摘要:
The present invention is directed to a monoclonal antibody that binds specifically to a Staphylococcus aureus glucosaminidase and inhibits in vivo growth of S. aureus. Also disclosed are monoclonal antibody binding portions, recombinant or hybridoma cell lines, pharmaceutical compositions containing the monoclonal antibody or binding portions thereof, and methods of treating 5*. aureus infection and osteomyelitis, and methods for introducing an orthopedic implant into a patient using the monoclonal antibody, binding portion, or pharmaceutical composition of the present invention.
摘要:
The present invention is directed to a monoclonal antibody that binds specifically to a Staphylococcus aureus glucosaminidase and inhibits in vivo growth of S. aureus. Also disclosed are monoclonal antibody binding portions, recombinant or hybridoma cell lines, pharmaceutical compositions containing the monoclonal antibody or binding portions thereof, and methods of treating 5*. aureus infection and osteomyelitis, and methods for introducing an orthopedic implant into a patient using the monoclonal antibody, binding portion, or pharmaceutical composition of the present invention.
摘要:
The present invention relates to an anti-idiotypic polypeptide scaffold that includes two or more peptide sequences that mimic a discontinuous epitope of a pathogen that is recognized by or induces formation of a broadly neutralizing antibody. Using a fibronectin FNfn10 scaffold bearing two or more modified discontinuous loops, scaffolds that recognize broadly neutralizing antibodies in vitro and from patient serum have been identified. These scaffolds should induce an immune response or mobilize germline specificities to initiate their affinity maturation.
摘要:
The present invention relates to an anti-idiotypic polypeptide scaffold that includes two or more peptide sequences that mimic a discontinuous epitope of a pathogen that is recognized by or induces formation of a broadly neutralizing antibody. Using a fibronectin FNfn10 scaffold bearing two or more modified discontinuous loops, scaffolds that recognize broadly neutralizing antibodies in vitro and from patient serum have been identified. These scaffolds should induce an immune response or mobilize germline specificities to initiate their affinity maturation.
摘要:
A method for programming a remote control device is disclosed and can include displaying a virtual remote control device at a display device. The virtual remote control device is a virtual rendition of a first remote control device to be programmed. The method can further include detecting when a first button is pressed on the first remote control device and indicating a corresponding button on the virtual remote control device.
摘要:
The present disclosure provides an improved system and method that allows a registrant to establish, generally through the Internet, an electronic account with a provider of services or products, and allows the registrant and others to add value to the account to raise the value through the collective contributory efforts. The value can include various forms such as monetary value from bank accounts and debit or credit charge cards. The value can also include in-kind value that is appropriate to the services from the provider, such as travel miles for an airline account. Still further, the provider can itself add value to the account, such as for promotional incentives. The incentives can include bonuses for timely use or the recipient's selection of certain services or products, and other promotional purposes. The collective efforts of several entities contributing to the account create a source for the recipient to select a service or product from the provider, such as travel. The system and method allows for the efficient and effective accumulation of value from multiple sources and multiple types of value that can be tracked and applied that has not been realized prior to the present invention.
摘要:
A system for employing the Coriolis effect for the generation and/or storage of energy generally comprises a vortex chamber for rotational acceleration therein of superheated, supersaturated water vapor and heated air and a water intake assembly and an adjustable air intake assembly each in fluid communication with the vortex chamber. The water intake assembly is adapted to deliver a directed flow of superheated water vapor to a lower portion of the vortex chamber while the air intake assembly is adapted to deliver a flow of heated air to the lower portion of said vortex chamber. The air intake assembly comprises an electrical generator operable by airflow drawn from the air intake assembly.
摘要:
The Thermus aquaticus gene encoding a thermostable DNA polymerase (Taq Pol) is altered in the N-terminus-encoding region to provide mutant genes with improved expression in E. coli.
摘要:
A centrifuge instrument has a vacuum pump responsive to a rotor recognition arrangement. The pump is operative to provide a predetermined pressure level in the chamber compatible with which one of a plurality of rotors is mounted within the chamber. The requested angular velocity can also be used to control the pressure level in the chamber.