公开(公告)号：US20080123099A1

公开(公告)日：2008-05-29

申请号：US11902279

申请日：2007-09-20

申请人： Eiji Takahashi ,  Ryo Katayama ,  Hiroyuki Takamatsu

发明人： Eiji Takahashi ,  Ryo Katayama ,  Hiroyuki Takamatsu

IPC分类号： G01B9/02 ,  G01N21/00

CPC分类号： G01N21/171 ,  G01N21/031

摘要： There is provided a photothermal conversion measuring instrument which can measure change in property caused by thermal effect in a sample with high sensitivity and high accuracy by a simple structure. The instrument includes a current control circuit for sequentially switching output light of a plurality of excitation light sources each outputting excitation light having a different wavelength band so that one of the output light is irradiated to the sample, a light detector for interfering measurement light transmitted through the sample with reference light and detecting the intensity of the interference light, and a signal processor for extracting the same cycle components as the switching cycle of the output light switched by the current control circuit from a signal of the interference light intensity obtained from the light detector and for obtaining a difference of signal values corresponding to each of the excitation light based on the extracted signals.

摘要翻译： 提供了一种光热转换测量仪器，可以通过简单的结构，以高灵敏度和高精度测量样品中热效应引起的性能变化。 该仪器包括电流控制电路，用于顺序地切换多个激发光源的输出光，每个激发光源输出具有不同波长带的激发光，使得输出光中的一个照射到样本，用于干扰测量光的光检测器， 具有参考光的样本并检测干涉光的强度;以及信号处理器，用于从由光获得的干涉光强度的信号中提取与由电流控制电路切换的输出光的切换周期相同的周期分量 并且用于基于所提取的信号获得与每个激发光对应的信号值的差异。

公开(公告)号：US08367329B2

公开(公告)日：2013-02-05

申请号：US12308370

申请日：2007-06-14

申请人： Kazunori Ikebukuro ,  Ryo Katayama ,  Eiji Takahashi ,  Hiroyuki Takamatsu

发明人： Kazunori Ikebukuro ,  Ryo Katayama ,  Eiji Takahashi ,  Hiroyuki Takamatsu

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6804 ,  G01N21/171 ,  C12Q2537/101 ,  C12Q2541/101

摘要： The invention is to easily detect an interaction between nucleic acid and protein with high sensitivity without the need of sample labeling with a fluorescent molecule or sample anchorage onto a metal thin-film. As means for it, the presence or absence of occurrence of the interaction between nucleic acid and protein in a sample (S) is detected in an optical manner. Specifically, the sample (S) is irradiated with excitation rays (Le) and with measuring rays (L2) for measuring a photothermal effect produced in the sample (S) through the irradiation with the excitation rays (Le). A measurement signal for the photothermal effect in the sample (S) by the excitation rays (Le) is produced on the basis of any phase change of the measuring rays (L2). A temporal variation in the measurement signal is used for making a judgment on the presence or absence of any occurrence of interaction between nucleic acid and protein.

摘要翻译： 本发明可以容易地以高灵敏度检测核酸和蛋白质之间的相互作用，而不需要用荧光分子或样品锚定物将样品标记在金属薄膜上。 作为其手段，以光学方式检测样品（S）中核酸和蛋白质之间的相互作用的存在或不存在。 具体地，用激发光线（Le）和用于通过激发光线（Le）的照射测量样品（S）中产生的光热效应的测量光线（L2）来照射样品（S）。 基于测量光线（L2）的任何相变，产生通过激发光线（Le）在样品（S）中的光热效应的测量信号。 使用测量信号的时间变化来判断核酸和蛋白质之间是否存在任何相互作用的发生。

公开(公告)号：US08023118B2

公开(公告)日：2011-09-20

申请号：US12224302

申请日：2007-03-16

申请人： Eiji Takahashi ,  Ryo Katayama ,  Masato Kannaka ,  Hiroyuki Takamatsu

发明人： Eiji Takahashi ,  Ryo Katayama ,  Masato Kannaka ,  Hiroyuki Takamatsu

IPC分类号： G01B9/02 ,  G01J3/45 ,  G01N21/00

CPC分类号： G01N21/00 ,  G01N21/171 ,  G01N21/45 ,  G01N21/85 ,  G01N21/94 ,  G01N33/18 ,  G01N2021/1712 ,  G01N2021/8557 ,  G01N2030/746

摘要： The concentration of impurities contained in ultrapure water or press water can be efficiently analyzed with high precision. A portion of a liquid to be measured is introduced into an absorption spectrometric portion from a predetermined line. The liquid is irradiated with exciting light from an exciting light irradiation system, and a measurement object region in which a photothermal effect of the impurities in the liquid is produced by the irradiation is irradiated with measuring light from a measuring light irradiation system. A change in phase of the measuring light is detected by a predetermined optical system and a photodetector, and the impurity concentration in the liquid is determined on the basis of the change in phase.

摘要翻译： 可以高精度地有效地分析超纯水或压水中所含杂质的浓度。 将待测量的液体的一部分从预定线引入吸收光谱测定部分。 用激发光照射系统的激发光照射液体，照射测量光照射系统的测量光照射通过照射产生液体中的杂质的光热效应的测量对象区域。 通过预定的光学系统和光电检测器检测测量光的相位变化，并且基于相位的变化来确定液体中的杂质浓度。

公开(公告)号：US20100159451A1

公开(公告)日：2010-06-24

申请号：US12308370

申请日：2007-06-14

申请人： Kazunori Ikebukuro ,  Ryo Katayama ,  Eiji Takahashi ,  Hiroyuki Takamatsu

发明人： Kazunori Ikebukuro ,  Ryo Katayama ,  Eiji Takahashi ,  Hiroyuki Takamatsu

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6804 ,  G01N21/171 ,  C12Q2537/101 ,  C12Q2541/101

摘要： The invention is to easily detect an interaction between nucleic acid and protein with high sensitivity without the need of sample labeling with a fluorescent molecule or sample anchorage onto a metal thin-film. As means for it, the presence or absence of occurrence of the interaction between nucleic acid and protein in a sample (S) is detected in an optical manner. Specifically, the sample (S) is irradiated with excitation rays (Le) and with measuring rays (L2) for measuring a photothermal effect produced in the sample (S) through the irradiation with the excitation rays (Le). A measurement signal for the photothermal effect in the sample (S) by the excitation rays (Le) is produced on the basis of any phase change of the measuring rays (L2). A temporal variation in the measurement signal is used for making a judgment on the presence or absence of any occurrence of interaction between nucleic acid and protein.

摘要翻译： 本发明可以容易地以高灵敏度检测核酸和蛋白质之间的相互作用，而不需要用荧光分子或样品锚定物将样品标记在金属薄膜上。 作为其手段，以光学方式检测样品（S）中核酸和蛋白质之间的相互作用的存在或不存在。 具体地，用激发光线（Le）和用于通过激发光线（Le）的照射测量样品（S）中产生的光热效应的测量光线（L2）来照射样品（S）。 基于测量光线（L2）的任何相变，产生通过激发光线（Le）在样品（S）中的光热效应的测量信号。 使用测量信号的时间变化来判断核酸和蛋白质之间是否存在任何相互作用的发生。

公开(公告)号：US20090027654A1

公开(公告)日：2009-01-29

申请号：US12224302

申请日：2007-03-16

申请人： Eiji Takahashi ,  Ryo Katayama ,  Masato Kannaka ,  Hiroyuki Takamatsu

发明人： Eiji Takahashi ,  Ryo Katayama ,  Masato Kannaka ,  Hiroyuki Takamatsu

IPC分类号： G01N21/31 ,  G01N1/20

CPC分类号： G01N21/00 ,  G01N21/171 ,  G01N21/45 ,  G01N21/85 ,  G01N21/94 ,  G01N33/18 ,  G01N2021/1712 ,  G01N2021/8557 ,  G01N2030/746

摘要： The concentration of impurities contained in ultrapure water or press water can be efficiently analyzed with high precision.A portion of a liquid to be measured is introduced into an absorption spectrometric portion 2c from a predetermined line. The liquid is irradiated with exciting light Le from an exciting light irradiation system 10, and a measurement objet region AS in which a photothermal effect of the impurities in the liquid is produced by the irradiation is irradiated with measuring light Lm from a measuring light irradiation system 20. A change in phase of the measuring light Lm is detected by a predetermined optical system and a photodetector 36, and the impurity concentration in the liquid is determined on the basis of the change in phase.

摘要翻译： 可以高精度地有效地分析超纯水或压水中所含杂质的浓度。 将待测量的液体的一部分从预定线引入吸收光谱测量部分2c。 用激发光照射系统10的激励光Le照射液体，并且通过照射产生液体中的杂质的光热效应的测量对象区域AS从测量光照射系统 通过预定的光学系统和光电检测器36检测测量光Lm的相位变化，并且基于相位的变化来确定液体中的杂质浓度。

公开(公告)号：US08310676B2

公开(公告)日：2012-11-13

申请号：US12667585

申请日：2008-07-03

申请人： Kazunori Ikebukuro ,  Ryo Katayama ,  Eiji Takahashi

发明人： Kazunori Ikebukuro ,  Ryo Katayama ,  Eiji Takahashi

IPC分类号： G01N21/00

CPC分类号： G01N33/54373 ,  B01L3/5027 ,  B01L7/00 ,  B01L2300/0654 ,  B01L2300/0861 ,  B01L2300/0877 ,  B01L2300/0883 ,  B01L2300/1827 ,  G01N21/171 ,  G01N35/1095 ,  G01N2035/1034

摘要： An object of the present invention is to detect a small biomolecule in a sample using simple and inexpensive equipment. To achieve this, the small biomolecule in a sample S is detected optically. Specifically, the sample S containing an aptamer capable of interacting with the small biomolecule is irradiated with an excitation light Le and irradiated with a measurement light L2 for measuring the photothermal effect produced in the sample S by the irradiation with the excitation light Le. The photothermal effect induced in the sample S by the excitation light Le is measured from the phase change in the measurement light L2, and the presence or absence of the interaction between the biomolecule and the aptamer is assessed based on the temporal variation in the measurement signal.

摘要翻译： 本发明的目的是使用简单且便宜的设备来检测样品中的小生物分子。 为了实现这一点，光学检测样品S中的小生物分子。 具体地说，将含有能够与小生物分子相互作用的适体的样品S用激发光Le1照射，并用用于通过照射激发光Le测量在样品S中产生的光热效应的测量光L2照射。 根据测量光L2的相变测量由激发光Le引起的样品S中的光热效应，并且基于测量信号的时间变化来评估生物分子和适体之间的相互作用的存在或不存在 。

公开(公告)号：US20110007317A1

公开(公告)日：2011-01-13

申请号：US12667585

申请日：2008-07-03

申请人： Kazunori Ikebukuro ,  Ryo Katayama ,  Eiji Takahashi

发明人： Kazunori Ikebukuro ,  Ryo Katayama ,  Eiji Takahashi

IPC分类号： G01N21/00

CPC分类号： G01N33/54373 ,  B01L3/5027 ,  B01L7/00 ,  B01L2300/0654 ,  B01L2300/0861 ,  B01L2300/0877 ,  B01L2300/0883 ,  B01L2300/1827 ,  G01N21/171 ,  G01N35/1095 ,  G01N2035/1034

摘要： An object of the present invention is to detect a small biomolecule in a sample using simple and inexpensive equipment. To achieve this, the small biomolecule in a sample S is detected optically. Specifically, the sample S containing an aptamer capable of interacting with the small biomolecule is irradiated with an excitation light Le and irradiated with a measurement light L2 for measuring the photothermal effect produced in the sample S by the irradiation with the excitation light Le. The photothermal effect induced in the sample S by the excitation light Le is measured from the phase change in the measurement light L2, and the presence or absence of the interaction between the biomolecule and the aptamer is assessed based on the temporal variation in the measurement signal.

摘要翻译： 本发明的目的是使用简单且便宜的设备来检测样品中的小生物分子。 为了实现这一点，光学检测样品S中的小生物分子。 具体地说，将含有能够与小生物分子相互作用的适体的样品S用激发光Le1照射，并用用于通过照射激发光Le测量在样品S中产生的光热效应的测量光L2照射。 根据测量光L2的相变测量由激发光Le引起的样品S中的光热效应，并且基于测量信号的时间变化来评估生物分子和适体之间的相互作用的存在或不存在 。

公开(公告)号：US07522287B2

公开(公告)日：2009-04-21

申请号：US11350954

申请日：2006-02-10

申请人： Eiji Takahashi ,  Hiroyuki Takamatsu ,  Masato Kannaka ,  Naokazu Sakoda ,  Tsutomu Morimoto

发明人： Eiji Takahashi ,  Hiroyuki Takamatsu ,  Masato Kannaka ,  Naokazu Sakoda ,  Tsutomu Morimoto

IPC分类号： G01B11/02 ,  G01N21/00 ,  G01N1/10

CPC分类号： G01N21/171 ,  G01N21/031 ,  G01N2021/1712 ,  G01N2021/178 ,  G01N2201/105

摘要： A liquid sample is irradiated with excitation light and measurement light, and a measurement position at which a traveling path of the measurement light passes through an excitation section of the excitation light in the sample is changed while the sample is being irradiated with the excitation light and the measurement light. Then, the phase change of the measurement light is measured for each measurement by optical interferometry on the basis of the measurement light after the measurement light passes through the sample. The measurement position is changed by, for example, scanning the excitation light, moving the sample, moving a lens that collects the excitation light in the sample so as to change the light-collecting position (focal position) in the sample, etc.

摘要翻译： 用激发光和测量光照射液体样品，并且在样品被激发光照射的同时改变测量光的行进路径通过样品中的激发光的激发部分的测量位置，以及 测量灯。 然后，基于测量光通过样品后的测量光，通过光学干涉测量对每次测量测量测量光的相位变化。 通过例如扫描激发光，移动样品，移动收集样品中的激发光的透镜来改变测量位置，以便改变样品中的聚光位置（焦点位置）等。

公开(公告)号：US20060181708A1

公开(公告)日：2006-08-17

申请号：US11350954

申请日：2006-02-10

申请人： Eiji Takahashi ,  Hiroyuki Takamatsu ,  Masato Kannaka ,  Naokazu Sakoda ,  Tsutomu Morimoto

发明人： Eiji Takahashi ,  Hiroyuki Takamatsu ,  Masato Kannaka ,  Naokazu Sakoda ,  Tsutomu Morimoto

IPC分类号： G01N21/59

CPC分类号： G01N21/171 ,  G01N21/031 ,  G01N2021/1712 ,  G01N2021/178 ,  G01N2201/105

摘要： A liquid sample is irradiated with excitation light and measurement light, and a measurement position at which a traveling path of the measurement light passes through an excitation section of the excitation light in the sample is changed while the sample is being irradiated with the excitation light and the measurement light. Then, the phase change of the measurement light is measured for each measurement by optical interferometry on the basis of the measurement light after the measurement light passes through the sample. The measurement position is changed by, for example, scanning the excitation light, moving the sample, moving a lens that collects the excitation light in the sample so as to change the light-collecting position (focal position) in the sample, etc.

公开(公告)号：US10541369B2

公开(公告)日：2020-01-21

申请号：US13979746

申请日：2012-01-16

申请人： Norimasa Yokoyama ,  Daizou Kanda ,  Shuichi Hayashi ,  Eiji Takahashi

发明人： Norimasa Yokoyama ,  Daizou Kanda ,  Shuichi Hayashi ,  Eiji Takahashi

IPC分类号： H01L51/50 ,  H01L51/00 ,  C07D471/04 ,  C07D401/14

摘要： To provide an organic compound of excellent characteristics that exhibits excellent electron-injecting/transporting performance with hole blocking ability, and has high stability in the thin-film state, as material for an organic electroluminescent device having high efficiency and high durability, and to provide the organic electroluminescent device having high efficiency and high durability using the compound. An organic electroluminescent device includes a pair of electrodes, and one or more organic layers sandwiched between the pair of electrodes, wherein the compound of general formula (1) in which a substituted bipyridyl group and a pyridoindole ring structure are bonded via a phenylene group, is used as a constituent material of at least one organic layer.