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    Implantable or insertable medical devices containing graft copolymer for controlled delivery of therapeutic agents
    5.
    发明授权
    Implantable or insertable medical devices containing graft copolymer for controlled delivery of therapeutic agents 有权
    含有接受共聚物的植入式或可插入医疗器械用于治疗剂的控制递送

    公开(公告)号：US07357940B2

    公开(公告)日：2008-04-15

    申请号：US10632413

    申请日：2003-07-31

    申请人： Robert E. Richard ,  Frederick H. Strickler

    发明人： Robert E. Richard ,  Frederick H. Strickler

    IPC分类号： A61F13/00

    CPC分类号： A61L31/16 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/602 ,  C08L51/00

    摘要： Implantable or insertable medical devices are described. The medical devices comprise (a) a therapeutic agent and (b) a polymeric release region that controls the release of the therapeutic agent upon administration to a patient. The polymer release region comprises a graft copolymer, which further comprises a main chain and a plurality of side chains. One of (a) the main chain and (b) the side chains corresponds to a rubbery phase within the release region at ambient temperatures, while the other corresponds to a hard phase within the release layer at ambient temperatures. Typically, the graft copolymer will comprise one glass transition temperature below ambient temperature and another second glass transition temperature above ambient temperature. Also described are methods for forming the above graft copolymers, methods for administering a therapeutic agent to a patient using the above implantable or insertable medical devices, as well as methods for making the above devices.

    摘要翻译： 描述了可植入或可插入的医疗装置。 医疗装置包括（a）治疗剂和（b）控制治疗剂在给予患者时释放的聚合物释放区域。 聚合物释放区域包括接枝共聚物，其还包含主链和多个侧链。 （a）主链和（b）侧链对应于环境温度下释放区内的橡胶相，而另一个对应于在环境温度下释放层内的硬相。 通常，接枝共聚物将包括低于环境温度的一个玻璃化转变温度和高于环境温度的另一个第二玻璃化转变温度。 还描述了形成上述接枝共聚物的方法，使用上述可植入或可插入的医疗装置向患者施用治疗剂的方法，以及制备上述装置的方法。

    Medical devices having porous polymeric regions for controlled drug delivery and regulated biocompatibility
    6.
    发明授权
    Medical devices having porous polymeric regions for controlled drug delivery and regulated biocompatibility 有权
    具有用于受控药物递送和调节的生物相容性的多孔聚合物区域的医疗装置

    公开(公告)号：US08535702B2

    公开(公告)日：2013-09-17

    申请号：US11048616

    申请日：2005-02-01

    申请人： Robert E. Richard ,  Frederick H. Strickler ,  Marlene C. Schwarz ,  Rudolf Faust ,  Shrirang V. Ranade ,  Michael N. Helmus

    发明人： Robert E. Richard ,  Frederick H. Strickler ,  Marlene C. Schwarz ,  Rudolf Faust ,  Shrirang V. Ranade ,  Michael N. Helmus

    IPC分类号： A61F2/00

    CPC分类号： A61L31/129 ,  A61L27/48 ,  A61N1/05

    摘要： The present invention relates to phase separated polymeric regions and to their use in conjunction with implantable or insertable medical devices. In some aspects of the invention, phase separated polymeric regions are provided that include (a) at least one biostable polymeric phase and (b) at least one biodisintegrable polymeric phase, which is of nanoscale dimensions and which undergoes biodisintegration such that the phase separated polymeric region becomes a nanoporous polymeric region in vivo. Other aspects of the invention are directed to methods of making implantable or insertable medical devices having at least one nanoporous polymeric region. These methods include (a) providing a phase separated polymeric region comprising a stable polymeric phase and a disintegrable polymeric phase of nanoscale dimensions, (b) selectively removing the disintegrable polymeric phase thereby producing the nanoporous polymeric region. In still other aspects, implantable or insertable medical devices are provided which have phase separated polymeric regions that include (a) at least one block copolymer having at least one biostable polymer block and at least one biodisintegrable polymer block and (b) at least one therapeutic agent which is released in vivo upon implantation or insertion of the medical device.

    摘要翻译： 本发明涉及相分离的聚合物区域以及它们与可植入或可插入的医疗装置结合使用。 在本发明的一些方面，提供了相分离的聚合物区域，其包括（a）至少一个生物稳定的聚合物相和（b）至少一个具有纳米级尺寸并且经历生物整合的生物分解聚合物相，并且经历相分离的聚合物 区域在体内成为纳米孔聚合物区域。 本发明的其它方面涉及制造具有至少一个纳米多孔聚合物区域的可植入或可插入医疗器械的方法。 这些方法包括（a）提供包含稳定聚合物相和纳米尺度的可分解聚合物相的相分离聚合物区域，（b）选择性地除去可分解的聚合物相，从而制备纳米多孔聚合物区域。 在另外的方面，提供了可植入或可插入的医疗装置，其具有相分离的聚合物区域，其包括（a）至少一种具有至少一种生物稳定聚合物嵌段和至少一种生物可分解聚合物嵌段的嵌段共聚物和（b）至少一种治疗 在植入或插入医疗装置时在体内释放的药剂。

    Medical devices containing radiation resistant block copolymer
    7.
    发明授权
    Medical devices containing radiation resistant block copolymer 有权
    含抗辐射嵌段共聚物的医疗器械

    公开(公告)号：US07713539B2

    公开(公告)日：2010-05-11

    申请号：US10894400

    申请日：2004-07-19

    申请人： Frederick H. Strickler ,  Robert E. Richard

    发明人： Frederick H. Strickler ,  Robert E. Richard

    IPC分类号： A61L31/04 ,  A61L31/16 ,  A61L29/04 ,  A61L29/16

    CPC分类号： A61L29/041 ,  A61L29/16 ,  A61L31/048 ,  A61L31/16 ,  A61L2300/00

    摘要： The present invention relates generally to radiation-resistant medical devices which contain polymer regions for release of therapeutic agents. The present invention also relates to radiation-resistant block copolymer materials for use in connection with insertable or implantable medical devices. The radiation-sterilized medical device comprise (a) a release region and (b) at least one therapeutic agent and the release region comprises a radiation resistant copolymer that includes (i) a low Tg hydrocarbon polymer block and (ii) one or more high Tg polymer blocks.

    摘要翻译： 本发明一般涉及含有用于释放治疗剂的聚合物区域的耐辐射医疗装置。 本发明还涉及用于与可插入或可植入的医疗装置结合使用的耐辐射嵌段共聚物材料。 放射线灭菌的医疗装置包括（a）释放区和（b）至少一种治疗剂，并且释放区包含抗辐射共聚物，其包括（i）低Tg烃聚合物嵌段和（ii）一种或多种高 Tg聚合物嵌段。

    Medical devices having polymeric regions based on vinyl ether block copolymers
    8.
    发明授权
    Medical devices having polymeric regions based on vinyl ether block copolymers 失效
    具有基于乙烯基醚嵌段共聚物的聚合物区域的医疗装置

    公开(公告)号：US07727541B2

    公开(公告)日：2010-06-01

    申请号：US11436813

    申请日：2006-05-18

    申请人： Robert E. Richard ,  Marlene C. Schwarz ,  Mark Boden

    发明人： Robert E. Richard ,  Marlene C. Schwarz ,  Mark Boden

    IPC分类号： A61F2/86 ,  A61F2/82 ,  A61K47/32

    CPC分类号： A61L27/34 ,  A61L27/16 ,  A61L31/10 ,  C08L53/00 ,  C08L35/08

    摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain one or more polymeric regions, which in turn contain at least one block copolymer. The block copolymer includes (a) at least one high Tg (glass transition temperature) polymer block that contains at least one high Tg vinyl ether monomer and (b) at least one low Tg polymer block that contains at least one low Tg vinyl ether monomer.

    摘要翻译： 根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含一个或多个聚合物区域，其又包含至少一个嵌段共聚物。 嵌段共聚物包括（a）含有至少一种高Tg乙烯基醚单体的至少一种高Tg（玻璃化转变温度）聚合物嵌段和（b）含有至少一种低Tg乙烯基醚单体的至少一种低Tg聚合物嵌段 。

    Medical devices having polymeric regions based on vinyl ether block copolymers
    9.
    发明申请
    Medical devices having polymeric regions based on vinyl ether block copolymers 失效
    具有基于乙烯基醚嵌段共聚物的聚合物区域的医疗装置

    公开(公告)号：US20070269485A1

    公开(公告)日：2007-11-22

    申请号：US11436813

    申请日：2006-05-18

    申请人： Robert E. Richard ,  Marlene C. Schwarz ,  Mark Boden

    发明人： Robert E. Richard ,  Marlene C. Schwarz ,  Mark Boden

    IPC分类号： A61F2/02

    CPC分类号： A61L27/34 ,  A61L27/16 ,  A61L31/10 ,  C08L53/00 ,  C08L35/08

    摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain one or more polymeric regions, which in turn contain at least one block copolymer. The block copolymer includes (a) at least one high Tg (glass transition temperature) polymer block that contains at least one high Tg vinyl ether monomer and (b) at least one low Tg polymer block that contains at least one low Tg vinyl ether monomer.

    摘要翻译： 根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含一个或多个聚合物区域，其又包含至少一个嵌段共聚物。 嵌段共聚物包括（a）至少一种高Tg（玻璃化转变温度）聚合物嵌段，其含有至少一种高级乙烯基醚单体和（b）在 含有至少一个低级乙烯基醚单体的至少一个低聚合物嵌段。