公开(公告)号：US5006210A

公开(公告)日：1991-04-09

申请号：US306071

申请日：1989-02-06

申请人： Edwards Yeung ,  Werner G. Kuhr

发明人： Edwards Yeung ,  Werner G. Kuhr

IPC分类号： G01N27/447

CPC分类号： G01N27/44721

摘要： A means and method for capillary zone electrphoresis with laser-induced indirect fluorescence detection. A detector is positioned on the capillary tube of a capillary zone electrophoresis system. The detector includes a laser which generates a laser beam which is imposed upon a small portion of the capillary tube. Fluorescence of the elutant electromigrating through the capillary tube is indirectly detected and recorded.

摘要翻译： 一种用激光诱导间接荧光检测进行毛细管电泳的手段和方法。 检测器位于毛细管区带电泳系统的毛细管上。 检测器包括产生施加在毛细管的一小部分上的激光束的激光器。 通过毛细管电解的洗脱液的荧光被间接检测和记录。

公开(公告)号：US07348206B2

公开(公告)日：2008-03-25

申请号：US10040059

申请日：2001-10-26

申请人： David F. Bocian ,  Werner G. Kuhr ,  Jonathan S. Lindsey ,  Rajeeve Balkrishna Dabke ,  Zhiming Liu

发明人： David F. Bocian ,  Werner G. Kuhr ,  Jonathan S. Lindsey ,  Rajeeve Balkrishna Dabke ,  Zhiming Liu

IPC分类号： H01L51/40

CPC分类号： G11C13/0019 ,  B05D1/185 ,  B82Y10/00 ,  B82Y30/00 ,  B82Y40/00 ,  G11B9/14 ,  G11B9/149 ,  G11C13/0014 ,  G11C13/025 ,  H01L51/0075 ,  H01L51/0077 ,  H01L51/0595

摘要： This invention provides a new method of forming a self-assembling monolayer (SAM) of alcohol-terminated or thiol-terminated organic molecules (e.g. ferrocenes, porphyrins, etc.) on a silicon or other group IV element surface. The assembly is based on the formation of an E-O— or an E-S— bond where E is the group IV element (e.g. Si, Ge, etc.). The procedure has been successfully used on both P- and n-type group IV element surfaces. The assemblies are stable under ambient conditions and can be exposed to repeated electrochemical cycling.

摘要翻译： 本发明提供了一种在硅或其它IV族元素表面上形成醇封端或硫醇封端的有机分子（例如二茂铁，卟啉等）的自组装单层（SAM）的新方法。 该组合基于形成E-O-或E-S-键，其中E是IV族元素（例如Si，Ge等）。 该程序已经成功地用于P型和N型IV族元件表面。 组件在环境条件下是稳定的并且可以暴露于重复的电化学循环。

公开(公告)号：US06657884B2

公开(公告)日：2003-12-02

申请号：US10053814

申请日：2002-01-18

申请人： David F. Bocian ,  Werner G. Kuhr ,  Jonathan Lindsey

发明人： David F. Bocian ,  Werner G. Kuhr ,  Jonathan Lindsey

IPC分类号： G11C1100

CPC分类号： H01L51/0078 ,  B82Y10/00 ,  C07D487/22 ,  C07D519/00 ,  C07F17/02 ,  G11B9/14 ,  G11B9/149 ,  G11C11/5664 ,  G11C13/0009 ,  G11C13/0014 ,  G11C13/0016 ,  G11C2213/15 ,  G11C2213/77 ,  H01L27/28 ,  H01L51/0077 ,  H01L51/0084 ,  H01L51/009 ,  H01L51/0595 ,  Y10S977/943

摘要： This invention provides novel high density memory devices that are electrically addressable permitting effective reading and writing, that provide a high memory density (e.g., 1015 bits/cm3), that provide a high degree of fault tolerance, and that are amenable to efficient chemical synthesis and chip fabrication. The devices are intrinsically latchable, defect tolerant, and support destructive or non-destructive read cycles. In a preferred embodiment, the device comprises a fixed electrode electrically coupled to a storage medium having a multiplicity of different and distinguishable oxidation states wherein data is stored in said oxidation states by the addition or withdrawal of one or more electrons from said storage medium via the electrically coupled electrode.

摘要翻译： 本发明提供了可提供高存储密度（例如，10,15bit / cm 3）的电位置可允许有效读/写的新型高密度存储器件，其提供高度的容错能力，并且 适合有效的化学合成和芯片制造。 器件本质上可锁定，缺陷容忍，并支持破坏性或非破坏性的读取周期。 在优选实施例中，该装置包括电耦合到存储介质的固定电极，该存储介质具有多种不同且可区分的氧化态，其中通过经由该存储介质从所述存储介质中添加或撤出一个或多个电子而将数据存储在所述氧化态中 电耦合电极。

公开(公告)号：US5958215A

公开(公告)日：1999-09-28

申请号：US896548

申请日：1997-07-18

申请人： Werner G. Kuhr ,  Pankaj Singhal

发明人： Werner G. Kuhr ,  Pankaj Singhal

IPC分类号： G01N27/416 ,  G01N27/49 ,  G01N27/26

CPC分类号： G01N27/3277

摘要： Sinusoidal voltammetry was employed to detect both purine and pyrimidine-based nucleic acids. Adenine and cytosine, representing these two classes of nucleic acids, could be detected with nanomolar detection limits at a copper electrode under these conditions, where the sensitivity for adenine was much higher than that for cytosine. Detection limits for purine-containing nucleotides (e.g., adenosine 5'-monophosphate (AMP), adenosine 5'-diphosphate (ADP), and adenosine 5'-triphosphate (ATP)) were on the order of 70-200 nM using this method. These detection limits are achieved for native nucleotides and are over two orders of magnitude lower than those found with UV absorbance detection. Pyrimidine-based nucleotides could also be detected with high sensitivity due to the presence of a sugar backbone which is electroactive at the copper surface. This detector is not fouled by the nucleotides and can be used for the sensitive detection of analyses eluting continuously from a chromatography column or a electrophoresis capillary. Entire nucleic acid molecules can be readily detected. For example, both single stranded and double stranded DNA is detected with a detection limit in the picomolar concentration range (i.e., 10.sup.-12 moles/L). In the present invention, the signal from a double stranded DNA is roughly twice that arising from a single stranded DNA strand of the same length.

摘要翻译： 采用正弦伏安法检测基于嘌呤和嘧啶的核酸。 代表这两类核酸的腺嘌呤和胞嘧啶可以在这些条件下在铜电极上用纳摩尔检测限检测，其中腺嘌呤的灵敏度比胞嘧啶的灵敏度高得多。 含嘌呤核苷酸（例如腺苷5'-单磷酸（AMP），腺苷5'-二磷酸（ADP）和腺苷5'-三磷酸（ATP））的检测限为70-200nM，使用该方法 。 对于天然核苷酸实现这些检测限，并且比用UV吸光度检测发现的检测限超过两个数量级。 由于在铜表面具有电活性的糖主链的存在，也可以高灵敏度地检测基于嘧啶的核苷酸。 该检测器不被核苷酸污染，可用于灵敏检测从色谱柱或电泳毛细管连续洗脱的分析。 可以容易地检测整个核酸分子。 例如，以皮摩尔浓度范围（即10-12摩尔/ L）的检测限检测单链和双链DNA。 在本发明中，来自双链DNA的信号大约是由相同长度的单链DNA链产生的信号。

公开(公告)号：US20130337477A1

公开(公告)日：2013-12-19

申请号：US13795373

申请日：2013-03-12

申请人： Werner G. Kuhr ,  Craig Rhodine

发明人： Werner G. Kuhr ,  Craig Rhodine

IPC分类号： G01N1/40 ,  G01N27/26

CPC分类号： G01N1/22 ,  G01N1/2214 ,  G01N1/4022 ,  G01N27/26

摘要： The present invention relates to the use of a distributable sampling and sensing system for the determination of volatile components of consumable foods and other agricultural products. This process is used to separate and concentrate the chemicals of interest from samples at remote locations onto a target substrate that can be analyzed on-site or at a central lab. The chemicals deposited onto the substrate can be analyzed on-site with specific sensors (e.g., electrochemical sensors) or the target substrate can be sent to a central lab where the components adsorbed within are analyzed with conventional chemical instrumental methods (e.g., GC-MS). This process provides sufficient flexibility to enable the chemical analysis of a wide range of chemical species of interest in target materials in remote locations.

摘要翻译： 本发明涉及可分配的采样和感测系统用于确定易消耗食品和其他农产品的挥发性成分的用途。 该过程用于将目标化学品从远程位置的样品分离并集中到可在现场或中央实验室进行分析的靶基质上。 可以使用特定的传感器（例如，电化学传感器）现场分析沉积在基底上的化学物质，或者将目标基底送到中心实验室，吸附在其中的组分用常规的化学仪器方法（例如，GC-MS ）。 该过程提供足够的灵活性，以便能够对远程位置的目标材料中各种各样的感兴趣的化学物质进行化学分析。

公开(公告)号：US07695756B2

公开(公告)日：2010-04-13

申请号：US10834630

申请日：2004-04-29

申请人： Antonio R. Gallo ,  Werner G. Kuhr

发明人： Antonio R. Gallo ,  Werner G. Kuhr

IPC分类号： B05D5/12

CPC分类号： G11C13/0014 ,  B82Y10/00 ,  G11C13/0016 ,  H01L51/0595

摘要： A tool for manufacturing molecular electronic devices having a coating unit contained in a controlled ambient environment. The coating unit is coupled to a source of active device molecules in solution. The coating unit is configured to apply a selected quantity of the solution to a surface of a substrate and the process tool processes the coated substrate in conditions that cause the active device molecules to attach to active areas of the substrate.

摘要翻译： 一种用于制造具有包含在受控环境环境中的涂层单元的分子电子器件的工具。 涂层单元耦合到溶液中的活性器件分子源。 涂覆单元被配置为将选定量的溶液施加到基底的表面，并且处理工具在使得活性元件分子附着到基底的有效区域的条件下处理涂覆的基底。

公开(公告)号：US20100075427A1

公开(公告)日：2010-03-25

申请号：US12628985

申请日：2009-12-01

申请人： Werner G. Kuhr ,  Steven Z. Shi ,  Jen-Chieh Wei ,  Zhiming Liu ,  Lingyun Wei

发明人： Werner G. Kuhr ,  Steven Z. Shi ,  Jen-Chieh Wei ,  Zhiming Liu ,  Lingyun Wei

IPC分类号： G01N33/20

CPC分类号： H05K3/389 ,  C23C18/1653 ,  C23C18/1844 ,  C23C18/1893 ,  C23C18/2086 ,  C23C18/40 ,  H05K3/181 ,  H05K3/182 ,  H05K2203/1105 ,  H05K2203/121 ,  Y10T428/24322 ,  Y10T428/31511 ,  Y10T428/31678 ,  Y10T428/31721

摘要： Embodiments of the present invention provide methods of treating a surface of a substrate. In one embodiment a kit for carrying out the binding of metals to a substrate is provided, comprising: a container comprising a heat-resistant organic molecule derivatized with an attachment group Y and a binding group X, the binding group X promotes binding of metals; and instructional materials teaching coupling the organic molecule to the substrate by heating the molecule and/or the surface to a temperature of at least 25° C.

摘要翻译： 本发明的实施方案提供了处理基材表面的方法。 在一个实施方案中，提供了一种用于进行金属与基底结合的试剂盒，其包含：包含用附着基团Y和结合基团X衍生的耐热有机分子的容器，所述结合基团X促进金属的结合; 以及通过将分子和/或表面加热至至少25℃的温度将有机分子耦合到基底上的教学材料。

公开(公告)号：US20100071938A1

公开(公告)日：2010-03-25

申请号：US12628978

申请日：2009-12-01

申请人： Werner G. Kuhr ,  Steven Z. Shi ,  Jen-Chich Wei ,  Zhiming Liu ,  Lingyun Wei

发明人： Werner G. Kuhr ,  Steven Z. Shi ,  Jen-Chich Wei ,  Zhiming Liu ,  Lingyun Wei

IPC分类号： H05K1/03 ,  H05K1/00

CPC分类号： H05K3/389 ,  C23C18/1653 ,  C23C18/1844 ,  C23C18/1893 ,  C23C18/2086 ,  C23C18/40 ,  H05K3/181 ,  H05K3/182 ,  H05K2203/1105 ,  H05K2203/121 ,  Y10T428/24322 ,  Y10T428/31511 ,  Y10T428/31678 ,  Y10T428/31721

摘要： Embodiments of the present invention provide methods of treating a surface of a substrate. In one particular aspect, embodiments of the present invention provide methods of treating a surface of a substrate that promote binding of one or more metal elements to the surface. According to some embodiments of the invention, films are formed on any conducting, semiconductive or non-conductive surface, by thermal reaction of molecules containing reactive groups in an organic solvent or in aqueous solution. The thermal reaction may be produced under a variety of conditions. In another aspect, the present invention provides a printed circuit board, comprising: at least one substrate; a layer of organic molecules attached to the at least one substrate; and a metal layer atop said layer of organic molecules.

摘要翻译： 本发明的实施方案提供了处理基材表面的方法。 在一个特定方面，本发明的实施方案提供了处理促进一种或多种金属元素与表面结合的基材表面的方法。 根据本发明的一些实施方案，通过在有机溶剂中或在水溶液中含有反应性基团的分子的热反应，在任何导电，半导体或非导电表面上形成膜。 热反应可以在各种条件下生产。 另一方面，本发明提供一种印刷电路板，包括：至少一个基板; 连接到所述至少一个基底的有机分子层; 以及在所述有机分子层顶上的金属层。

公开(公告)号：US20080219041A1

公开(公告)日：2008-09-11

申请号：US12048427

申请日：2008-03-14

申请人： Werner G. Kuhr ,  Ritu Shrivastava ,  Antonio R. Gallo ,  Kenneth J. Mobley ,  Tom DeBolske

发明人： Werner G. Kuhr ,  Ritu Shrivastava ,  Antonio R. Gallo ,  Kenneth J. Mobley ,  Tom DeBolske

IPC分类号： G11C13/00

CPC分类号： H01L51/0006 ,  B82Y10/00 ,  G11C13/0009 ,  G11C13/0014 ,  G11C13/0016 ,  G11C2213/34 ,  H01L27/285 ,  H01L51/0595

摘要： Molecular memories, i.e., memories that incorporate molecules for charge storage, are disclosed. Molecular memory cells, molecular memory arrays, and electronic devices including molecular memory are also disclosed, as are processing systems and methods for manufacturing molecular memories. Methods of manufacturing molecular memories that enable semiconductor devices and interconnections to be manufactured monolithically with molecular memory are also disclosed.

摘要翻译： 公开了分子存储器，即结合用于电荷存储的分子的存储器。 还公开了分子记忆单元，分子存储器阵列和包括分子存储器的电子器件，以及用于制造分子存储器的处理系统和方法。 还公开了使半导体器件和互连能够与分子存储器一体制造的分子存储器的制造方法。

公开(公告)号：US07061791B2

公开(公告)日：2006-06-13

申请号：US10723315

申请日：2003-11-25

申请人： David F. Bocian ,  Werner G. Kuhr ,  Jonathan Lindsey

发明人： David F. Bocian ,  Werner G. Kuhr ,  Jonathan Lindsey

IPC分类号： G11C11/00

CPC分类号： H01L51/0078 ,  B82Y10/00 ,  C07D487/22 ,  C07D519/00 ,  C07F17/02 ,  G11B9/14 ,  G11B9/149 ,  G11C11/5664 ,  G11C13/0009 ,  G11C13/0014 ,  G11C13/0016 ,  G11C2213/15 ,  G11C2213/77 ,  H01L27/28 ,  H01L51/0077 ,  H01L51/0084 ,  H01L51/009 ,  H01L51/0595 ,  Y10S977/943

摘要： This invention provides novel high density memory devices that are electrically addressable permitting effective reading and writing, that provide a high memory density (e.g., 1015 bits/cm3), that provide a high degree of fault tolerance, and that are amenable to efficient chemical synthesis and chip fabrication. The devices are intrinsically latchable, defect tolerant, and support destructive or non-destructive read cycles. In a preferred embodiment, the device comprises a fixed electrode electrically coupled to a storage medium having a multiplicity of different and distinguishable oxidation states wherein data is stored in said oxidation states by the addition or withdrawal of one or more electrons from said storage medium via the electrically coupled electrode.

摘要翻译： 本发明提供了可提供高存储密度（例如，10位/ cm 3以上）的可电寻址以允许有效读取和写入的新型高密度存储器件，该 提供高度的容错性，并且适合高效的化学合成和芯片制造。 器件本质上可锁定，缺陷容忍，并支持破坏性或非破坏性的读取周期。 在优选实施例中，该装置包括电耦合到存储介质的固定电极，该存储介质具有多种不同且可区分的氧化态，其中通过经由该存储介质从所述存储介质中添加或撤出一个或多个电子而将数据存储在所述氧化态中 电耦合电极。