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8 条记录 (耗时 0.048 秒)

    Secreted proteins and uses thereof
    5.
    发明授权
    Secreted proteins and uses thereof 失效
    分泌蛋白及其用途

    公开(公告)号：US06406884B1

    公开(公告)日：2002-06-18

    申请号：US09336536

    申请日：1999-06-18

    申请人： Steven Bossone

    发明人： Steven Bossone

    IPC分类号： C12P2102

    CPC分类号： C07K14/47

    摘要： The invention provides isolated nucleic acid molecules, designated TANGO 281, which encode proteins downregulated in megakaryocytes that fail to express the gata-1 transcription factor (a factor critical for blood cell formulation) and can, therefore, represent direct or indirect gata-1 targets. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic polypeptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供分离的核酸分子，命名为TANGO 281，其编码在未表达gata-1转录因子（对于血细胞制剂至关重要的因子）的巨核细胞中下调的蛋白质，因此可以代表直接或间接的gata-1靶 。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供了分离的多肽，融合多肽，抗原多肽和抗体。 还提供利用本发明组合物的诊断，筛选和治疗方法。

    Genes encoding polypeptides containing signal sequences
    6.
    发明授权
    Genes encoding polypeptides containing signal sequences 失效
    编码含有信号序列的多肽的基因

    公开(公告)号：US06410315B1

    公开(公告)日：2002-06-25

    申请号：US09436183

    申请日：1999-11-08

    申请人： Sean A. McCarthy ,  Steven Bossone

    发明人： Sean A. McCarthy ,  Steven Bossone

    IPC分类号： C12N1563

    CPC分类号： C12Q1/6897 ,  C12N15/1034 ,  C12N15/1051 ,  C12N15/81

    摘要： The invention involves a method of identifying nucleic acid sequences encoding signal peptide-containing proteins. The method features chimeric constructs containing a KRE9 gene that lacks a signal sequence. Yeast containing chimeric KRE9 plasmid constructs that encode signal sequences are selected based on their ability to grow on media in which sucrose is the sole carbon source.

    摘要翻译： 本发明涉及鉴定编码含有信号肽的蛋白质的核酸序列的方法。 该方法具有含有缺少信号序列的KRE9基因的嵌合构建体。 基于它们在其中蔗糖是唯一碳源的培养基上生长的能力来选择含有编码信号序列的嵌合KRE9质粒构建体的酵母。

    Method for identifying genes encoding signal sequences
    7.
    发明申请
    Method for identifying genes encoding signal sequences 审中-公开
    识别编码信号序列的基因的方法

    公开(公告)号：US20050164393A1

    公开(公告)日：2005-07-28

    申请号：US11048658

    申请日：2005-01-25

    申请人： Sean McCarthy ,  Steven Bossone

    发明人： Sean McCarthy ,  Steven Bossone

    IPC分类号： C12N1/19 ,  C12N15/10 ,  C12N15/81 ,  C12Q1/68 ,  C12N1/18 ,  C12N15/74

    CPC分类号： C12Q1/6897 ,  C12N15/1034 ,  C12N15/1051 ,  C12N15/81

    摘要： The invention involves a method of identifying nucleic acid sequences encoding signal peptide-containing proteins. The method features chimeric constructs containing a KRE9 gene that lacks a signal sequence. Yeast containing chimeric KRE9 plasmid constructs that encode signal sequences are selected based on their ability to grow on media in which sucrose is the sole carbon source.

    摘要翻译： 本发明涉及鉴定编码含有信号肽的蛋白质的核酸序列的方法。 该方法具有含有缺少信号序列的KRE9基因的嵌合构建体。 基于它们在其中蔗糖是唯一碳源的培养基上生长的能力来选择含有编码信号序列的嵌合KRE9质粒构建体的酵母。