公开(公告)号：US20070036680A1

公开(公告)日：2007-02-15

申请号：US11137701

申请日：2005-05-25

申请人： Douglas Hobbs ,  Curtis Lockshin ,  James Cowan ,  Robert Nilsen

发明人： Douglas Hobbs ,  Curtis Lockshin ,  James Cowan ,  Robert Nilsen

IPC分类号： G01N21/00

CPC分类号： G03H1/02 ,  G01N21/4788 ,  G01N21/7743 ,  G01N33/18 ,  G01N33/22 ,  G02B5/32 ,  G02F1/133553 ,  G02F1/216 ,  G03H1/0244 ,  G03H1/0248 ,  G03H1/0256 ,  G03H1/0272 ,  G03H1/28 ,  G03H2223/17 ,  G03H2223/18 ,  G03H2223/19 ,  G03H2250/38 ,  G03H2270/24 ,  G03H2270/31

摘要： A microstructure-based chemical sensor that can be interrogated by a remote observer. The device acts as an electromagnetic wave filter in the optical region of the spectrum, filtering one or more wavelength bands where the band spectral notch location shifts in response to the accumulation of material on the surface of the microstructure sensor. The apparatus has a substrate having a surface relief structure containing dielectric bodies with one or more physical dimensions smaller than the wavelength of the filtered electromagnetic waves, such structures repeated in an array covering at least a portion of the surface of the substrate. A retro-reflecting structure allows interrogation of the sensor over a wide field of view. The device is particularly useful as a water monitoring device in hard to reach locations, and as a chemical warfare or explosives detector that can be read from a safe distance.

摘要翻译： 可由远程观察者询问的基于微结构的化学传感器。 该装置在光谱的光学区域中用作电磁波滤波器，对一个或多个波长带进行滤波，其中带隙陷波位置响应于微结构传感器表面上的材料积累而移动。 该装置具有一个具有表面浮雕结构的基片，该表面浮雕结构包含一个或多个物理尺寸小于滤波后的电磁波的波长的电介质体，这种结构以覆盖基片表面的至少一部分的阵列重复。 回射结构允许传感器在广泛的视野下进行询问。 该设备特别适用于难以到达的地点的水监测装置，以及可从安全距离读取的化学战或爆炸物探测器。

公开(公告)号：US07098028B2

公开(公告)日：2006-08-29

申请号：US10390472

申请日：2003-03-17

申请人： Todd Holmes ,  Shuguang Zhang ,  Alexander Rich ,  C. Michael DiPersio ,  Curtis Lockshin

发明人： Todd Holmes ,  Shuguang Zhang ,  Alexander Rich ,  C. Michael DiPersio ,  Curtis Lockshin

IPC分类号： C12N5/02 ,  C12N5/00 ,  C07K7/06

CPC分类号： C07K7/08 ,  A61K9/009 ,  C07K5/0815 ,  C07K7/06 ,  C07K14/001 ,  C07K14/395 ,  C12N5/0068 ,  C12N2533/30 ,  C12N2533/50

摘要： Described herein is the self-assembly of amphiphilic peptides, i.e., peptides with alternating hydrophobic and hydrophilic residues, into macroscopic membranes. The membrane-forming peptides are greater than 12 amino acids in length, and preferably at least 16 amino acids, are complementary and are structurally compatible. Specifically, two peptides, (AEAEAKAK)2 (ARARADAD)2, were shown to self-assemble into macroscopic membranes. Conditions under which the peptides self-assemble into macroscopic membranes and methods for producing the membranes are also described. The macroscopic membranes have several interesting properties: they are stable in aqueous solution, serum, and ethanol, are highly resistant to heat, alkaline and acidic pH, chemical denaturants, and proteolytic digestion, and are non-cytotoxic. The membranes are potentially useful in biomaterial applications such as slow-diffusion drug delivery systems, artificial skin, and separation matrices, and as experimental models for Alzheimer's disease and scrapie infection. The sequence of the peptide, EAK16, was derived from a putative Z-DNA binding protein from yeast, called zuotin. The cloning and characterization of the ZUO1 gene are also described.

摘要翻译： 这里描述的是将两亲肽，即具有交替疏水和亲水残基的肽自组装成宏观膜。 成膜肽长度大于12个氨基酸，优选至少16个氨基酸是互补的并且在结构上相容。 具体来说，显示两种肽（AEAEAKAK）2（ARARADAD）2 N自组装成宏观膜。 还描述了肽自组装成宏观膜的条件和制备膜的方法。 肉眼膜具有几个有趣的性质：它们在水溶液，血清和乙醇中稳定，对热，碱性和酸性pH，化学变性剂和蛋白水解消化具有高度抗性，并且是非细胞毒性的。 该膜可用于生物材料应用，如慢扩散药物递送系统，人造皮肤和分离基质，以及阿尔茨海默病和瘙痒病感染的实验模型。 肽EAK16的序列衍生自称为佐酮的来自酵母的推定的Z-DNA结合蛋白。 还描述了ZUO1基因的克隆和表征。

公开(公告)号：US20060281742A1

公开(公告)日：2006-12-14

申请号：US11439529

申请日：2006-05-23

申请人： Brian Aquila ,  Seth Hopkins ,  Curtis Lockshin ,  Fengjiang Wang

发明人： Brian Aquila ,  Seth Hopkins ,  Curtis Lockshin ,  Fengjiang Wang

IPC分类号： A61K31/537 ,  A61K31/445 ,  C07D211/26 ,  C07D265/32

CPC分类号： C40B40/04 ,  C07C217/58 ,  C07C2601/02 ,  C07D307/14 ,  C40B20/08 ,  C40B30/04 ,  C40B40/00 ,  C40B50/14

摘要： One aspect of the present invention relates to amines. A second aspect of the present invention relates to the use of the amines as inhibitors of a mammalian anandamide transporter. The compounds of the present invention will also find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to asthma, neuropathic pain, persistent pain, inflammatory pain, hyperactivity, hypertension, brain ischemia, Parkinson's disease, spasticity, Tourette's syndrome, schizophrenia, hemorrhagic shock, septic shock, cardiac shock, migrane, Horton's headache, multiple sclerosis, anorexia, AIDS wasting syndrome, organ rejection, autoimmune diseases, allergy, arthritis, Crohn's disease, malignant gliomas, neurodegenerative diseases, Huntington's chorea, glaucoma, nausea, anxiety, psychosis, attention deficit hyperactivity disorder, premature ejaculation, and stroke. Another aspect of the present invention relates to combinatorial libraries of amines, and methods for preparing the libraries.

公开(公告)号：US06800481B1

公开(公告)日：2004-10-05

申请号：US08824513

申请日：1997-03-26

申请人： Todd Holmes ,  Shuguang Zhang ,  Alexander Rich ,  C. Michael DiPersio ,  Curtis Lockshin

发明人： Todd Holmes ,  Shuguang Zhang ,  Alexander Rich ,  C. Michael DiPersio ,  Curtis Lockshin

IPC分类号： C12N502

CPC分类号： C07K7/08 ,  A61K9/009 ,  C07K5/0815 ,  C07K7/06 ,  C07K14/001 ,  C07K14/395 ,  C12N5/0068 ,  C12N2533/30 ,  C12N2533/50

摘要： Described herein is the self-assembly of amphiphilic peptides, i.e., peptides with alternating hydrophobic and hydrophilic residues, into macroscopic membranes. The membrane-forming peptides are greater than 12 amino acids in length, and preferably at least 16 amino acids, are complementary and are structurally compatible. Specifically, two peptides, (AEAEAKAK)2 (ARARADAD)2, were shown to self-assemble into macroscopic membranes. Conditions under which the peptides self-assemble into macroscopic membranes and methods for producing the membranes are also described. The macroscopic membranes have several interesting properties: they are stable in aqueous solution, serum, and ethanol, are highly resistant to heat, alkaline and acidic pH, chemical denaturants, and proteolytic digestion, and are non-cytotoxic. The membranes are potentially useful in biomaterial applications such as slow-diffusion drug delivery systems, artificial skin, and separation matrices, and as experimental models for Alzheimer's disease and scrapie infection. The sequence of the peptide, EAK16, was derived from a putative Z-DNA binding protein from yeast, called zuotin. The cloning and characterization of the ZUO1 gene are also described.

摘要翻译： 这里描述的是将两亲肽，即具有交替疏水和亲水残基的肽自组装成宏观膜。 成膜肽长度大于12个氨基酸，优选至少16个氨基酸是互补的并且在结构上相容。 具体来说，显示两种肽（AEAEAKAK）2（ARARADAD）2自组装成宏观膜。 还描述了肽自组装成宏观膜的条件和制备膜的方法。 肉眼膜具有几个有趣的性质：它们在水溶液，血清和乙醇中稳定，对热，碱性和酸性pH，化学变性剂和蛋白水解消化具有高度抗性，并且是非细胞毒性的。 该膜可用于生物材料应用，如慢扩散药物递送系统，人造皮肤和分离基质，以及阿尔茨海默病和瘙痒病感染的实验模型。 肽EAK16的序列衍生自称为佐酮的来自酵母的推定的Z-DNA结合蛋白。 还描述了ZUO1基因的克隆和表征。

公开(公告)号：US5955343A

公开(公告)日：1999-09-21

申请号：US293284

申请日：1994-08-22

申请人： Todd Holmes ,  Shuguang Zhang ,  Alexander Rich ,  C. Michael DiPersio ,  Curtis Lockshin

发明人： Todd Holmes ,  Shuguang Zhang ,  Alexander Rich ,  C. Michael DiPersio ,  Curtis Lockshin

IPC分类号： A61K9/00 ,  C07K7/08 ,  C07K14/00 ,  C07K14/395 ,  C12N5/00 ,  C12N5/02

CPC分类号： C07K7/08 ,  C07K14/001 ,  C07K14/395 ,  C07K5/0815 ,  C07K7/06 ,  C12N5/0068 ,  A61K9/009 ,  C12N2533/30 ,  C12N2533/50

摘要： Described herein is the self-assembly of amphiphilic peptides, i.e., peptides with alternating hydrophobic and hydrophilic residues, into macroscopic membranes. The membrane-forming peptides are greater than 12 amino acids in length, and preferably at least 16 amino acids, are complementary and are structurally compatible. Specifically, two peptides, (AEAEAKAK).sub.2 (ARARADAD).sub.2, were shown to self-assemble into macroscopic membranes. Conditions under which the peptides self-assemble into macroscopic membranes and methods for producing the membranes are also described. The macroscopic membranes have several interesting properties: they are stable in aqueous solution, serum, and ethanol, are highly resistant to heat, alkaline and acidic pH, chemical denaturants, and proteolytic digestion, and are non-cytotoxic. The membranes are potentially useful in biomaterial applications such as slow-diffusion drug delivery systems, artificial skin, and separation matrices, and as experimental models for Alzheimer's disease and scrapie infection. The sequence of the peptide, EAK16, was derived from a putative Z-DNA binding protein from yeast, called zuotin. The cloning and characterization of the ZUO1 gene are also described.

公开(公告)号：US20070190603A1

公开(公告)日：2007-08-16

申请号：US11512753

申请日：2006-08-29

申请人： Todd Holmes ,  Shuguang Zhang ,  Alexander Rich ,  C. DiPersio ,  Curtis Lockshin

发明人： Todd Holmes ,  Shuguang Zhang ,  Alexander Rich ,  C. DiPersio ,  Curtis Lockshin

IPC分类号： C12P21/06 ,  C07H21/04 ,  C12N5/08 ,  C07K14/47

CPC分类号： C07K7/08 ,  A61K9/009 ,  C07K5/0815 ,  C07K7/06 ,  C07K14/001 ,  C07K14/395 ,  C12N5/0068 ,  C12N2533/30 ,  C12N2533/50

摘要： Described herein is the self-assembly of amphiphilic peptides, i.e., peptides with alternating hydrophobic and hydrophilic residues, into macroscopic membranes. The membrane-forming peptides are greater than 12 amino acids in length, and preferably at least 16 amino acids, are complementary and are structurally compatible. Specifically, two peptides, (AEAEAKAK)2 (ARARADAD)2, were shown to self-assemble into macroscopic membranes. Conditions under which the peptides self-assemble into macroscopic membranes and methods for producing the membranes are also described. The macroscopic membranes have several interesting properties: they are stable in aqueous solution, serum, and ethanol, are highly resistant to heat, alkaline and acidic pH, chemical denaturants, and proteolytic digestion, and are non-cytotoxic. The membranes are potentially useful in biomaterial applications such as slow-diffusion drug delivery systems, artificial skin, and separation matrices, and as experimental models for Alzheimer's disease and scrapie infection. The sequence of the peptide, EAK16, was derived from a putative Z-DNA binding protein from yeast, called zuotin. The cloning and characterization of the ZUO1 gene are also described.

摘要翻译： 这里描述的是将两亲肽，即具有交替疏水和亲水残基的肽自组装成宏观膜。 成膜肽长度大于12个氨基酸，优选至少16个氨基酸是互补的并且在结构上相容。 具体来说，显示两种肽（AEAEAKAK）2（ARARADAD）2 N自组装成宏观膜。 还描述了肽自组装成宏观膜的条件和制备膜的方法。 肉眼膜具有几个有趣的性质：它们在水溶液，血清和乙醇中稳定，对热，碱性和酸性pH，化学变性剂和蛋白水解消化具有高度抗性，并且是非细胞毒性的。 该膜可用于生物材料应用，如慢扩散药物递送系统，人造皮肤和分离基质，以及阿尔茨海默病和瘙痒病感染的实验模型。 肽EAK16的序列衍生自称为佐酮的来自酵母的推定的Z-DNA结合蛋白。 还描述了ZUO1基因的克隆和表征。

公开(公告)号：US06548630B1

公开(公告)日：2003-04-15

申请号：US08898300

申请日：1997-07-22

申请人： Shuguang Zhang ,  Curtis Lockshin ,  Alexander Rich ,  Todd Holmes

发明人： Shuguang Zhang ,  Curtis Lockshin ,  Alexander Rich ,  Todd Holmes

IPC分类号： C07K700

CPC分类号： C07K7/08 ,  A61K9/009 ,  C07K14/001 ,  C07K14/395 ,  C12N5/0068 ,  C12N2533/30 ,  C12N2533/50

摘要： Described herein is the self-assembly of amphiphilic peptides, i.e., peptides with alternating hydrophobic and hydrophilic residues, into macroscopic membranes. The membrane-forming peptides are greater than 12 amino acids in length, and preferably at least 16 amino acids, are complementary and are structurally compatible. Specifically, two peptides, (AEAEAKAK)2 (ARARADAD)2, were shown to self-assemble into macroscopic membranes. Conditions under which the peptides self-assemble into macroscopic membranes and methods for producing the membranes are also described. The macroscopic membranes have several interesting properties: they are stable in aqueous solution, serum, and ethanol, are highly resistant to heat, alkaline and acidic pH, chemical denaturants, and proteolytic digestion, and are non-cytotoxic. The membranes are potentially useful in biomaterial applications such as slow-diffusion drug delivery systems, artificial skin, and separation matrices, and as experimental models for Alzheimer's disease and scrapie infection. The sequence of the peptide, EAK16, was derived from a putative Z-DNA binding protein from yeast, called zuotin. The cloning and characterization of the ZUO1 gene are also described.

摘要翻译： 这里描述的是将两亲肽，即具有交替疏水和亲水残基的肽自组装成宏观膜。 成膜肽长度大于12个氨基酸，优选至少16个氨基酸是互补的并且在结构上相容。 具体来说，显示两种肽（AEAEAKAK）2（ARARADAD）2自组装成宏观膜。 还描述了肽自组装成宏观膜的条件和制备膜的方法。 肉眼膜具有几个有趣的性质：它们在水溶液，血清和乙醇中稳定，对热，碱性和酸性pH，化学变性剂和蛋白水解消化具有高度抗性，并且是非细胞毒性的。 该膜可用于生物材料应用，如慢扩散药物递送系统，人造皮肤和分离基质，以及阿尔茨海默病和瘙痒病感染的实验模型。 肽EAK16的序列衍生自称为佐酮的来自酵母的推定的Z-DNA结合蛋白。 还描述了ZUO1基因的克隆和表征。

公开(公告)号：US5670483A

公开(公告)日：1997-09-23

申请号：US346849

申请日：1994-11-30

申请人： Shuguang Zhang ,  Curtis Lockshin ,  Alexander Rich ,  Todd Holmes

发明人： Shuguang Zhang ,  Curtis Lockshin ,  Alexander Rich ,  Todd Holmes

IPC分类号： A61K9/00 ,  C07K7/08 ,  C07K14/00 ,  C07K14/395 ,  C12N5/00 ,  C12N5/02 ,  A61K7/08 ,  A61K14/00 ,  C07K38/10 ,  C07K38/16

CPC分类号： C07K7/08 ,  C07K14/001 ,  C07K14/395 ,  C12N5/0068 ,  A61K9/009 ,  C12N2533/30 ,  C12N2533/50

摘要： Described herein is the self-assembly of amphiphilic peptides, i.e., peptides with alternating hydrophobic and hydrophilic residues, into macroscopic membranes. The membrane-forming peptides are greater than 12 amino acids in length, and preferably at least 16 amino acids, are complementary and are structurally compatible. Specifically, two peptides, (AEAEAKAK).sub.2 (ARARADAD).sub.2, were shown to self-assemble into macroscopic membranes. Conditions under which the peptides self-assemble into macroscopic membranes and methods for producing the membranes are also described. The macroscopic membranes have several interesting properties: they are stable in aqueous solution, serum, and ethanol, are highly resistant to heat, alkaline and acidic pH, chemical denaturants, and proteolytic digestion, and are non-cytotoxic. The membranes are potentially useful in biomaterial applications such as slow-diffusion drug delivery systems, artificial skin, and separation matrices, and as experimental models for Alzheimer's disease and scrapie infection. The sequence of the peptide, EAK16, was derived from a putative Z-DNA binding protein from yeast, called zuotin. The cloning and characterization of the ZUO1 gene are also described.

摘要翻译： 这里描述的是将两亲肽，即具有交替疏水和亲水残基的肽自组装成宏观膜。 成膜肽长度大于12个氨基酸，优选至少16个氨基酸是互补的并且在结构上相容。 具体来说，显示两种肽（AEAEAKAK）2（ARARADAD）2自组装成宏观膜。 还描述了肽自组装成宏观膜的条件和制备膜的方法。 肉眼膜具有几个有趣的性质：它们在水溶液，血清和乙醇中稳定，对热，碱性和酸性pH，化学变性剂和蛋白水解消化具有高度抗性，并且是非细胞毒性的。 该膜可用于生物材料应用，如慢扩散药物递送系统，人造皮肤和分离基质，以及阿尔茨海默病和瘙痒病感染的实验模型。 肽EAK16的序列衍生自称为佐酮的来自酵母的推定的Z-DNA结合蛋白。 还描述了ZUO1基因的克隆和表征。