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    Methods and pharmaceutical compositions for reliable achievement of acceptable serum testosterone levels
    3.
    发明授权
    Methods and pharmaceutical compositions for reliable achievement of acceptable serum testosterone levels 有权
    可靠地达到可接受的血清睾酮水平的方法和药物组合物

    公开(公告)号：US07718640B2

    公开(公告)日：2010-05-18

    申请号：US10798780

    申请日：2004-03-12

    申请人： Doris Hubler ,  Sabine Fricke ,  Jan-Peter Ingwersen ,  Wilhelm Kuhnz

    发明人： Doris Hubler ,  Sabine Fricke ,  Jan-Peter Ingwersen ,  Wilhelm Kuhnz

    IPC分类号： A61K31/56

    CPC分类号： A61K31/565 ,  A61K9/0019 ,  A61K31/56 ,  A61K31/568 ,  A61K31/57 ,  A61K47/14 ,  A61K47/44

    摘要： The present invention relates to pharmaceutical compositions, formulated for injectable administration, which comprises a testosterone ester, in particularly testosterone undecanoate, in a vehicle comprising castor oil and a co-solvent. Upon injecting the compositions according to a particular administration scheme, reliable levels of testosterone in serum in the normal physiological range is achieved for a long period. This allows for the use of the compositions in hormone replacement therapy and male contraception without concomitant monitoring of testosterone levels in serum by a physician.

    摘要翻译： 本发明涉及配制用于可注射给药的药物组合物，其包含睾酮酯，特别是十一酸睾酮，载体包含蓖麻油和共溶剂。 在根据特定给药方案注射组合物时，长时间内可获得在正常生理范围内血清中可靠水平的睾丸激素。 这允许在激素替代治疗和男性避孕中使用组合物，而无需伴随地监测医师对血清中的睾酮水平。

    EXTENDED STEP-DOWN ESTROGEN REGIMEN
    5.
    发明申请
    EXTENDED STEP-DOWN ESTROGEN REGIMEN 审中-公开
    扩展的降压雌雄同株

    公开(公告)号：US20080021003A1

    公开(公告)日：2008-01-24

    申请号：US11761616

    申请日：2007-06-12

    申请人： Vladimir Hanes ,  Jan-Peter Ingwersen

    发明人： Vladimir Hanes ,  Jan-Peter Ingwersen

    IPC分类号： A61K31/56 ,  A61P5/24

    CPC分类号： A61K31/565 ,  A61K2300/00

    摘要： The present invention relates to methods for treating diseases, conditions or symptoms associated with deficient endogenous levels of estrogen comprising administration of a higher first dose of an estrogen followed by administration of a lower second dose of an estrogen once therapy has been effectively established. The invention further relates to a combination treatment comprising administration of an estrogen and a progestin.

    摘要翻译： 本发明涉及用于治疗与内源性雌激素水平不足相关的疾病，病症或症状的方法，包括施用较高的第一剂雌激素，然后施用较低的第二剂量的雌激素，一旦有效地建立了治疗。 本发明还涉及包括施用雌激素和孕激素的组合治疗。

    Uv stable transdermal therapeutic plaster
    9.
    发明申请
    Uv stable transdermal therapeutic plaster 有权
    Uv稳定透皮治疗膏药

    公开(公告)号：US20060251707A1

    公开(公告)日：2006-11-09

    申请号：US10545826

    申请日：2004-02-04

    申请人： Jochen Schumacher ,  Manfred Suesse ,  Michael Dittgen ,  Stephan Mletzko ,  Jan-Peter Ingwersen ,  Thomas Langguth ,  Dirk Schenk ,  Hubert Kaffl

    发明人： Jochen Schumacher ,  Manfred Suesse ,  Michael Dittgen ,  Stephan Mletzko ,  Jan-Peter Ingwersen ,  Thomas Langguth ,  Dirk Schenk ,  Hubert Kaffl

    IPC分类号： A61K9/70

    CPC分类号： A61K31/567 ,  A61K9/0014 ,  A61K9/7084 ,  A61K47/08 ,  A61K47/12 ,  A61K47/22 ,  A61M35/00

    摘要： The invention relates to a UV stable transdermal therapeutic system (TTS) consisting of a back layer, at least one matrix containing an active substance and, optionally, a withdrawal film and an UV-radiation absorber. An adhesive layer containing said UV-radiation absorber is arranged between the back layer and the matrix containing an active substance which is distant as much as possible from a surface, a separation layer is arranged between the adhesive layer containing said UV-radiation absorber and the matrix containing an active substance, which is as remote as possible from the surface which is impermeable to the active substance and UV radiation absorber. The inventive transdermal therapeutic system exhibits a high stability and is devoid of inconveniences of existing TTS containing a light-sensitive substance.

    摘要翻译： 本发明涉及由背层，至少一种含有活性物质的基质和任选的取出膜和UV-辐射吸收剂组成的UV稳定透皮治疗系统（TTS）。 含有所述紫外线吸收剂的粘合剂层被布置在背层和含有活性物质的基质之间，所述活性物质尽可能远离表面，分离层设置在包含所述紫外线吸收剂的粘合剂层和 含有活性物质的基质，该活性物质尽可能远离活性物质和紫外线吸收剂不可渗透的表面。 本发明的透皮治疗系统表现出高稳定性，并且没有含有光敏物质的现有TTS的不便。