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公开(公告)号：US20070198053A1
公开(公告)日：2007-08-23
申请号：US11506815
申请日：2006-08-21
申请人： Eisuke Tatsumi , Toshihide Mizuno , Yoshiyuki Taenaka , Yasushi Nemoto , Yoshihiro Okamoto , Hare Tazawa
发明人： Eisuke Tatsumi , Toshihide Mizuno , Yoshiyuki Taenaka , Yasushi Nemoto , Yoshihiro Okamoto , Hare Tazawa
IPC分类号： A61B17/00
CPC分类号： A61M25/02 , A61L31/146 , A61M2025/0266 , A61M2025/0293
摘要： A cuff member that enhances the invasion and engraftment of cells from subcutaneous tissue of a living body and robustly adheres to the subcutaneous tissue through the vascularization of capillary vessels, and can consequently isolate a wound from the outside, block exacerbating factors such as bacterial infection during healing, inhibit the downgrowth, and reduce infection problems including tunnel infection. A cuff member 2 includes a flange 3 and a tubular portion 4. The cuff member 2 includes a three-dimensional network open-cell porous structure, which is formed of a thermoplastic resin or a thermosetting resin and has an average pore size of 100 to 1000 μm and an apparent density of 0.01 to 0.5 g/cm3. A pad 5 overlies the flange 3. A tube 6 passes through the pad 5 and the flange 3.
摘要翻译： 一种增强从生物体皮下组织侵入和移植细胞的囊袋，通过毛细血管的血管化牢固地粘附在皮下组织上，从而将伤口从外部分离出来，阻止诸如细菌感染的加重因素 愈合，抑制下丘，减少感染问题，包括隧道感染。 套箍构件2包括凸缘3和管状部分4。 袖带构件2包括由热塑性树脂或热固性树脂形成的平均孔径为100〜1000μm，表观密度为0.01〜0.5g / cm 3的三维网状开孔多孔结构体， SUP> 3 。 垫5叠在凸缘3上。 管6穿过垫5和凸缘3。
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公开(公告)号：US06967003B2
公开(公告)日：2005-11-22
申请号：US09964894
申请日：2001-09-28
申请人： Toru Takehisa , Kazunari Sakai , Susumu Kashiwabara , Hidenori Tanaka , Masaki Satoh , Hisateru Takano , Yoshiyuki Taenaka , Eisuke Tatsumi , Tomohiro Nishinaka
发明人： Toru Takehisa , Kazunari Sakai , Susumu Kashiwabara , Hidenori Tanaka , Masaki Satoh , Hisateru Takano , Yoshiyuki Taenaka , Eisuke Tatsumi , Tomohiro Nishinaka
IPC分类号： A61M1/16 , A61M1/36 , B01D67/00 , B01D69/02 , B01D69/08 , B01D71/26 , A61M37/00 , A61M1/14 , B01D63/00
CPC分类号： B01D67/0088 , A61M1/1698 , A61M1/3672 , A61M1/3673 , B01D69/02 , B01D69/08 , B01D71/26 , Y10S261/28
摘要： A membrane artificial lung performs gas exchange between blood and a gas via the membrane by flowing the blood in one side of the membrane and flowing oxygen or an oxygen-containing gas in the other side of the membrane. The membrane has a hollow fiber membrane of poly-4-methylpentene-1 and an oxygen permeation rate Q(O2) at 25° C. of from 1×10−6 to 3×10−3 (cm3(STP)/cm2·sec·cmHg) and an ethanol flux of from 0.1 to 100 ml/min·m2. The membrane has, in the side of the blood flow, a surface having an ionic complex derived from: quaternary aliphatic alkylammonium salts; and heparin or a heparin derivative. The quaternary alkylammonium salts are a quaternary aliphatic alkylammonium salt having from 22 to 26 carbon atoms in total and a quaternary aliphatic alkylammonium salt having from 37 to 40 carbon atoms in total.
摘要翻译： 膜人造肺通过使血液在膜的一侧流动并在膜的另一侧流动氧气或含氧气体，通过膜进行血液和气体之间的气体交换。 该膜具有聚-4-甲基戊烯-1的中空纤维膜和25℃下的氧渗透速率Q（O 2 O 2），为1×10 -6以上至 3×10 -3（cm 3）（STP）/ cm 2·sec·secHg），乙醇流量为0.1〜100ml / min .m 2 。 膜在血流侧具有一个具有衍生自：季脂族烷基铵盐的离子络合物的表面; 和肝素或肝素衍生物。 季烷基铵盐是总共具有22至26个碳原子的季脂族烷基铵盐和总共具有37至40个碳原子的季脂族烷基铵盐。
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公开(公告)号：US20090012498A1
公开(公告)日：2009-01-08
申请号：US11665007
申请日：2005-10-27
CPC分类号： A61K38/1833 , A61K48/005
摘要： The present invention provides a medicament comprising a gene encoding an angiogenic cytokine for the treatment of acute myocardial infarction (AMI), idiopathic cardiomyopathy (ICM), dilated cardiomyopathy (DCM) or heart failure, to be given in combination with ventricular assist device (VAD).
摘要翻译： 本发明提供了包含编码用于治疗急性心肌梗死（AMI），特发性心肌病（ICM），扩张性心肌病（DCM）或心力衰竭）的血管生成细胞因子的基因与心室辅助装置（VAD）组合的药物 ）。
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4.发明申请公开(公告)号：US20050107868A1
公开(公告)日：2005-05-19
申请号：US10950620
申请日：2004-09-28
CPC分类号： A61L27/38 , A61L27/507 , A61L27/56
摘要： The invention provides a porous scaffold for tissue engineering which allows easy cell engraftment and cell culture and thus enables stable organization and an artificial blood vessel which exhibits high patency rate even if the inner diameter is small. The scaffold for tissue engineering is made of thermoplastic resin which forms a porous three-dimensional network structure having communication property, wherein the porous three-dimensional network structure has an average pore diameter of from 100 to 650 μm and an apparent density of from 0.01 to 0.5 g/cm3. The artificial blood vessel is composed of this scaffold. The invention provides a cuff which allows easy infiltration of cells from living subcutaneous tissues, easy engraftment of cells, and neovascularization of capillary vessels so as to obtain robust bonding with subcutaneous tissues and, as a result, ensures separation of a wounded portion from the outside, thereby blocking exacerbation factors such as bacterial infection on healing and inhibiting progression of downgrowth. That is, the invention provides a cuff with none or little infection trouble such as tunnel infection. The cuff comprises a porous three-dimensional network structure which is made of thermoplastic resin or thermosetting resin and has communication property, wherein the porous three-dimensional network structure has an average pore diameter of from 100 to 1000 μm and apparent density of from 0.01 to 0.5 g/cm3. The invention provides a biological implant covering member which allows easy infiltration of cells from living subcutaneous tissues, easy engraftment of cells, and organization, thereby obtaining robust bonding with native tissues and therefore protecting a living body from adverse effect which may occur due to the insertion of a biological implantation member into the living body. The biological implant covering member comprises a porous three-dimensional network structure which is made of thermoplastic resin or thermosetting resin and has communication property, wherein the porous three-dimensional network structure has an average pore diameter of from 100 to 1000 μm and apparent density of from 0.01 to 0.5 g/cm3.
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