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公开(公告)号：US20100126862A1
公开(公告)日：2010-05-27
申请号：US12576148
申请日：2009-10-08
IPC分类号： G01N33/559 , G01N27/26
CPC分类号： G01N27/447 , G01N27/4473
摘要： The invention provides an electrophoresis cassette, methods for making the electrophoresis cassette, and method of fractionating analytes from a sample based upon electrophoretic mobility in a single application of the sample to an electrophoretic system.
摘要翻译： 本发明提供一种电泳盒，用于制备电泳盒的方法，和从样品的单一应用基于电泳迁移率的电泳系统的样品分馏的分析物的方法。
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公开(公告)号：US08361298B2
公开(公告)日：2013-01-29
申请号：US12576148
申请日：2009-10-08
IPC分类号： G01N27/453
CPC分类号： G01N27/447 , G01N27/4473
摘要： The invention provides an electrophoresis cassette, methods for making the electrophoresis cassette, and method of fractionating analytes from a sample based upon electrophoretic mobility in a single application of the sample to an electrophoretic system.
摘要翻译： 本发明提供一种电泳盒，用于制作电泳盒的方法，以及在将样品单次施用到电泳系统中基于电泳迁移率从样品中分馏分析物的方法。
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公开(公告)号：US08361299B2
公开(公告)日：2013-01-29
申请号：US12760548
申请日：2010-04-14
IPC分类号： G01N27/453
CPC分类号： G01N27/44756 , G01N27/44791
摘要： The invention provides an electrophoresis cassette, methods for making the electrophoresis cassette, and method of fractionating analytes from a sample based upon electrophoretic mobility in a single application of the sample to an electrophoretic system.
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公开(公告)号：US20110062024A1
公开(公告)日：2011-03-17
申请号：US12760548
申请日：2010-04-14
IPC分类号： G01N27/447 , G01N27/453 , G01F11/00
CPC分类号： G01N27/44756 , G01N27/44791
摘要： The invention provides an electrophoresis cassette, methods for making the electrophoresis cassette, and method of fractionating analytes from a sample based upon electrophoretic mobility in a single application of the sample to an electrophoretic system.
摘要翻译： 本发明提供一种电泳盒，用于制作电泳盒的方法，以及在将样品单次施用到电泳系统中基于电泳迁移率从样品中分馏分析物的方法。
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公开(公告)号：US5932711A
公开(公告)日：1999-08-03
申请号：US812105
申请日：1997-03-05
摘要： Disclosed is a polymerizable complex containing a covalently attached nucleic acid molecule which, under appropriate conditions, is capable of copolymerization with a second polymerizable ethylene-containing monomer unit to form a polymerized layer. The polymerized layer containing attached nucleic acid is useful in a variety of contexts including, for example, hybridization assays. The polymerized layer containing the covalently attached nucleic acid molecule can be formed into a variety of shapes, or attached to a formed material through appropriate chemistry.
摘要翻译： 公开了含有共价连接的核酸分子的可聚合复合物，其在合适的条件下能够与第二可聚合的含乙烯单体单元共聚以形成聚合层。 含有连接核酸的聚合层可用于多种情况，包括例如杂交测定。 含有共价连接的核酸分子的聚合层可以形成多种形状，或通过适当的化学成分连接到成形材料上。
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公开(公告)号：US06214187B1
公开(公告)日：2001-04-10
申请号：US09336228
申请日：1999-06-18
IPC分类号： B01D5702
CPC分类号： C12Q1/6834 , C12Q1/68 , C12Q1/6827 , Y10T436/143333 , C12Q2565/519 , C12Q2565/125
摘要： Methods are described for separation and analysis, and a kit for separation and analysis, of single nucleotide polymorphisms, or mutations, in target nucleic acid using denaturing gradient electrophoresis through supporting media containing one or more immobilized nucleic acid capture ligand. The method is especially useful for analyzing genetic haplotypes in samples with multiple linked polymorphic sites.
摘要翻译： 描述用于分离和分析的方法，以及用于使用变性梯度电泳通过支持含有一种或多种固定化核酸捕获配体的培养基的靶核酸中单核苷酸多态性或突变进行分离和分析的试剂盒。 该方法对于分析具有多个连锁多态性位点的样品中的遗传单倍体特别有用。
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7.发明授权公开(公告)号：US06251660B1
公开(公告)日：2001-06-26
申请号：US09200126
申请日：1998-11-25
IPC分类号： C12M134
CPC分类号： C12Q1/689 , B01L3/502 , B01L3/505 , C12Q1/6834 , C12Q1/703 , C12Q2565/125 , C12Q2531/119
摘要： Devices and methods for detecting the presence, or absence of the presence of at least one target molecule employing a receptacle housing a reaction chamber comprised of at least one compartment containing suitable reagents for the detection of the target molecule are disclosed.
摘要翻译： 公开了用于检测存在或不存在至少一个靶分子存在的装置和方法，所述靶分子使用容纳包含至少一个包含用于检测靶分子的合适试剂的隔室的反应室的容器。
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公开(公告)号：US06180770B2
公开(公告)日：2001-01-30
申请号：US09183092
申请日：1998-10-30
IPC分类号： C12Q168
摘要： Disclosed is a polymerizable complex containing a covalently attached nucleic acid molecule which, under appropriate conditions, is capable of copolymerization with a second polymerizable ethylene-containing monomer unit to form a polymerized layer. The polymerized layer containing attached nucleic acid is useful in a variety of contexts including, for example, hybridization assays. The polymerized layer containing the covalently attached nucleic acid molecule can be formed into a variety of shapes, or attached to a formed material through appropriate chemistry.
摘要翻译： 公开了含有共价连接的核酸分子的可聚合复合物，其在合适的条件下能够与第二可聚合的含乙烯单体单元共聚以形成聚合层。 含有连接核酸的聚合层可用于多种情况，包括例如杂交测定。 含有共价连接的核酸分子的聚合层可以形成多种形状，或通过适当的化学成分连接到成形材料上。
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公开(公告)号：US09012373B2
公开(公告)日：2015-04-21
申请号：US13566806
申请日：2012-08-03
CPC分类号： C12N15/1003 , B01L3/502715 , B01L3/502753 , B01L3/502761 , B01L3/502776 , B01L2200/0652 , B01L2300/0819 , B01L2400/086 , C12M45/09 , C12N15/102 , C12P19/34 , C40B50/06
摘要： Systems and methods for processing fluid samples are disclosed. Fluid sample processing is accomplished using a series of microfluidic bump arrays include an automated and integrated system for sorting particles from a biological sample, lysing those particles to expose total RNA or DNA, purifying the RNA or DNA, processing the RNA or DNA by chemical or enzymatic modification, to select RNA or DNA molecules by size, or to generate, optionally, a sequencing library. The sequencing library is suitable for use in next generation sequencing (“NGS”).
摘要翻译： 公开了用于处理流体样品的系统和方法。 使用一系列微流体凸块阵列实现流体样品处理，其包括用于从生物样品分选颗粒的自动化和集成系统，裂解那些颗粒以暴露总RNA或DNA，纯化RNA或DNA，通过化学或处理RNA或DNA 酶修饰，按大小选择RNA或DNA分子，或产生任选的测序文库。 测序文库适用于下一代测序（“NGS”）。
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公开(公告)号：US20130079251A1
公开(公告)日：2013-03-28
申请号：US13566806
申请日：2012-08-03
申请人： T. Christian Boles
发明人： T. Christian Boles
CPC分类号： C12N15/1003 , B01L3/502715 , B01L3/502753 , B01L3/502761 , B01L3/502776 , B01L2200/0652 , B01L2300/0819 , B01L2400/086 , C12M45/09 , C12N15/102 , C12P19/34 , C40B50/06
摘要： Systems and methods for processing fluid samples are disclosed. Fluid sample processing is accomplished using a series of microfluidic bump arrays include an automated and integrated system for sorting particles from a biological sample, lysing those particles to expose total RNA or DNA, purifying the RNA or DNA, processing the RNA or DNA by chemical or enzymatic modification, to select RNA or DNA molecules by size, or to generate, optionally, a sequencing library. The sequencing library is suitable for use in next generation sequencing (“NGS”).
摘要翻译： 公开了用于处理流体样品的系统和方法。 使用一系列微流体凸块阵列实现流体样品处理，其包括用于从生物样品分选颗粒的自动化和集成系统，裂解那些颗粒以暴露总RNA或DNA，纯化RNA或DNA，通过化学或处理RNA或DNA 酶修饰，按大小选择RNA或DNA分子，或产生任选的测序文库。 测序文库适用于下一代测序（NGS）。
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