公开(公告)号：US20090023589A1

公开(公告)日：2009-01-22

申请号：US12109189

申请日：2008-04-24

申请人： Douglas Levinson ,  Christine Kitsos ,  Irena MeInikova ,  Christopher McNulty

发明人： Douglas Levinson ,  Christine Kitsos ,  Irena MeInikova ,  Christopher McNulty

IPC分类号： C40B20/04

CPC分类号： G01N33/5023 ,  G01N33/502 ,  G01N33/56966

摘要： The present invention is directed to methods for identifying agents which affect cell state. The instant invention provides rapid and efficient methods for identifying agents which affect cell state. Methods are directed toward the screening of complex combinations of agents for their ability to affect cell state. In one embodiment, cells are incubated under suitable conditions and subjected to different agents. After an appropriate amount of time, the cells are assayed to determine what, if any, characteristics they possess. Cell characteristics can be organized in a manner such that different and novel cell states can be identified.

摘要翻译： 本发明涉及用于鉴定影响细胞状态的药剂的方法。 本发明提供用于鉴定影响细胞状态的试剂的快速和有效的方法。 方法的目的是筛选复合物的组合，使其能够影响细胞状态。 在一个实施方案中，将细胞在合适的条件下培养并进行不同的试剂。 在适当的时间后，测定细胞以确定它们具有的特征（如果有的话）。 可以以能够识别不同和新颖的细胞状态的方式来组织细胞特征。

公开(公告)号：US20060035211A1

公开(公告)日：2006-02-16

申请号：US11149863

申请日：2005-06-10

申请人： Douglas Levinson ,  Christine Kitsos ,  Irena Melnikova ,  Christopher McNulty

发明人： Douglas Levinson ,  Christine Kitsos ,  Irena Melnikova ,  Christopher McNulty

IPC分类号： C12Q1/00 ,  G06F19/00 ,  G01N33/48 ,  G01N33/50

CPC分类号： G01N33/5023 ,  G01N33/502 ,  G01N33/56966

摘要： The present invention is directed to methods for identifying agents which affect cell state. The instant invention provides rapid and efficient methods for identifying agents which affect cell state. Methods are directed toward the screening of complex combinations of agents for their ability to affect cell state. In one embodiment, cells are incubated under suitable conditions and subjected to different agents. After an appropriate amount of time, the cells are assayed to determine what, if any, characteristics they possess. Cell characteristics can be organized in a manner such that different and novel cell states can be identified.

摘要翻译： 本发明涉及用于鉴定影响细胞状态的药剂的方法。 本发明提供用于鉴定影响细胞状态的试剂的快速和有效的方法。 方法的目的是筛选复合物的组合，使其能够影响细胞状态。 在一个实施方案中，将细胞在合适的条件下培养并进行不同的试剂。 在适当的时间后，测定细胞以确定它们具有的特征（如果有的话）。 可以以能够识别不同和新颖的细胞状态的方式来组织细胞特征。

公开(公告)号：US06977723B2

公开(公告)日：2005-12-20

申请号：US10235922

申请日：2002-09-06

申请人： Anthony V. Lemmo ,  Javier P. Gonzalez-Zugasti ,  Michael J. Cima ,  Douglas Levinson ,  Alasdair Y. Johnson ,  Örn Almarsson ,  Christopher McNulty

发明人： Anthony V. Lemmo ,  Javier P. Gonzalez-Zugasti ,  Michael J. Cima ,  Douglas Levinson ,  Alasdair Y. Johnson ,  Örn Almarsson ,  Christopher McNulty

IPC分类号： B01J19/00 ,  B01L3/14 ,  B01L7/00 ,  C12M1/34 ,  C12Q1/68 ,  C30B7/00 ,  C40B60/14 ,  C40B70/00 ,  G01J3/28 ,  G01J3/44 ,  G01N21/25 ,  G01N21/35 ,  G01N21/65 ,  G01N33/48 ,  G01N33/50 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G06F19/00

CPC分类号： G01N35/028 ,  B01J19/0046 ,  B01J2219/00274 ,  B01J2219/00283 ,  B01J2219/0031 ,  B01J2219/00335 ,  B01J2219/00344 ,  B01J2219/00495 ,  B01J2219/00547 ,  B01J2219/00587 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00756 ,  B01L3/5082 ,  B01L7/52 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/1805 ,  C30B7/00 ,  C30B29/58 ,  C40B60/14 ,  C40B70/00 ,  G01J3/28 ,  G01N21/253 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/65 ,  G01N35/0099 ,  G01N2021/651 ,  G01N2035/041 ,  G01N2035/042 ,  G01N2035/0425

摘要： Systems and methods are described that allow the high-throughput preparation, processing, and study of arrays of samples, each of which comprises at least one compound. Particular embodiments of the invention allow a large number of experiments to be performed in parallel on samples that comprised of one or more compounds on the milligram or microgram quantities of compounds. Other embodiments of the invention encompass methods and devices for the rapid screening of the results of such experiments, as well as methods and devices for rapidly determining whether or not similarities exist among groups of samples in an array. Particular embodiments of the invention encompass methods and devices for the high-throughput preparation of different forms of compounds (e.g., different crystalline forms), for the discovery of new forms of old compounds, and for the discovery of new methods of producing such forms. Embodiments of the invention also allow for the high-throughput determination of how specific compounds or forms of compounds behave when exposed to other chemicals or environmental conditions.

公开(公告)号：US20050089923A9

公开(公告)日：2005-04-28

申请号：US10142812

申请日：2002-05-10

申请人： Douglas Levinson ,  Christopher McNulty ,  Christopher Moore

发明人： Douglas Levinson ,  Christopher McNulty ,  Christopher Moore

IPC分类号： G01N30/86 ,  G06F19/00 ,  G01N33/53 ,  G01N33/48 ,  G01N33/50

CPC分类号： G06F19/704 ,  B01J2219/007 ,  B01J2219/00756 ,  C40B30/02 ,  G01N30/8617 ,  G01N30/8693 ,  G06F19/707

摘要： A method and system for planning and assessing the results of high-throughput solid form screening and high-throughput formulation screening are disclosed. Also disclosed are methods and systems for using high-throughput solid form screening and high-throughput formulation screening to select compounds and formulations for further testing, or to prioritize testing.

摘要翻译： 公开了一种用于规划和评估高通量固体筛选和高通量制剂筛选结果的方法和系统。 还公开了使用高通量固体形式筛选和高通量制剂筛选来选择用于进一步测试或优先化测试的化合物和制剂的方法和系统。

公开(公告)号：US20070021929A1

公开(公告)日：2007-01-25

申请号：US11467096

申请日：2006-08-24

申请人： Anthony Lemmo ,  Javier Gonzalez-Zugasti ,  Michael Cima ,  Douglas Levinson ,  Alasdair Johnson ,  Orn Almarsson ,  Hongming Chen ,  Christopher McNulty

发明人： Anthony Lemmo ,  Javier Gonzalez-Zugasti ,  Michael Cima ,  Douglas Levinson ,  Alasdair Johnson ,  Orn Almarsson ,  Hongming Chen ,  Christopher McNulty

IPC分类号： G06F19/00

CPC分类号： G01N35/0092 ,  G01N35/00613 ,  G01N35/00712 ,  G01N2015/1493

摘要： Computer-controlled automated high-throughput systems can be used to design, prepare, process, screen, and analyze a large number of samples in removable sample vials each containing a compound of interest formulated with differing component combinations and varying concentrations. The computer-controlled methods of the present invention allow for a determination of the effects of additional or inactive components, such as excipients, carriers, enhancers, adhesives, additives, and the like, on the compound of interest, such as a pharmaceutical. The invention thus encompasses the computer systems, computer methods, and computer-program products for computer-controlled automated high-throughput testing of experimental formulations in order to identify experimental formulations that can be further processed. Identified experimental formulations from multiple arrays can be removed and re-arrayed together to form a new array for further processing.

摘要翻译： 计算机控制的自动化高通量系统可用于设计，制备，处理，筛选和分析大量可拆卸样品瓶中的样品，每个样品瓶均含有不同成分组合和不同浓度配制的感兴趣的化合物。 本发明的计算机控制的方法允许确定附加或非活性组分如赋形剂，载体，增强剂，粘合剂，添加剂等对目的化合物如药物的作用。 本发明因此包括计算机系统，计算机方法和计算机程序产品，用于实验制剂的计算机控制的自动高通量测试，以便鉴定可进一步处理的实验制剂。 来自多个阵列的识别的实验制剂可以被去除并重新排列在一起以形成用于进一步处理的新阵列。

公开(公告)号：US20070020662A1

公开(公告)日：2007-01-25

申请号：US11467061

申请日：2006-08-24

申请人： Michael Cima ,  Douglas Levinson ,  Donovan Chin ,  Christopher McNulty ,  Christopher Moore ,  Anthony Lemmo ,  Javier Gonzalez-Zugasti ,  Alasdair Johnson ,  Hongming Chen ,  Orn Almarsson

发明人： Michael Cima ,  Douglas Levinson ,  Donovan Chin ,  Christopher McNulty ,  Christopher Moore ,  Anthony Lemmo ,  Javier Gonzalez-Zugasti ,  Alasdair Johnson ,  Hongming Chen ,  Orn Almarsson

IPC分类号： C12Q1/68 ,  G01N33/53 ,  G06F19/00

CPC分类号： G16C20/60 ,  B01J2219/007 ,  B01J2219/00756 ,  G16B15/00 ,  G16B35/00 ,  G16B40/00

摘要： The present invention relates to computer-controlled automated high-throughput systems and/or computer-program products to design, prepare, process, and analyze a large number of samples having experimental formulations each containing a compound of interest formulated with differing component combinations and varying concentrations and component identities. The computer-controlled methods of the present invention allow determination of the effects of additional or inactive components, such as excipients, carriers, enhancers, adhesives, additives, and the like, on the compound of interest, such as pharmaceuticals. The invention thus encompasses the computer systems, computer methods, and computer-program products for computer-controlled automated high-throughput testing of pharmaceutical compositions or formulations in order to determine the overall optimal composition or formulation for an intended use or purpose.

摘要翻译： 本发明涉及计算机控制的自动化高通量系统和/或计算机程序产品，用于设计，制备，处理和分析大量具有实验制剂的样品，每个试样含有不同成分组合配制的感兴趣的化合物， 浓度和组分特征。 本发明的计算机控制方法允许确定附加或不活泼组分如赋形剂，载体，增强剂，粘合剂，添加剂等对目标化合物如药物的作用。 因此，本发明包括计算机系统，计算机方法和用于药物组合物或制剂的计算机控制的自动化高通量测试的计算机程序产品，以便为预期用途或目的确定总体最佳组成或配方。

公开(公告)号：US20050130220A1

公开(公告)日：2005-06-16

申请号：US11051517

申请日：2005-01-31

申请人： Anthony Lemmo ,  Javier Gonzalez-Zugasti ,  Michael Cima ,  Douglas Levinson ,  Alasdair Johnson ,  Orn Almarsson ,  Christopher McNulty

发明人： Anthony Lemmo ,  Javier Gonzalez-Zugasti ,  Michael Cima ,  Douglas Levinson ,  Alasdair Johnson ,  Orn Almarsson ,  Christopher McNulty

IPC分类号： B01J19/00 ,  B01L3/14 ,  B01L7/00 ,  C12M1/34 ,  C12Q1/68 ,  C30B7/00 ,  C40B60/14 ,  C40B70/00 ,  G01J3/28 ,  G01J3/44 ,  G01N21/25 ,  G01N21/35 ,  G01N21/65 ,  G01N33/48 ,  G01N33/50 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G06F19/00

CPC分类号： G01N35/028 ,  B01J19/0046 ,  B01J2219/00274 ,  B01J2219/00283 ,  B01J2219/0031 ,  B01J2219/00335 ,  B01J2219/00344 ,  B01J2219/00495 ,  B01J2219/00547 ,  B01J2219/00587 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00756 ,  B01L3/5082 ,  B01L7/52 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/1805 ,  C30B7/00 ,  C30B29/58 ,  C40B60/14 ,  C40B70/00 ,  G01J3/28 ,  G01N21/253 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/65 ,  G01N35/0099 ,  G01N2021/651 ,  G01N2035/041 ,  G01N2035/042 ,  G01N2035/0425

摘要： Systems and methods are described that allow the high-throughput preparation, processing, and study of arrays of samples, each of which comprises at least one compound. Particular embodiments of the invention allow a large number of experiments to be performed in parallel on samples that comprised of one or more compounds on the milligram or microgram quantities of compounds. Other embodiments of the invention encompass methods and devices for the rapid screening of the results of such experiments, as well as methods and devices for rapidly determining whether or not similarities exist among groups of samples in an array. Particular embodiments of the invention encompass methods and devices for the high-throughput preparation of different forms of compounds (e.g., different crystalline forms), for the discovery of new forms of old compounds, and for the discovery of new methods of producing such forms. Embodiments of the invention also allow for the high-throughput determination of how specific compounds or forms of compounds behave when exposed to other chemicals or environmental conditions.

摘要翻译： 描述了允许高通量制备，处理和研究样品阵列的系统和方法，每个样品包含至少一种化合物。 本发明的具体实施方案允许在由毫克或微克数量的化合物上的一种或多种化合物组成的样品上并行进行大量实验。 本发明的其它实施例包括用于快速筛选这些实验的结果的方法和装置，以及用于快速确定阵列中的样品组之间是否存在相似性的方法和装置。 本发明的具体实施方案包括用于高通量制备不同形式的化合物（例如不同结晶形式）的方法和装置，用于发现新形式的旧化合物，以及发现生产此类形式的新方法。 本发明的实施方案还允许高通量测定当化合物或形式的化合物在暴露于其它化学物质或环境条件时的表现。

公开(公告)号：US08601619B2

公开(公告)日：2013-12-10

申请号：US12749019

申请日：2010-03-29

申请人： Christopher McNulty

发明人： Christopher McNulty

IPC分类号： A61G1/003

CPC分类号： A61G7/1032 ,  A61G2203/42

摘要： A system for transferring a body from a first surface to a second surface, or supporting a body during such translation with substantially no agitation of the body, is provided. The system can include yaw feedback control to promote and/or insure straightness of travel. The system could additionally or alternatively include a patient rotation sensing and adjustment system. The body can be supported by a pad, but it is not essential in all embodiments.

摘要翻译： 提供了一种用于将身体从第一表面转移到第二表面或在基本上不搅动身体的这种平移期间支撑身体的系统。 该系统可以包括偏航反馈控制以促进和/或确保行驶的平直度。 该系统可以附加地或替代地包括患者旋转感测和调节系统。 身体可以由垫支撑，但在所有实施例中并不是必需的。

公开(公告)号：US07748062B2

公开(公告)日：2010-07-06

申请号：US12341744

申请日：2008-12-22

申请人： Christopher McNulty

发明人： Christopher McNulty

IPC分类号： A61G7/14

CPC分类号： A61G7/1032 ,  A61G1/003 ,  A61G1/017 ,  A61G2200/32 ,  A61G2203/12 ,  Y10S414/134

摘要： A body transfer system, includes a housing having a substantially planar top portion configured to support a body and having a substantially planar bottom portion; a bottom translation mechanism disposed at the bottom portion and configured to translate the system across a first surface upon which a body rests; and a top translation mechanism disposed at the top portion and configured to burrow the system between the first surface and the body as the bottom translation mechanism translates the first surface. A method of transferring a body is also included.

摘要翻译： 一种身体转移系统，包括壳体，其具有构造成支撑身体并且具有基本平坦的底部部分的基本平坦的顶部部分; 底部平移机构，其设置在底部部分处并且被配置成使系统平移身体靠在身体的第一表面上; 以及顶部平移机构，其设置在所述顶部部分处并且构造成当所述底部平移机构平移所述第一表面时在所述第一表面和所述主体之间挖掘所述系统。 还包括转移身体的方法。

公开(公告)号：US20090094742A1

公开(公告)日：2009-04-16

申请号：US12341744

申请日：2008-12-22

申请人： Christopher McNulty

发明人： Christopher McNulty

IPC分类号： A61G7/10

CPC分类号： A61G7/1032 ,  A61G1/003 ,  A61G1/017 ,  A61G2200/32 ,  A61G2203/12 ,  Y10S414/134

摘要： A body transfer system, includes a housing having a substantially planar top portion configured to support a body and having a substantially planar bottom portion; a bottom translation mechanism disposed at the bottom portion and configured to translate the system across a first surface upon which a body rests; and a top translation mechanism disposed at the top portion and configured to burrow the system between the first surface and the body as the bottom translation mechanism translates the first surface. A method of transferring a body is also included.

摘要翻译： 一种身体转移系统，包括壳体，其具有构造成支撑身体并且具有基本平坦的底部部分的基本平坦的顶部部分; 底部平移机构，其设置在底部部分处并且被配置成使系统平移身体靠在身体的第一表面上; 以及顶部平移机构，其设置在所述顶部部分处并且构造成当所述底部平移机构平移所述第一表面时在所述第一表面和所述主体之间挖掘所述系统。 还包括转移身体的方法。