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公开(公告)号：US11008543B2
公开(公告)日：2021-05-18
申请号：US15762470
申请日：2016-09-22
申请人： ELTEK S.P.A.
发明人： Marco Pizzi , Massimo Zanin , Enrica Mortara
摘要： Herein described is an apparatus for disgregating a biological tissue, such as an adipose tissue including stem and/or multipotent cells for use in regenerative medicine. The apparatus comprises a disposable device having a first duct for the passage of the biological tissue, the first duct having a first end and a second end. Each end of the first duct is configured for connection to an inlet/outlet opening of a respective handling and/or collecting device, particularly a pump device, such as a syringe. The disposable device further comprises an adjustment arrangement operable to cause a reduction of a passage section of the first duct.
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公开(公告)号：US11982584B2
公开(公告)日：2024-05-14
申请号：US17295909
申请日：2019-11-22
申请人： ELTEK S.p.A.
发明人： Costanzo Gadini , Marco Pizzi , Massimo Zanin , Stefano Allera
CPC分类号： G01L3/101 , F16C19/527 , F16C43/00 , G01L1/183 , G01L3/108 , G01L5/0019 , G01M13/045 , F16C2202/36 , F16C2233/00
摘要： A bearing detection device comprises a housing body, to be fixed to a stationary ring of a bearing, and a detection arrangement on the housing body, comprising a piezoelectric transducer. The detection arrangement also comprises: a floating body, mounted on the housing body and suitable for mechanically transmitting vibrations of the bearing, and a sensor unit, which is mounted in a stationary position on the housing body and has a detection surface configured for receiving thereon a corresponding surface of the floating body. The piezoelectric transducer defines at least part of the detection surface and is configured for generating an electrical potential difference that is substantially proportional to the magnitude of a stress exerted by the floating body on the piezoelectric transducer.
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公开(公告)号：US12109564B2
公开(公告)日：2024-10-08
申请号：US16972283
申请日：2019-06-05
申请人： ELTEK S.p.A.
发明人： Marco Pizzi , Giovanni Melioli , Valentina Gallo , Massimo Zanin
CPC分类号： B01L3/502753 , C12Q1/18 , B01L2200/0668 , B01L2300/0645 , B01L2300/0806 , B01L2300/161
摘要： A microfluidic device for concentrating particles contained in a fluid sample (FS) comprises a substrate (11) configured for being set in rotation about a centre of rotation (5a), the substrate (11) having a surface (11b) defined in which is at least one microfluidic arrangement (12) that extends substantially according to a plane identified by the substrate (11). The at least one microfluidic arrangement (12) comprises at least one microchannel (13) having a first end (13a) and a second end (13b), wherein: —the at least one microchannel (13) comprises, in a region thereof intermediate between its first end (13a) and its second end (13a), at least one accumulation area (15) that is at a first distance (R1) in a radial direction (R) from the centre of rotation (5a) of the substrate (11); —the first end (13a) and the second end (13b) of the at least one microchannel (13) are at second distances (R2) in a radial direction (R) from the centre of rotation (5a) of the substrate (11); and —the first distance (R1) in a radial direction (R) is greater than the second distances (R2) in a radial direction (R), in such a way that particles (P) possibly contained in a volume of fluid of the fluid sample (FS) that penetrates into the at least one microchannel (13) tend to concentrate in the at least one accumulation area (15) as a result of the centrifugal force caused by a rotation of the substrate (11) about the centre of rotation (5a).
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公开(公告)号：US11982561B2
公开(公告)日：2024-05-14
申请号：US17282222
申请日：2019-10-03
申请人： ELTEK S.p.A.
发明人： Fulvio Cerutti , Stefano Allera , Massimo Zanin , Matteo Rondano , Giorgio Fagnola , Mauro Zorzetto , Marco Pizzi
IPC分类号： G01F23/263 , G01F23/24 , G01F25/20
CPC分类号： G01F23/268 , G01F23/24 , G01F23/266 , G01F25/20
摘要： A level sensor comprises an electrical-connection structure and a level-detection structure. The level-detection structure comprises a plurality of elongated electrodes, which include at least three measuring electrodes. The elongated electrodes extend at least partially in side-by-sidey positions in a length direction of the level-detection structure and each have a proximal end and a distal end relative to the electrical-connection structure. The level-detection structure is divided, in the length direction, into a succession of detection sections, each of which includes two effective portions of two respective measuring electrodes, the two effective portions extending to a prevalent extent substantially parallel and equidistant, at a first predetermined distance from each other, in the length direction. In the detection sections there also extends, in the length direction, a non-effective portion of one further elongated electrode other than the two measuring electrodes that define the two effective portions of the corresponding detection section, the at least one further elongated electrode being one measuring electrode or else a reference electrode. The elongated electrodes are shaped in such a way that, at one or more of the detection sections, the non-effective portion of the at least one further elongated electrode extends to a prevalent extent at respective second predetermined distances from the corresponding two effective portions, the second predetermined distances being greater than the first predetermined distance.
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公开(公告)号：US11446421B2
公开(公告)日：2022-09-20
申请号：US16716800
申请日：2019-12-17
申请人： ELTEK S.p.A.
发明人： Massimo Zanin , Marco Pizzi , Laura Mazzucco , Marco Bertoni
摘要： A medical device for separating a fluid, in particular for separating platelet-rich plasma from whole blood, includes three containers and at least one corresponding connection line having an intermediate bifurcation. Provided on the connection line are valve means for enabling or preventing a flow of fluid. At least one container includes a hollow container body and a plunger associated in a movable way to the container body. The device also includes a filtering member on the connection line.
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公开(公告)号：US11761483B2
公开(公告)日：2023-09-19
申请号：US17296132
申请日：2019-11-22
申请人： ELTEK S.P.A.
发明人： Marco Pizzi , Massimo Zanin , Stefano Allera
CPC分类号： F16C19/522 , F16C35/047 , G01L5/0019 , F16C2202/36 , F16C2233/00
摘要： A sensorized supporting device for bearings (1) comprises: • a bearing housing (2), configured for being secured to a mounting structure and defining at least one seat (2c) for a bearing (3); and • a sensorized supporting base (4), having a supporting body (4′) prearranged for being at least partially positioned between the mounting structure (S) and the bearing housing (2). The supporting body (4′) has a detection surface (4c) which extends in a longitudinal direction (L) and a transverse direction (W) and is configured for resting, directly or via interposition of at least one further element, on a corresponding surface of one of the bearing housing (2) and the mounting structure, the supporting base (4) being provided with a mechanical-stress sensor. The mechanical-stress sensor comprises at least one piezoelectric transducer (101, 102, 20) defining at least part of the detection surface (4c), the at least one piezoelectric transducer (10; 20; 101, 102) being configured for generating an electrical potential difference that is substantially proportional to the magnitude of a mechanical stress (SS) applied to the bearing housing (2).
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公开(公告)号：US10687749B2
公开(公告)日：2020-06-23
申请号：US15522100
申请日：2015-10-29
申请人： ELTEK S.p.A.
发明人： Marco Pizzi , Massimo Zanin , Enrica Mortara , Chadée Chappoz , Laura Mazzucco
摘要： A medical device for the separation of a concentrate enriched with cells from a biological fluid, in particular a concentrate of stromal or stem cells from medullar aspirate or venous blood, comprises: a treatment container for receiving and treating the biological fluid for the purposes of its separation into a number of fractions; a first collection container, for receiving a first fraction of the fluid, in particular a fraction poor in said cells; a second collection container, for receiving a second concentrated fraction of the fluid enriched with said cells; a deviator valve having a first way connected or prearranged for connection to the treatment container, a second way connected or prearranged for connection to the first collection container, and a third way connected or prearranged for connection to the second collection container; a first line for connection of the treatment container to the first way of the deviator valve, a second line for connection of the first collection container to the second way of the deviator valve, and a third line for connection of the second collection container with the third way of the deviator valve. The treatment container is a syringe container with a plunger having a plunger stem associated in a releasable way to a corresponding plunger head, and the first connection line comprises a first transparent tube, in particular a flexible transparent tube, and at least one of the second and third connection lines preferably comprises a second flexible tube. At least one connection line, or each connection line, further comprises: at least one respective hydraulic connector, for separable connection of a corresponding tube to the corresponding container and/or to the corresponding way of the deviator valve; and at least one automatic-closing or one-way valve.
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公开(公告)号：US10549025B2
公开(公告)日：2020-02-04
申请号：US15036640
申请日：2014-11-13
申请人： ELTEK S.p.A.
发明人： Massimo Zanin , Marco Pizzi , Laura Mazzucco , Marco Bertoni
摘要： A medical device for separating a fluid, in particular for separating platelet-rich plasma from whole blood, includes three containers and at least one corresponding connection line having an intermediate bifurcation. Provided on the connection line are valve means for enabling or preventing a flow of fluid. At least one container includes a hollow container body and a plunger associated in a movable way to the container body. A modular structure has modules connected to enable separation thereof. A first module includes at least the first container and a corresponding portion of the first connection line, and a second module, which has at least one between the second and third containers with a corresponding portion of the first connection line. Provided at least at the interface between two modules of the modular structure are releasable connectors, in particular hydraulic connectors having at least two parts that can be coupled together, each of which belongs to a corresponding module.
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