利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

9 条记录 (耗时 0.033 秒)

    KITS FOR MULTIPARAMETRIC PHOSPHO ANALYSIS
    1.
    发明申请
    KITS FOR MULTIPARAMETRIC PHOSPHO ANALYSIS 有权
    多功能磷光体分析仪

    公开(公告)号：US20100240542A1

    公开(公告)日：2010-09-23

    申请号：US12730170

    申请日：2010-03-23

    申请人： David Soper ,  David Rosen ,  Todd Covey ,  Ying-Wen Huang ,  Wendy Fantl ,  Ralph Lin

    发明人： David Soper ,  David Rosen ,  Todd Covey ,  Ying-Wen Huang ,  Wendy Fantl ,  Ralph Lin

    IPC分类号： C40B30/02 ,  C12N5/071 ,  G01N33/53 ,  C12N5/078

    CPC分类号： G01N33/6842 ,  G01N33/5011 ,  G01N33/5041 ,  G01N33/5094 ,  G01N33/6845 ,  G01N33/80 ,  G01N2440/14 ,  G01N2510/00

    摘要： As disclosed herein, the present invention provides for kits and a composition for diagnosis, prognosis, drug discovery, drug development, and patient stratification. The kits can comprise a plurality of binding elements for cell surface markers, and a plurality of binding elements for state-specific intracellular markers. The kits can further comprise a plurality of modulators directed for the particular cell function or signaling pathways. The kits can further include fixatives, permeabilizing agent, buffers, containers, instructions, and software for data analysis/compilation.

    摘要翻译： 如本文所公开的，本发明提供用于诊断，预后，药物发现，药物开发和患者分层的试剂盒和组合物。 试剂盒可以包含用于细胞表面标记的多个结合元件，以及用于状态特异性细胞内标记物的多个结合元件。 试剂盒还可以包含针对特定细胞功能或信号传导途径的多个调节剂。 试剂盒还可以包括固定剂，渗透剂，缓冲液，容器，说明书和用于数据分析/汇编的软件。

    KITS FOR MULTIPARAMETRIC PHOSPHO ANALYSIS
    2.
    发明申请
    KITS FOR MULTIPARAMETRIC PHOSPHO ANALYSIS 审中-公开
    多功能磷光体分析仪

    公开(公告)号：US20120276558A1

    公开(公告)日：2012-11-01

    申请号：US13544053

    申请日：2012-07-09

    申请人： David Soper ,  David Rosen ,  Todd Covey ,  Ying-Wen Huang ,  Wenday Fantl ,  Ralph Lin

    发明人： David Soper ,  David Rosen ,  Todd Covey ,  Ying-Wen Huang ,  Wenday Fantl ,  Ralph Lin

    IPC分类号： G01N33/53

    CPC分类号： G01N33/6842 ,  G01N33/5011 ,  G01N33/5041 ,  G01N33/5094 ,  G01N33/6845 ,  G01N33/80 ,  G01N2440/14 ,  G01N2510/00

    摘要： As disclosed herein, the present invention provides for kits and a composition for diagnosis, prognosis, drug discovery, drug development, and patient stratification. The kits can comprise a plurality of binding elements for cell surface markers, and a plurality of binding elements for state-specific intracellular markers. The kits can further comprise a plurality of modulators directed for the particular cell function or signaling pathways. The kits can further include fixatives, permeabilizing agent, buffers, containers, instructions, and software for data analysis/compilation.

    摘要翻译： 如本文所公开的，本发明提供用于诊断，预后，药物发现，药物开发和患者分层的试剂盒和组合物。 试剂盒可以包含用于细胞表面标记的多个结合元件，以及用于状态特异性细胞内标记物的多个结合元件。 试剂盒还可以包含针对特定细胞功能或信号传导途径的多个调节剂。 试剂盒还可以包括固定剂，渗透剂，缓冲液，容器，说明书和用于数据分析/汇编的软件。

    Fibroblast Growth Factor Receptor-Like Molecules and Uses Thereof
    6.
    发明申请
    Fibroblast Growth Factor Receptor-Like Molecules and Uses Thereof 审中-公开
    成纤维细胞生长因子受体样分子及其用途

    公开(公告)号：US20140273089A1

    公开(公告)日：2014-09-18

    申请号：US13828198

    申请日：2013-03-14

    申请人： Christiaan M. Saris ,  Sharon X. Mu ,  Min Xia ,  Thomas Charles Boone ,  Todd Covey

    发明人： Christiaan M. Saris ,  Sharon X. Mu ,  Min Xia ,  Thomas Charles Boone ,  Todd Covey

    IPC分类号： C07K14/71

    CPC分类号： C07K14/71

    摘要： The present invention provides Fibroblast Growth Factor Receptor-Like (FGFR-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing FGFR-L polypeptides. The inventio further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with FGFR-L polypeptides.

    摘要翻译： 本发明提供成纤维细胞生长因子受体样（FGFR-L）多肽和编码该多肽的核酸分子。 本发明还提供选择性结合剂，载体，宿主细胞和用于产生FGFR-L多肽的方法。 本发明还提供用于诊断，治疗，改善和/或预防与FGFR-L多肽相关的疾病，病症和病症的药物组合物和方法。

    METHODS FOR DETERMINING THE EFFECTS OF COMPOUNDS ON JAK/STAT ACTIVITY
    7.
    发明申请
    METHODS FOR DETERMINING THE EFFECTS OF COMPOUNDS ON JAK/STAT ACTIVITY 审中-公开
    用于测定化合物对JAK / STAT活性的影响的方法

    公开(公告)号：US20140065633A1

    公开(公告)日：2014-03-06

    申请号：US13913029

    申请日：2013-06-07

    申请人： Wendy J. Fantl ,  Alessandra Cesano ,  Todd Covey

    发明人： Wendy J. Fantl ,  Alessandra Cesano ,  Todd Covey

    IPC分类号： G01N33/50

    CPC分类号： G01N33/5041 ,  A61K38/17 ,  A61K38/193 ,  A61K38/2013 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/154 ,  C12Q2600/178 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/5017 ,  G01N33/5023 ,  G01N33/5047 ,  G01N33/5073 ,  G01N2333/91205 ,  G01N2500/02 ,  G01N2500/10

    摘要： An embodiment of the present invention is a method for subjecting a hematopoetic cell to a JAK/STAT inhibitor, determining the activity of gain-of-function mutations of a Jak family kinase, determining the expression levels and activity of JAK/STAT regulatory proteins, correlating the expression levels and the activity of JAK/STAT regulatory proteins with the activity of gain-of-function mutations of a Jak family kinase and with a response to the JAK/STAT inhibitor, and then classifying the cells. A further embodiment of the invention includes determining the clinical outcome based on the cell classification, determining a method of treatment, determining dosing and scheduling of at least one of the JAK/STAT inhibitors or other compounds.

    摘要翻译： 本发明的一个实施方案是一种使造血细胞经历JAK / STAT抑制剂，测定Jak家族激酶的功能功能突变的活性，确定JAK / STAT调节蛋白的表达水平和活性的方法， 将JAK / STAT调节蛋白的表达水平和活性与Jak家族激酶的功能增强突变的活性和对JAK / STAT抑制剂的应答相关，然后对细胞进行分类。 本发明的另一个实施方案包括基于细胞分类确定临床结果，确定治疗方法，确定至少一种JAK / STAT抑制剂或其它化合物的给药和调度。

    MULTIPLE MECHANISMS FOR MODULATION OF JAK/STAT ACTIVITY
    9.
    发明申请
    MULTIPLE MECHANISMS FOR MODULATION OF JAK/STAT ACTIVITY 审中-公开
    用于调节JAK / STAT活性的多种机制

    公开(公告)号：US20100209929A1

    公开(公告)日：2010-08-19

    申请号：US12687873

    申请日：2010-01-14

    申请人： Wendy J. Fantl ,  Alessandra Casano ,  Todd Covey

    发明人： Wendy J. Fantl ,  Alessandra Casano ,  Todd Covey

    IPC分类号： C12Q1/68 ,  C12Q1/02

    CPC分类号： G01N33/5041 ,  A61K38/17 ,  A61K38/193 ,  A61K38/2013 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/154 ,  C12Q2600/178 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/5017 ,  G01N33/5023 ,  G01N33/5047 ,  G01N33/5073 ,  G01N2333/91205 ,  G01N2500/02 ,  G01N2500/10

    摘要： An embodiment of the present invention is a method for subjecting a hematopoetic cell to a JAK/STAT inhibitor, determining the activity of gain-of-function mutations of a Jak family kinase, determining the expression levels and activity of JAK/STAT regulatory proteins, correlating the expression levels and the activity of JAK/STAT regulatory proteins with the activity of gain-of-function mutations of a Jak family kinase and with a response to the JAK/STAT inhibitor, and then classifying the cells. A further embodiment of the invention includes determining the clinical outcome based on the cell classification, determining a method of treatment, determining dosing and scheduling of at least one of the JAK/STAT inhibitors or other compounds.

    摘要翻译： 本发明的一个实施方案是一种使造血细胞经历JAK / STAT抑制剂，测定Jak家族激酶的功能功能突变的活性，确定JAK / STAT调节蛋白的表达水平和活性的方法， 将JAK / STAT调节蛋白的表达水平和活性与Jak家族激酶的功能增强突变的活性和对JAK / STAT抑制剂的应答相关，然后对细胞进行分类。 本发明的另一个实施方案包括基于细胞分类确定临床结果，确定治疗方法，确定至少一种JAK / STAT抑制剂或其它化合物的给药和调度。