公开(公告)号：US10241013B2

公开(公告)日：2019-03-26

申请号：US15368803

申请日：2016-12-05

Applicant: Elemental Scientific, Inc.

Inventor： Paul Field ,  Daniel R. Wiederin ,  Patrick Sullivan

IPC: G01N1/38 ,  G01N30/04 ,  G01N35/10 ,  G01N30/00 ,  H01J49/10

Abstract: Systems and methods for inline and automatic dilution of chemicals of interest for speciation and subsequent analysis by ICP spectrometry are described. A system embodiment includes a first valve to receive a sample into a holding loop; a plurality of syringe pumps coupled to the first valve to deliver an inline diluted sample from the first valve; and a second valve coupled to the first valve to receive the inline diluted sample from the first valve into a sample holding loop coupled to the second valve, the second valve configured to couple to at least one of an eluent source or a carrier fluid source to receive at least one of an eluent fluid or a carrier fluid to transfer the inline diluted sample from the sample holding loop to a speciation column to separate one or more species from the inline diluted sample.

公开(公告)号：US09953822B1

公开(公告)日：2018-04-24

申请号：US14740472

申请日：2015-06-16

Applicant: Elemental Scientific, Inc.

Inventor： Daniel R. Wiederin ,  Paul Field

IPC: G01N30/46 ,  H01J49/10 ,  H01J49/00 ,  G01N30/72 ,  G01N30/74 ,  G01J3/443

CPC classification number: G01J3/443 ,  G01N30/7253 ,  G01N30/74

Abstract: A system includes a sample selector device, a chromatographic column selectively connectable to the sample selector device, and a spectrometry analysis device selectively connectable to the sample selector device. The sample selector device is configured to supply multiple individual samples to the chromatographic column to separate components of the individual samples. The sample selector device is also configured to store the separated components of the individual samples. The sample selector device is further configured to supply the separated components of the individual samples to the spectrometry analysis device. In embodiments of the disclosure, the components of the individual samples can be chromatographically separated while the spectrometry analysis device is offline.

公开(公告)号：US09620343B1

公开(公告)日：2017-04-11

申请号：US14566493

申请日：2014-12-10

Applicant: Elemental Scientific, Inc.

Inventor： Paul Field

IPC: H01J49/04 ,  H01J49/10

CPC classification number: H01J49/0422 ,  G01N1/00 ,  G01N1/22 ,  G01N21/73 ,  G01N35/1095 ,  H01J49/0445 ,  H01J49/105

Abstract: A system includes a first aerosolization device (e.g., a nebulizer and a spray chamber/desolvation device in fluid communication with the nebulizer) configured to furnish a first aerosol, and a second aerosolization device (e.g., a second nebulizer and a second spray chamber/desolvation device in fluid communication with the second nebulizer) configured to furnish a second aerosol. The first aerosolization device is balanced with the second aerosolization device. The system also includes an output coupled with the first aerosolization device and the second aerosolization device. The output is configured to supply at least one of the first aerosol or the second aerosol (e.g., to a torch). The system further includes a selection device coupling the first aerosolization device and the second aerosolization device to the output. The selection device is configured to selectively provide at least one of the first aerosol or the second aerosol to the output.

公开(公告)号：US10018543B1

公开(公告)日：2018-07-10

申请号：US14297590

申请日：2014-06-05

Applicant: Elemental Scientific, Inc.

Inventor： Daniel R. Wiederin ,  Paul Field

IPC: G01N1/34 ,  G01N30/02 ,  G01N30/46

CPC classification number: G01N1/34 ,  B01D15/08 ,  G01N1/405 ,  G01N30/02 ,  G01N30/08 ,  G01N30/40 ,  G01N30/468 ,  G01N35/1097 ,  Y10T436/11 ,  Y10T436/255

Abstract: A method includes supplying a reagent to a column, where the column is configured to purify an element from a sample matrix for isotopic analysis. The method also includes loading the column with the sample matrix, and supplying a second reagent to collect the element retained by the column. The method further includes loading the column with a second sample mixture, and collecting an element from the second sample mixture retained by the column. A column configured to separate an element from a sample matrix for isotopic analysis includes a resin configured to retain the element. The column also includes a first frit disposed of a first end of the column and a second frit disposed of a second end of the column. The column is configured to receive a first reagent in a first flow direction and a second reagent in a second flow direction different from the first flow direction.

公开(公告)号：US20170162373A1

公开(公告)日：2017-06-08

申请号：US15368803

申请日：2016-12-05

Applicant: Elemental Scientific, Inc.

Inventor： Paul Field ,  Daniel R. Wiederin ,  Patrick Sullivan

IPC: H01J49/04 ,  G01N1/38 ,  H01J49/10

CPC classification number: G01N1/38 ,  G01N30/00 ,  G01N30/04 ,  G01N35/1097 ,  G01N2035/1032 ,  H01J49/105

Abstract: Systems and methods for inline and automatic dilution of chemicals of interest for speciation and subsequent analysis by ICP spectrometry are described. A system embodiment includes a first valve to receive a sample into a holding loop; a plurality of syringe pumps coupled to the first valve to deliver an inline diluted sample from the first valve; and a second valve coupled to the first valve to receive the inline diluted sample from the first valve into a sample holding loop coupled to the second valve, the second valve configured to couple to at least one of an eluent source or a carrier fluid source to receive at least one of an eluent fluid or a carrier fluid to transfer the inline diluted sample from the sample holding loop to a speciation column to separate one or more species from the inline diluted sample.

公开(公告)号：US09343283B1

公开(公告)日：2016-05-17

申请号：US14830601

申请日：2015-08-19

Applicant: Elemental Scientific, Inc.

Inventor： Paul Field ,  Daniel R. Wiederin ,  Austin Schultz

IPC: H01J49/10 ,  H01J49/00 ,  H01J49/04

CPC classification number: H01J49/105 ,  H01J49/0009

Abstract: A method for internal standardization of cool plasma ICP-MS using one or more enriched stable isotopes includes introducing an enriched stable isotope of a chemical species to a sample containing a non-enriched isotope of the chemical species to form a sample and standard mixture. In implementations, the enriched stable isotope is introduced via an inline syringe addition to a flow of a sample solution containing a non-enriched isotope of the chemical species to be analyzed. The method also includes introducing the sample and standard mixture to an ICP-MS under cool plasma conditions. The method also includes determining an ionization amount of the enriched stable isotope by the ICP-MS. The method further includes correlating an ionization amount of the non-enriched isotope based on the determined ionization amount of the enriched stable isotope.

Abstract translation: 使用一种或多种富集的稳定同位素的冷等离子体ICP-MS的内部标准化方法包括将含有化学物质的富集的稳定同位素引入到含有化学物质的非富集同位素的样品中以形成样品和标准混合物。 在实施方案中，将富集的稳定同位素通过在线注射器加入到含有要分析的化学物质的非富集同位素的样品溶液的流中。 该方法还包括在冷等离子体条件下将样品和标准混合物引入ICP-MS。 该方法还包括通过ICP-MS确定富集的稳定同位素的电离量。 该方法还包括基于所确定的富集的稳定同位素的电离量来关联非富集同位素的电离量。