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    Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
    1.
    发明授权
    Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor 失效
    通过两亲肽的自组装形成稳定的宏观膜并用于其

    公开(公告)号：US07098028B2

    公开(公告)日：2006-08-29

    申请号：US10390472

    申请日：2003-03-17

    申请人： Todd Holmes ,  Shuguang Zhang ,  Alexander Rich ,  C. Michael DiPersio ,  Curtis Lockshin

    发明人： Todd Holmes ,  Shuguang Zhang ,  Alexander Rich ,  C. Michael DiPersio ,  Curtis Lockshin

    IPC分类号： C12N5/02 ,  C12N5/00 ,  C07K7/06

    CPC分类号： C07K7/08 ,  A61K9/009 ,  C07K5/0815 ,  C07K7/06 ,  C07K14/001 ,  C07K14/395 ,  C12N5/0068 ,  C12N2533/30 ,  C12N2533/50

    摘要： Described herein is the self-assembly of amphiphilic peptides, i.e., peptides with alternating hydrophobic and hydrophilic residues, into macroscopic membranes. The membrane-forming peptides are greater than 12 amino acids in length, and preferably at least 16 amino acids, are complementary and are structurally compatible. Specifically, two peptides, (AEAEAKAK)2 (ARARADAD)2, were shown to self-assemble into macroscopic membranes. Conditions under which the peptides self-assemble into macroscopic membranes and methods for producing the membranes are also described. The macroscopic membranes have several interesting properties: they are stable in aqueous solution, serum, and ethanol, are highly resistant to heat, alkaline and acidic pH, chemical denaturants, and proteolytic digestion, and are non-cytotoxic. The membranes are potentially useful in biomaterial applications such as slow-diffusion drug delivery systems, artificial skin, and separation matrices, and as experimental models for Alzheimer's disease and scrapie infection. The sequence of the peptide, EAK16, was derived from a putative Z-DNA binding protein from yeast, called zuotin. The cloning and characterization of the ZUO1 gene are also described.

    摘要翻译： 这里描述的是将两亲肽，即具有交替疏水和亲水残基的肽自组装成宏观膜。 成膜肽长度大于12个氨基酸，优选至少16个氨基酸是互补的并且在结构上相容。 具体来说，显示两种肽（AEAEAKAK）2（ARARADAD）2 N自组装成宏观膜。 还描述了肽自组装成宏观膜的条件和制备膜的方法。 肉眼膜具有几个有趣的性质：它们在水溶液，血清和乙醇中稳定，对热，碱性和酸性pH，化学变性剂和蛋白水解消化具有高度抗性，并且是非细胞毒性的。 该膜可用于生物材料应用，如慢扩散药物递送系统，人造皮肤和分离基质，以及阿尔茨海默病和瘙痒病感染的实验模型。 肽EAK16的序列衍生自称为佐酮的来自酵母的推定的Z-DNA结合蛋白。 还描述了ZUO1基因的克隆和表征。

    Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
    3.
    发明申请
    Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor 审中-公开
    通过两亲肽的自组装形成稳定的宏观膜并用于其

    公开(公告)号：US20070190603A1

    公开(公告)日：2007-08-16

    申请号：US11512753

    申请日：2006-08-29

    申请人： Todd Holmes ,  Shuguang Zhang ,  Alexander Rich ,  C. DiPersio ,  Curtis Lockshin

    发明人： Todd Holmes ,  Shuguang Zhang ,  Alexander Rich ,  C. DiPersio ,  Curtis Lockshin

    IPC分类号： C12P21/06 ,  C07H21/04 ,  C12N5/08 ,  C07K14/47

    CPC分类号： C07K7/08 ,  A61K9/009 ,  C07K5/0815 ,  C07K7/06 ,  C07K14/001 ,  C07K14/395 ,  C12N5/0068 ,  C12N2533/30 ,  C12N2533/50

    摘要： Described herein is the self-assembly of amphiphilic peptides, i.e., peptides with alternating hydrophobic and hydrophilic residues, into macroscopic membranes. The membrane-forming peptides are greater than 12 amino acids in length, and preferably at least 16 amino acids, are complementary and are structurally compatible. Specifically, two peptides, (AEAEAKAK)2 (ARARADAD)2, were shown to self-assemble into macroscopic membranes. Conditions under which the peptides self-assemble into macroscopic membranes and methods for producing the membranes are also described. The macroscopic membranes have several interesting properties: they are stable in aqueous solution, serum, and ethanol, are highly resistant to heat, alkaline and acidic pH, chemical denaturants, and proteolytic digestion, and are non-cytotoxic. The membranes are potentially useful in biomaterial applications such as slow-diffusion drug delivery systems, artificial skin, and separation matrices, and as experimental models for Alzheimer's disease and scrapie infection. The sequence of the peptide, EAK16, was derived from a putative Z-DNA binding protein from yeast, called zuotin. The cloning and characterization of the ZUO1 gene are also described.

    摘要翻译： 这里描述的是将两亲肽，即具有交替疏水和亲水残基的肽自组装成宏观膜。 成膜肽长度大于12个氨基酸，优选至少16个氨基酸是互补的并且在结构上相容。 具体来说，显示两种肽（AEAEAKAK）2（ARARADAD）2 N自组装成宏观膜。 还描述了肽自组装成宏观膜的条件和制备膜的方法。 肉眼膜具有几个有趣的性质：它们在水溶液，血清和乙醇中稳定，对热，碱性和酸性pH，化学变性剂和蛋白水解消化具有高度抗性，并且是非细胞毒性的。 该膜可用于生物材料应用，如慢扩散药物递送系统，人造皮肤和分离基质，以及阿尔茨海默病和瘙痒病感染的实验模型。 肽EAK16的序列衍生自称为佐酮的来自酵母的推定的Z-DNA结合蛋白。 还描述了ZUO1基因的克隆和表征。

    Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
    4.
    发明授权
    Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor 失效
    通过两亲肽的自组装形成稳定的宏观膜并用于其

    公开(公告)号：US06548630B1

    公开(公告)日：2003-04-15

    申请号：US08898300

    申请日：1997-07-22

    申请人： Shuguang Zhang ,  Curtis Lockshin ,  Alexander Rich ,  Todd Holmes

    发明人： Shuguang Zhang ,  Curtis Lockshin ,  Alexander Rich ,  Todd Holmes

    IPC分类号： C07K700

    CPC分类号： C07K7/08 ,  A61K9/009 ,  C07K14/001 ,  C07K14/395 ,  C12N5/0068 ,  C12N2533/30 ,  C12N2533/50

    摘要： Described herein is the self-assembly of amphiphilic peptides, i.e., peptides with alternating hydrophobic and hydrophilic residues, into macroscopic membranes. The membrane-forming peptides are greater than 12 amino acids in length, and preferably at least 16 amino acids, are complementary and are structurally compatible. Specifically, two peptides, (AEAEAKAK)2 (ARARADAD)2, were shown to self-assemble into macroscopic membranes. Conditions under which the peptides self-assemble into macroscopic membranes and methods for producing the membranes are also described. The macroscopic membranes have several interesting properties: they are stable in aqueous solution, serum, and ethanol, are highly resistant to heat, alkaline and acidic pH, chemical denaturants, and proteolytic digestion, and are non-cytotoxic. The membranes are potentially useful in biomaterial applications such as slow-diffusion drug delivery systems, artificial skin, and separation matrices, and as experimental models for Alzheimer's disease and scrapie infection. The sequence of the peptide, EAK16, was derived from a putative Z-DNA binding protein from yeast, called zuotin. The cloning and characterization of the ZUO1 gene are also described.

    摘要翻译： 这里描述的是将两亲肽，即具有交替疏水和亲水残基的肽自组装成宏观膜。 成膜肽长度大于12个氨基酸，优选至少16个氨基酸是互补的并且在结构上相容。 具体来说，显示两种肽（AEAEAKAK）2（ARARADAD）2自组装成宏观膜。 还描述了肽自组装成宏观膜的条件和制备膜的方法。 肉眼膜具有几个有趣的性质：它们在水溶液，血清和乙醇中稳定，对热，碱性和酸性pH，化学变性剂和蛋白水解消化具有高度抗性，并且是非细胞毒性的。 该膜可用于生物材料应用，如慢扩散药物递送系统，人造皮肤和分离基质，以及阿尔茨海默病和瘙痒病感染的实验模型。 肽EAK16的序列衍生自称为佐酮的来自酵母的推定的Z-DNA结合蛋白。 还描述了ZUO1基因的克隆和表征。

    Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
    5.
    发明授权
    Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor 失效
    通过两亲肽的自组装形成稳定的宏观膜并用于其

    公开(公告)号：US5670483A

    公开(公告)日：1997-09-23

    申请号：US346849

    申请日：1994-11-30

    申请人： Shuguang Zhang ,  Curtis Lockshin ,  Alexander Rich ,  Todd Holmes

    发明人： Shuguang Zhang ,  Curtis Lockshin ,  Alexander Rich ,  Todd Holmes

    IPC分类号： A61K9/00 ,  C07K7/08 ,  C07K14/00 ,  C07K14/395 ,  C12N5/00 ,  C12N5/02 ,  A61K7/08 ,  A61K14/00 ,  C07K38/10 ,  C07K38/16

    CPC分类号： C07K7/08 ,  C07K14/001 ,  C07K14/395 ,  C12N5/0068 ,  A61K9/009 ,  C12N2533/30 ,  C12N2533/50

    摘要： Described herein is the self-assembly of amphiphilic peptides, i.e., peptides with alternating hydrophobic and hydrophilic residues, into macroscopic membranes. The membrane-forming peptides are greater than 12 amino acids in length, and preferably at least 16 amino acids, are complementary and are structurally compatible. Specifically, two peptides, (AEAEAKAK).sub.2 (ARARADAD).sub.2, were shown to self-assemble into macroscopic membranes. Conditions under which the peptides self-assemble into macroscopic membranes and methods for producing the membranes are also described. The macroscopic membranes have several interesting properties: they are stable in aqueous solution, serum, and ethanol, are highly resistant to heat, alkaline and acidic pH, chemical denaturants, and proteolytic digestion, and are non-cytotoxic. The membranes are potentially useful in biomaterial applications such as slow-diffusion drug delivery systems, artificial skin, and separation matrices, and as experimental models for Alzheimer's disease and scrapie infection. The sequence of the peptide, EAK16, was derived from a putative Z-DNA binding protein from yeast, called zuotin. The cloning and characterization of the ZUO1 gene are also described.

    摘要翻译： 这里描述的是将两亲肽，即具有交替疏水和亲水残基的肽自组装成宏观膜。 成膜肽长度大于12个氨基酸，优选至少16个氨基酸是互补的并且在结构上相容。 具体来说，显示两种肽（AEAEAKAK）2（ARARADAD）2自组装成宏观膜。 还描述了肽自组装成宏观膜的条件和制备膜的方法。 肉眼膜具有几个有趣的性质：它们在水溶液，血清和乙醇中稳定，对热，碱性和酸性pH，化学变性剂和蛋白水解消化具有高度抗性，并且是非细胞毒性的。 该膜可用于生物材料应用，如慢扩散药物递送系统，人造皮肤和分离基质，以及阿尔茨海默病和瘙痒病感染的实验模型。 肽EAK16的序列衍生自称为佐酮的来自酵母的推定的Z-DNA结合蛋白。 还描述了ZUO1基因的克隆和表征。

    Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
    6.
    发明授权
    Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor 失效
    通过两亲肽的自组装形成稳定的宏观膜并用于其

    公开(公告)号：US06800481B1

    公开(公告)日：2004-10-05

    申请号：US08824513

    申请日：1997-03-26

    申请人： Todd Holmes ,  Shuguang Zhang ,  Alexander Rich ,  C. Michael DiPersio ,  Curtis Lockshin

    发明人： Todd Holmes ,  Shuguang Zhang ,  Alexander Rich ,  C. Michael DiPersio ,  Curtis Lockshin

    IPC分类号： C12N502

    CPC分类号： C07K7/08 ,  A61K9/009 ,  C07K5/0815 ,  C07K7/06 ,  C07K14/001 ,  C07K14/395 ,  C12N5/0068 ,  C12N2533/30 ,  C12N2533/50

    摘要： Described herein is the self-assembly of amphiphilic peptides, i.e., peptides with alternating hydrophobic and hydrophilic residues, into macroscopic membranes. The membrane-forming peptides are greater than 12 amino acids in length, and preferably at least 16 amino acids, are complementary and are structurally compatible. Specifically, two peptides, (AEAEAKAK)2 (ARARADAD)2, were shown to self-assemble into macroscopic membranes. Conditions under which the peptides self-assemble into macroscopic membranes and methods for producing the membranes are also described. The macroscopic membranes have several interesting properties: they are stable in aqueous solution, serum, and ethanol, are highly resistant to heat, alkaline and acidic pH, chemical denaturants, and proteolytic digestion, and are non-cytotoxic. The membranes are potentially useful in biomaterial applications such as slow-diffusion drug delivery systems, artificial skin, and separation matrices, and as experimental models for Alzheimer's disease and scrapie infection. The sequence of the peptide, EAK16, was derived from a putative Z-DNA binding protein from yeast, called zuotin. The cloning and characterization of the ZUO1 gene are also described.

    摘要翻译： 这里描述的是将两亲肽，即具有交替疏水和亲水残基的肽自组装成宏观膜。 成膜肽长度大于12个氨基酸，优选至少16个氨基酸是互补的并且在结构上相容。 具体来说，显示两种肽（AEAEAKAK）2（ARARADAD）2自组装成宏观膜。 还描述了肽自组装成宏观膜的条件和制备膜的方法。 肉眼膜具有几个有趣的性质：它们在水溶液，血清和乙醇中稳定，对热，碱性和酸性pH，化学变性剂和蛋白水解消化具有高度抗性，并且是非细胞毒性的。 该膜可用于生物材料应用，如慢扩散药物递送系统，人造皮肤和分离基质，以及阿尔茨海默病和瘙痒病感染的实验模型。 肽EAK16的序列衍生自称为佐酮的来自酵母的推定的Z-DNA结合蛋白。 还描述了ZUO1基因的克隆和表征。