摘要:
The present invention provides compositions and methods for targeting recombinant retroviral particles specifically to cells of interest for delivery of desired therapeutic or toxic agents. The invention provides chimeric nucleotide constructs, chimeric proteins formed of a selected viral envelope gene from which a selected sequence has been deleted and into which has been inserted all or an effective portion of a heterologous ligand, said ligand or portion thereof capable of binding to a selected receptor, recombinant viral particles formed of the chimeric proteins, a biological mediator for delivery to the target cell; and retroviral gag and pol proteins. The lack of retroviral nucleic acid renders the viral particle replication defective and non-pathogenic.
摘要:
Methods of introducing genetic material into cells of an individual and compositions and kits for practicing the same are disclosed. The methods comprise the steps of contacting cells of an individual with a polynucleotide function enhancer and administering to the cells, a nucleic acid molecule that is free of retroviral particles. The nucleic acid molecule comprises a nucleotide sequence that encodes a protein that comprises at least one epitope that is identical or substantially similar to an epitope of a pathogen antigen or an antigen associated with a hyperproliferative or autoimmune disease, a protein otherwise missing from the individual due to a missing, non-functional or partially functioning gene, or a protein that produces a therapeutic effect on an individual. Methods of prophylactically and therapeutically immunizing an individual against HIV am disclosed. Pharmaceutical compositions and kits for practicing methods of the present invention are disclosed.
摘要:
Scalable, thermally efficient pump diode systems. These systems may include an arrangement of pump diodes and thermally conductive spacers mounted within a single indentation in a substrate or substrate clamps, so as to provide enhanced heat removal from the system. These systems also may include a plurality of such pump diode assemblies mounted, in a symmetric or partially symmetric arrangement, around a lasing medium in a diode pumped laser system, to improve heat removal and/or excitation of the medium.
摘要:
The present invention relates to Pyridyl-Substituted Porphyrin Compounds, compositions comprising an effective amount of a Pyridyl-Substituted Porphyrin Compound and methods for treating or preventing injury due to exposure to a reactive species, erectile dysfunction due to surgery, lung disease, hyperoxia, neurodegenerative disease, liver disease, myocardial damage during cardioplegia, an inflammatory condition, a reperfusion injury, an ischemic condition, a cardiovascular disease, diabetes, a diabetic complication, cancer, a side effect of cancer chemotherapy, or a radiation-induced injury, or to prolong the half-life of an oxidation-prone compound, comprising administering to a subject in need thereof an effective amount of a Pyridyl-Substituted Porphyrin Compound.
摘要:
A streamed database archival process with background synchronization. Archive logs are streamed asynchronously such that a plurality of files can be transferred simultaneously from a host operational database to a backup archive database. By streaming the logs, the backup database is kept up to date and backlogs can quickly be resolved. Furthermore, an automatic recovery process is run in the background. This process automatically detects files on the backup database which may have been accidentally deleted or corrupted. The process recopies those missing or corrupted files from the host database without any human intervention.
摘要:
A method of superplastic forming of titanium packs and an associated assembly is provided. The titanium packs can include sheets having different granular structures so that the different sheets are adapted to superplastically form at different temperatures. One or more of the sheets can be formed at a temperature that is below the superplastic forming temperature of another sheet in the pack. In some cases, the occurrence of markoff can be reduced or eliminated.
摘要:
Liquid such as water is deaerated by dissolving stripping gas such as carbon dioxide into the water while maintaining pressure, reducing the pressure, and then feeding the liquid into a vessel wherein a gas space is maintained over said water, wherein the pressure of said gas space is less than the pressure upstream, and separately withdrawing degassed liquid and evolved gas from said vessel at rates which maintain the pressure of said gas space below the pressure upstream of said means.
摘要:
The present invention relates to N-Benzyl-Substituted Pyridyl Porphyrin Compounds and compositions comprising an effective amount of N-Benzyl-Substituted Pyridyl Porphyrin Compounds. The N-Benzyl-Substituted Pyridyl Porphyrin Compounds include compounds of the following formula: wherein: M is Fe or Mn; f is 0 or 1; each R is independently —C(O)(amino acid residue) or —SO2(amino acid residue); and n is the number of counterions sufficient to balance the charges of the compound of Formula (A).
摘要:
A shipping container is constructed for shipping channeled fuel bundle assemblies. The shipping container includes an outer container, an inner container sized to fit within the outer container, and shock absorbing material disposed at least between the outer and inner containers. The inner container is shaped to house at least one pre-channeled fuel bundle assembly including a channel, a channel fastener, and an array of fuel rods supported by grid spacers between an upper tie plate and a lower tie plate. The inner container includes a lower tie plate restraint device shaped to receive the lower tie plate and a lower portion of the channel, and an upper tie plate restraint device shaped to receive the upper tie plate and an upper portion of the channel and channel fastener assembly. The lower and upper tie plate restraint devices are lockable within the inner shipping container.
摘要:
Systems and methods may be utilized to obtain and evaluate data from various information resources associated with a diagnostic testing business for the purpose of identifying at-risk clients. A set of risk indicators is defined. Each risk indicator relates to a type of event that is determined to be indicative of client risk, and about which data may be obtained from information resources associated with the testing process. Data is obtained from the various information resources through respective interfaces and is stored in a risk indicator database. A reporting application associated with the risk indicator database applies score generation rules to the risk indicator data associated with each risk indicator to generate a risk score associated with each risk indicator for each client. The risk scores may then be evaluated to identify at-risk clients and to identify systemic problems of the organization that occur across many clients.