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    MEDICAL DEVICES HAVING A COATING FOR PROMOTING ENDOTHELIAL CELL ADHESION
    3.
    发明申请
    MEDICAL DEVICES HAVING A COATING FOR PROMOTING ENDOTHELIAL CELL ADHESION 审中-公开
    具有促进内皮细胞粘附的涂层的医疗装置

    公开(公告)号：US20080057097A1

    公开(公告)日：2008-03-06

    申请号：US11847921

    申请日：2007-08-30

    申请人： John Benco ,  Mark Boden ,  Shaina Brito ,  Wendy Naimark ,  Lan Pham

    发明人： John Benco ,  Mark Boden ,  Shaina Brito ,  Wendy Naimark ,  Lan Pham

    IPC分类号： A61F2/02 ,  A61K38/02 ,  A61K38/06 ,  A61K38/08 ,  A61P43/00 ,  B05D3/00

    CPC分类号： A61L31/148 ,  A61L27/227 ,  A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L27/58 ,  A61L31/047 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/608

    摘要： A medical device having a coating of cell adhesion polypeptides to enhance endothelial cell adhesion onto the medical device. The cell adhesion polypeptides may be any of the proteins of the extracellular matrix which are known to play a role in cell adhesion or derivative peptides such as RGD or YIGSR. The polypeptides may be incorporated into the backbone of a polymer such as polyurethane, or grafted onto a polymer such polybisphosphonate. The polypeptides may also be carried on antibodies or displayed on bacteriophages. The polypeptides may also be modified to have adhesive amino acid sequences. In certain embodiments, the medical device further comprises a temporary barrier that protects the polypeptides from biofouling. The temporary barrier may be formed of a biodegradable polymer and be constructed as a coating over the polypeptides or as a plurality of micelles encapsulating the polypeptides. In certain embodiments, the polypeptides may be coated onto the medical device in such a manner as to form a monolayer of the polypeptides.

    摘要翻译： 具有细胞粘附多肽包被以增强内皮细胞粘附到医疗装置上的医疗装置。 细胞粘附多肽可以是已知在细胞粘附或衍生肽如RGD或YIGSR中起作用的细胞外基质的任何蛋白质。 多肽可以并入聚合物如聚氨酯的主链中，或者接枝到诸如聚二膦酸盐的聚合物上。 多肽也可以携带在抗体上或显示在噬菌体上。 多肽也可以被修饰以具有粘性氨基酸序列。 在某些实施方案中，医疗装置还包括保护多肽免于生物污损的临时屏障。 临时屏障可以由可生物降解的聚合物形成，并且被构建为多肽上的涂层或者作为包封多肽的多个胶束。 在某些实施方案中，多肽可以以形成多肽单层的方式被包被到医疗装置上。

    Method for spray coating a medical device using a micronozzle
    6.
    发明申请
    Method for spray coating a medical device using a micronozzle 有权
    使用微喷嘴喷涂医疗器械的方法

    公开(公告)号：US20070231457A1

    公开(公告)日：2007-10-04

    申请号：US11390179

    申请日：2006-03-28

    申请人： Lan Pham ,  Gerald Fredrickson

    发明人： Lan Pham ,  Gerald Fredrickson

    IPC分类号： A61L33/00 ,  B05D1/02

    CPC分类号： B05B1/3421 ,  B05B7/0441 ,  B05B7/066 ,  B05D1/02

    摘要： The present invention provides for a method for spray application of a coating material onto a medical device by spraying coating material from a micronozzle fabricated from a plurality of sheets that are etched with holes or openings. The openings are aligned to form fluid channels and the sheets are fused together in a planar fashion to define a micronozzle. In another embodiment, the invention provides for a method for spray application of a coating material onto a medical device using micronozzles fabricated in batches by a simplified manufacturing process. In other embodiments, the invention provides for a method for spray application of a coating material onto a medical device by spraying coating material from a micronozzle that includes a swirl or gas-assist atomizer.

    摘要翻译： 本发明提供了一种通过从由孔或开口蚀刻的多个片材制成的微型喷嘴喷涂涂层材料来将涂层材料喷涂到医疗装置上的方法。 开口对准以形成流体通道，并且片材以平面方式熔合在一起以限定微喷嘴。 在另一个实施方案中，本发明提供了一种使用通过简化的制造过程分批制造的微喷嘴将涂料施用到医疗装置上的方法。 在其它实施例中，本发明提供了一种通过从包括旋流或气体辅助雾化器的微喷嘴喷涂涂层材料来将涂层材料喷涂到医疗装置上的方法。

    Methods for Coating Medical Devices
    7.
    发明申请
    Methods for Coating Medical Devices 审中-公开
    医疗器械涂层方法

    公开(公告)号：US20130156935A1

    公开(公告)日：2013-06-20

    申请号：US13325346

    申请日：2011-12-14

    申请人： Rachit Ohri ,  Phillip Blaskovich ,  Lan Pham ,  David Giusti ,  Valentino Tramontano

    发明人： Rachit Ohri ,  Phillip Blaskovich ,  Lan Pham ,  David Giusti ,  Valentino Tramontano

    IPC分类号： B05D7/00 ,  B05D1/12 ,  B05C19/04 ,  B05D3/02 ,  B05D1/06 ,  B82Y5/00

    CPC分类号： A61L31/10 ,  A61L15/22 ,  A61L17/145 ,  A61L27/34 ,  A61L29/085 ,  A61L2420/02

    摘要： Processes for coating medical devices are provided herein. The processes include heating a surface of the particles used to form the coating as the particles are being applied to the medical device. The resulting coating has improved adherence to the medical device, and does not require the use of solvents and/or water, obviating the need for any steps that otherwise might be required to remove these solvents and/or water. Sufficient adherence of the particles to the medical device may also occur without the need for heating the substrate used to form the medical device.

    摘要翻译： 本文提供了涂敷医疗器械的方法。 这些方法包括当颗粒被施加到医疗装置时加热用于形成涂层的颗粒的表面。 所得到的涂层具有改善对医疗装置的粘附性，并且不需要使用溶剂和/或水，从而避免需要除去这些溶剂和/或水以外可能需要的任何步骤。 也可以在不需要加热用于形成医疗装置的基板的情况下发生颗粒到医疗装置的足够的附着。

    System and method of using threads and thread-local storage
    8.
    发明授权
    System and method of using threads and thread-local storage 有权
    使用线程和线程本地存储的系统和方法

    公开(公告)号：US07991962B2

    公开(公告)日：2011-08-02

    申请号：US11953480

    申请日：2007-12-10

    申请人： Liam James Finnie ,  Lan Pham ,  Matthew Albert Huras

    发明人： Liam James Finnie ,  Lan Pham ,  Matthew Albert Huras

    IPC分类号： G06F12/00

    CPC分类号： G06F9/5016

    摘要： A system is provided that includes processing logic and a memory management module. The memory management module is configured to allocate a portion of memory space for a thread stack unit and to partition the thread stack unit to include a stack and a thread-local storage region. The stack is associated with a thread that is executable by the processing logic and the thread-local storage region is adapted to store data associated with the thread. The portion of memory space allocated for the thread stack unit is based on a size of the thread-local storage region that is determined when the thread is generated and a size of the stack.

    摘要翻译： 提供了一种包括处理逻辑和存储器管理模块的系统。 存储器管理模块被配置为为线程堆栈单元分配一部分存储器空间，并且将线程堆栈单元划分为包括堆栈和线程本地存储区域。 堆栈与可由处理逻辑执行的线程相关联，并且线程本地存储区域适于存储与线程相关联的数据。 为线程堆栈单元分配的内存空间的部分是基于当生成线程时确定的线程本地存储区域的大小和堆栈的大小。

    Method for spray coating a medical device using a micronozzle
    10.
    发明授权
    Method for spray coating a medical device using a micronozzle 有权
    使用微喷嘴喷涂医疗器械的方法

    公开(公告)号：US07758908B2

    公开(公告)日：2010-07-20

    申请号：US11390179

    申请日：2006-03-28

    申请人： Lan Pham ,  Gerald Fredrickson

    发明人： Lan Pham ,  Gerald Fredrickson

    IPC分类号： B05D1/02 ,  B05B7/10

    CPC分类号： B05B1/3421 ,  B05B7/0441 ,  B05B7/066 ,  B05D1/02

    摘要： The present invention provides for a method for spray application of a coating material onto a medical device by spraying coating material from a micronozzle fabricated from a plurality of sheets that are etched with holes or openings. The openings are aligned to form fluid channels and the sheets are fused together in a planar fashion to define a micronozzle. In another embodiment, the invention provides for a method for spray application of a coating material onto a medical device using micronozzles fabricated in batches by a simplified manufacturing process. In other embodiments, the invention provides for a method for spray application of a coating material onto a medical device by spraying coating material from a micronozzle that includes a swirl or gas-assist atomizer.

    摘要翻译： 本发明提供了一种通过从由孔或开口蚀刻的多个片材制成的微型喷嘴喷涂涂层材料来将涂层材料喷涂到医疗装置上的方法。 开口对准以形成流体通道，并且片材以平面方式熔合在一起以限定微喷嘴。 在另一个实施方案中，本发明提供了一种使用通过简化的制造过程分批制造的微喷嘴将涂料施用到医疗装置上的方法。 在其它实施例中，本发明提供了一种通过从包括旋流或气体辅助雾化器的微喷嘴喷涂涂层材料来将涂层材料喷涂到医疗装置上的方法。