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    Multichamber device for processing of biological samples using high pressure
    4.
    发明申请
    Multichamber device for processing of biological samples using high pressure 审中-公开
    用于使用高压处理生物样品的多室设备

    公开(公告)号：US20070014690A1

    公开(公告)日：2007-01-18

    申请号：US11484293

    申请日：2006-07-10

    申请人： Nathan Lawrence ,  Feng Tao ,  Allan Kakita ,  Mark Manak ,  Richard Schumacher ,  James Laugharn

    发明人： Nathan Lawrence ,  Feng Tao ,  Allan Kakita ,  Mark Manak ,  Richard Schumacher ,  James Laugharn

    IPC分类号： G01N31/22

    CPC分类号： B01L3/502 ,  B01L2200/026 ,  B01L2300/044 ,  B01L2300/0663 ,  B01L2300/0832 ,  B01L2300/087 ,  B01L2400/0481 ,  B01L2400/0677 ,  B01L2400/0683 ,  G01N1/286 ,  G01N1/4077 ,  G01N2001/2866 ,  Y10T436/25375

    摘要： Devices and methods are described for homogenization, processing, detection, and analysis of biological samples such as insects, fungi, bacteria, and plant and animal tissues. Multiple chambers in these devices permit different processing functions to be carried out at each stage, such that the resulting homogenized product can be further processed, purified, analyzed, and/or biomolecules such as metabolites, proteins and nucleic acids, or pharmaceutical products can be detected. The device can be used in a hydrostatic pressure apparatus, in which different activities, i.e. incubations, addition or renewal of reagent, and generation and detection of signal can be carried out in the appropriate chamber. The method improves the preservation of biomolecules from chemical and enzymatic degradation relative to conventional means. Additionally, this method enables automated sample preparation and analytical processes.

    摘要翻译： 描述了用于均匀化，处理，检测和分析生物样品例如昆虫，真菌，细菌以及植物和动物组织的装置和方法。 这些装置中的多个室允许在每个阶段进行不同的处理功能，使得得到的均质产物可进一步加工，纯化，分析，和/或生物分子如代谢物，蛋白质和核酸或药物产品可以是 检测到。 该装置可以用在静水压力装置中，其中可以在适当的室中进行不同的活动，即温育，试剂的添加或更新，以及信号的产生和检测。 该方法相对于常规方法改善了化学和酶降解生物分子的保存。 此外，该方法可实现自动化样品制备和分析过程。

    Methods for producing partially hydrated and cooked bean products
    5.
    发明授权
    Methods for producing partially hydrated and cooked bean products 有权
    生产部分水合和煮熟的豆制品的方法

    公开(公告)号：US08372464B2

    公开(公告)日：2013-02-12

    申请号：US12530733

    申请日：2008-03-12

    申请人： Mark Dierking ,  Richard Schumacher ,  Jerry Hopkins

    发明人： Mark Dierking ,  Richard Schumacher ,  Jerry Hopkins

    IPC分类号： A23L1/20

    CPC分类号： A23L11/10 ,  A23L5/13 ,  A23L11/05 ,  A23P30/20

    摘要： Methods for producing a partially hydrated bean paste are disclosed. The methods include inputting a quantity of uncooked whole beans or split beans into an extruder comprising an inlet, one or more temperature zones in series downstream of the inlet, and a die downstream of the one or more temperature zones; rotating a screw assembly of the extruder to extrude the beans and force the beans through the one or more temperature zones, wherein a quantity of steam and a quantity of water is added to the beans as the beans are forced through each temperature zone; and forcing the beans exiting the final temperature zone of said one or more temperature zones in series through the die to produce a bean paste. The partially hydrated bean paste produced by the methods of the disclosure comprises a water content of at least about 45% by weight. The partially hydrated bean paste can be further processed into partially hydrated bean products, such as refried beans.

    摘要翻译： 公开了生产部分水合豆酱的方法。 所述方法包括将一批未煮熟的全豆或分裂豆输入到挤出机中，所述挤出机包括入口，在入口下游的串联的一个或多个温度区域和在所述一个或多个温度区域下游的模具; 旋转挤出机的螺杆组件以挤出豆子并迫使豆子通过一个或多个温度区域，其中当豆被强制通过每个温度区域时，将一定量的蒸汽和一定量的水加入到豆中; 并迫使通过模具串联的所述一个或多个温度区域的最终温度区域离开出来的豆以产生豆浆。 通过本公开的方法制备的部分水合的豆酱包含至少约45重量％的水含量。 部分水合的豆酱可以进一步加工成部分水合的豆制品，例如重烧豆。

    NICOTINIC ALPHA-7 RECEPTOR LIGANDS AND PREPARATION AND USES THEREOF
    10.
    发明申请
    NICOTINIC ALPHA-7 RECEPTOR LIGANDS AND PREPARATION AND USES THEREOF 审中-公开
    NICOTINIC ALPHA-7受体配体及其制备及其用途

    公开(公告)号：US20100016351A1

    公开(公告)日：2010-01-21

    申请号：US12551020

    申请日：2009-08-31

    申请人： Truc Minh Nguyen ,  Wenge Xie ,  Richard Schumacher ,  Brian Herbert ,  Ashok Tehim

    发明人： Truc Minh Nguyen ,  Wenge Xie ,  Richard Schumacher ,  Brian Herbert ,  Ashok Tehim

    IPC分类号： A61K31/4375 ,  C07D453/02

    CPC分类号： C07D453/02

    摘要： The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds which act as ligands for the α7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

    摘要翻译： 本发明一般涉及烟碱乙酰胆碱受体（nAChR）的配体领域，nAChR的活化以及与缺陷或功能不良的烟碱乙酰胆碱受体，特别是脑的疾病相关的疾病状况的治疗。 此外，本发明涉及作为α7nAChR亚型配体的新型化合物，制备此类化合物的方法，含有这些化合物的组合物及其使用方法。