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    Tandem ion modulator for characterizing larger biomolecules in a differential mobility spectrometer
    3.
    发明授权
    Tandem ion modulator for characterizing larger biomolecules in a differential mobility spectrometer 有权

    公开(公告)号：US10203305B1

    公开(公告)日：2019-02-12

    申请号：US15659945

    申请日：2017-07-26

    申请人： David R. Hall ,  Dan Allen ,  Joe Fox

    发明人： David R. Hall ,  Dan Allen ,  Joe Fox

    IPC分类号： G01N27/62 ,  H01J49/00

    摘要： The tandem differential mobility spectrometer (DMS)-ion modulator instrument provides improved resolution relative to traditional DMS for molecules with larger masses. The instrument includes multiple ion-bunching electrodes, each with an AC field synchronized to the transit time of the ion flow which is positioned downstream of a DMS. The ion bunching electrodes produce each a mobility-dependent modulation of the ion current. The ratio of AC to DC current provides a measure of the mobility of a large ion, even if it has little differential mobility, thereby extending the useful range of mobility characterization of a DMS system. The instrument does not require high voltages or high frequencies. Modulation before DMS separation or between tandem DMS separations produces a variable range of analyte and reactant ion densities as well as spatially separating negative and positive ions to reduce ion recombination.

    ION MODULATOR FOR CHARACTERIZING LARGER BIOMOLECULES IN A DIFFERENTIAL MOBILITY SPECTROMETER
    4.
    发明申请
    ION MODULATOR FOR CHARACTERIZING LARGER BIOMOLECULES IN A DIFFERENTIAL MOBILITY SPECTROMETER 审中-公开

    公开(公告)号：US20180374693A1

    公开(公告)日：2018-12-27

    申请号：US15632636

    申请日：2017-06-26

    申请人： David R. Hall ,  Dan Allen ,  Joe Fox

    发明人： David R. Hall ,  Dan Allen ,  Joe Fox

    IPC分类号： H01J49/06 ,  H01J49/40 ,  H01J49/04 ,  G01N27/62

    摘要： The tandem differential mobility spectrometer (DMS)-ion modulator instrument provides improved resolution relative to traditional DMS for molecules with larger masses. The instrument includes an ion-bunching electrode with an AC field synchronized to the transit time of the ion flow which is positioned downstream of a DMS. The ion bunching electrode produces a mobility-dependent modulation of the ion current. The ratio of AC to DC current provides a measure of the mobility of a large ion, even if it has little differential mobility, thereby extending the useful range of mobility characterization of a DMS system. The instrument is more compact than a larger traditional ion mobility spectrometer and does not require high voltages or high frequencies. Modulation before DMS separation or between tandem DMS separations produces a variable range of analyte and reactant ion densities as well as spatially separating negative and positive ions to reduce ion recombination.

    Flushable Test Strip
    7.
    发明申请
    Flushable Test Strip 审中-公开

    公开(公告)号：US20180188247A1

    公开(公告)日：2018-07-05

    申请号：US15398052

    申请日：2017-01-04

    申请人： David R. Hall ,  Dan Allen

    发明人： David R. Hall ,  Dan Allen

    IPC分类号： G01N33/543

    CPC分类号： G01N33/54386

    摘要： We disclose a novel diagnostic test strip which may be used to conduct biochemical assays for analytes in liquid samples. The disclosed test strip may be loaded with much smaller volumes of sample than traditional test strips. The disclosed test strip may be loaded with a precision dispenser instead of submersing the test strip into a larger volume of liquid sample. In addition, the disclosed test strip dissolves in aqueous fluid so it may be flushed into the sewer system. Consequently, it is not necessary to dispose of the disclosed test strip in biological waste containers.

    Urinalysis cassette and system
    9.
    发明授权
    Urinalysis cassette and system 有权

    公开(公告)号：US09810686B1

    公开(公告)日：2017-11-07

    申请号：US15265144

    申请日：2016-09-14

    申请人： David R. Hall ,  Dan Allen ,  Joshua Larsen ,  Ben Swenson ,  Jared Reynolds ,  Joe Fox ,  Lloyd J. Wilson

    发明人： David R. Hall ,  Dan Allen ,  Joshua Larsen ,  Ben Swenson ,  Jared Reynolds ,  Joe Fox ,  Lloyd J. Wilson

    IPC分类号： G01N21/00 ,  G01N33/52 ,  A61B5/20 ,  A61B5/00 ,  A61B10/00

    CPC分类号： G01N33/521 ,  A61B5/207 ,  A61B5/6891 ,  A61B5/742 ,  A61B10/007

    摘要： A urinalysis cassette and system that includes a toilet, into which a urinalysis cassette is inserted. The cassette is comprised of a roll of color-change-reagent strips. Each strip includes a plurality of strip sections wherein an absorbent material is imbued with color-change reagent, or onto which one or more color-change reagents are dispensed. The color-change-reagent strips are consecutive and contiguous on the roll. A cassette includes two spools arranged such that when the spools turn, the reagent strip moves from a first (source spool) to a second (waste spool). The section of the reagent strip that is between the two spools may be exposed to a urine specimen. The absorbent-material strips that have been exposed to both a urine specimen and a color-change reagent may undergo a chemical reaction. Selective-lighting illumination may be applied to absorbent-material strips that have undergone such chemical reactions to measure reflectivity of certain color wavelengths. This measurement may be expressed in terms of a digital readout, which may be displayed on a user interface.