公开(公告)号：US20240207046A1

公开(公告)日：2024-06-27

申请号：US18522551

申请日：2023-11-29

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Nikolai Gurovich ,  Michael Bukin ,  Anatoly Dvorsky ,  Eran Grosu ,  Noam Nir ,  Joseph Mordechai Leichner ,  Elena Sherman ,  Guillermo W. Moratorio

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2220/0008 ,  A61F2220/0025

Abstract: A prosthetic heart valve comprises a radially expandable frame comprising an outflow end and an inflow end, and a plurality of valve leaflets disposed within and coupled to the frame. Each leaflet comprises a main body having an outflow edge portion and an inflow edge portion, wherein the leaflets are configured to move between an open state and a closed state in which the outflow edge portions coapt with each other and block the flow of blood through the frame from the outlet end to the inlet end, wherein the inflow edge portion of each leaflet includes a movable portion that can move radially inwardly when the leaflets move to the closed state to assist with the coaptation of the outflow edge portions of the leaflets and radially outwardly when the leaflets move to the open state.

公开(公告)号：US20240180696A1

公开(公告)日：2024-06-06

申请号：US18402589

申请日：2024-01-02

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Michael Bukin ,  Nikolai Gurovich ,  Elena Sherman ,  Anatoly Dvorsky ,  Eran Grosu

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/243 ,  A61F2/2436

Abstract: A prosthetic valve includes an annular frame and a valvular structure mounted within the annular frame. The valvular structure comprises a plurality of leaflets defining a plurality of commissures coupled to the annular frame. Each leaflet includes a leaflet free edge that is offset in a downstream direction from the commissures by side edges that are not attached to the frame. A material portion of the leaflet disposed between the side edges contributes a material slack that extends a radial reach of the leaflet free edge for coaptation. The prosthetic valve can be releasably coupled to a delivery device to form a delivery apparatus. The prosthetic valve can be delivered to a selected implantation site by the delivery apparatus and released at the implantation site by a handle of the delivery device.

公开(公告)号：US20250143876A1

公开(公告)日：2025-05-08

申请号：US19016497

申请日：2025-01-10

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Eran Grosu ,  Eran Goldberg ,  Sean Timothy O'keeffe ,  Douglas Thomas Dominick ,  Michal Lipperman

IPC: A61F2/24

Abstract: In some examples, a medical implant includes a frame and a radiopaque marker. The radiopaque marker is coupled to the strut with a recessed surface portion of the radiopaque marker positioned in opposing relation to a first concave surface of a strut portion of the frame. In some examples, at least one strut of the frame has a bore, an eyelet, and a strut portion between the bore and the eyelet. The radiopaque marker is disposed within the bore and has an edge surface with a recessed surface portion positioned in opposing relation to a first surface of the strut portion. In some examples, a medical assembly includes a delivery apparatus, a frame, and a radiopaque marker.

公开(公告)号：US20240374384A1

公开(公告)日：2024-11-14

申请号：US18780203

申请日：2024-07-22

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Anatoly Dvorsky ,  Nikolai Gurovich ,  Michael Bukin ,  Eran Grosu

IPC: A61F2/24

Abstract: A prosthetic heart valve can include a radially expandable and compressible frame and a valvular structure. The frame can include a plurality of circumferentially spaced axial struts, a plurality of pairs of axial posts, and a plurality of rows of angled struts. Each pair of axial posts can be positioned circumferentially between two axial struts. The plurality of rows can include at least a first row, a second row downstream of the first row, a third row downstream of the second row, and a fourth row downstream of the third row. Each of the angled struts can be connected at one end to one of the axial struts and at another end to one of the axial posts. The angled struts of the first and fourth rows can be shorter than the struts of the second and third rows.

公开(公告)号：US20240366367A1

公开(公告)日：2024-11-07

申请号：US18772519

申请日：2024-07-15

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Anatoly Dvorsky ,  Alon Ben-Yosef ,  Eran Grosu ,  Nikolai Gurovich ,  Michael Bukin ,  Ilan Leshecz ,  Joseph Mordechai Leichner

IPC: A61F2/24

Abstract: This disclosure is directed to prosthetic heart valves and frames for prosthetic heart valves having actuation assemblies with at least two bolts coupled to each other. The actuation assembly with at least two bolts allow different portions of the actuation assembly to be designed to meet different needs. In one example, the actuation mechanism can include a first bolt coupled end-to-end with a second bolt. The second bolt can have a greater diameter and correspondingly greater mechanical strength than the first bolt. The first bolt can have a lesser diameter suitable for minimizing the thickness of surrounding and adjacent valve frame components. The actuation assembly can also include one or more of a nut, a washer, and a portion designed to attach to components of a delivery system. Also disclosed herein are actuation assemblies including a washer secured by a pin extending through the bolt of the actuation assembly.

公开(公告)号：US20250143898A1

公开(公告)日：2025-05-08

申请号：US19016134

申请日：2025-01-10

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Eran Grosu ,  Tal Reich ,  Yuval Kasher ,  Roei Mayo ,  Ben Shitrit ,  Nikolai Gurovich ,  Emil Karapetian ,  Arvin T. Chang ,  Scott Louis Pool ,  Leonardo Paim Nicolau Da Costa ,  Michael G. Valdez

IPC: A61F2/86 ,  A61F2/95

Abstract: An implant for adding compliance to a blood vessel includes a first elongate rail shaped to contact an inner wall of a blood vessel and a second elongate rail shaped to contact an opposing inner wall of the blood vessel. Connectors extend between the first and second rails for providing a separation therebetween and maintaining the rails at locations on opposing sides of the lumen after implantation. The connectors push the rails outwardly for biasing the blood vessel toward a substantially oval shape. The connectors are preferably flexible for allowing the blood vessel to change shape during use for adding compliance to the blood vessel. The elongate rails are preferably curved or hemi-spherical for conforming to the shape of the inner wall of the blood vessel.

公开(公告)号：US20250099239A1

公开(公告)日：2025-03-27

申请号：US18969878

申请日：2024-12-05

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Anatoly Dvorsky ,  Eran Grosu ,  Ilan Leshecz ,  Michael Bukin ,  Nikolai Gurovich ,  Assaf Sharon ,  David Maimon

IPC: A61F2/24

Abstract: Prosthetic valves that include support arms extending from support posts thereof, and methods for utilizing such prosthetic valves, are disclosed herein. As one example, a prosthetic valve can include an annular frame movable between a radially compressed state and a radially expanded state, and at least one support arm. The frame can include a plurality of support posts, each extending between a post inflow end and an opposite post outflow end. The support arm can extend from a corresponding support post, and terminate at a free-ended tip which is biased radially away from the corresponding support post.

公开(公告)号：US20240277473A1

公开(公告)日：2024-08-22

申请号：US18645284

申请日：2024-04-24

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Michael Bukin ,  Nikolai Gurovich ,  Anatoly Dvorsky ,  Eran Grosu ,  Noam Nir ,  Joseph Mordechai Leichner

IPC: A61F2/24

CPC classification number: A61F2/243 ,  A61F2/2418 ,  A61F2250/001

Abstract: A prosthetic device, such as a prosthetic heart valve, can include a radially compressible and expandable frame and a screw actuator that is coupled to the frame and configured to be rotated to radially expand the frame from a radially compressed state to a first radially expanded state. The frame includes an over-expansion structure that is configured to allow relative sliding movement between the screw actuator and the frame in a longitudinal direction to permit the frame to radially expand from the first radially expanded state to a second radially expanded state when an external expansion force applied to the prosthetic heart valve exceeds a predetermined force.

公开(公告)号：US20250090317A1

公开(公告)日：2025-03-20

申请号：US18967404

申请日：2024-12-03

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Nikolai Gurovich ,  Michael Bukin ,  Eran Grosu ,  Ilan Leshecz

IPC: A61F2/24

Abstract: A prosthetic heart valve includes a valve frame comprising an outflow end and an inflow end, a plurality of leaflets disposed within and coupled to the valve frame, and a skirt assembly mounted to an outer surface of the valve frame. The skirt assembly includes a sealing layer and a skirt frame including a plurality of interconnected struts, wherein the skirt frame has a plurality of inflow apices and outflow apices, wherein selected ones of the inflow apices are fixed to the valve frame and selected ones of the outflow apices are fixed to the valve frame, wherein one or more of the struts are configured to flex in an outward radial direction when the valve frame is in a radially expanded state to cause the sealing layer to protrude outwardly from the valve frame.

公开(公告)号：US20240423790A1

公开(公告)日：2024-12-26

申请号：US18825316

申请日：2024-09-05

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Anatoly Dvorsky ,  Michael Bukin ,  Nikolai Gurovich ,  Eran Grosu

IPC: A61F2/24

Abstract: This disclosure is directed to prosthetic heart valves and actuators for prosthetic heart valves. In some examples, the actuator can comprise an internally threaded bore that engages an externally threaded portion of the frame component, such as a stationary post. In some examples, the actuator can comprise an externally threaded end portion that engages an internally threaded bore in a frame component, such as a stationary post.