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公开(公告)号：US5858684A
公开(公告)日：1999-01-12
申请号：US480751
申请日：1995-06-07
申请人： Edward F. Nemeth , Edward M. Brown , Steven C. Hebert , James E. Garrett, Jr. , Bradford C. Van Wagenen , Manuel F. Balandrin , Eric G. Del Mar
发明人： Edward F. Nemeth , Edward M. Brown , Steven C. Hebert , James E. Garrett, Jr. , Bradford C. Van Wagenen , Manuel F. Balandrin , Eric G. Del Mar
IPC分类号： A61K31/135 , A61K20060101 , A61K31/13 , A61K31/137 , A61K31/165 , A61K31/195 , A61K31/215 , A61K31/275 , A61K31/335 , A61K31/34 , A61K31/35 , A61K31/36 , A61K31/38 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/55 , A61K31/715 , A61K38/16 , A61P3/00 , A61P3/14 , A61P9/12 , A61P19/10 , A61P43/00 , C07C20060101 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/42 , C07C215/50 , C07C215/52 , C07C217/58 , C07C217/60 , C07C217/62 , C07C219/28 , C07C225/16 , C07C229/38 , C07C233/05 , C07C237/30 , C07C255/58 , C07C317/32 , C07C323/32 , C07D209/14 , C07D209/16 , C07D209/18 , C07D213/38 , C07D233/54 , C07D317/58 , C07D319/18 , C07K14/705 , C12N15/12 , G01N33/50 , G01N33/566 , G01N33/567 , G01N33/68 , G01N33/84 , C12Q1/68
CPC分类号： A61K31/13 , A61K31/135 , A61K31/137 , A61K31/165 , A61K31/195 , A61K31/215 , A61K31/275 , A61K31/335 , A61K31/34 , A61K31/35 , A61K31/36 , A61K31/38 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/55 , A61K31/70 , A61K31/715 , A61K38/16 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/42 , C07C215/52 , C07C217/58 , C07C217/60 , C07C217/62 , C07C225/16 , C07C229/38 , C07C233/05 , C07C255/58 , C07C317/32 , C07C323/32 , C07D209/14 , C07D209/16 , C07D209/18 , C07D213/38 , C07D233/64 , C07D319/18 , C07K14/705 , G01N33/5008 , G01N33/502 , G01N33/5044 , G01N33/5091 , G01N33/566 , G01N33/567 , G01N33/6872 , G01N33/6893 , G01N33/84 , A01K2227/50 , C07C2101/14 , G01N2500/10 , G01N2800/04
摘要： The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can mimic or block an effect of an extracellular ion on a cell having an inorganic ion receptor, more preferably the extracellular ion is Ca.sup.2+ and the effect is on a cell having a calcium receptor; (2) inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (3) nucleic acids encoding inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (4) antibodies and fragments thereof, targeted to inorganic ion receptor proteins, preferably calcium receptor protein; and (5) uses of such molecules, proteins, nucleic acids and antibodies.
摘要翻译： 本发明涉及无机离子受体在细胞和身体过程中的不同作用。 本发明的特征在于：（1）可以调节一种或多种无机离子受体活性的分子，优选地该分子可以模拟或阻断细胞外离子对具有无机离子受体的细胞的影响，更优选细胞外离子是Ca 2+和 该效果在具有钙受体的细胞上; （2）无机离子受体蛋白及其片段，优选钙受体蛋白及其片段; （3）编码无机离子受体蛋白质及其片段的核酸，优选钙受体蛋白及其片段; （4）抗体及其片段，靶向无机离子受体蛋白，优选钙受体蛋白; 和（5）使用这些分子，蛋白质，核酸和抗体。
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公开(公告)号：US6001884A
公开(公告)日：1999-12-14
申请号：US469204
申请日：1995-06-06
申请人： Edward F. Nemeth , Bradford C. Van Wagenen , Manuel F. Balandrin , Eric G. Delmar , Scott T. Moe
发明人： Edward F. Nemeth , Bradford C. Van Wagenen , Manuel F. Balandrin , Eric G. Delmar , Scott T. Moe
IPC分类号： A61K31/13 , A61K31/135 , A61K31/137 , A61K31/165 , A61K31/195 , A61K31/215 , A61K31/275 , A61K31/335 , A61K31/34 , A61K31/35 , A61K31/36 , A61K31/38 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/55 , A61K31/715 , A61K38/16 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/42 , C07C215/52 , C07C217/58 , C07C217/60 , C07C217/62 , C07C225/16 , C07C229/38 , C07C233/05 , C07C255/58 , C07C317/32 , C07C323/32 , C07D209/14 , C07D209/16 , C07D209/18 , C07D213/38 , C07D233/54 , C07D319/18 , C07K14/705 , G01N33/50 , G01N33/566 , G01N33/567 , G01N33/68 , G01N33/84 , A01N35/00
CPC分类号： G01N33/5044 , A61K31/13 , A61K31/135 , A61K31/137 , A61K31/165 , A61K31/195 , A61K31/215 , A61K31/275 , A61K31/335 , A61K31/34 , A61K31/35 , A61K31/36 , A61K31/38 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/55 , A61K31/70 , A61K31/715 , A61K38/16 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/42 , C07C215/52 , C07C217/58 , C07C217/60 , C07C217/62 , C07C225/16 , C07C229/38 , C07C233/05 , C07C255/58 , C07C317/32 , C07C323/32 , C07D209/14 , C07D209/16 , C07D209/18 , C07D213/38 , C07D233/64 , C07D319/18 , C07K14/705 , G01N33/5008 , G01N33/5014 , G01N33/5041 , G01N33/5091 , G01N33/566 , G01N33/567 , G01N33/6872 , G01N33/6893 , G01N33/84 , A01K2227/50 , C07C2101/14 , G01N2500/10 , G01N2800/04
摘要： The present invention features molecules which can modulate one or activities of an inorganic ion receptor. Preferably, the molecule can mimic or block the effect of extracellular Ca.sup.2+ on a calcium receptor. The preferred use of such molecules is to treat diseases or disorders by altering inorganic ion receptor activity, preferably calcium receptor activity.
摘要翻译： 本发明的特征在于可以调节一种或多种无机离子受体活性的分子。 优选地，分子可以模拟或阻断细胞外Ca 2+对钙受体的作用。 这种分子的优选用途是通过改变无机离子受体活性，优选钙受体活性来治疗疾病或病症。
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公开(公告)号：US06211244B1
公开(公告)日：2001-04-03
申请号：US08546998
申请日：1995-10-23
申请人： Bradford C. Van Wagenen , Scott T. Moe , Manuel F. Balandrin , Eric G. DelMar , Edward F. Nemeth
发明人： Bradford C. Van Wagenen , Scott T. Moe , Manuel F. Balandrin , Eric G. DelMar , Edward F. Nemeth
IPC分类号： A61K31135
CPC分类号： G01N33/6872 , A61K31/135 , A61K31/137 , C07C211/27 , C07C211/28 , C07C211/30 , C07C217/58 , C07C217/62 , C07C225/16 , C07C317/32 , C07C323/32 , C07D319/18 , G01N33/566 , G01N2500/10 , G01N2800/04
摘要： The present invention features compounds able to modulate one or more activities of an inorganic ion receptor and methods for treating diseases or disorders by modulating inorganic ion receptor activity. Preferably, the compound can mimic or block the effect of extracellular Ca2+ on a calcium receptor.
摘要翻译： 本发明具有能够调节一种或多种无机离子受体活性的化合物和通过调节无机离子受体活性来治疗疾病或病症的方法。 优选地，化合物可以模拟或阻断细胞外Ca 2+对钙受体的作用。
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公开(公告)号：US6011068A
公开(公告)日：2000-01-04
申请号：US353784
申请日：1994-12-08
申请人： Edward F. Nemeth , Bradford C. Van Wagenen , Manuel F. Balandrin , Eric G. DelMar , Scott T. Moe
发明人： Edward F. Nemeth , Bradford C. Van Wagenen , Manuel F. Balandrin , Eric G. DelMar , Scott T. Moe
IPC分类号： A61K31/135 , A61K20060101 , A61K31/13 , A61K31/137 , A61K31/165 , A61K31/195 , A61K31/215 , A61K31/275 , A61K31/335 , A61K31/34 , A61K31/35 , A61K31/36 , A61K31/38 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/55 , A61K31/715 , A61K38/16 , A61P3/00 , A61P3/14 , A61P9/12 , A61P19/10 , A61P43/00 , C07C20060101 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/42 , C07C215/50 , C07C215/52 , C07C217/58 , C07C217/60 , C07C217/62 , C07C219/28 , C07C225/16 , C07C229/38 , C07C233/05 , C07C237/30 , C07C255/58 , C07C317/32 , C07C323/32 , C07D209/14 , C07D209/16 , C07D209/18 , C07D213/38 , C07D233/54 , C07D317/58 , C07D319/18 , C07K14/705 , C12N15/12 , G01N33/50 , G01N33/566 , G01N33/567 , G01N33/68 , G01N33/84 , C07C211/00 , C07C213/00
CPC分类号： G01N33/5044 , A61K31/13 , A61K31/135 , A61K31/137 , A61K31/165 , A61K31/195 , A61K31/215 , A61K31/275 , A61K31/335 , A61K31/34 , A61K31/35 , A61K31/36 , A61K31/38 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/55 , A61K31/70 , A61K31/715 , A61K38/16 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/42 , C07C215/52 , C07C217/58 , C07C217/60 , C07C217/62 , C07C225/16 , C07C229/38 , C07C233/05 , C07C255/58 , C07C317/32 , C07C323/32 , C07D209/14 , C07D209/16 , C07D209/18 , C07D213/38 , C07D233/64 , C07D319/18 , C07K14/705 , G01N33/5008 , G01N33/502 , G01N33/5091 , G01N33/566 , G01N33/567 , G01N33/6872 , G01N33/6893 , G01N33/84 , A01K2227/50 , C07C2101/14 , G01N2500/10 , G01N2800/04
摘要： The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can mimic or block an effect of an extracellular ion on a cell having an inorganic ion receptor, more preferably the extracellular ion is Ca.sup.2+ and the effect is on a cell having a calcium receptor; (2) inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (3) nucleic acids encoding inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (4) antibodies and fragments thereof, targeted to inorganic ion receptor proteins, preferably calcium receptor protein; and (5) uses of such molecules, proteins, nucleic acids and antibodies.
摘要翻译： 本发明涉及无机离子受体在细胞和身体过程中的不同作用。 本发明的特征在于：（1）可以调节一种或多种无机离子受体活性的分子，优选地该分子可以模拟或阻断细胞外离子对具有无机离子受体的细胞的影响，更优选细胞外离子是Ca 2+和 该效果在具有钙受体的细胞上; （2）无机离子受体蛋白及其片段，优选钙受体蛋白及其片段; （3）编码无机离子受体蛋白质及其片段的核酸，优选钙受体蛋白及其片段; （4）抗体及其片段，靶向无机离子受体蛋白，优选钙受体蛋白; 和（5）使用这些分子，蛋白质，核酸和抗体。
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公开(公告)号：US06313146B1
公开(公告)日：2001-11-06
申请号：US08484159
申请日：1995-06-07
IPC分类号： A01N4340
CPC分类号： A61K31/13 , A01K2227/50 , A61K31/135 , A61K31/137 , A61K31/165 , A61K31/195 , A61K31/215 , A61K31/275 , A61K31/335 , A61K31/34 , A61K31/35 , A61K31/36 , A61K31/38 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/55 , A61K31/70 , A61K31/715 , A61K38/16 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/42 , C07C215/52 , C07C217/58 , C07C217/60 , C07C217/62 , C07C225/16 , C07C229/38 , C07C233/05 , C07C255/58 , C07C317/32 , C07C323/32 , C07C2601/14 , C07D209/14 , C07D209/16 , C07D209/18 , C07D213/38 , C07D233/64 , C07D319/18 , C07K14/705 , G01N33/5008 , G01N33/502 , G01N33/5044 , G01N33/5091 , G01N33/566 , G01N33/567 , G01N33/6872 , G01N33/6893 , G01N33/84 , G01N2500/10 , G01N2800/04
摘要： The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can mimic or block an effect of an extracellular ion on a cell having an inorganic ion receptor, more preferably the extracellular ion is Ca2+ and the effect is on a cell having a calcium receptor; (2) inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (3) nucleic acids encoding inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (4) antibodies and fragments thereof, targeted to inorganic ion receptor proteins, preferably calcium receptor protein; and (5) uses of such molecules, proteins, nucleic acids and antibodies.
摘要翻译： 本发明涉及无机离子受体在细胞和身体过程中的不同作用。 本发明的特征在于：（1）可以调节一种或多种无机离子受体活性的分子，优选地该分子可以模拟或阻断细胞外离子对具有无机离子受体的细胞的影响，更优选细胞外离子是Ca 2+和 该效果在具有钙受体的细胞上; （2）无机离子受体蛋白及其片段，优选钙受体蛋白及其片段; （3）编码无机离子受体蛋白质及其片段的核酸，优选钙受体蛋白及其片段; （4）抗体及其片段，靶向无机离子受体蛋白，优选钙受体蛋白; 和（5）使用这些分子，蛋白质，核酸和抗体。
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公开(公告)号：US6031003A
公开(公告)日：2000-02-29
申请号：US484719
申请日：1995-06-07
申请人： Edward F. Nemeth , Bradford C. Van Wagenen , Manuel F. Balandrin , Eric G. DelMar , Scott T. Moe
发明人： Edward F. Nemeth , Bradford C. Van Wagenen , Manuel F. Balandrin , Eric G. DelMar , Scott T. Moe
IPC分类号： A61K31/13 , A61K31/135 , A61K31/137 , A61K31/165 , A61K31/195 , A61K31/215 , A61K31/275 , A61K31/335 , A61K31/34 , A61K31/35 , A61K31/36 , A61K31/38 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/55 , A61K31/715 , A61K38/16 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/42 , C07C215/52 , C07C217/58 , C07C217/60 , C07C217/62 , C07C225/16 , C07C229/38 , C07C233/05 , C07C255/58 , C07C317/32 , C07C323/32 , C07D209/14 , C07D209/16 , C07D209/18 , C07D213/38 , C07D233/54 , C07D319/18 , C07K14/705 , G01N33/50 , G01N33/566 , G01N33/567 , G01N33/68 , G01N33/84 , A01N33/02 , A01N37/18
CPC分类号： A61K31/13 , A61K31/135 , A61K31/137 , A61K31/165 , A61K31/195 , A61K31/215 , A61K31/275 , A61K31/335 , A61K31/34 , A61K31/35 , A61K31/36 , A61K31/38 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/55 , A61K31/70 , A61K31/715 , A61K38/16 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/42 , C07C215/52 , C07C217/58 , C07C217/60 , C07C217/62 , C07C225/16 , C07C229/38 , C07C233/05 , C07C255/58 , C07C317/32 , C07C323/32 , C07D209/14 , C07D209/16 , C07D209/18 , C07D213/38 , C07D233/64 , C07D319/18 , C07K14/705 , G01N33/5008 , G01N33/5014 , G01N33/502 , G01N33/5041 , G01N33/5044 , G01N33/5091 , G01N33/566 , G01N33/567 , G01N33/6872 , G01N33/6893 , G01N33/84 , A01K2227/50 , C07C2101/14 , G01N2500/10 , G01N2800/04
摘要： The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can mimic or block an effect of an extracellular ion on a cell having an inorganic ion receptor, more preferably the extracellular ion is Ca.sup.2+ and the effect is on a cell having a calcium receptor; (2) inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (3) nucleic acids encoding inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (4) antibodies and fragments thereof, targeted to inorganic ion receptor proteins, preferably calcium receptor protein; and (5) uses of such molecules, proteins, nucleic acids and antibodies.
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公开(公告)号：US20070249702A1
公开(公告)日：2007-10-25
申请号：US11668966
申请日：2007-01-30
申请人： Eric G. Del Mar , Robert M. Barmore , Derek Sheehan , Bradford C. Van Wagenen , James F. Callahan , Richard M. Keenan , Nikesh R. Kotecha , Maria Amparo Lago , Linda Sue Southall , Mervyn Thompson
发明人： Eric G. Del Mar , Robert M. Barmore , Derek Sheehan , Bradford C. Van Wagenen , James F. Callahan , Richard M. Keenan , Nikesh R. Kotecha , Maria Amparo Lago , Linda Sue Southall , Mervyn Thompson
IPC分类号： A61K31/135 , A61K31/18 , A61K31/357 , A61K31/404 , A61P43/00 , C07C211/03 , C07C307/02 , C07D209/04 , C07D317/46
CPC分类号： C07D209/43 , C07B2200/07 , C07C217/60 , C07C255/46 , C07C311/29 , C07C323/25 , C07C2601/14 , C07C2603/74 , C07D317/54 , C07D317/64
摘要： The present invention features calcilytic compounds. “Calcilytic compounds” refer to compounds able to inhibit calcium receptor activity. Also described are the use of calcilytic compounds to inhibit calcium receptor activity and/or achieve a beneficial effect in a patient; and techniques which can be used to obtain additional calcilytic compounds.
摘要翻译： 本发明具有钙化合物。 “钙化合物”是指能够抑制钙受体活性的化合物。 还描述了使用钙化合物抑制钙受体活性和/或在患者中获得有益效果; 以及可用于获得另外的钙化合物的技术。
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公开(公告)号：US07202261B2
公开(公告)日：2007-04-10
申请号：US10896614
申请日：2004-07-21
申请人： Eric G. Del Mar , Robert M. Barmore , Derek Sheehan , Bradford C. Van Wagenen , James F. Callahan , Richard M. Keenan , Nikesh R. Kotecha , Maria Amparo Lago , Linda Sue Southall , Mervyn Thompson
发明人： Eric G. Del Mar , Robert M. Barmore , Derek Sheehan , Bradford C. Van Wagenen , James F. Callahan , Richard M. Keenan , Nikesh R. Kotecha , Maria Amparo Lago , Linda Sue Southall , Mervyn Thompson
IPC分类号： A01N43/40
CPC分类号： A61K31/137 , A61K31/18 , A61K31/277
摘要： The present invention features calcilytic compounds. “Calcilytic compounds” refer to compounds able to inhibit calcium receptor activity. Also described are the use of calcilytic compounds to inhibit calcium receptor activity and/or achieve a beneficial effect in a patient; and techniques which can be used to obtain additional calcilytic compounds.
摘要翻译： 本发明具有钙化合物。 “钙化合物”是指能够抑制钙受体活性的化合物。 还描述了使用钙化合物抑制钙受体活性和/或在患者中获得有益效果; 以及可用于获得另外的钙化合物的技术。
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公开(公告)号：US06818660B2
公开(公告)日：2004-11-16
申请号：US10033001
申请日：2001-10-19
申请人： Eric G. Del Mar , Robert M. Barmore , Derek Sheehan , Bradford C. Van Wagenen , James F. Callahan , Richard M. Keenan , Nikesh R. Kotecha , Maria Amparo Lago , Linda Sue Southall , Mervyn Thompson
发明人： Eric G. Del Mar , Robert M. Barmore , Derek Sheehan , Bradford C. Van Wagenen , James F. Callahan , Richard M. Keenan , Nikesh R. Kotecha , Maria Amparo Lago , Linda Sue Southall , Mervyn Thompson
IPC分类号： A61K31135
CPC分类号： C07C323/25 , A61K31/137 , A61K31/18 , A61K31/277 , C07C217/30 , C07C217/60 , C07C217/62 , C07C255/46 , C07C255/54 , C07C2601/14 , C07C2603/74 , C07D213/65 , C07D317/58 , C07D333/70
摘要： The present invention features calcilytic compounds. “Calcilytic compounds” refer to compounds able to inhibit calcium receptor activity. Also described are the use of calcilytic compounds to inhibit calcium receptor activity and/or achieve a beneficial effect in a patient; and techniques which can be used to obtain additional calcilytic compounds.
摘要翻译： 本发明具有钙化合物。 “钙化合物”是指能够抑制钙受体活性的化合物。 还描述了使用钙化合物抑制钙受体活性和/或在患者中获得有益效果; 以及可用于获得另外的钙化合物的技术。
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公开(公告)号：US06521667B1
公开(公告)日：2003-02-18
申请号：US09132179
申请日：1998-08-11
申请人： Eric G. Del Mar , Robert M. Barmore , Derek Sheehan , Bradford C. Van Wagenen , James F. Callahan , Richard M. Keenan , Nikesh R. Kotecha , Maria Amparo Lago , Linda Sue Southall , Mervyn Thompson
发明人： Eric G. Del Mar , Robert M. Barmore , Derek Sheehan , Bradford C. Van Wagenen , James F. Callahan , Richard M. Keenan , Nikesh R. Kotecha , Maria Amparo Lago , Linda Sue Southall , Mervyn Thompson
IPC分类号： A01N3302
CPC分类号： C07C311/29 , A61K31/137 , A61K31/18 , A61K31/277 , C07C217/30 , C07C217/60 , C07C217/62 , C07C255/46 , C07C255/54 , C07C323/25 , C07C2601/14 , C07C2603/74 , C07D213/65 , C07D317/58 , C07D333/70
摘要： The present invention features calcilytic compounds. “Calcilytic compounds” refer to compounds able to inhibit calcium receptor activity. Also described are the use of calcilytic compounds to inhibit calcium receptor activity and/or achieve a beneficial effect in a patient; and techniques which can be used to obtain additional calcilytic compounds.
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