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公开(公告)号：US20090012498A1
公开(公告)日：2009-01-08
申请号：US11665007
申请日：2005-10-27
CPC分类号： A61K38/1833 , A61K48/005
摘要： The present invention provides a medicament comprising a gene encoding an angiogenic cytokine for the treatment of acute myocardial infarction (AMI), idiopathic cardiomyopathy (ICM), dilated cardiomyopathy (DCM) or heart failure, to be given in combination with ventricular assist device (VAD).
摘要翻译： 本发明提供了包含编码用于治疗急性心肌梗死（AMI），特发性心肌病（ICM），扩张性心肌病（DCM）或心力衰竭）的血管生成细胞因子的基因与心室辅助装置（VAD）组合的药物 ）。
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2.发明申请Method for preserving organs for transplantation with a HGF-containing solution 审中-公开用含HGF溶液保存移植器官的方法公开(公告)号：US20050233299A1
公开(公告)日：2005-10-20
申请号：US10967247
申请日：2004-10-19
IPC分类号： A01N1/02
CPC分类号： A01N1/02 , A01N1/0226
摘要： A method of preserving a harvested organ, a harvested organ tissue or a part thereof for a long time, which comprises perfusing and/or immersing the harvested organ with a solution containing HGF having a temperature of 0 to 6° C., and which method is capable of maintaining harvested organs for transplantation in a high physiological state and preventing ischemia/reperfusion injury of the organs transplanted.
摘要翻译： 一种长期保存收获的器官，收获的器官组织或其部分的方法，其包括用含有0至6℃温度的HGF的溶液灌注和/或浸没收获的器官，以及哪种方法 能够在高生理状态下维持收集的器官移植，并预防移植器官的缺血/再灌注损伤。
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公开(公告)号：US20050187221A1
公开(公告)日：2005-08-25
申请号：US10935466
申请日：2004-09-07
申请人： Hikaru Matsuda , Yoshiki Sawa , Masahiro Ryugo
发明人： Hikaru Matsuda , Yoshiki Sawa , Masahiro Ryugo
IPC分类号： A61K31/495
CPC分类号： A61K31/495
摘要： The invention provides a method of treating or preventing ischemia reperfusion injury in a subject in need thereof comprising administering a cytokine production inhibitor to a subject.
摘要翻译： 本发明提供了治疗或预防有需要的受试者的缺血再灌注损伤的方法，包括向受试者施用细胞因子产生抑制剂。
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公开(公告)号：US20070244568A1
公开(公告)日：2007-10-18
申请号：US10584740
申请日：2004-12-24
申请人： Hikaru Matsuda , Yoshiki Sawa , Satoshi Taketani , Shigeru Miyagawa , Shigemitau Iwai , Takeyoshi Ota , Jun Miyake , Masayuki Hara , Masakazu Furuta , Eiichiro Uchimura
发明人： Hikaru Matsuda , Yoshiki Sawa , Satoshi Taketani , Shigeru Miyagawa , Shigemitau Iwai , Takeyoshi Ota , Jun Miyake , Masayuki Hara , Masakazu Furuta , Eiichiro Uchimura
IPC分类号： A61F2/02
CPC分类号： A61L27/3683 , A61L27/3604
摘要： Decellularization of tissue by means of an amphipathic solvent a well-established practice. However, situations exist where the provision of enhanced decellularization is preferred. There is a demand for treating methods for coping with such situations. Thus, it is intended to provide a method for enhancing decellularization. The method comprises not only the immersing of a tissue in a solution containing an amphiphilic molecule in non-micellar form (for example, 1,2-epoxide polymer) but also performing a radical reaction (for example, treatment selected from the group consisting of exposure to gamma-ray irradiation, ultraviolet irradiation, a free radical supply source, ultrasonication, electron beam irradiation, and X-ray irradiation).
摘要翻译： 通过两性溶剂去除细胞组织，这是一个很好的做法。 然而，存在提供增强脱细胞化优先的情况。 需要处理这种情况的方法。 因此，旨在提供一种增强脱细胞化的方法。 该方法不仅包括将组织浸入含有非胶束形式的两亲分子（例如1,2-环氧化物聚合物）的溶液中，而且还进行自由基反应（例如，选自由 暴露于γ射线照射，紫外线照射，自由基供应源，超声波处理，电子束照射和X射线照射）。
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公开(公告)号：US20070092492A1
公开(公告)日：2007-04-26
申请号：US10567728
申请日：2004-02-02
CPC分类号： C12N5/0658 , A61K35/12 , A61K35/34 , A61L27/3804 , A61L27/3834 , A61L27/3839 , A61L27/3895 , A61L2430/20 , C12N5/0068 , C12N5/0657 , C12N2506/02 , C12N2506/1392 , C12N2513/00 , C12N2523/00 , C12N2533/40 , C12N2539/10
摘要： The present invention provides a prosthetic tissue or sheet capable of withstanding implantation operations, which can be used in actual operation and can be produced by culture. The present invention also provides a novel therapy which can substitute for cell therapy. Particularly, the present invention provides a method for producing a prosthetic tissue comprising a cell derived from a part other than myocardium and capable of withstanding implantation operation. The above-described objects of the present invention were partially achieved by finding that by culturing cells under specific culture conditions, the cells are unexpectedly organized into a tissue, and the resultant prosthetic tissue is capable of being detached from culture dishes. The present invention also provides a three-dimensional structure applicable to heart, comprising a cell derived from a part other than the myocardium of an adult.
摘要翻译： 本发明提供能够承受植入操作的假体组织或片材，其可以在实际操作中使用并且可以通过培养产生。 本发明还提供了可代替细胞治疗的新型治疗方法。 特别地，本发明提供了一种用于制造假体组织的方法，所述假体组织包含源于除了心肌之外的部分的细胞并且能够承受植入操作。 通过发现通过在特定培养条件下培养细胞，细胞意外地组织成组织，并且所得到的假体组织能够从培养皿中分离，部分实现了本发明的上述目的。 本发明还提供了适用于心脏的三维结构，其包含源自成人心肌之外的部分的细胞。
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公开(公告)号：US20060252981A1
公开(公告)日：2006-11-09
申请号：US10537678
申请日：2003-12-05
CPC分类号： B32B7/02 , A61F2/142 , A61L31/00 , B32B1/08 , B32B5/02 , B32B5/024 , B32B5/026 , B32B5/18 , B32B5/26 , B32B27/28 , B32B2305/186 , B32B2305/188 , B32B2305/38 , B32B2307/7163 , B32B2307/7242 , B32B2535/00 , B32B2597/00
摘要： The present invention provides an implant capable of being cellularized in treatment of an injured organ or tissue in organisms. The present inventors found that a biocompatible implant comprising a biological molecule and a support is capable of being cellularized. The implant can be used instead of conventional implants which essentially comprise cells. The present invention provides a biocompatible implant comprising A) a biological molecule and B) a support. The present invention also provides A) a first layer having a rough surface, B) a rough surface; B) a second layer having a strength which allows the support to resist in vivo shock. The first layer is attached to the second layer via at least one point.
摘要翻译： 本发明提供能够在生物体内损伤的器官或组织的治疗中被细胞化的植入物。 本发明人发现包含生物分子和载体的生物相容性植入物能够被细胞化。 可以使用植入物代替基本上包含细胞的常规植入物。 本发明提供一种生物相容性植入物，其包含A）生物分子和B）支持物。 本发明还提供了A）具有粗糙表面的第一层，B）粗糙表面; B）具有允许支持体抵抗体内冲击的强度的第二层。 第一层通过至少一个点连接到第二层。
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7.发明申请Decoy compositions for treating and preventing brain diseases and disorders 审中-公开用于治疗和预防脑部疾病和疾病的诱饵组合物公开(公告)号：US20060135449A1
公开(公告)日：2006-06-22
申请号：US10509799
申请日：2002-03-29
CPC分类号： A61K9/0019 , A61K9/127 , A61K31/711 , A61K48/005 , A61K48/0075 , C07K14/4705 , C12N15/1131 , C12N15/115 , C12N15/86 , C12N2310/13 , C12N2310/315 , C12N2760/18811
摘要： The present invention provides introduction of NF-κB decoy oligodeoxynucleotide into rat cranial nerve through a carotid artery during global brain ischemia. Polymerase chain reaction demonstrated that one hour after global brain ischemia, transfected NF-κB decoy oligodeoxynucleotide effectively suppressed expression of tumor necrosis factor α, interleukin 1β and intracellular adhesion molecule 1 messenger RNAs. Terminal deoxynucleotidyl transferase-mediated deoxyuridine nick-end labeling staining and immunohistochemistry using microtubule-associated protein 2 demonstrated that transfected NF-κB decoy oligodeoxynucleotide significantly attenuated neuronal damage seven days after global brain ischemia. Therapeutic transfection of NF-κB decoy oligodeoxynucleotide during brain ischemia may be effective for attenuation of neuronal damage, suggesting a strategy for protecting the cerebrum from global ischemia.
摘要翻译： 本发明提供了在全脑缺血期间通过颈动脉将NF-κB诱饵寡脱氧核苷酸引入大鼠颅神经中。 聚合酶链反应表明，全球脑缺血后1小时，转染的NF-κB诱饵寡脱氧核苷酸有效抑制肿瘤坏死因子α，白细胞介素1β和细胞内粘附分子1信使RNA的表达。 末端脱氧核苷酸转移酶介导的脱氧尿苷切口标记染色和使用微管相关蛋白2的免疫组织化学证实，转染的NF-κB诱饵寡脱氧核苷酸在全脑缺血后7天显着减弱神经元损伤。 在脑缺血期间，NF-κB诱饵寡脱氧核苷酸的治疗转染对于减少神经元损伤可能是有效的，这表明保护大脑免受全身缺血的策略。
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公开(公告)号：US09587222B2
公开(公告)日：2017-03-07
申请号：US10567728
申请日：2004-02-02
CPC分类号： C12N5/0658 , A61K35/12 , A61K35/34 , A61L27/3804 , A61L27/3834 , A61L27/3839 , A61L27/3895 , A61L2430/20 , C12N5/0068 , C12N5/0657 , C12N2506/02 , C12N2506/1392 , C12N2513/00 , C12N2523/00 , C12N2533/40 , C12N2539/10
摘要： The present invention provides a prosthetic tissue or sheet capable of withstanding implantation operations, which can be used in actual operation and can be produced by culture. The present invention also provides a novel therapy which can substitute for cell therapy. Particularly, the present invention provides a method for producing a prosthetic tissue comprising a cell derived from a part other than myocardium and capable of withstanding implantation operation. The above-described objects of the present invention were partially achieved by finding that by culturing cells under specific culture conditions, the cells are unexpectedly organized into a tissue, and the resultant prosthetic tissue is capable of being detached from culture dishes. The present invention also provides a three-dimensional structure applicable to heart, comprising a cell derived from a part other than the myocardium of an adult.
摘要翻译： 本发明提供能够承受植入操作的假体组织或片材，其可以在实际操作中使用并且可以通过培养产生。 本发明还提供了可代替细胞治疗的新型治疗方法。 特别地，本发明提供了一种用于制造假体组织的方法，所述假体组织包含源于除了心肌之外的部分的细胞并且能够承受植入操作。 通过发现通过在特定培养条件下培养细胞，细胞意外地组织成组织，并且所得到的假体组织能够从培养皿中分离，部分实现了本发明的上述目的。 本发明还提供了适用于心脏的三维结构，其包含源自成人心肌之外的部分的细胞。
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9.发明申请Decoy compositions for treating and preventing brain diseases and disorders 审中-公开用于治疗和预防脑部疾病和疾病的诱饵组合物公开(公告)号：US20080207552A1
公开(公告)日：2008-08-28
申请号：US11982970
申请日：2007-11-05
IPC分类号： A61K31/7088 , A61P9/10
CPC分类号： A61K9/0019 , A61K9/127 , A61K31/711 , A61K48/005 , A61K48/0075 , C07K14/4705 , C12N15/1131 , C12N15/115 , C12N15/86 , C12N2310/13 , C12N2310/315 , C12N2760/18811
摘要： The present invention provides introduction of NF-κB decoy oligodeoxynucleotide into rat cranial nerve through a carotid artery during global brain ischemia. Polymerase chain reaction demonstrated that one hour after global brain ischemia, transfected NF-κB decoy oligodeoxynucleotide effectively suppressed expression of tumor necrosis factor α, interleukin 1β and intracellular adhesion molecule 1 messenger RNAs. Terminal deoxynucleotidyl transferase-mediated deoxyuridine nick-end labeling staining and immunohistochemistry using microtubule-associated protein 2 demonstrated that transfected NF-κB decoy oligodeoxynucleotide significantly attenuated neuronal damage seven days after global brain ischemia. Therapeutic transfection of NF-κB decoy oligodeoxynucleotide during brain ischemia may be effective for attenuation of neuronal damage, suggesting a strategy for protecting the cerebrum from global ischemia.
摘要翻译： 本发明提供了在全脑缺血期间通过颈动脉将NF-κB诱饵寡脱氧核苷酸引入大鼠颅神经中。 聚合酶链反应表明，全球脑缺血后1小时，转染的NF-κB诱饵寡脱氧核苷酸有效抑制肿瘤坏死因子α，白细胞介素1β和细胞内粘附分子1信使RNA的表达。 末端脱氧核苷酸转移酶介导的脱氧尿苷切口末端标记染色和使用微管相关蛋白2的免疫组织化学证实，转染的NF-κB诱饵寡脱氧核苷酸在全脑缺血后7天显着减弱神经元损伤。 在脑缺血期间，NF-κB诱饵寡脱氧核苷酸的治疗转染对于减少神经元损伤可能是有效的，这表明保护大脑免受全身缺血的策略。
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10.发明申请公开(公告)号：US20060018941A1
公开(公告)日：2006-01-26
申请号：US10954639
申请日：2004-09-30
申请人： Hikaru Matsuda , Yoshiki Sawa , Satoshi Taketani , Shin Kawamata , Shigeru Miyagawa , Emi Maeno , Yoshiho Toyota , Shinji Ozawa
发明人： Hikaru Matsuda , Yoshiki Sawa , Satoshi Taketani , Shin Kawamata , Shigeru Miyagawa , Emi Maeno , Yoshiho Toyota , Shinji Ozawa
IPC分类号： A61F13/00
CPC分类号： A61M5/1456 , A61M5/14566 , A61M5/14593 , A61M5/482 , A61M5/488 , A61M2005/14513 , C12M35/00
摘要： A method for injecting a liquid drug containing a biological material is provided, which comprises the step of injecting the liquid drug containing the biological material contained in an injector into a subject at a predetermined range of velocity.
摘要翻译： 提供了一种用于注射含有生物材料的液体药物的方法，其包括将包含在注射器中的生物材料的液体药物以预定的速度范围注射到受试者中的步骤。
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