公开(公告)号：US06518291B1

公开(公告)日：2003-02-11

申请号：US09395798

申请日：1999-09-14

申请人： Jeffrey O. Saunders ,  David M. Armistead ,  Michael C. Badia ,  Randy S. Bethiel ,  Catherine A. Frank ,  Doug Naegele ,  Perry M. Novak ,  David A. Pearlman ,  Steven M. Ronkin

发明人： Jeffrey O. Saunders ,  David M. Armistead ,  Michael C. Badia ,  Randy S. Bethiel ,  Catherine A. Frank ,  Doug Naegele ,  Perry M. Novak ,  David A. Pearlman ,  Steven M. Ronkin

IPC分类号： A61K31136

CPC分类号： C07D263/58 ,  A61K31/4184 ,  A61K31/423 ,  A61K31/428 ,  C07D235/30 ,  C07D413/12 ,  C07D417/12 ,  Y02A50/385 ,  Y02A50/389

摘要： The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.

公开(公告)号：US5932600A

公开(公告)日：1999-08-03

申请号：US816764

申请日：1997-03-14

申请人： Jeffrey O. Saunders ,  David M. Armistead ,  Michael C. Badia ,  Randy S. Bethiel ,  Catharine A. Frank ,  Doug Naegele ,  Perry M. Novak ,  David A. Pearlman ,  Steven M. Ronkin

发明人： Jeffrey O. Saunders ,  David M. Armistead ,  Michael C. Badia ,  Randy S. Bethiel ,  Catharine A. Frank ,  Doug Naegele ,  Perry M. Novak ,  David A. Pearlman ,  Steven M. Ronkin

IPC分类号： A61K31/4184 ,  A61K31/423 ,  A61K31/428 ,  C07D235/30 ,  C07D263/58 ,  C07D413/12 ,  C07D417/12 ,  A61K31/425 ,  A61K31/42

CPC分类号： C07D263/58 ,  A61K31/4184 ,  A61K31/423 ,  A61K31/428 ,  C07D235/30 ,  C07D413/12 ,  C07D417/12

摘要： The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.

公开(公告)号：US06541496B1

公开(公告)日：2003-04-01

申请号：US09556253

申请日：2000-04-24

申请人： David M. Armistead ,  Michael C. Badia ,  Guy W. Bemis ,  Randy S. Bethiel ,  Catharine A. Frank ,  Perry M. Novak ,  Steven M. Ronkin ,  Jeffrey O. Saunders

发明人： David M. Armistead ,  Michael C. Badia ,  Guy W. Bemis ,  Randy S. Bethiel ,  Catharine A. Frank ,  Perry M. Novak ,  Steven M. Ronkin ,  Jeffrey O. Saunders

IPC分类号： A61K3142

CPC分类号： C07D413/12 ,  A61K31/404 ,  A61K31/42 ,  A61K31/422 ,  C07C275/42 ,  C07D263/32 ,  Y02P20/55

摘要： The present invention relates to a novel class of compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.

摘要翻译： 本发明涉及抑制IMPDH的新一类化合物。 本发明还涉及包含这些化合物的药物组合物。 本发明的化合物和药物组合物特别适用于抑制IMPDH酶活性，因此可有利地用作IMPDH介导的过程的治疗剂。 本发明还涉及使用本发明化合物和相关化合物抑制IMPDH活性的方法。

公开(公告)号：US6054472A

公开(公告)日：2000-04-25

申请号：US832165

申请日：1997-04-02

申请人： David M. Armistead ,  Michael C. Badia ,  Guy W. Bemis ,  Randy S. Bethiel ,  Catharine A. Frank ,  Perry M. Novak ,  Steven M. Ronkin ,  Jeffrey O. Saunders

发明人： David M. Armistead ,  Michael C. Badia ,  Guy W. Bemis ,  Randy S. Bethiel ,  Catharine A. Frank ,  Perry M. Novak ,  Steven M. Ronkin ,  Jeffrey O. Saunders

IPC分类号： A61K31/404 ,  A61K31/42 ,  A61K31/422 ,  C07C275/42 ,  C07D263/32 ,  C07D413/12 ,  A01N43/76 ,  C07D263/02 ,  C07D263/34

CPC分类号： C07D413/12 ,  A61K31/404 ,  A61K31/42 ,  A61K31/422 ,  C07C275/42 ,  C07D263/32

摘要： The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.

公开(公告)号：US5807876A

公开(公告)日：1998-09-15

申请号：US636361

申请日：1996-04-23

申请人： David M. Armistead ,  Michael C. Badia ,  Guy W. Bemis ,  Randy S. Bethiel ,  Catharine A. Frank ,  Perry M. Novak ,  Steven M. Ronkin ,  Jeffrey O. Saunders

发明人： David M. Armistead ,  Michael C. Badia ,  Guy W. Bemis ,  Randy S. Bethiel ,  Catharine A. Frank ,  Perry M. Novak ,  Steven M. Ronkin ,  Jeffrey O. Saunders

IPC分类号： A61K31/17 ,  A61K31/18 ,  A61K31/404 ,  A61K31/42 ,  A61K31/421 ,  A61K31/422 ,  A61P9/14 ,  A61P29/00 ,  A61P31/12 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00 ,  C07C275/42 ,  C07D263/18 ,  C07D263/32 ,  C07D277/18 ,  C07D413/12 ,  C07D263/34 ,  C07D413/00

CPC分类号： C07D413/12 ,  A61K31/404 ,  A61K31/42 ,  A61K31/422 ,  C07C275/42 ,  C07D263/32

摘要： The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as agents for immunosuppression. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.

摘要翻译： 本发明涉及一类新颖的IMPDH抑制剂。 本发明还涉及包含这些化合物的药物组合物。 本发明的化合物和药物组合物特别适用于抑制IMPDH酶活性，因此可有利地用作免疫抑制剂。 本发明还涉及使用本发明化合物和相关化合物抑制IMPDH活性的方法。

公开(公告)号：US06967214B2

公开(公告)日：2005-11-22

申请号：US10351731

申请日：2003-01-23

申请人： David M. Armistead ,  Michael C. Badia ,  Guy W. Bemis ,  Randy S. Bethiel ,  Catharine A. Frank ,  Perry M. Novak ,  Steven M. Ronkin ,  Jeffrey O. Saunders

发明人： David M. Armistead ,  Michael C. Badia ,  Guy W. Bemis ,  Randy S. Bethiel ,  Catharine A. Frank ,  Perry M. Novak ,  Steven M. Ronkin ,  Jeffrey O. Saunders

IPC分类号： A61K31/17 ,  A61K31/18 ,  A61K31/404 ,  A61K31/42 ,  A61K31/421 ,  A61K31/422 ,  A61P9/14 ,  A61P29/00 ,  A61P31/12 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00 ,  C07C275/42 ,  C07D263/18 ,  C07D263/32 ,  C07D277/18 ,  C07D413/12 ,  A61P31/22

CPC分类号： C07D413/12 ,  A61K31/404 ,  A61K31/42 ,  A61K31/422 ,  C07C275/42 ,  C07D263/32 ,  Y02P20/55

摘要： The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.

摘要翻译： 本发明涉及一类新颖的IMPDH抑制剂。 本发明还涉及包含这些化合物的药物组合物。 本发明的化合物和药物组合物特别适用于抑制IMPDH酶活性，因此可有利地用作IMPDH介导的过程的治疗剂。 本发明还涉及使用本发明化合物和相关化合物抑制IMPDH活性的方法。

公开(公告)号：US06344465B1

公开(公告)日：2002-02-05

申请号：US08801780

申请日：1997-02-14

申请人： David M. Armistead ,  Michael C. Badia ,  Guy W. Bemis ,  Randy S. Bethiel ,  Catharine A. Frank ,  Perry M. Novak ,  Steven M. Ronkin ,  Jeffrey O. Saunders

发明人： David M. Armistead ,  Michael C. Badia ,  Guy W. Bemis ,  Randy S. Bethiel ,  Catharine A. Frank ,  Perry M. Novak ,  Steven M. Ronkin ,  Jeffrey O. Saunders

IPC分类号： A61K31445

CPC分类号： C07D413/12 ,  A61K31/404 ,  A61K31/42 ,  A61K31/422 ,  C07C275/42 ,  C07D263/32

摘要： The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.

摘要翻译： 本发明涉及一类新颖的IMPDH抑制剂。 本发明还涉及包含这些化合物的药物组合物。 本发明的化合物和药物组合物特别适用于抑制IMPDH酶活性，因此可有利地用作IMPDH介导的过程的治疗剂。 本发明还涉及使用本发明化合物和相关化合物抑制IMPDH活性的方法。

公开(公告)号：US06653309B1

公开(公告)日：2003-11-25

申请号：US09702991

申请日：2000-10-30

申请人： Jeffrey O. Saunders ,  Daniel Elbaum ,  Perry M. Novak ,  Douglas Naegele ,  Randy S. Bethiel ,  Steven M. Ronkin ,  Michael C. Badia ,  Catharine Frank ,  Dean P. Stamos ,  William Walters ,  David Pearlman

发明人： Jeffrey O. Saunders ,  Daniel Elbaum ,  Perry M. Novak ,  Douglas Naegele ,  Randy S. Bethiel ,  Steven M. Ronkin ,  Michael C. Badia ,  Catharine Frank ,  Dean P. Stamos ,  William Walters ,  David Pearlman

IPC分类号： C07D25102

CPC分类号： C07D213/75 ,  A61K31/4965 ,  A61K31/53 ,  C07C217/84 ,  C07C235/64 ,  C07C311/21 ,  C07C311/29 ,  C07C317/40 ,  C07C323/42 ,  C07C333/08 ,  C07D263/32 ,  C07D271/06 ,  C07D307/91 ,  C07D317/68 ,  C07D413/12

摘要： The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well-suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.

摘要翻译： 本发明涉及抑制IMPDH的化合物。 本发明还涉及包含这些化合物的药物组合物。 本发明的化合物和药物组合物特别适合于抑制IMPDH酶活性，因此可有利地用作IMPDH介导的方法的治疗剂。 本发明还涉及使用本发明化合物和相关化合物抑制IMPDH活性的方法。

公开(公告)号：US07432290B2

公开(公告)日：2008-10-07

申请号：US10997810

申请日：2004-11-24

申请人： Dean Stamos ,  Martin Trudeau ,  Randy S. Bethiel ,  Steven M. Ronkin ,  Michael C. Badia ,  Jeffrey O. Saunders

发明人： Dean Stamos ,  Martin Trudeau ,  Randy S. Bethiel ,  Steven M. Ronkin ,  Michael C. Badia ,  Jeffrey O. Saunders

IPC分类号： A61K31/41 ,  A61K31/425 ,  C07D263/00 ,  C07D263/02

CPC分类号： C07C275/40 ,  C07B2200/07 ,  C07C275/42 ,  C07D263/32 ,  C07F9/653

摘要： The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH-mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.

摘要翻译： 本发明涉及抑制IMPDH的化合物。 本发明还涉及包含这些化合物的药物组合物。 本发明的化合物和药物组合物特别适用于抑制IMPDH酶活性，因此可有利地用作IMPDH介导的方法的治疗剂。 本发明还涉及使用本发明化合物和相关化合物抑制IMPDH活性的方法。

公开(公告)号：US08268873B2

公开(公告)日：2012-09-18

申请号：US12221921

申请日：2008-08-07

申请人： Dean Stamos ,  Martin Trudeau ,  Randy S. Bethiel ,  Steven M. Ronkin ,  Michael C. Badia ,  Jeffrey O. Saunders

发明人： Dean Stamos ,  Martin Trudeau ,  Randy S. Bethiel ,  Steven M. Ronkin ,  Michael C. Badia ,  Jeffrey O. Saunders

IPC分类号： A61K31/42 ,  A61K31/27 ,  C07D263/14 ,  C07D207/00

CPC分类号： C07C275/40 ,  C07B2200/07 ,  C07C275/42 ,  C07D263/32 ,  C07F9/653

摘要： The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH-mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.

摘要翻译： 本发明涉及抑制IMPDH的化合物。 本发明还涉及包含这些化合物的药物组合物。 本发明的化合物和药物组合物特别适用于抑制IMPDH酶活性，因此可有利地用作IMPDH介导的方法的治疗剂。 本发明还涉及使用本发明化合物和相关化合物抑制IMPDH活性的方法。