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    Ultrasound enhanced central venous catheter
    1.
    发明申请
    Ultrasound enhanced central venous catheter 审中-公开
    超声增强中心静脉导管

    公开(公告)号：US20060122507A1

    公开(公告)日：2006-06-08

    申请号：US11255785

    申请日：2005-10-20

    申请人： Peter Rule ,  Douglas Hansmann ,  Dominic Vogt ,  Curtis Genstler ,  Thomas McNamara

    发明人： Peter Rule ,  Douglas Hansmann ,  Dominic Vogt ,  Curtis Genstler ,  Thomas McNamara

    IPC分类号： A61B8/00

    CPC分类号： B08B9/00 ,  A61B17/2202 ,  A61B90/70 ,  A61B2090/701 ,  A61M2025/0019 ,  B08B9/043 ,  B08B2209/005

    摘要： A central venous catheter comprises an ultrasound assembly. In one arrangement, the radiating member is used to remove a blockage from the central venous catheter. In another arrangement, inserting an ultrasound assembly into a central venous catheter. The ultrasound assembly comprises an ultrasound radiating member mounted on an elongate support structure. The method further comprises positioning the ultrasound assembly within the central venous catheter such that the ultrasound radiating member is adjacent to a deposited material formed on a portion of the central venous catheter. The method further comprises supplying an electrical current to the ultrasound radiating member to expose the deposited material to ultrasonic energy. The method further comprises passing a therapeutic compound through the central venous catheter to expose the deposited material to the therapeutic compound simultaneously with ultrasonic energy.

    摘要翻译： 中心静脉导管包括超声组件。 在一种布置中，辐射构件用于从中心静脉导管移除堵塞物。 在另一种布置中，将超声组件插入中心静脉导管中。 超声组件包括安装在细长支撑结构上的超声辐射构件。 该方法还包括将超声组件定位在中心静脉导管内，使得超声辐射构件与形成在中心静脉导管的一部分上的沉积材料相邻。 该方法还包括向超声辐射构件提供电流以将沉积的材料暴露于超声波能量。 该方法还包括使治疗化合物通过中心静脉导管，以同时用超声能量将沉积的材料暴露于治疗化合物。

    External ultrasonic therapy
    2.
    发明申请
    External ultrasonic therapy 审中-公开
    外部超声波治疗

    公开(公告)号：US20060184070A1

    公开(公告)日：2006-08-17

    申请号：US11272022

    申请日：2005-11-11

    申请人： Douglas Hansmann ,  Peter Rule

    发明人： Douglas Hansmann ,  Peter Rule

    IPC分类号： A61H1/00 ,  A61B8/12

    CPC分类号： A61N7/00 ,  A61B2017/2253

    摘要： A coupling pad can be used with a transducer element. Ultrasound produced by the transducer element can be propagated through the coupling pad to a patient. In one arrangement, the pad is a pouch containing a pliant substance. In other arrangements, the pad is a somewhat solid member formed of a material that transmits ultrasound waves efficiently. The pad may be configured to fit between a patient's skin and a transducer element so that output from the transducer element passes through the pad to a treatment site of the patient.

    摘要翻译： 耦合垫可以与换能器元件一起使用。 由换能器元件产生的超声能够通过耦合垫传播到患者身上。 在一种布置中，垫是包含柔韧物质的袋。 在其他布置中，垫是由有效地发射超声波的材料形成的稍微实心的部件。 垫可以被配置成适合于患者皮肤和换能器元件之间，使得来自换能器元件的输出通过垫穿过患者的治疗部位。

    Treatment of vascular occlusions using elevated temperatures
    3.
    发明申请
    Treatment of vascular occlusions using elevated temperatures 有权
    使用升高的温度治疗血管闭塞

    公开(公告)号：US20050240151A1

    公开(公告)日：2005-10-27

    申请号：US11046209

    申请日：2005-01-28

    申请人： Douglas Hansmann ,  Peter Rule

    发明人： Douglas Hansmann ,  Peter Rule

    IPC分类号： A61B17/22 ,  A61B18/04 ,  A61F7/12

    CPC分类号： A61B17/2202 ,  A61B2018/046

    摘要： A method for providing a therapeutic effect to a treatment site within a patient's vasculature comprises positioning a catheter at the treatment site. The catheter includes a heating element and a fluid delivery lumen that is coupled to an exit port within a distal region of the catheter. The method further comprises passing the therapeutic compound through the delivery lumen and the exit port at a flow rate. The heated therapeutic compound is provided to the treatment site. The method further comprises exposing at least a portion of the treatment site and at least a portion of the delivered heated therapeutic compound to ultrasonic energy generated by the ultrasound radiating member.

    摘要翻译： 用于向患者的脉管系统内的治疗部位提供治疗效果的方法包括将导管定位在治疗部位。 导管包括加热元件和流体输送腔，其与导管的远侧区域内的出口连接。 该方法还包括以流速使治疗化合物通过输送腔和出口。 将加热的治疗化合物提供给治疗部位。 所述方法还包括将所述处理部位的至少一部分和所递送的加热治疗化合物的至少一部分暴露于由所述超声波辐射部件产生的超声波能量。

    TREATMENT OF VASCULAR OCCLUSIONS USING ELEVATED TEMPERATURES
    5.
    发明申请
    TREATMENT OF VASCULAR OCCLUSIONS USING ELEVATED TEMPERATURES 审中-公开
    使用高温治疗血管闭塞症

    公开(公告)号：US20070161951A1

    公开(公告)日：2007-07-12

    申请号：US11685643

    申请日：2007-03-13

    申请人： Douglas Hansmann ,  Peter Rule

    发明人： Douglas Hansmann ,  Peter Rule

    IPC分类号： A61F7/12

    CPC分类号： A61B17/2202 ,  A61B2018/046

    摘要： A method for providing a therapeutic effect to a treatment site within a patient's vasculature comprises positioning a catheter at the treatment site. The catheter includes a heating element and a fluid delivery lumen that is coupled to an exit port within a distal region of the catheter. The method further comprises passing the therapeutic compound through the delivery lumen and the exit port at a flow rate. The heated therapeutic compound is provided to the treatment site. The method further comprises exposing at least a portion of the treatment site and at least a portion of the delivered heated therapeutic compound to ultrasonic energy generated by the ultrasound radiating member.

    摘要翻译： 用于向患者的脉管系统内的治疗部位提供治疗效果的方法包括将导管定位在治疗部位。 导管包括加热元件和流体输送腔，其与导管的远侧区域内的出口连接。 该方法还包括以流速使治疗化合物通过输送腔和出口。 将加热的治疗化合物提供给治疗部位。 所述方法还包括将所述处理部位的至少一部分和所递送的加热治疗化合物的至少一部分暴露于由所述超声波辐射部件产生的超声波能量。

    Ultrasound enhanced central venous catheter
    6.
    发明申请
    Ultrasound enhanced central venous catheter 有权
    超声增强中心静脉导管

    公开(公告)号：US20050197619A1

    公开(公告)日：2005-09-08

    申请号：US11046052

    申请日：2005-01-28

    申请人： Peter Rule ,  Douglas Hansmann ,  Dominic Vogt ,  Curtis Genstler ,  Thomas McNamara

    发明人： Peter Rule ,  Douglas Hansmann ,  Dominic Vogt ,  Curtis Genstler ,  Thomas McNamara

    IPC分类号： A61B20060101 ,  A61B17/20

    CPC分类号： B08B9/00 ,  A61B17/2202 ,  A61B90/70 ,  A61B2090/701 ,  A61M2025/0019 ,  B08B9/043 ,  B08B2209/005

    摘要： A central venous catheter comprises an ultrasound assembly. In one arrangement, the radiating member is used to remove a blockage from the central venous catheter. In another arrangement, inserting an ultrasound assembly into a central venous catheter. The ultrasound assembly comprises an ultrasound radiating member mounted on an elongate support structure. The method further comprises positioning the ultrasound assembly within the central venous catheter such that the ultrasound radiating member is adjacent to a deposited material formed on a portion of the central venous catheter. The method further comprises supplying an electrical current to the ultrasound radiating member to expose the deposited material to ultrasonic energy. The method further comprises passing a therapeutic compound through the central venous catheter to expose the deposited material to the therapeutic compound simultaneously with ultrasonic energy.

    摘要翻译： 中心静脉导管包括超声组件。 在一种布置中，辐射构件用于从中心静脉导管移除堵塞物。 在另一种布置中，将超声组件插入中心静脉导管中。 超声组件包括安装在细长支撑结构上的超声辐射构件。 该方法还包括将超声组件定位在中心静脉导管内，使得超声辐射构件与形成在中心静脉导管的一部分上的沉积材料相邻。 该方法还包括向超声辐射构件提供电流以将沉积的材料暴露于超声波能量。 该方法还包括使治疗化合物通过中心静脉导管，以同时用超声能量将沉积的材料暴露于治疗化合物。

    Catheter with ultrasound-controllable porous membrane
    7.
    发明申请
    Catheter with ultrasound-controllable porous membrane 审中-公开
    导管与超声可控多孔膜

    公开(公告)号：US20050137520A1

    公开(公告)日：2005-06-23

    申请号：US10977502

    申请日：2004-10-29

    申请人： Peter Rule ,  Douglas Hansmann ,  Robert Wilcox

    发明人： Peter Rule ,  Douglas Hansmann ,  Robert Wilcox

    IPC分类号： A61B17/22 ,  A61M37/00 ,  A61B17/20

    CPC分类号： A61B17/2202 ,  A61M37/0092

    摘要： A catheter system for delivering ultrasonic energy and a therapeutic compound to a treatment site within a patient's vasculature comprises a tubular body having an energy delivery section. The catheter system further comprises a fluid delivery lumen extending at least partially through the tubular body. The catheter system further comprises a semi-permeable membrane positioned along a portion of the fluid delivery lumen. The membrane has an increased porosity when exposed to ultrasonic energy. The catheter system further comprises an inner core configured for insertion into the tubular body. The inner core comprises an elongate electrical conductor having a plurality of flattened regions. Each flattened region has a first flat side and a second flat side opposite the first flat side. The inner core further comprises a plurality of ultrasound radiating members mounted in pairs to the flattened regions of the elongate electrical conductor. A first ultrasound radiating member is mounted to the first flat side of the elongate electrical conductor, and a second ultrasound radiating member is mounted to the second flat side of the elongate electrical conductor. The inner core further comprises wiring such that a voltage can be applied from the elongate electrical conductor across the first and second ultrasound radiating members allowing the first and second ultrasound radiating members to be driven simultaneously.

    摘要翻译： 用于将超声能量和治疗性化合物输送到患者脉管系统内的治疗部位的导管系统包括具有能量输送部分的管状体。 导管系统还包括至少部分地延伸通过管状体的流体输送腔。 导管系统还包括沿流体输送腔的一部分定位的半透膜。 当暴露于超声能量时，膜具有增加的孔隙率。 该导管系统还包括被配置成插入到管状体内的内芯。 内芯包括具有多个扁平区域的细长电导体。 每个扁平区域具有与第一平坦侧相对的第一平坦侧和第二平坦侧。 内芯还包括与细长电导体的扁平区域成对安装的多个超声波辐射构件。 第一超声波辐射构件安装到细长电导体的第一平坦侧，并且第二超声波辐射构件安装到细长电导体的第二平坦侧。 内芯还包括布线，使得可以从细长的导体穿过第一和第二超声波辐射构件施加电压，允许同时驱动第一和第二超声波辐射构件。

    Treatment of vascular occlusions using ultrasonic energy and microbubbles
    8.
    发明申请
    Treatment of vascular occlusions using ultrasonic energy and microbubbles 有权
    使用超声能量和微泡治疗血管闭塞

    公开(公告)号：US20050192556A1

    公开(公告)日：2005-09-01

    申请号：US11046208

    申请日：2005-01-28

    申请人： Azita Soltani ,  Douglas Hansmann

    发明人： Azita Soltani ,  Douglas Hansmann

    IPC分类号： A61M31/00 ,  A61M37/00

    CPC分类号： A61N7/00 ,  A61B17/2202 ,  A61B2017/22001 ,  A61M37/0092 ,  A61N2007/0039 ,  A61N2007/0043

    摘要： In one embodiment of the present invention, a method of treating a vascular occlusion located at a treatment site within a patient's vasculature comprises positioning an ultrasound catheter at the treatment site. The method further comprises delivering a microbubble therapeutic compound from the ultrasound catheter to the vascular occlusion during a first treatment phase. The method further comprises pausing the delivery of the microbubble compound and delivering ultrasonic energy from the ultrasound catheter in combination with other therapeutic compounds to the vascular occlusion during a second treatment phase while the delivery of microbubble therapeutic compound remains paused.

    摘要翻译： 在本发明的一个实施方案中，治疗位于患者脉管系统内的治疗部位的血管闭塞的方法包括将超声导管定位在治疗部位。 该方法还包括在第一处理阶段期间将微泡治疗化合物从超声导管输送到血管闭塞。 该方法还包括在微泡治疗化合物的递送保持暂停期间，暂停微泡化合物的递送并将超声能量从其他治疗化合物与超声导管输送到第二治疗阶段期间的血管闭塞。

    Ultrasound catheter with cavitation promoting surface
    10.
    发明申请
    Ultrasound catheter with cavitation promoting surface 审中-公开
    超声导管与气蚀促进表面

    公开(公告)号：US20060264809A1

    公开(公告)日：2006-11-23

    申请号：US11402626

    申请日：2006-04-12

    申请人： Douglas Hansmann ,  Azita Soltani

    发明人： Douglas Hansmann ,  Azita Soltani

    IPC分类号： A61B17/20

    CPC分类号： A61B17/22 ,  A61B17/2202 ,  A61B2017/00154 ,  A61B2017/22008 ,  A61B2017/22088 ,  A61M37/0092 ,  A61N7/00 ,  A61N2007/0039

    摘要： In one embodiment of the present invention, a method of applying ultrasonic energy to a treatment site within a patient's vasculature comprises positioning an ultrasound radiating member at a treatment site within a patient's vasculature. The method further comprises activating the ultrasound radiating member to produce pulses of ultrasonic energy at a cycle period T≦1 second. Each pulse of ultrasonic energy has a first peak amplitude for a first duration, and a second reduced amplitude that is less than the first peak amplitude for a second duration.

    摘要翻译： 在本发明的一个实施例中，将超声能量施加到患者脉管系统内的治疗部位的方法包括将超声波辐射构件定位在患者脉管系统内的治疗部位。 该方法还包括激活超声波辐射构件以在循环周期T 1 = 1秒产生超声能量的脉冲。 超声能量的每个脉冲具有第一持续时间的第一峰值振幅，以及在第二持续时间内小于第一峰值振幅的第二降低幅度。