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1.发明申请公开(公告)号：US20130296281A1
公开(公告)日：2013-11-07
申请号：US13704531
申请日：2011-06-16
申请人： Donald J. Kyle , Chiyou Ni , Laykea Tafesse , Jiangchao Yao
发明人： Donald J. Kyle , Chiyou Ni , Laykea Tafesse , Jiangchao Yao
IPC分类号： C07D209/20 , C07D209/12 , C07D401/12 , C07D209/18 , C07D231/56 , G01N33/50 , C07D413/06 , C07D209/14 , C07D471/04
CPC分类号： C07D209/20 , C07B59/002 , C07B2200/05 , C07D209/12 , C07D209/14 , C07D209/16 , C07D209/18 , C07D231/56 , C07D401/12 , C07D413/06 , C07D471/04 , G01N33/5008
摘要： The invention relates to aryl and heteroaryl substituted compounds of Formula (I), and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein G, R1, and Z1-Z5 are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.
摘要翻译： 本发明涉及式（I）的芳基和杂芳基取代的化合物及其药学上可接受的盐，前药或溶剂化物，其中G，R1和Z1-Z5如说明书所述定义。 本发明还涉及式（I）化合物用于治疗对钠通道阻断作出反应的病症。 本发明的化合物特别适用于治疗疼痛。
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2.发明授权公开(公告)号：US09212139B2
公开(公告)日：2015-12-15
申请号：US13704531
申请日：2011-06-16
申请人： Donald J. Kyle , Chiyou Ni , Laykea Tafesse , Jiangchao Yao
发明人： Donald J. Kyle , Chiyou Ni , Laykea Tafesse , Jiangchao Yao
IPC分类号： C07D209/12 , C07D209/20 , C07D209/16 , C07D231/56 , C07D471/04 , C07D209/14 , C07D209/18 , C07D401/12 , C07D413/06 , G01N33/50
CPC分类号： C07D209/20 , C07B59/002 , C07B2200/05 , C07D209/12 , C07D209/14 , C07D209/16 , C07D209/18 , C07D231/56 , C07D401/12 , C07D413/06 , C07D471/04 , G01N33/5008
摘要： The invention relates to aryl and heteroaryl substituted compounds of Formula (I), and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein G, R1, and Z1-Z5 are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.
摘要翻译： 本发明涉及式（I）的芳基和杂芳基取代的化合物及其药学上可接受的盐，前药或溶剂化物，其中G，R1和Z1-Z5如说明书所述定义。 本发明还涉及式（I）化合物用于治疗对钠通道阻断作出反应的病症。 本发明的化合物特别适用于治疗疼痛。
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公开(公告)号：US20140005212A1
公开(公告)日：2014-01-02
申请号：US13996082
申请日：2011-12-21
申请人： Chiyou Ni , Minnie Park , Bin Shao , Laykea Tafesse , Jiangchao Yao , Mark Youngman , Xiaoming Zhou
发明人： Chiyou Ni , Minnie Park , Bin Shao , Laykea Tafesse , Jiangchao Yao , Mark Youngman , Xiaoming Zhou
IPC分类号： C07D213/75 , C07D413/12 , C07D401/12 , C07D401/14 , C07D213/81 , C07D213/76
CPC分类号： C07D213/75 , C07D213/76 , C07D213/81 , C07D401/02 , C07D401/12 , C07D401/14 , C07D413/12
摘要： The invention relates to substituted pyridine compounds of Formula I: (I) and the pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein R1a, R1b, R2a, R2b, R2c, A1, A2, and X are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.
摘要翻译： 本发明涉及式I的取代的吡啶化合物：（I）及其药学上可接受的盐，前药和溶剂化物，其中R1a，R1b，R2a，R2b，R2c，A1，A2和X定义如 规范。 本发明还涉及式I化合物用于治疗对钠通道阻断有反应的病症。 本发明的化合物特别适用于治疗疼痛。
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公开(公告)号：US09656959B2
公开(公告)日：2017-05-23
申请号：US13996082
申请日：2011-12-21
申请人： Chiyou Ni , Minnie Park , Bin Shao , Laykea Tafesse , Jiangchao Yao , Mark A. Youngman , Xiaoming Zhou
发明人： Chiyou Ni , Minnie Park , Bin Shao , Laykea Tafesse , Jiangchao Yao , Mark A. Youngman , Xiaoming Zhou
IPC分类号： C07D213/75 , C07D401/02 , C07D401/12 , C07D401/14 , C07D213/76 , C07D213/81 , C07D413/12
CPC分类号： C07D213/75 , C07D213/76 , C07D213/81 , C07D401/02 , C07D401/12 , C07D401/14 , C07D413/12
摘要： The invention relates to substituted pyridine compounds of Formula I: (I) and the pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein R1a, R1b, R2a, R2b, R2c, A1, A2, and X are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.
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公开(公告)号：US20130303526A1
公开(公告)日：2013-11-14
申请号：US13821732
申请日：2011-09-16
申请人： Chiyou NI , Bin Shao , Laykea Tafesse , Jiangchao Yao , Jianming Yu , Xiaoming Zhou
发明人： Chiyou NI , Bin Shao , Laykea Tafesse , Jiangchao Yao , Jianming Yu , Xiaoming Zhou
IPC分类号： C07D213/30 , C07D213/81 , C07D213/58 , C07D213/643 , C07D401/12 , C07D401/04 , C07D401/14
CPC分类号： C07D213/81 , C07D213/30 , C07D213/46 , C07D213/50 , C07D213/57 , C07D213/58 , C07D213/643 , C07D213/65 , C07D213/74 , C07D213/79 , C07D213/84 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14
摘要： The invention relates to substituted pyridine compounds of Formula (I) and the pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein R1a, A1, A2, E, G, Z1, and Z2 are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.
摘要翻译： 本发明涉及式（I）的取代吡啶化合物及其药学上可接受的盐，前体药物和溶剂合物，其中R1a，A1，A2，E，G，Z1和Z2如本说明书所述定义。 本发明还涉及式I化合物用于治疗对钠通道阻断有反应的病症。 本发明的化合物特别适用于治疗疼痛。
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公开(公告)号：US09637458B2
公开(公告)日：2017-05-02
申请号：US14771212
申请日：2014-03-03
申请人： Jeffrey Lockman , Chiyou Ni , Jae Hyun Park , Minnie Park , Bin Shao , Laykea Tafesse , Jiangchao Yao , Mark A. Youngman
发明人： Jeffrey Lockman , Chiyou Ni , Jae Hyun Park , Minnie Park , Bin Shao , Laykea Tafesse , Jiangchao Yao , Mark A. Youngman
IPC分类号： C07D239/34 , C07D239/42 , C07D403/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/14 , C07D405/12 , C07D413/04 , C07D471/08 , C07D487/08
CPC分类号： C07D239/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/08 , C07D487/08
摘要： The present disclosure provides substituted pyrimidine carboxamides of Formula (I) and the pharmaceutically acceptable salts and solvates thereof, wherein A1, X, A2, W1, W2, W3, E, Z, and R4 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.
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公开(公告)号：US20160009659A1
公开(公告)日：2016-01-14
申请号：US14771212
申请日：2014-03-03
申请人： Jeffrey LOCKMAN , Chiyou NI , Jae Hyun PARK , Minnie PARK , Bin SHAO , Laykea TAFESSE , Jiangchao YAO , Mark A. YOUNGMAN
发明人： Jeffrey Lockman , Chiyou Ni , Jae Hyun Park , Minnie Park , Bin Shao , Laykea Tafesse , Jiangchao Yao , Mark A. Youngman
IPC分类号： C07D239/42 , C07D403/12 , C07D413/04 , C07D401/12 , C07D413/14 , C07D401/04 , C07D405/14 , C07D487/08 , C07D401/14 , C07D403/14 , C07D403/04 , C07D405/12
CPC分类号： C07D239/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/08 , C07D487/08
摘要： The present disclosure provides substituted pyrimidine carboxamides of Formula (I) and the pharmaceutically acceptable salts and solvates thereof, wherein A1, X, A2, W1, W2, W3, E, Z, and R4 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.
摘要翻译： 本公开提供式（I）的取代的嘧啶甲酰胺及其药学上可接受的盐和溶剂化物，其中A1，X，A2，W1，W2，W3，E，Z和R4如本说明书所述定义。 本公开还涉及式（I）化合物用于治疗对钠通道阻断有反应的病症。 本公开的化合物特别可用于治疗疼痛。
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公开(公告)号：US09056832B2
公开(公告)日：2015-06-16
申请号：US13821732
申请日：2011-09-16
申请人： Chiyou Ni , Bin Shao , Laykea Tafesse , Jiangchao Yao , Jianming Yu , Xiaoming Zhou
发明人： Chiyou Ni , Bin Shao , Laykea Tafesse , Jiangchao Yao , Jianming Yu , Xiaoming Zhou
IPC分类号： C07D401/04 , C07D213/81 , C07D213/30 , C07D401/12 , C07D213/58 , C07D213/643 , C07D401/14 , C07D213/79 , C07D213/74 , A61K31/444 , A61K31/4418 , A61P23/00 , C07D213/46 , C07D213/84 , C07D403/14
CPC分类号： C07D213/81 , C07D213/30 , C07D213/46 , C07D213/50 , C07D213/57 , C07D213/58 , C07D213/643 , C07D213/65 , C07D213/74 , C07D213/79 , C07D213/84 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14
摘要： The invention relates to substituted pyridine compounds of Formula (I) and the pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein R1a, A1, A2, E, G, Z1, and Z2 are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.
摘要翻译： 本发明涉及式（I）的取代吡啶化合物及其药学上可接受的盐，前体药物和溶剂合物，其中R1a，A1，A2，E，G，Z1和Z2如本说明书所述定义。 本发明还涉及式I化合物用于治疗对钠通道阻断有反应的病症。 本发明的化合物特别适用于治疗疼痛。
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公开(公告)号：US09045435B2
公开(公告)日：2015-06-02
申请号：US13878004
申请日：2011-10-05
IPC分类号： C07D239/74 , C07D239/84 , A01N43/54 , A61K31/517 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D471/08
CPC分类号： A61K31/517 , C07D239/74 , C07D239/84 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D471/08
摘要： The invention relates to aryl substituted quinazolines of Formula I, and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein G, A, and R1-R4 are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.
摘要翻译： 本发明涉及式I的芳基取代喹唑啉及其药学上可接受的盐，前药或溶剂化物，其中G，A和R 1 -R 4如说明书所述定义。 本发明还涉及式I化合物用于治疗对钠通道阻断有反应的病症。 本发明的化合物特别适用于治疗疼痛。
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公开(公告)号：US20130289044A1
公开(公告)日：2013-10-31
申请号：US13878004
申请日：2011-10-05
IPC分类号： C07D239/74 , C07D401/04 , C07D403/12 , C07D239/84 , C07D403/04
CPC分类号： A61K31/517 , C07D239/74 , C07D239/84 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D471/08
摘要： The invention relates to aryl substituted quinazolines of Formula I, and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein G, A, and R1-R4 are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.
摘要翻译： 本发明涉及式I的芳基取代喹唑啉及其药学上可接受的盐，前药或溶剂合物，其中G，A和R 1 -R 4如说明书所述定义。 本发明还涉及式I化合物用于治疗对钠通道阻断有反应的病症。 本发明的化合物特别适用于治疗疼痛。
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