申请人： David M. Armistead , Michael C. Badia , Guy W. Bemis , Randy S. Bethiel , Catharine A. Frank , Perry M. Novak , Steven M. Ronkin , Jeffrey O. Saunders
发明人： David M. Armistead , Michael C. Badia , Guy W. Bemis , Randy S. Bethiel , Catharine A. Frank , Perry M. Novak , Steven M. Ronkin , Jeffrey O. Saunders
IPC分类号： A61K31/17 , A61K31/18 , A61K31/404 , A61K31/42 , A61K31/421 , A61K31/422 , A61P9/14 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/06 , A61P43/00 , C07C275/42 , C07D263/18 , C07D263/32 , C07D277/18 , C07D413/12 , C07D263/34 , C07D413/00
CPC分类号： C07D413/12 , A61K31/404 , A61K31/42 , A61K31/422 , C07C275/42 , C07D263/32
摘要： The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as agents for immunosuppression. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.
摘要翻译： 本发明涉及一类新颖的IMPDH抑制剂。 本发明还涉及包含这些化合物的药物组合物。 本发明的化合物和药物组合物特别适用于抑制IMPDH酶活性，因此可有利地用作免疫抑制剂。 本发明还涉及使用本发明化合物和相关化合物抑制IMPDH活性的方法。
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公开(公告)号：US5932600A
公开(公告)日：1999-08-03
申请号：US816764
申请日：1997-03-14
申请人： Jeffrey O. Saunders , David M. Armistead , Michael C. Badia , Randy S. Bethiel , Catharine A. Frank , Doug Naegele , Perry M. Novak , David A. Pearlman , Steven M. Ronkin
发明人： Jeffrey O. Saunders , David M. Armistead , Michael C. Badia , Randy S. Bethiel , Catharine A. Frank , Doug Naegele , Perry M. Novak , David A. Pearlman , Steven M. Ronkin
IPC分类号： A61K31/4184 , A61K31/423 , A61K31/428 , C07D235/30 , C07D263/58 , C07D413/12 , C07D417/12 , A61K31/425 , A61K31/42
CPC分类号： C07D263/58 , A61K31/4184 , A61K31/423 , A61K31/428 , C07D235/30 , C07D413/12 , C07D417/12
摘要： The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.
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公开(公告)号：US06967214B2
公开(公告)日：2005-11-22
申请号：US10351731
申请日：2003-01-23
申请人： David M. Armistead , Michael C. Badia , Guy W. Bemis , Randy S. Bethiel , Catharine A. Frank , Perry M. Novak , Steven M. Ronkin , Jeffrey O. Saunders
发明人： David M. Armistead , Michael C. Badia , Guy W. Bemis , Randy S. Bethiel , Catharine A. Frank , Perry M. Novak , Steven M. Ronkin , Jeffrey O. Saunders
IPC分类号： A61K31/17 , A61K31/18 , A61K31/404 , A61K31/42 , A61K31/421 , A61K31/422 , A61P9/14 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/06 , A61P43/00 , C07C275/42 , C07D263/18 , C07D263/32 , C07D277/18 , C07D413/12 , A61P31/22
CPC分类号： C07D413/12 , A61K31/404 , A61K31/42 , A61K31/422 , C07C275/42 , C07D263/32 , Y02P20/55
摘要： The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.
摘要翻译： 本发明涉及一类新颖的IMPDH抑制剂。 本发明还涉及包含这些化合物的药物组合物。 本发明的化合物和药物组合物特别适用于抑制IMPDH酶活性，因此可有利地用作IMPDH介导的过程的治疗剂。 本发明还涉及使用本发明化合物和相关化合物抑制IMPDH活性的方法。
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公开(公告)号：US06518291B1
公开(公告)日：2003-02-11
申请号：US09395798
申请日：1999-09-14
申请人： Jeffrey O. Saunders , David M. Armistead , Michael C. Badia , Randy S. Bethiel , Catherine A. Frank , Doug Naegele , Perry M. Novak , David A. Pearlman , Steven M. Ronkin
发明人： Jeffrey O. Saunders , David M. Armistead , Michael C. Badia , Randy S. Bethiel , Catherine A. Frank , Doug Naegele , Perry M. Novak , David A. Pearlman , Steven M. Ronkin
IPC分类号： A61K31136
CPC分类号： C07D263/58 , A61K31/4184 , A61K31/423 , A61K31/428 , C07D235/30 , C07D413/12 , C07D417/12 , Y02A50/385 , Y02A50/389
摘要： The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.
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公开(公告)号：US06344465B1
公开(公告)日：2002-02-05
申请号：US08801780
申请日：1997-02-14
申请人： David M. Armistead , Michael C. Badia , Guy W. Bemis , Randy S. Bethiel , Catharine A. Frank , Perry M. Novak , Steven M. Ronkin , Jeffrey O. Saunders
发明人： David M. Armistead , Michael C. Badia , Guy W. Bemis , Randy S. Bethiel , Catharine A. Frank , Perry M. Novak , Steven M. Ronkin , Jeffrey O. Saunders
IPC分类号： A61K31445
CPC分类号： C07D413/12 , A61K31/404 , A61K31/42 , A61K31/422 , C07C275/42 , C07D263/32
摘要： The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.
摘要翻译： 本发明涉及一类新颖的IMPDH抑制剂。 本发明还涉及包含这些化合物的药物组合物。 本发明的化合物和药物组合物特别适用于抑制IMPDH酶活性，因此可有利地用作IMPDH介导的过程的治疗剂。 本发明还涉及使用本发明化合物和相关化合物抑制IMPDH活性的方法。
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