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19 条记录 (耗时 0.02 秒)

    Methods and pharmaceutical compositions for reliable achievement of acceptable serum testosterone levels
    3.
    发明授权
    Methods and pharmaceutical compositions for reliable achievement of acceptable serum testosterone levels 有权
    可靠地达到可接受的血清睾酮水平的方法和药物组合物

    公开(公告)号：US07718640B2

    公开(公告)日：2010-05-18

    申请号：US10798780

    申请日：2004-03-12

    申请人： Doris Hubler ,  Sabine Fricke ,  Jan-Peter Ingwersen ,  Wilhelm Kuhnz

    发明人： Doris Hubler ,  Sabine Fricke ,  Jan-Peter Ingwersen ,  Wilhelm Kuhnz

    IPC分类号： A61K31/56

    CPC分类号： A61K31/565 ,  A61K9/0019 ,  A61K31/56 ,  A61K31/568 ,  A61K31/57 ,  A61K47/14 ,  A61K47/44

    摘要： The present invention relates to pharmaceutical compositions, formulated for injectable administration, which comprises a testosterone ester, in particularly testosterone undecanoate, in a vehicle comprising castor oil and a co-solvent. Upon injecting the compositions according to a particular administration scheme, reliable levels of testosterone in serum in the normal physiological range is achieved for a long period. This allows for the use of the compositions in hormone replacement therapy and male contraception without concomitant monitoring of testosterone levels in serum by a physician.

    摘要翻译： 本发明涉及配制用于可注射给药的药物组合物，其包含睾酮酯，特别是十一酸睾酮，载体包含蓖麻油和共溶剂。 在根据特定给药方案注射组合物时，长时间内可获得在正常生理范围内血清中可靠水平的睾丸激素。 这允许在激素替代治疗和男性避孕中使用组合物，而无需伴随地监测医师对血清中的睾酮水平。

    Melatonin for the production of a peroral pulsatile form of medication
    5.
    发明授权
    Melatonin for the production of a peroral pulsatile form of medication 失效
    褪黑激素用于产生口服脉搏形式的药物

    公开(公告)号：US06214377B1

    公开(公告)日：2001-04-10

    申请号：US08567294

    申请日：1995-12-05

    申请人： Michael Dittgen ,  Sabine Fricke ,  Thomas Gräser ,  Hermann Osterwald ,  Michael Oettel ,  Theodor Hermann Lippert

    发明人： Michael Dittgen ,  Sabine Fricke ,  Thomas Gräser ,  Hermann Osterwald ,  Michael Oettel ,  Theodor Hermann Lippert

    IPC分类号： A61K958

    CPC分类号： A61K9/4875 ,  A61K9/4858 ,  A61K31/4045

    摘要： The use of melatonin for the production of peroral pulsatile forms of medications assures the safeguard of an effective level of the medical substance of melatonin in the blood, and which realize a relatively short invasion phase with a controlled delivery in comparison to conventional forms of medication containing melatonin, and which simultaneously exclude the known side effects. A control of the delivery of the melatonin is effected which is associated with the precise adaptation to the illness episodes or the pain attacks of certain illnesses, which can be treated prophylactically and therapeutically with the active agent melatonin.

    摘要翻译： 使用褪黑激素来生产口服脉搏形式的药物确保维持血液中褪黑激素的有效水平，并且与常规形式的药物相比，其具有受控递送的相对较短的入侵期 褪黑激素，同时排除已知的副作用。 对褪黑激素的输送进行控制，这与精神适应疾病发作或某些疾病的疼痛攻击有关，可以用活性剂褪黑激素进行预防和治疗。

    Multistage preparation for contraception based on natural estrogens
    8.
    发明申请
    Multistage preparation for contraception based on natural estrogens 审中-公开
    基于天然雌激素的避孕多步骤准备

    公开(公告)号：US20050032756A1

    公开(公告)日：2005-02-10

    申请号：US10891729

    申请日：2004-07-15

    申请人： Michael Dittgen ,  Sabine Fricke ,  Herbert Hoffmann ,  Claudia Moore ,  Michael Oettel ,  Monika Oster Wald

    发明人： Michael Dittgen ,  Sabine Fricke ,  Herbert Hoffmann ,  Claudia Moore ,  Michael Oettel ,  Monika Oster Wald

    IPC分类号： A61K31/57 ,  A61K31/56

    CPC分类号： A61K31/57 ,  A61K2300/00

    摘要： A multistage preparation for contraception based on a combination of natural estrogen and synthetic gestogen is described. The preferred preparation contains estradiol valerate as the natural estrogen and dienogest or drospirenone as the synthetic gestogen. In comparison to conventional multistage preparations the multistage preparation according to the invention has a higher contraceptive reliability over the entire cycle, improved cyclic bleeding behavior and minimizes or prevents side effects, such as breast tension, headaches, depressive moods and libido changes.

    摘要翻译： 描述了基于天然雌激素和合成gestogen的组合的用于避孕的多级制剂。 优选的制剂包含戊酸雌二醇作为天然雌激素和依诺孕酮或屈螺酮作为合成孕酮。 与常规多级制剂相比，根据本发明的多级制剂在整个循环中具有更高的避孕可靠性，改善的循环出血行为并且最小化或预防副作用，例如乳房张力，头痛，抑郁情绪和性欲改变。

    Combination preparation for contraception based on natural estrogens
    9.
    发明授权
    Combination preparation for contraception based on natural estrogens 失效
    基于天然雌激素的避孕组合制剂

    公开(公告)号：US06884793B2

    公开(公告)日：2005-04-26

    申请号：US09950915

    申请日：2001-09-12

    申请人： Michael Dittgen ,  Sabine Fricke ,  Herbert Hoffmann ,  Claudia Moore ,  Michael Oettel ,  Monika Ostertag

    发明人： Michael Dittgen ,  Sabine Fricke ,  Herbert Hoffmann ,  Claudia Moore ,  Michael Oettel ,  Monika Ostertag

    IPC分类号： A61K31/565 ,  A61K31/57 ,  A61P15/00 ,  A61P15/18 ,  C07J1/00 ,  C07J7/00 ,  A61K33/56

    CPC分类号： A61K31/57 ,  Y10S514/843 ,  A61K31/565 ,  A61K2300/00

    摘要： The combination preparation for contraception includes from 2 to 4 first stage daily dosage portions each including an effective amount of at least one natural estrogen as sole active ingredient, from 16 to 22 second stage daily dosage portions each including an effective amount of a combination of at least one natural estrogen and at least one natural or synthetic gestogen as active ingredient; from 2 to 4 third stage daily dosage portions each including an effective amount of at least one natural estrogen as sole active ingredient; and from 2 to 4 final stage daily dosage portions containing a pharmaceutically acceptable placebo. The estrogen may be estradiol, an estradiol compound that is metabolized to estradiol when taken into the body, a conjugated equine estrogen or a phytoestrogen. The natural or synthetic gestogen can be natural progesterone or a synthetic gestogens, such as medroxyprogesterone acetate.

    摘要翻译： 用于避孕的组合制剂包括2至4个第一阶段每日剂量部分，每个剂量部分包含有效量的至少一种天然雌激素作为唯一活性成分，16至22个第二阶段日剂量部分，每个包含有效量的组合 至少一种天然雌激素和至少一种天然或合成的Gestogen作为活性成分; 2至4个第三阶段每日剂量部分，每个包含有效量的至少一种天然雌激素作为唯一活性成分; 和含有药学上可接受的安慰剂的2至4个最终阶段每日剂量部分。 雌激素可以是雌二醇，当被摄入体内时被代谢为雌二醇的雌二醇化合物，共轭马雌激素或植物雌激素。 天然或合成的gestogen可以是天然孕酮或合成的gestogens，如醋酸甲羟孕酮。