公开(公告)号：US20050148625A1

公开(公告)日：2005-07-07

申请号：US11071955

申请日：2005-03-03

Applicant: David MacLean ,  David Thompson

Inventor： David MacLean ,  David Thompson

IPC: C07D295/08 ,  A01N43/36 ,  A61K31/40 ,  A61K31/404 ,  A61K31/4184 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/4453 ,  A61K31/454 ,  A61K31/46 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/472 ,  A61K31/4725 ,  A61K31/506 ,  A61K31/517 ,  A61K31/55 ,  A61K31/5513 ,  A61P3/08 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P17/00 ,  A61P25/04 ,  A61P25/20 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  C07D217/12

CPC classification number: A61K31/4725 ,  A61K31/40 ,  A61K31/4439 ,  A61K31/4453

Abstract: The present invention provides novel methods of inhibiting pathological conditions related to organ systems which respond to estrogen agonists comprising administering to a mammal in need of such treatment an effective amount of a compound of formula I

Abstract translation: 本发明提供抑制与对雌激素激动剂作出反应的器官系统有关的病理状态的新方法，其包括对需要这种治疗的哺乳动物施用有效量的式I化合物

公开(公告)号：US20050203086A1

公开(公告)日：2005-09-15

申请号：US10793530

申请日：2004-03-04

Applicant: Alexander Constan ,  Prakash Keshary ,  David MacLean ,  Vishwas Paralkar ,  Doina Roman ,  David Thompson ,  Timothy Wright

Inventor： Alexander Constan ,  Prakash Keshary ,  David MacLean ,  Vishwas Paralkar ,  Doina Roman ,  David Thompson ,  Timothy Wright

IPC: A61K31/4245 ,  A61K31/433 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541

CPC classification number: A61K31/00 ,  A61K31/197 ,  A61K31/277 ,  A61K31/381 ,  A61K31/4025 ,  A61K31/4045 ,  A61K31/4164 ,  A61K31/422 ,  A61K31/427 ,  A61K31/433 ,  A61K31/4406 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/506 ,  A61K31/517 ,  A61K31/53 ,  A61K31/5377

Abstract: The present invention relates to methods of treating pulmonary hypertension, facilitating joint fusion, facilitating tendon and ligament repair, reducing the occurrence of secondary fracture, treating avascular necrosis, facilitating cartilage repair, facilitating bone healing after limb transplantation, facilitating liver regeneration, facilitating wound healing, reducing the occurrence of gastric ulceration, treating hypertension, facilitating the growth of tooth enamel or finger or toe nails, treating glaucoma, treating ocular hypertension, and repairing damage caused by metastatic bone disease using an EP2 selective receptor agonist.

Abstract translation: 本发明涉及治疗肺动脉高压，促进关节融合，促进肌腱和韧带修复，减少二次骨折的发生，治疗无血管性坏死，促进软骨修复，促进肢体移植后骨愈合，促进肝再生，促进伤口愈合的方法 ，减少胃溃疡的发生，治疗高血压，促进牙釉质或手指或脚趾指甲的生长，治疗青光眼，治疗高眼压症和使用EP 2选择性修复由转移性骨病引起的损伤 受体激动剂。

公开(公告)号：US20080045907A1

公开(公告)日：2008-02-21

申请号：US11907766

申请日：2007-10-17

Applicant: David MacLean

Inventor： David MacLean

IPC: A61M5/32

CPC classification number: A61M5/3216 ,  A61M5/24 ,  A61M5/28

Abstract: A safety device to be used with a vial, or capsule, has a collar dimensioned to slidably fit about the body of the vial. Extending from the collar is a neck member that has connected to its other end a housing pivotable to a position along the longitudinal axis of the vial. A latch member having a lip is integrated to the neck member and extends out from the neck member in a direction towards the center of the collar. Neck member is fabricated to have an elastic characteristic so that if it is not biased by any external force, it will return to its original position. As the collar of the safety device is moved along the body of the vial, neck member is biased away from the vial as the latch member maintains contact along the outer surface of the vial, and then the outer surface of the hub formed at the top end of the vial. Once the collar of the safety device is moved to a position adjacent the hub, given the configuration of the neck member forms a space between the top of the collar and the lip of the latch member, the hub of the vial would fit within the space thus formed, as neck member snaps back to its original position. At which time the lip of latch member latches onto a shoulder portion of the hub. Once latched onto the hub, the latch member would prevent the safety device from being removed from the vial. Instead of the neck member, another embodiment of the inventive safety device has extending from the collar a rigid support frame and an elongate elastic latch member.

Abstract translation: 与小瓶或胶囊一起使用的安全装置具有尺寸适于可滑动地装配在小瓶主体上的套环。 从套环延伸的是颈部件，其连接到另一端，可枢转到沿着小瓶的纵向轴线的位置的壳体。 具有唇缘的闩锁构件被集成到颈部构件中，并且沿着朝向颈圈中心的方向从颈部构件延伸出来。 制造颈部构件以具有弹性特性，使得如果它没有被任何外力所偏压，则其将返回其初始位置。 当安全装置的轴环沿着小瓶的主体移动时，当闩锁构件沿着小瓶的外表面保持接触时，颈部构件被偏压远离小瓶，然后在顶部形成的外表面 小瓶的末端。 一旦安全装置的轴环移动到与轮毂相邻的位置，鉴于颈部构件的构型在轴环的顶部和闩锁构件的唇缘之间形成一个空间，小瓶的轮毂将装配在空​​间内 这样形成，因为颈部构件回到其初始位置。 此时，闩锁构件的唇缘锁定在轮毂的肩部上。 一旦锁定到轮毂上，闩锁构件将防止安全装置从小瓶中移出。 代替颈部构件，本发明的安全装置的另一实施例具有从套环延伸的刚性支撑框架和细长弹性闩锁构件。

公开(公告)号：US20090206514A1

公开(公告)日：2009-08-20

申请号：US12385740

申请日：2009-04-17

Applicant: David MacLean ,  Frank Blinkhorn ,  Troy M. Derby ,  Quinton Farrar ,  Marius Hauri ,  Lawrence P. Hudon ,  Robert Simas, JR.

Inventor： David MacLean ,  Frank Blinkhorn ,  Troy M. Derby ,  Quinton Farrar ,  Marius Hauri ,  Lawrence P. Hudon ,  Robert Simas, JR.

IPC: B29C39/12

CPC classification number: A61M5/3129 ,  A61M5/32 ,  A61M5/3202 ,  A61M5/3213 ,  A61M5/3216 ,  A61M2205/6081 ,  Y10T29/49826

Abstract: To enable a user to readily determine the gauge of the needle of a needle assembly that has a base and a needle protective housing pivotably attached thereto, the needle assembly is injection molded from a color coded molding material which color was preassigned to correspond to the gauge of the needle. As a result, both the base and the protective housing of the needle assembly are the same specific color, and reflect or provide an indication of the given gauge of the needle. The needle sheath that covers the needle prior to use may be made of a plastics material that may be clear, or have the same or a different color than that of the needle assembly.

Abstract translation: 为了使用户能够容易地确定具有基座和可枢转地附接到其上的针保护壳体的针组件的针的规格，针组件由颜色编码的模制材料注塑成型，其颜色被预先分配以对应于规格 的针。 结果，针组件的底座和保护壳都是相同的特定颜色，并且反映或提供针的给定规格的指示。 在使用前覆盖针的针鞘可以由塑料材料制成，其可以是清洁的，或具有与针组件相同或不同的颜色。

公开(公告)号：US08608695B2

公开(公告)日：2013-12-17

申请号：US13413103

申请日：2012-03-06

Applicant: Marius Hauri ,  Frank Blinkhorn ,  David MacLean ,  Lawrence P. Hudon ,  Robert Simas, Jr. ,  Troy M. Derby

Inventor： Marius Hauri ,  Frank Blinkhorn ,  David MacLean ,  Lawrence P. Hudon ,  Robert Simas, Jr. ,  Troy M. Derby

IPC: A61M5/00

CPC classification number: A61M5/3202 ,  A61M5/3216 ,  A61M5/50 ,  A61M2005/3217 ,  A61M2205/6081

Abstract: A safety needle assembly has a collar or ring that is rotatably mounted to a needle hub. The needle assembly may be connected to a syringe by the user grasping the needle hub in first and second embodiments, or turning of the needle sheath in other embodiments. The collar of the needle assembly may be rotated by turning the needle sheath. The needle hub may also interact with the collar by rotating the needle sheath. Mechanisms are provided at both the collar and the housing so that once the contaminated needle is covered, the needle assembly may be removed from the syringe for disposal by rotating the needle housing.

Abstract translation: 安全针组件具有可旋转地安装到针座的套环或环。 在其它实施例中，针组件可以通过使用者在第一和第二实施例中抓住针座来进行连接，或者在其他实施例中转动针鞘。 可以通过转动针套来旋转针组件的套环。 针座也可以通过旋转针鞘与套环相互作用。 在轴环和壳体两端提供机构，使得一旦被污染的针被覆盖，针组件可以从注射器中取出，以通过旋转针壳来处置。

公开(公告)号：US08603042B2

公开(公告)日：2013-12-10

申请号：US13137294

申请日：2011-08-04

Applicant: Robert Simas, Jr. ,  David MacLean

Inventor： Robert Simas, Jr. ,  David MacLean

IPC: A61M5/32 ,  A61M5/00

CPC classification number: A61M5/3216 ,  A61M5/3202 ,  A61M2005/3217 ,  Y10T29/49 ,  Y10T29/49826

Abstract: The present invention safety device is a one-piece needle assembly that has a base and a housing pivotally connected to the base. The base has a distal portion to which a needle is fitted. At the base there is formed longitudinally along its distal portion a catch mechanism that may be in the form of an anchor projection. At the back wall of the housing there is extended another catch mechanism that may be configured in the form of two clasping fingers. Also providing in the housing is an integral hook. As the housing and the base are pivoted relative to each other, and as the needle makes contact with the hook, the respective catch mechanisms at the base and the housing also make contact with each other, resulting in the coupling of the catch mechanisms and the coupling of the needle to the hook. As a result, the catch mechanisms are interlocked and the needle is fixedly retained by the hook within the housing. The catch mechanisms may also be configured as a hook and a latch in the form of a rib with an opening whereto the hook is fixedly coupled. The catch mechanisms may further be configured as respective interlockable pairs of loops and bosses. The gauge of the needle may be determined by the color of both the base and the housing, which are molded as a unitary single unit.

Abstract translation: 本发明的安全装置是一体式针组件，其具有基部和枢转地连接到基座的壳体。 底座具有一个远端部分，针头装配到该远端部分。 在基部处，沿着其远端部分纵向地形成可以是锚定突起的形式的捕捉机构。 在壳体的后壁处延伸另一个可以被配置成两个扣紧手指形式的止动机构。 在外壳中也提供了一个整体的钩子。 当壳体和基座相对于彼此枢转时，并且当针与钩接触时，基部和壳体处的相应的卡止机构也彼此接触，导致卡扣机构和 针与钩的耦合。 结果，锁定机构是互锁的，并且针被壳体内的钩固定地保持。 捕获机构还可以被配置为具有开口的肋形式的钩和闩锁，钩子固定地联接在该开口上。 捕获机构还可以被配置为各自可互锁的环和凸起对。 针的尺寸可以由基座和外壳的颜色确定，这两种颜色被模制成一体的单一单元。

公开(公告)号：US08152761B2

公开(公告)日：2012-04-10

申请号：US10832339

申请日：2004-04-27

Applicant: Marius Hauri ,  Frank Blinkhorn ,  David MacLean ,  Lawrence P. Hudon ,  Robert Simas, Jr. ,  Troy M. Derby

Inventor： Marius Hauri ,  Frank Blinkhorn ,  David MacLean ,  Lawrence P. Hudon ,  Robert Simas, Jr. ,  Troy M. Derby

IPC: A61M5/00

CPC classification number: A61M5/3202 ,  A61M5/3216 ,  A61M5/50 ,  A61M2005/3217 ,  A61M2205/6081

Abstract: A safety needle assembly has a collar or ring that is rotatably mounted to a needle hub, which may be connected to a medical device such as a syringe. The needle assembly may be connected to the syringe by the user grasping the needle hub in first and second embodiments, or turning of the needle sheath in other embodiments. In all of the embodiments, the collar of the needle assembly may be rotated by turning the needle sheath, which is designed to interact with the collar. In some of the embodiments, the needle hub likewise interacts with the collar in such a way that by rotating the needle sheath, the needle hub is likewise rotated for connection to a syringe. When an exposed needle is to be covered, after the needle sheath has been removed, a housing connected to the collar is pivotally moved to cover the needle. Mechanisms are provided at both the collar and the housing so that once the contaminated needle is covered, the needle assembly may be removed from the syringe for disposal by rotating the needle housing. In all of the embodiments disclosed, the needle sheath does not come into contact with the needle hub and the collar is rotatable about the needle hub.

Abstract translation: 安全针组件具有可旋转地安装到针座的套环或环，所述针座可以连接到例如注射器的医疗装置。 在其它实施例中，针组件可以通过在第一和第二实施例中抓住针座的用户连接到注射器，或者在其他实施例中可以转动针鞘。 在所有实施例中，可以通过转动设计成与套环相互作用的针护套来旋转针组件的套环。 在一些实施例中，针毂同样地以这样的方式与套环相互作用，即通过旋转针鞘，针座同样被旋转以连接到注射器。 当外露针头被覆盖时，在鞘鞘被移除之后，连接到套环的壳体被枢转地移动以覆盖针头。 在轴环和壳体两端提供机构，使得一旦被污染的针被覆盖，针组件可以从注射器中取出，以通过旋转针壳来处置。 在所公开的所有实施例中，针护套不与针座接触，并且套环可围绕针毂旋转。

公开(公告)号：US07992078B2

公开(公告)日：2011-08-02

申请号：US11777957

申请日：2007-07-13

Applicant: Terry Wayne Penner ,  Francis Wai Gee Lui ,  Wai Sing Wang ,  Michael Akio Tsumura ,  David MacLean

Inventor： Terry Wayne Penner ,  Francis Wai Gee Lui ,  Wai Sing Wang ,  Michael Akio Tsumura ,  David MacLean

IPC: G06F17/00

CPC classification number: G06F17/248

Abstract: A computer readable storage medium comprises a publication definition module to create and define properties for a publication object. The publication definition module includes executable instructions to associate a set of static documents and a set of report templates with the publication object. Executable instructions define a conditional delivery rule for the publication object. The conditional delivery rule specifies a condition for the inclusion of a report template from the set of report templates to be merged with a static document from the set of static documents.

Abstract translation: 计算机可读存储介质包括用于创建和定义出版物对象的属性的发布定义模块。 发布定义模块包括将一组静态文档和一组报告模板与发布对象相关联的可执行指令。 可执行指令为发布对象定义条件传递规则。 条件传递规则指定了从报告模板集合中包含报告模板的条件，以便与静态文档集合中的静态文档合并。

公开(公告)号：US06997916B2

公开(公告)日：2006-02-14

申请号：US10749514

申请日：2004-01-02

Applicant: Robert Simas, Jr. ,  David MacLean

Inventor： Robert Simas, Jr. ,  David MacLean

IPC: A61B19/00

CPC classification number: A61J1/2096 ,  A61B10/0045 ,  A61J1/201 ,  A61J1/2055 ,  Y10S604/905

Abstract: A fluid transfer system has a holder that is made of a cylindrical member having a closed end and an open end. The closed end has fitted thereto a luer and a cannula that extends into the interior of the holder. The holder has a distal portion that has a first cross section and a proximal portion that has a second cross section. The cross section of the distal portion is smaller than the cross section of the proximal portion. The distal and proximal portions are joined by a shoulder. The fluid transfer system also includes an adapter that is inserted to the holder from the open end of the holder. The adapter has a base having a central opening and a cylindrical tube that extends from the central opening. The diameter of the cylindrical tube is slightly smaller than the diameter of the distal portion and is configured to accept a first type of fluid collection store such as a vacuum tube. With the adapter removed, the holder can accept a differently dimensioned fluid collection store such as for example a blood culture collection bottle.

Abstract translation: 流体输送系统具有由具有封闭端和开口端的圆柱形构件制成的保持器。 封闭的端部装配有延伸到保持器内部的路厄尔和套管。 保持器具有具有第一横截面的远端部分和具有第二横截面的近端部分。 远侧部分的横截面小于近端部分的横截面。 远端和近端部分由肩部连接。 流体输送系统还包括从保持器的开口端插入到保持器中的适配器。 适配器具有具有中心开口的基部和从中心开口延伸的圆柱形管。 圆柱形管的直径略小于远端部分的直径，并且构造成接受第一类型的流体收集储存器，例如真空管。 随着适配器被移除，保持器可以接受不同尺寸的流体收集储存器，例如血液培养收集瓶。

公开(公告)号：US20050148992A1

公开(公告)日：2005-07-07

申请号：US10749514

申请日：2004-01-02

Applicant: Robert Simas ,  David MacLean

Inventor： Robert Simas ,  David MacLean

IPC: B67D99/00 ,  A61B10/00 ,  A61J1/00 ,  A61J1/20 ,  A61B19/00

CPC classification number: A61J1/2096 ,  A61B10/0045 ,  A61J1/201 ,  A61J1/2055 ,  Y10S604/905

Abstract: A fluid transfer system has a holder that is made of a cylindrical member having a closed end and an open end. The closed end has fitted thereto a luer and a cannula that extends into the interior of the holder. The holder has a distal portion that has a first cross section and a proximal portion that has a second cross section. The cross section of the distal portion is smaller than the cross section of the proximal portion. The distal and proximal portions are joined by a shoulder. The fluid transfer system also includes an adapter that is inserted to the holder from the open end of the holder. The adapter has a base having a central opening and a cylindrical tube that extends from the central opening. The diameter of the cylindrical tube is slightly smaller than the diameter of the distal portion and is configured to accept a first type of fluid collection store such as a vacuum tube. A non-continuous wall extends from the base of the adapter to surround the cylindrical tube. The cross section of the wall is slightly smaller than the diameter of the proximal portion. At each section of the non-continuous wall there is formed a protuberance. A groove is formed about the inner surface of the proximal portion. When the adapter is fully inserted to the holder, the protuberances would snap fit to the groove so that the adapter is prevented from being inadvertently removed from the holder. With the adapter removed, the holder can accept a differently dimensioned fluid collection store such as for example a blood culture collection bottle.

Abstract translation: 流体输送系统具有由具有封闭端和开口端的圆柱形构件制成的保持器。 封闭的端部装配有延伸到保持器内部的路厄尔和套管。 保持器具有具有第一横截面的远端部分和具有第二横截面的近端部分。 远侧部分的横截面小于近端部分的横截面。 远端和近端部分由肩部连接。 流体输送系统还包括从保持器的开口端插入到保持器中的适配器。 适配器具有具有中心开口的基部和从中心开口延伸的圆柱形管。 圆柱形管的直径略小于远端部分的直径，并且构造成接受第一类型的流体收集储存器，例如真空管。 不连续的壁从适配器的底部延伸以围绕圆柱形管。 壁的横截面略小于近端部分的直径。 在非连续墙的每个部分形成一个突起。 围绕近端部分的内表面形成凹槽。 当适配器完全插入保持器时，突起将卡扣配合到凹槽，使得防止适配器被无意地从保持器移除。 随着适配器被移除，保持器可以接受不同尺寸的流体收集储存器，例如血液培养收集瓶。