公开(公告)号：US20050192556A1

公开(公告)日：2005-09-01

申请号：US11046208

申请日：2005-01-28

申请人： Azita Soltani ,  Douglas Hansmann

发明人： Azita Soltani ,  Douglas Hansmann

IPC分类号： A61M31/00 ,  A61M37/00

CPC分类号： A61N7/00 ,  A61B17/2202 ,  A61B2017/22001 ,  A61M37/0092 ,  A61N2007/0039 ,  A61N2007/0043

摘要： In one embodiment of the present invention, a method of treating a vascular occlusion located at a treatment site within a patient's vasculature comprises positioning an ultrasound catheter at the treatment site. The method further comprises delivering a microbubble therapeutic compound from the ultrasound catheter to the vascular occlusion during a first treatment phase. The method further comprises pausing the delivery of the microbubble compound and delivering ultrasonic energy from the ultrasound catheter in combination with other therapeutic compounds to the vascular occlusion during a second treatment phase while the delivery of microbubble therapeutic compound remains paused.

摘要翻译： 在本发明的一个实施方案中，治疗位于患者脉管系统内的治疗部位的血管闭塞的方法包括将超声导管定位在治疗部位。 该方法还包括在第一处理阶段期间将微泡治疗化合物从超声导管输送到血管闭塞。 该方法还包括在微泡治疗化合物的递送保持暂停期间，暂停微泡化合物的递送并将超声能量从其他治疗化合物与超声导管输送到第二治疗阶段期间的血管闭塞。

公开(公告)号：US20060264809A1

公开(公告)日：2006-11-23

申请号：US11402626

申请日：2006-04-12

申请人： Douglas Hansmann ,  Azita Soltani

发明人： Douglas Hansmann ,  Azita Soltani

IPC分类号： A61B17/20

CPC分类号： A61B17/22 ,  A61B17/2202 ,  A61B2017/00154 ,  A61B2017/22008 ,  A61B2017/22088 ,  A61M37/0092 ,  A61N7/00 ,  A61N2007/0039

摘要： In one embodiment of the present invention, a method of applying ultrasonic energy to a treatment site within a patient's vasculature comprises positioning an ultrasound radiating member at a treatment site within a patient's vasculature. The method further comprises activating the ultrasound radiating member to produce pulses of ultrasonic energy at a cycle period T≦1 second. Each pulse of ultrasonic energy has a first peak amplitude for a first duration, and a second reduced amplitude that is less than the first peak amplitude for a second duration.

摘要翻译： 在本发明的一个实施例中，将超声能量施加到患者脉管系统内的治疗部位的方法包括将超声波辐射构件定位在患者脉管系统内的治疗部位。 该方法还包括激活超声波辐射构件以在循环周期T 1 = 1秒产生超声能量的脉冲。 超声能量的每个脉冲具有第一持续时间的第一峰值振幅，以及在第二持续时间内小于第一峰值振幅的第二降低幅度。

公开(公告)号：US20060122507A1

公开(公告)日：2006-06-08

申请号：US11255785

申请日：2005-10-20

申请人： Peter Rule ,  Douglas Hansmann ,  Dominic Vogt ,  Curtis Genstler ,  Thomas McNamara

发明人： Peter Rule ,  Douglas Hansmann ,  Dominic Vogt ,  Curtis Genstler ,  Thomas McNamara

IPC分类号： A61B8/00

CPC分类号： B08B9/00 ,  A61B17/2202 ,  A61B90/70 ,  A61B2090/701 ,  A61M2025/0019 ,  B08B9/043 ,  B08B2209/005

摘要： A central venous catheter comprises an ultrasound assembly. In one arrangement, the radiating member is used to remove a blockage from the central venous catheter. In another arrangement, inserting an ultrasound assembly into a central venous catheter. The ultrasound assembly comprises an ultrasound radiating member mounted on an elongate support structure. The method further comprises positioning the ultrasound assembly within the central venous catheter such that the ultrasound radiating member is adjacent to a deposited material formed on a portion of the central venous catheter. The method further comprises supplying an electrical current to the ultrasound radiating member to expose the deposited material to ultrasonic energy. The method further comprises passing a therapeutic compound through the central venous catheter to expose the deposited material to the therapeutic compound simultaneously with ultrasonic energy.

摘要翻译： 中心静脉导管包括超声组件。 在一种布置中，辐射构件用于从中心静脉导管移除堵塞物。 在另一种布置中，将超声组件插入中心静脉导管中。 超声组件包括安装在细长支撑结构上的超声辐射构件。 该方法还包括将超声组件定位在中心静脉导管内，使得超声辐射构件与形成在中心静脉导管的一部分上的沉积材料相邻。 该方法还包括向超声辐射构件提供电流以将沉积的材料暴露于超声波能量。 该方法还包括使治疗化合物通过中心静脉导管，以同时用超声能量将沉积的材料暴露于治疗化合物。

公开(公告)号：US20060106308A1

公开(公告)日：2006-05-18

申请号：US11291355

申请日：2005-12-01

申请人： Douglas Hansmann ,  Robert Wilcox ,  Floyd Karp ,  Natalya Peskin ,  Kim Volz

发明人： Douglas Hansmann ,  Robert Wilcox ,  Floyd Karp ,  Natalya Peskin ,  Kim Volz

IPC分类号： A61B8/12 ,  A61B8/14

CPC分类号： A61B17/22012 ,  A61B2017/00057 ,  A61B2017/00084 ,  A61B2017/00101 ,  A61B2017/22021 ,  A61B2017/22082 ,  A61B2017/22084

摘要： A method for monitoring a clot dissolution treatment in a patient's vasculature comprises positioning a catheter at a treatment site in the patient's vasculature. The method further comprises performing a clot dissolution treatment at the treatment site. The clot dissolution treatment comprises delivering ultrasonic energy and a therapeutic compound from the catheter to the treatment site such that a clot located at the treatment site at least partially dissolves. The method further comprises delivering a thermal measurement signal from a first portion of the catheter to the treatment site during the clot dissolution treatment. The method further comprises receiving the thermal measurement signal at a second portion of the catheter. The method further comprises comparing the delivered thermal measurement signal with the received thermal measurement signal to evaluate a blood flow rate at the treatment site.

公开(公告)号：US20060184070A1

公开(公告)日：2006-08-17

申请号：US11272022

申请日：2005-11-11

申请人： Douglas Hansmann ,  Peter Rule

发明人： Douglas Hansmann ,  Peter Rule

IPC分类号： A61H1/00 ,  A61B8/12

CPC分类号： A61N7/00 ,  A61B2017/2253

摘要： A coupling pad can be used with a transducer element. Ultrasound produced by the transducer element can be propagated through the coupling pad to a patient. In one arrangement, the pad is a pouch containing a pliant substance. In other arrangements, the pad is a somewhat solid member formed of a material that transmits ultrasound waves efficiently. The pad may be configured to fit between a patient's skin and a transducer element so that output from the transducer element passes through the pad to a treatment site of the patient.

摘要翻译： 耦合垫可以与换能器元件一起使用。 由换能器元件产生的超声能够通过耦合垫传播到患者身上。 在一种布置中，垫是包含柔韧物质的袋。 在其他布置中，垫是由有效地发射超声波的材料形成的稍微实心的部件。 垫可以被配置成适合于患者皮肤和换能器元件之间，使得来自换能器元件的输出通过垫穿过患者的治疗部位。

公开(公告)号：US20050240151A1

公开(公告)日：2005-10-27

申请号：US11046209

申请日：2005-01-28

申请人： Douglas Hansmann ,  Peter Rule

发明人： Douglas Hansmann ,  Peter Rule

IPC分类号： A61B17/22 ,  A61B18/04 ,  A61F7/12

CPC分类号： A61B17/2202 ,  A61B2018/046

摘要： A method for providing a therapeutic effect to a treatment site within a patient's vasculature comprises positioning a catheter at the treatment site. The catheter includes a heating element and a fluid delivery lumen that is coupled to an exit port within a distal region of the catheter. The method further comprises passing the therapeutic compound through the delivery lumen and the exit port at a flow rate. The heated therapeutic compound is provided to the treatment site. The method further comprises exposing at least a portion of the treatment site and at least a portion of the delivered heated therapeutic compound to ultrasonic energy generated by the ultrasound radiating member.

摘要翻译： 用于向患者的脉管系统内的治疗部位提供治疗效果的方法包括将导管定位在治疗部位。 导管包括加热元件和流体输送腔，其与导管的远侧区域内的出口连接。 该方法还包括以流速使治疗化合物通过输送腔和出口。 将加热的治疗化合物提供给治疗部位。 所述方法还包括将所述处理部位的至少一部分和所递送的加热治疗化合物的至少一部分暴露于由所述超声波辐射部件产生的超声波能量。

公开(公告)号：US20050215946A1

公开(公告)日：2005-09-29

申请号：US11047363

申请日：2005-01-31

申请人： Douglas Hansmann ,  Robert Wilcox ,  Peter Rule ,  Francisco Villar

发明人： Douglas Hansmann ,  Robert Wilcox ,  Peter Rule ,  Francisco Villar

IPC分类号： A61B5/027 ,  A61B5/028 ,  A61B8/06 ,  A61M25/00 ,  A61M31/00

CPC分类号： A61B5/027 ,  A61B5/028 ,  A61B8/06 ,  A61B8/0808 ,  A61B17/2202 ,  A61B17/221 ,  A61B2017/00022 ,  A61B2017/00057 ,  A61B2017/00061 ,  A61B2017/00084 ,  A61B2017/22084 ,  A61M25/0045 ,  A61M25/0068 ,  A61M25/0082 ,  A61M37/0092 ,  A61N7/022

摘要： A method for treating an occlusion comprises positioning a catheter at a treatment site in a patient's vasculature. A blockage is located at the treatment site. The method further comprises performing a medical treatment at the treatment site. The medical treatment is configured to reduce the blockage. The method further comprises making a plurality of measurements at the treatment site.

摘要翻译： 用于治疗闭塞的方法包括将导管定位在患者脉管系统的治疗部位。 阻塞位于治疗部位。 该方法还包括在治疗部位进行医疗处理。 该治疗被配置为减少阻塞。 该方法还包括在治疗部位进行多次测量。

公开(公告)号：US20070161951A1

公开(公告)日：2007-07-12

申请号：US11685643

申请日：2007-03-13

申请人： Douglas Hansmann ,  Peter Rule

发明人： Douglas Hansmann ,  Peter Rule

IPC分类号： A61F7/12

CPC分类号： A61B17/2202 ,  A61B2018/046

摘要： A method for providing a therapeutic effect to a treatment site within a patient's vasculature comprises positioning a catheter at the treatment site. The catheter includes a heating element and a fluid delivery lumen that is coupled to an exit port within a distal region of the catheter. The method further comprises passing the therapeutic compound through the delivery lumen and the exit port at a flow rate. The heated therapeutic compound is provided to the treatment site. The method further comprises exposing at least a portion of the treatment site and at least a portion of the delivered heated therapeutic compound to ultrasonic energy generated by the ultrasound radiating member.

摘要翻译： 用于向患者的脉管系统内的治疗部位提供治疗效果的方法包括将导管定位在治疗部位。 导管包括加热元件和流体输送腔，其与导管的远侧区域内的出口连接。 该方法还包括以流速使治疗化合物通过输送腔和出口。 将加热的治疗化合物提供给治疗部位。 所述方法还包括将所述处理部位的至少一部分和所递送的加热治疗化合物的至少一部分暴露于由所述超声波辐射部件产生的超声波能量。

公开(公告)号：US20060173387A1

公开(公告)日：2006-08-03

申请号：US11297979

申请日：2005-12-09

申请人： Douglas Hansmann ,  Curtis Genstler ,  Francisco Villar

发明人： Douglas Hansmann ,  Curtis Genstler ,  Francisco Villar

IPC分类号： A61H1/00

CPC分类号： A61H23/0245 ,  A61B2017/00106 ,  A61H7/006 ,  A61H39/007 ,  A61H2201/165 ,  A61H2205/02 ,  A61H2205/10 ,  A61N7/02 ,  A61N7/022

摘要： In one embodiment, a method for treating a vascular occlusion in a patient's body comprises exposing the vascular occlusion to an external ultrasonic energy field that is generated outside the patient's body. The method further comprises positioning an ultrasound radiating member in the patient's body in the vicinity of the vascular occlusion. The method further comprises exposing the vascular occlusion to an internal ultrasonic energy field that is generated by the ultrasound radiating member. The method further comprises using the ultrasound radiating member to detect a first characteristic of the external ultrasonic energy field. The method further comprises adjusting a second characteristic of the external ultrasonic energy field based on the detected first characteristic of the external ultrasonic energy field.

摘要翻译： 在一个实施方案中，用于治疗患者体内的血管闭塞的方法包括将血管闭塞暴露于在患者体外产生的外部超声波能量场。 该方法还包括将超声波辐射构件定位在患者体内的血管闭塞附近。 该方法还包括将血管闭塞暴露于由超声波辐射构件产生的内部超声波能量场。 该方法还包括使用超声波辐射构件来检测外部超声能量场的第一特性。 该方法还包括基于检测到的外部超声能量场的第一特性来调整外部超声能量场的第二特性。

公开(公告)号：US20050197619A1

公开(公告)日：2005-09-08

申请号：US11046052

申请日：2005-01-28

申请人： Peter Rule ,  Douglas Hansmann ,  Dominic Vogt ,  Curtis Genstler ,  Thomas McNamara

发明人： Peter Rule ,  Douglas Hansmann ,  Dominic Vogt ,  Curtis Genstler ,  Thomas McNamara

IPC分类号： A61B20060101 ,  A61B17/20

CPC分类号： B08B9/00 ,  A61B17/2202 ,  A61B90/70 ,  A61B2090/701 ,  A61M2025/0019 ,  B08B9/043 ,  B08B2209/005

摘要： A central venous catheter comprises an ultrasound assembly. In one arrangement, the radiating member is used to remove a blockage from the central venous catheter. In another arrangement, inserting an ultrasound assembly into a central venous catheter. The ultrasound assembly comprises an ultrasound radiating member mounted on an elongate support structure. The method further comprises positioning the ultrasound assembly within the central venous catheter such that the ultrasound radiating member is adjacent to a deposited material formed on a portion of the central venous catheter. The method further comprises supplying an electrical current to the ultrasound radiating member to expose the deposited material to ultrasonic energy. The method further comprises passing a therapeutic compound through the central venous catheter to expose the deposited material to the therapeutic compound simultaneously with ultrasonic energy.

摘要翻译： 中心静脉导管包括超声组件。 在一种布置中，辐射构件用于从中心静脉导管移除堵塞物。 在另一种布置中，将超声组件插入中心静脉导管中。 超声组件包括安装在细长支撑结构上的超声辐射构件。 该方法还包括将超声组件定位在中心静脉导管内，使得超声辐射构件与形成在中心静脉导管的一部分上的沉积材料相邻。 该方法还包括向超声辐射构件提供电流以将沉积的材料暴露于超声波能量。 该方法还包括使治疗化合物通过中心静脉导管，以同时用超声能量将沉积的材料暴露于治疗化合物。