-
公开(公告)号：US5858684A
公开(公告)日：1999-01-12
申请号：US480751
申请日：1995-06-07
申请人： Edward F. Nemeth , Edward M. Brown , Steven C. Hebert , James E. Garrett, Jr. , Bradford C. Van Wagenen , Manuel F. Balandrin , Eric G. Del Mar
发明人： Edward F. Nemeth , Edward M. Brown , Steven C. Hebert , James E. Garrett, Jr. , Bradford C. Van Wagenen , Manuel F. Balandrin , Eric G. Del Mar
IPC分类号： A61K31/135 , A61K20060101 , A61K31/13 , A61K31/137 , A61K31/165 , A61K31/195 , A61K31/215 , A61K31/275 , A61K31/335 , A61K31/34 , A61K31/35 , A61K31/36 , A61K31/38 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/55 , A61K31/715 , A61K38/16 , A61P3/00 , A61P3/14 , A61P9/12 , A61P19/10 , A61P43/00 , C07C20060101 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/42 , C07C215/50 , C07C215/52 , C07C217/58 , C07C217/60 , C07C217/62 , C07C219/28 , C07C225/16 , C07C229/38 , C07C233/05 , C07C237/30 , C07C255/58 , C07C317/32 , C07C323/32 , C07D209/14 , C07D209/16 , C07D209/18 , C07D213/38 , C07D233/54 , C07D317/58 , C07D319/18 , C07K14/705 , C12N15/12 , G01N33/50 , G01N33/566 , G01N33/567 , G01N33/68 , G01N33/84 , C12Q1/68
CPC分类号： A61K31/13 , A61K31/135 , A61K31/137 , A61K31/165 , A61K31/195 , A61K31/215 , A61K31/275 , A61K31/335 , A61K31/34 , A61K31/35 , A61K31/36 , A61K31/38 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/55 , A61K31/70 , A61K31/715 , A61K38/16 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/42 , C07C215/52 , C07C217/58 , C07C217/60 , C07C217/62 , C07C225/16 , C07C229/38 , C07C233/05 , C07C255/58 , C07C317/32 , C07C323/32 , C07D209/14 , C07D209/16 , C07D209/18 , C07D213/38 , C07D233/64 , C07D319/18 , C07K14/705 , G01N33/5008 , G01N33/502 , G01N33/5044 , G01N33/5091 , G01N33/566 , G01N33/567 , G01N33/6872 , G01N33/6893 , G01N33/84 , A01K2227/50 , C07C2101/14 , G01N2500/10 , G01N2800/04
摘要： The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can mimic or block an effect of an extracellular ion on a cell having an inorganic ion receptor, more preferably the extracellular ion is Ca.sup.2+ and the effect is on a cell having a calcium receptor; (2) inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (3) nucleic acids encoding inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (4) antibodies and fragments thereof, targeted to inorganic ion receptor proteins, preferably calcium receptor protein; and (5) uses of such molecules, proteins, nucleic acids and antibodies.
摘要翻译： 本发明涉及无机离子受体在细胞和身体过程中的不同作用。 本发明的特征在于：（1）可以调节一种或多种无机离子受体活性的分子，优选地该分子可以模拟或阻断细胞外离子对具有无机离子受体的细胞的影响，更优选细胞外离子是Ca 2+和 该效果在具有钙受体的细胞上; （2）无机离子受体蛋白及其片段，优选钙受体蛋白及其片段; （3）编码无机离子受体蛋白质及其片段的核酸，优选钙受体蛋白及其片段; （4）抗体及其片段，靶向无机离子受体蛋白，优选钙受体蛋白; 和（5）使用这些分子，蛋白质，核酸和抗体。
-
公开(公告)号：US6001884A
公开(公告)日：1999-12-14
申请号：US469204
申请日：1995-06-06
申请人： Edward F. Nemeth , Bradford C. Van Wagenen , Manuel F. Balandrin , Eric G. Delmar , Scott T. Moe
发明人： Edward F. Nemeth , Bradford C. Van Wagenen , Manuel F. Balandrin , Eric G. Delmar , Scott T. Moe
IPC分类号： A61K31/13 , A61K31/135 , A61K31/137 , A61K31/165 , A61K31/195 , A61K31/215 , A61K31/275 , A61K31/335 , A61K31/34 , A61K31/35 , A61K31/36 , A61K31/38 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/55 , A61K31/715 , A61K38/16 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/42 , C07C215/52 , C07C217/58 , C07C217/60 , C07C217/62 , C07C225/16 , C07C229/38 , C07C233/05 , C07C255/58 , C07C317/32 , C07C323/32 , C07D209/14 , C07D209/16 , C07D209/18 , C07D213/38 , C07D233/54 , C07D319/18 , C07K14/705 , G01N33/50 , G01N33/566 , G01N33/567 , G01N33/68 , G01N33/84 , A01N35/00
CPC分类号： G01N33/5044 , A61K31/13 , A61K31/135 , A61K31/137 , A61K31/165 , A61K31/195 , A61K31/215 , A61K31/275 , A61K31/335 , A61K31/34 , A61K31/35 , A61K31/36 , A61K31/38 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/55 , A61K31/70 , A61K31/715 , A61K38/16 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/42 , C07C215/52 , C07C217/58 , C07C217/60 , C07C217/62 , C07C225/16 , C07C229/38 , C07C233/05 , C07C255/58 , C07C317/32 , C07C323/32 , C07D209/14 , C07D209/16 , C07D209/18 , C07D213/38 , C07D233/64 , C07D319/18 , C07K14/705 , G01N33/5008 , G01N33/5014 , G01N33/5041 , G01N33/5091 , G01N33/566 , G01N33/567 , G01N33/6872 , G01N33/6893 , G01N33/84 , A01K2227/50 , C07C2101/14 , G01N2500/10 , G01N2800/04
摘要： The present invention features molecules which can modulate one or activities of an inorganic ion receptor. Preferably, the molecule can mimic or block the effect of extracellular Ca.sup.2+ on a calcium receptor. The preferred use of such molecules is to treat diseases or disorders by altering inorganic ion receptor activity, preferably calcium receptor activity.
摘要翻译： 本发明的特征在于可以调节一种或多种无机离子受体活性的分子。 优选地，分子可以模拟或阻断细胞外Ca 2+对钙受体的作用。 这种分子的优选用途是通过改变无机离子受体活性，优选钙受体活性来治疗疾病或病症。
-
公开(公告)号：US06211244B1
公开(公告)日：2001-04-03
申请号：US08546998
申请日：1995-10-23
申请人： Bradford C. Van Wagenen , Scott T. Moe , Manuel F. Balandrin , Eric G. DelMar , Edward F. Nemeth
发明人： Bradford C. Van Wagenen , Scott T. Moe , Manuel F. Balandrin , Eric G. DelMar , Edward F. Nemeth
IPC分类号： A61K31135
CPC分类号： G01N33/6872 , A61K31/135 , A61K31/137 , C07C211/27 , C07C211/28 , C07C211/30 , C07C217/58 , C07C217/62 , C07C225/16 , C07C317/32 , C07C323/32 , C07D319/18 , G01N33/566 , G01N2500/10 , G01N2800/04
摘要： The present invention features compounds able to modulate one or more activities of an inorganic ion receptor and methods for treating diseases or disorders by modulating inorganic ion receptor activity. Preferably, the compound can mimic or block the effect of extracellular Ca2+ on a calcium receptor.
摘要翻译： 本发明具有能够调节一种或多种无机离子受体活性的化合物和通过调节无机离子受体活性来治疗疾病或病症的方法。 优选地，化合物可以模拟或阻断细胞外Ca 2+对钙受体的作用。
-
公开(公告)号：US6011068A
公开(公告)日：2000-01-04
申请号：US353784
申请日：1994-12-08
申请人： Edward F. Nemeth , Bradford C. Van Wagenen , Manuel F. Balandrin , Eric G. DelMar , Scott T. Moe
发明人： Edward F. Nemeth , Bradford C. Van Wagenen , Manuel F. Balandrin , Eric G. DelMar , Scott T. Moe
IPC分类号： A61K31/135 , A61K20060101 , A61K31/13 , A61K31/137 , A61K31/165 , A61K31/195 , A61K31/215 , A61K31/275 , A61K31/335 , A61K31/34 , A61K31/35 , A61K31/36 , A61K31/38 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/55 , A61K31/715 , A61K38/16 , A61P3/00 , A61P3/14 , A61P9/12 , A61P19/10 , A61P43/00 , C07C20060101 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/42 , C07C215/50 , C07C215/52 , C07C217/58 , C07C217/60 , C07C217/62 , C07C219/28 , C07C225/16 , C07C229/38 , C07C233/05 , C07C237/30 , C07C255/58 , C07C317/32 , C07C323/32 , C07D209/14 , C07D209/16 , C07D209/18 , C07D213/38 , C07D233/54 , C07D317/58 , C07D319/18 , C07K14/705 , C12N15/12 , G01N33/50 , G01N33/566 , G01N33/567 , G01N33/68 , G01N33/84 , C07C211/00 , C07C213/00
CPC分类号： G01N33/5044 , A61K31/13 , A61K31/135 , A61K31/137 , A61K31/165 , A61K31/195 , A61K31/215 , A61K31/275 , A61K31/335 , A61K31/34 , A61K31/35 , A61K31/36 , A61K31/38 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/55 , A61K31/70 , A61K31/715 , A61K38/16 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/42 , C07C215/52 , C07C217/58 , C07C217/60 , C07C217/62 , C07C225/16 , C07C229/38 , C07C233/05 , C07C255/58 , C07C317/32 , C07C323/32 , C07D209/14 , C07D209/16 , C07D209/18 , C07D213/38 , C07D233/64 , C07D319/18 , C07K14/705 , G01N33/5008 , G01N33/502 , G01N33/5091 , G01N33/566 , G01N33/567 , G01N33/6872 , G01N33/6893 , G01N33/84 , A01K2227/50 , C07C2101/14 , G01N2500/10 , G01N2800/04
摘要： The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can mimic or block an effect of an extracellular ion on a cell having an inorganic ion receptor, more preferably the extracellular ion is Ca.sup.2+ and the effect is on a cell having a calcium receptor; (2) inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (3) nucleic acids encoding inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (4) antibodies and fragments thereof, targeted to inorganic ion receptor proteins, preferably calcium receptor protein; and (5) uses of such molecules, proteins, nucleic acids and antibodies.
摘要翻译： 本发明涉及无机离子受体在细胞和身体过程中的不同作用。 本发明的特征在于：（1）可以调节一种或多种无机离子受体活性的分子，优选地该分子可以模拟或阻断细胞外离子对具有无机离子受体的细胞的影响，更优选细胞外离子是Ca 2+和 该效果在具有钙受体的细胞上; （2）无机离子受体蛋白及其片段，优选钙受体蛋白及其片段; （3）编码无机离子受体蛋白质及其片段的核酸，优选钙受体蛋白及其片段; （4）抗体及其片段，靶向无机离子受体蛋白，优选钙受体蛋白; 和（5）使用这些分子，蛋白质，核酸和抗体。
-
公开(公告)号：US06313146B1
公开(公告)日：2001-11-06
申请号：US08484159
申请日：1995-06-07
IPC分类号： A01N4340
CPC分类号： A61K31/13 , A01K2227/50 , A61K31/135 , A61K31/137 , A61K31/165 , A61K31/195 , A61K31/215 , A61K31/275 , A61K31/335 , A61K31/34 , A61K31/35 , A61K31/36 , A61K31/38 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/55 , A61K31/70 , A61K31/715 , A61K38/16 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/42 , C07C215/52 , C07C217/58 , C07C217/60 , C07C217/62 , C07C225/16 , C07C229/38 , C07C233/05 , C07C255/58 , C07C317/32 , C07C323/32 , C07C2601/14 , C07D209/14 , C07D209/16 , C07D209/18 , C07D213/38 , C07D233/64 , C07D319/18 , C07K14/705 , G01N33/5008 , G01N33/502 , G01N33/5044 , G01N33/5091 , G01N33/566 , G01N33/567 , G01N33/6872 , G01N33/6893 , G01N33/84 , G01N2500/10 , G01N2800/04
摘要： The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can mimic or block an effect of an extracellular ion on a cell having an inorganic ion receptor, more preferably the extracellular ion is Ca2+ and the effect is on a cell having a calcium receptor; (2) inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (3) nucleic acids encoding inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (4) antibodies and fragments thereof, targeted to inorganic ion receptor proteins, preferably calcium receptor protein; and (5) uses of such molecules, proteins, nucleic acids and antibodies.
摘要翻译： 本发明涉及无机离子受体在细胞和身体过程中的不同作用。 本发明的特征在于：（1）可以调节一种或多种无机离子受体活性的分子，优选地该分子可以模拟或阻断细胞外离子对具有无机离子受体的细胞的影响，更优选细胞外离子是Ca 2+和 该效果在具有钙受体的细胞上; （2）无机离子受体蛋白及其片段，优选钙受体蛋白及其片段; （3）编码无机离子受体蛋白质及其片段的核酸，优选钙受体蛋白及其片段; （4）抗体及其片段，靶向无机离子受体蛋白，优选钙受体蛋白; 和（5）使用这些分子，蛋白质，核酸和抗体。
-
公开(公告)号：US6031003A
公开(公告)日：2000-02-29
申请号：US484719
申请日：1995-06-07
申请人： Edward F. Nemeth , Bradford C. Van Wagenen , Manuel F. Balandrin , Eric G. DelMar , Scott T. Moe
发明人： Edward F. Nemeth , Bradford C. Van Wagenen , Manuel F. Balandrin , Eric G. DelMar , Scott T. Moe
IPC分类号： A61K31/13 , A61K31/135 , A61K31/137 , A61K31/165 , A61K31/195 , A61K31/215 , A61K31/275 , A61K31/335 , A61K31/34 , A61K31/35 , A61K31/36 , A61K31/38 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/55 , A61K31/715 , A61K38/16 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/42 , C07C215/52 , C07C217/58 , C07C217/60 , C07C217/62 , C07C225/16 , C07C229/38 , C07C233/05 , C07C255/58 , C07C317/32 , C07C323/32 , C07D209/14 , C07D209/16 , C07D209/18 , C07D213/38 , C07D233/54 , C07D319/18 , C07K14/705 , G01N33/50 , G01N33/566 , G01N33/567 , G01N33/68 , G01N33/84 , A01N33/02 , A01N37/18
CPC分类号： A61K31/13 , A61K31/135 , A61K31/137 , A61K31/165 , A61K31/195 , A61K31/215 , A61K31/275 , A61K31/335 , A61K31/34 , A61K31/35 , A61K31/36 , A61K31/38 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/55 , A61K31/70 , A61K31/715 , A61K38/16 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/42 , C07C215/52 , C07C217/58 , C07C217/60 , C07C217/62 , C07C225/16 , C07C229/38 , C07C233/05 , C07C255/58 , C07C317/32 , C07C323/32 , C07D209/14 , C07D209/16 , C07D209/18 , C07D213/38 , C07D233/64 , C07D319/18 , C07K14/705 , G01N33/5008 , G01N33/5014 , G01N33/502 , G01N33/5041 , G01N33/5044 , G01N33/5091 , G01N33/566 , G01N33/567 , G01N33/6872 , G01N33/6893 , G01N33/84 , A01K2227/50 , C07C2101/14 , G01N2500/10 , G01N2800/04
摘要： The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can mimic or block an effect of an extracellular ion on a cell having an inorganic ion receptor, more preferably the extracellular ion is Ca.sup.2+ and the effect is on a cell having a calcium receptor; (2) inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (3) nucleic acids encoding inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (4) antibodies and fragments thereof, targeted to inorganic ion receptor proteins, preferably calcium receptor protein; and (5) uses of such molecules, proteins, nucleic acids and antibodies.
-
公开(公告)号：US06710088B2
公开(公告)日：2004-03-23
申请号：US10060959
申请日：2002-01-29
申请人： Scott T. Moe , Bradford C. Van Wagenen , Eric G. DelMar , Richard Trovato , Manuel F. Balandrin
发明人： Scott T. Moe , Bradford C. Van Wagenen , Eric G. DelMar , Richard Trovato , Manuel F. Balandrin
IPC分类号： A61K31135
CPC分类号： C07C255/58 , A61K31/137 , A61K31/36 , C07C211/29 , C07C211/30 , C07C217/58 , C07C217/62 , C07C255/54 , C07C2601/02 , C07D307/81 , C07D317/58
摘要： The present invention features compounds able to modulate one or more activities of an inorganic ion receptor and methods for treating diseases or disorders using such compounds. Preferred compounds can mimic or block the effect of extracellular calcium on a cell surface calcium receptor.
摘要翻译： 本发明的特征在于能够调节一种或多种无机离子受体活性的化合物和使用这些化合物治疗疾病或病症的方法。 优选的化合物可以模拟或阻断细胞外钙对细胞表面钙受体的作用。
-
公开(公告)号：US5506268A
公开(公告)日：1996-04-09
申请号：US075126
申请日：1993-06-11
CPC分类号： A61K31/16 , Y10S514/923
摘要： Isovaleramide has been found to exhibit mild anxiolytic activity at low to moderate dosage levels and mildly sedative at somewhat higher dosage levels. In contrast to certain other materials thought to be anxiolytic or mildly sedative, isovaleramide is non-cytotoxic and does not paradoxically stimulate the central nervous system. Isovaleramide is therefore useful as a mild anxiolytic and mild sedative which can be made available to the general public.
摘要翻译： 已经发现异戊酰胺在低至中等剂量水平下表现出轻度的抗焦虑活性，并且在稍高的剂量水平下轻度镇静。 与被认为是抗焦虑或轻度镇静的某些其他物质相反，异戊酰胺是非细胞毒性的，并不矛盾地刺激中枢神经系统。 因此，异戊酰胺可作为轻度抗焦虑和轻度镇静剂而使用，可向公众提供。
-
公开(公告)号：US5981599A
公开(公告)日：1999-11-09
申请号：US846721
申请日：1997-04-30
申请人： Scott T. Moe , Bradford C. Van Wagenen , Eric G. DelMar , Richard Trovato , Manuel F. Balandrin
发明人： Scott T. Moe , Bradford C. Van Wagenen , Eric G. DelMar , Richard Trovato , Manuel F. Balandrin
IPC分类号： C07C211/58 , A61K31/00 , A61K31/135 , A61K31/137 , A61K31/138 , A61K31/36 , A61P3/00 , A61P3/14 , A61P5/00 , A61P5/16 , A61P9/00 , A61P9/12 , A61P19/00 , A61P19/10 , C07C211/29 , C07C211/30 , C07C217/58 , C07C217/62 , C07C217/92 , C07C255/54 , C07C255/58 , C07D307/81 , C07D317/58
CPC分类号： C07C255/58 , A61K31/137 , A61K31/36 , C07C211/29 , C07C211/30 , C07C217/58 , C07C217/62 , C07C255/54 , C07D307/81 , C07D317/58 , C07C2101/02
摘要： The present invention features compounds able to modulate one or more activities of an inorganic ion receptor and methods for treating diseases or disorders using such compounds. Preferred compounds can mimic or block the effect of extracellular calcium on a cell surface calcium receptor.
-
公开(公告)号：US06342532B1
公开(公告)日：2002-01-29
申请号：US09415179
申请日：1999-10-06
申请人： Scott T. Moe , Bradford C. Van Wagenen , Eric G. DelMar , Richard Trovato , Manuel F. Balandrin
发明人： Scott T. Moe , Bradford C. Van Wagenen , Eric G. DelMar , Richard Trovato , Manuel F. Balandrin
IPC分类号： A61K31137
CPC分类号： C07C255/58 , A61K31/137 , A61K31/36 , C07C211/29 , C07C211/30 , C07C217/58 , C07C217/62 , C07C255/54 , C07C2601/02 , C07D307/81 , C07D317/58
摘要： The present invention features compounds able to modulate one or more activities of an inorganic ion receptor and methods for treating diseases or disorders using such compounds. Preferred compounds can mimic or block the effect of extracellular calcium on a cell surface calcium receptor.
摘要翻译： 本发明的特征在于能够调节一种或多种无机离子受体活性的化合物和使用这些化合物治疗疾病或病症的方法。 优选的化合物可以模拟或阻断细胞外钙对细胞表面钙受体的作用。
-
-
-
-
-
-
-
-
-
搜索结果
19 条记录 (耗时 0.052 秒)
