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    Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses
    3.
    发明申请
    Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses 失效
    编码具有预后，诊断，预防，治疗和其他用途的蛋白质的新基因

    公开(公告)号：US20070048771A1

    公开(公告)日：2007-03-01

    申请号：US11491318

    申请日：2006-07-21

    申请人： Sean McCarthy ,  Christopher Fraser ,  John Sharp ,  Thomas Barnes ,  Susan Kirst ,  Paul Myers ,  Nicholas Wrighton ,  Andrew Goodearl ,  Douglas Holtzman ,  Mehran Khodadoust

    发明人： Sean McCarthy ,  Christopher Fraser ,  John Sharp ,  Thomas Barnes ,  Susan Kirst ,  Paul Myers ,  Nicholas Wrighton ,  Andrew Goodearl ,  Douglas Holtzman ,  Mehran Khodadoust

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705

    CPC分类号： C07K14/47

    摘要： The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

    摘要翻译： 本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质的分离的核酸。 这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供了使用本发明组合物的诊断，筛选和治疗方法。 本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

    Antibodies having diagnostic, preventive, therapeutic, and other uses
    4.
    发明申请
    Antibodies having diagnostic, preventive, therapeutic, and other uses 失效
    具有诊断，预防，治疗和其他用途的抗体

    公开(公告)号：US20070053904A1

    公开(公告)日：2007-03-08

    申请号：US11499835

    申请日：2006-08-04

    申请人： Susan Kirst ,  Douglas Holtzman ,  Christopher Fraser ,  John Sharp ,  Thomas Barnes

    发明人： Susan Kirst ,  Douglas Holtzman ,  Christopher Fraser ,  John Sharp ,  Thomas Barnes

    IPC分类号： G01N33/567 ,  A61K39/395 ,  C07K16/28

    CPC分类号： C07K16/18 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/47 ,  C07K16/28 ,  G01N33/5058

    摘要： The invention provides isolated nucleic acids encoding a variety of proteins and nucleic acids having diagnostic, preventive, therapeutic, and other uses. These nucleic acids and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

    摘要翻译： 本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质和核酸的分离的核酸。 这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供了利用本发明组合物的诊断，筛选和治疗方法。 本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

    Gas turbine, especially an aircraft engine
    5.
    发明申请
    Gas turbine, especially an aircraft engine 失效
    燃气轮机，特别是飞机发动机

    公开(公告)号：US20070169462A1

    公开(公告)日：2007-07-26

    申请号：US10587822

    申请日：2005-01-29

    申请人： John Sharp ,  Andreas Kreiner

    发明人： John Sharp ,  Andreas Kreiner

    IPC分类号： F02G3/00

    CPC分类号： F01D15/10 ,  F02C3/10 ,  F02K3/04 ,  F02K3/06 ,  F05D2220/323

    摘要： A gas turbine, especially an aircraft engine is provided. The gas turbine comprises at least one compressor (15, 16), at least one combustion chamber (17), at least one turbine (18, 19), and at least one generator (20) for generating electrical energy, the or each generator (20) comprising at least one stator (25) and at least one rotor (22). The or each rotor (22) of the or each generator (20) is embodied as a free-wheeling generator turbine that is driven by a gas flow in such a way that it rotates in relation to the respective stator (25) of the respective generator (20) and thus generates electrical energy from the kinetic energy of the gas flow.

    摘要翻译： 提供燃气轮机，特别是飞机发动机。 燃气轮机包括至少一个压缩机（15,16），至少一个燃烧室（17），至少一个涡轮机（18,19）和用于产生电能的至少一个发电机（20），所述或每个发电机 （20）包括至少一个定子（25）和至少一个转子（22）。 或每个发电机（20）的每个转子（22）被实施为由气流驱动的续流发电机涡轮机，使得其相对于相应的定子（25）旋转， 发电机（20），从而从气流的动能产生电能。

    Rotating assembly and support therefor
    6.
    发明授权
    Rotating assembly and support therefor 有权
    旋转组件和支架

    公开(公告)号：US06249070B1

    公开(公告)日：2001-06-19

    申请号：US09415462

    申请日：1999-10-14

    申请人： John Sharp

    发明人： John Sharp

    IPC分类号： H02K709

    CPC分类号： B60R16/027

    摘要： A shaft (14) is formed with a magnetically transparent portion within its length, so as to enable passage therethrough of electromagnetic flux from stator poles, to a further shaft (20) to cause shaft (20) to move to a position in space, coaxial with the shaft (20).

    摘要翻译： 轴（14）在其长度内形成有磁性透明部分，以便使电磁通从定子极通过到另一个轴（20），以使轴（20）移动到空间中的位置， 与轴（20）同轴。

    Mining installation equipment
    7.
    发明授权
    Mining installation equipment 失效
    采矿安装设备

    公开(公告)号：US4545621A

    公开(公告)日：1985-10-08

    申请号：US532500

    申请日：1983-09-15

    申请人： John Sharp

    发明人： John Sharp

    IPC分类号： E21C35/04 ,  E21F17/06

    CPC分类号： E21C35/046

    摘要： Services, such as electricity and water, are supplied through conduits to moving machinery such as a longwall mining machine which moves along a conveyor or other fixed path. A channel having an open mouth which is flexibly sealed is disposed alongside the path and contains supply conduits for the machine. A sleeve projects through the channel seals into the body of the channel and guides the conduits to the machine. A gas may be fed to the machine via the channel and sleeve. As the machine moves the conduits bend over themselves.

    摘要翻译： 诸如电力和水的服务通过导管供应到移动机械，例如沿输送机或其他固定路径移动的长壁采矿机。 具有柔性密封的开口的通道沿着路径布置并且包含用于机器的供应管道。 套筒通过通道密封件突出到通道的主体中并将导管引导到机器上。 气体可以通过通道和套筒供给机器。 当机器移动导管弯曲自己。

    Gas turbine with free-running generator driven by by-pass gas flow
    8.
    发明授权
    Gas turbine with free-running generator driven by by-pass gas flow 失效
    燃气轮机带有旁通气流驱动的自由运行发电机

    公开(公告)号：US07721555B2

    公开(公告)日：2010-05-25

    申请号：US10587822

    申请日：2005-01-29

    申请人： John Sharp ,  Andreas Kreiner

    发明人： John Sharp ,  Andreas Kreiner

    IPC分类号： F02C6/00

    CPC分类号： F01D15/10 ,  F02C3/10 ,  F02K3/04 ,  F02K3/06 ,  F05D2220/323

    摘要： A gas turbine, especially an aircraft engine is provided. The gas turbine comprises at least one compressor (15, 16), at least one combustion chamber (17), at least one turbine (18, 19), and at least one generator (20) for generating electrical energy, each generator (20) comprising at least one stator (25) and at least one rotor (22). Each rotor (22) of each generator (20) is embodied as a free-wheeling generator turbine that is driven by a gas flow in such a way that it rotates in relation to the respective stator (25) of the respective generator (20) and thus generates electrical energy from the kinetic energy of the gas flow.

    摘要翻译： 提供燃气轮机，特别是飞机发动机。 燃气轮机包括至少一个压缩机（15,16），至少一个燃烧室（17），至少一个涡轮机（18,19）和用于产生电能的至少一个发电机（20），每个发电机 ）包括至少一个定子（25）和至少一个转子（22）。 每个发电机（20）的每个转子（22）被实施为由气流驱动的续流发电机涡轮机，使得其相对于相应发电机（20）的相应定子（25）旋转， 从而从气流的动能产生电能。

    Aircraft engine
    9.
    发明申请
    Aircraft engine 审中-公开
    飞机发动机

    公开(公告)号：US20070157597A1

    公开(公告)日：2007-07-12

    申请号：US10587346

    申请日：2005-04-23

    申请人： John Sharp

    发明人： John Sharp

    IPC分类号： F02K3/02

    CPC分类号： F02K3/06 ,  F01D15/10 ,  F05D2220/36 ,  F05D2220/76 ,  F05D2260/20 ,  Y02T50/675

    摘要： The invention relates to an aircraft engine, particularly a gas turbine engine. The aircraft engine comprises at least one fan (11) and a core engine (12). The fan (11) comprises a fan housing (13) which encloses a fan flow channel and at least one fan wheel (15). The core engine (12) comprises at least one compressor (15, 16), at least one combustion chamber (17) and at least one turbine (18, 19). The aircraft engine further comprises at least one generator (24) for producing electrical energy whereby the or each generator (24) produces electrical energy by withdrawing shaft power from the core engine (12). According to the invention the or each generator (24) for producing electrical energy is integrated into at least one strut (21) extending in the radial direction of the fan flow channel and is thus positioned within the fan flow channel.

    摘要翻译： 本发明涉及飞机发动机，特别是燃气涡轮发动机。 飞机发动机包括至少一个风扇（11）和核心发动机（12）。 风扇（11）包括风扇壳体（13），其包围风扇流动通道和至少一个风扇叶轮（15）。 核心发动机（12）包括至少一个压缩机（15,16），至少一个燃烧室（17）和至少一个涡轮机（18,19）。 飞机发动机还包括用于产生电能的至少一个发电机（24），由此所述发电机（24）通过从核心发动机（12）抽出轴功率而产生电能。 根据本发明，用于产生电能的或每个发电机（24）集成在沿着风扇流动通道的径向方向延伸的至少一个支柱（21）中，因此位于风扇流动通道内。

    Gas turbine engine system
    10.
    发明授权
    Gas turbine engine system 失效
    燃气轮机系统

    公开(公告)号：US5867979A

    公开(公告)日：1999-02-09

    申请号：US812042

    申请日：1997-03-06

    申请人： Arnold C. Newton ,  John Sharp

    发明人： Arnold C. Newton ,  John Sharp

    IPC分类号： F02C3/113 ,  F02C7/32 ,  F02K3/02

    CPC分类号： F02C3/113 ,  F02C7/32 ,  F05D2220/50

    摘要： An aircraft mounted gas turbine engine system comprises a three shaft propulsive gas turbine engine having three electrical generators; each one respectively associated with one shaft of the engine. Two of the electrical generators are additionally configured so as to function as electric motors so as to facilitate power transfer between the engine shafts. One of the electric generators provides the primary source of electrical power for the aircraft, while the remaining electrical generators provide electrical power for the engine and back-up power for the aircraft.

    摘要翻译： 飞机安装的燃气涡轮发动机系统包括具有三个发电机的三轴推进式燃气涡轮发动机; 每个分别与发动机的一个轴相关联。 两个发电机另外构造成用作电动机，以便于发动机轴之间的动力传递。 其中一台发电机为飞机提供电力的主要来源，而其余的发电机为发动机提供电力并为飞机提供备用电力。