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    System and method for generating and using cardiac ischemia diagnostics based on arrhythmia precursors and arrhythmia episodes
    1.
    发明授权
    System and method for generating and using cardiac ischemia diagnostics based on arrhythmia precursors and arrhythmia episodes 有权
    基于心律失常前兆和心律失常事件产生和使用心脏缺血诊断的系统和方法

    公开(公告)号：US08204592B1

    公开(公告)日：2012-06-19

    申请号：US11949532

    申请日：2007-12-03

    申请人： Eliot L. Ostrow ,  Jay Snell ,  Xiaoyi Min

    发明人： Eliot L. Ostrow ,  Jay Snell ,  Xiaoyi Min

    IPC分类号： A61N1/36

    CPC分类号： A61B5/0464 ,  A61B5/686 ,  A61N1/36585 ,  A61N1/37258 ,  G06F19/00 ,  G06F19/3418 ,  G06F19/3468 ,  G06F19/3481

    摘要： Techniques are described for generating diagnostic information to aid in determining whether cardiac ischemia within a patient is clinically actionable. In one example, a pacemaker or implantable cardioverter/defibrillator (ICD) detects information pertaining to arrhythmia precursors and to episodes of sustained arrhythmias, as well as information pertaining to episodes of cardiac ischemia. The implanted device then correlates the arrhythmia precursors and the sustained arrhythmias with the episodes of cardiac ischemia so as to generate diagnostics permitting a physician reviewing the diagnostics to determine whether the ischemia is clinically actionable. In some implementations, the diagnostics are instead generated by an external system based on raw data provided by the implanted device. In some implementations, the device itself determines whether the ischemia is clinically actionable and automatically controls therapy or generates warning signals accordingly.

    摘要翻译： 描述了用于产生诊断信息以帮助确定患者心脏缺血是否具有临床可行性的技术。 在一个示例中，起搏器或植入式心律转复除颤器（ICD）检测与心律失常前体有关的信息和持续性心律不齐的发作以及与心脏缺血发作有关的信息。 然后植入的装置将心律失常前体和持续性心律失常与心脏缺血发作相关联，以便产生诊断，允许医师检查诊断以确定缺血是否具有临床可操作性。 在一些实施方式中，诊断代替地由外部系统基于植入设备提供的原始数据生成。 在一些实施方案中，装置本身确定缺血是否具有临床作用并且自动控制治疗或相应地产生警告信号。

    Method and system for discrimination of VT and SVT arrhythmias
    2.
    发明授权
    Method and system for discrimination of VT and SVT arrhythmias 有权
    用于鉴别VT和SVT心律失常的方法和系统

    公开(公告)号：US08670825B2

    公开(公告)日：2014-03-11

    申请号：US13563311

    申请日：2012-07-31

    申请人： Xiaoyi Min ,  Eliot L. Ostrow

    发明人： Xiaoyi Min ,  Eliot L. Ostrow

    IPC分类号： A61N1/00

    CPC分类号： A61N1/3621 ,  A61B5/04012 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/4836 ,  A61N1/395 ,  A61N1/3962

    摘要： Methods and systems are provided for discriminating heart arrhythmias. The methods and systems include identifying an arrhythmia, recording a predetermined number of beats during the arrhythmia as a base arrhythmia (BA) beats; delivering anti-tachy pacing (ATP) therapy to at least one chamber of the heart. After delivering the ATP therapy, the methods and system record at least one return beat representing cardiac activity following the ATP therapy, determines whether the return beat originated in a reference chamber of the heart, compares a morphology of the return beat to a morphology of the BA beat; and declares a VT or SVT based on the comparing operation.

    摘要翻译： 提供方法和系统用于区分心律失常。 方法和系统包括鉴定心律失常，在心律失常期间记录预定数量的搏动作为基础心律失常（BA）; 向心脏至少一个室提供抗速度起搏（ATP）治疗。 在ATP疗法交付之后，方法和系统记录在ATP治疗后代表心脏活动的至少一个返回搏动，确定起搏于心脏的参考室的返回搏动是否将返回搏动的形态与 BA打败 并根据比较操作声明VT或SVT。

    METHOD AND SYSTEM FOR DISCRIMINATION OF VT AND SVT ARRHYTHMIAS
    4.
    发明申请
    METHOD AND SYSTEM FOR DISCRIMINATION OF VT AND SVT ARRHYTHMIAS 有权
    用于辨别VT和SVT ARRHYTHMIAS的方法和系统

    公开(公告)号：US20140039332A1

    公开(公告)日：2014-02-06

    申请号：US13563311

    申请日：2012-07-31

    申请人： Xiaoyi Min ,  Eliot L. Ostrow

    发明人： Xiaoyi Min ,  Eliot L. Ostrow

    IPC分类号： A61B5/0452

    CPC分类号： A61N1/3621 ,  A61B5/04012 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/4836 ,  A61N1/395 ,  A61N1/3962

    摘要： Methods and systems are provided for discriminating heart arrhythmias. The methods and systems include identifying an arrhythmia, recording a predetermined number of beats during the arrhythmia as a base arrhythmia (BA) beats; delivering anti-tachy pacing (ATP) therapy to at least one chamber of the heart. After delivering the ATP therapy, the methods and system record at least one return beat representing cardiac activity following the ATP therapy, determines whether the return beat originated in a reference chamber of the heart, compares a morphology of the return beat to a morphology of the BA beat; and declares a VT or SVT based on the comparing operation.

    摘要翻译： 提供方法和系统用于区分心律失常。 方法和系统包括鉴定心律失常，在心律失常期间记录预定数量的搏动作为基础心律失常（BA）; 向心脏至少一个室提供抗速度起搏（ATP）治疗。 在ATP疗法交付之后，方法和系统记录在ATP治疗后代表心脏活动的至少一个返回搏动，确定起搏于心脏的参考室的返回搏动是否将返回搏动的形态与 BA打败 并根据比较操作声明VT或SVT。

    System and method for efficiently distinguishing among cardiac ischemia, hypoglycemia and hyperglycemia using an implantable medical device and an external system
    6.
    发明授权
    System and method for efficiently distinguishing among cardiac ischemia, hypoglycemia and hyperglycemia using an implantable medical device and an external system 有权
    使用可植入医疗器械和外部系统有效区分心脏缺血，低血糖和高血糖的系统和方法

    公开(公告)号：US07756572B1

    公开(公告)日：2010-07-13

    申请号：US11740175

    申请日：2007-04-25

    申请人： Mohssen Fard ,  Xiaoyi Min ,  Peter Boileau ,  Jong Gill ,  Bing Zhu ,  Jay Snell ,  Laleh Jalali ,  Josh Reiss ,  Gene Bornzin

    发明人： Mohssen Fard ,  Xiaoyi Min ,  Peter Boileau ,  Jong Gill ,  Bing Zhu ,  Jay Snell ,  Laleh Jalali ,  Josh Reiss ,  Gene Bornzin

    IPC分类号： A61B5/0468

    CPC分类号： A61N1/36585 ,  A61B5/0452 ,  A61B5/0468 ,  A61B5/14532 ,  A61N1/36557

    摘要： Techniques are described for efficiently detecting and distinguishing among cardiac ischemia, hypoglycemia or hyperglycemia based on intracardiac electrogram (IEGM) signals. In one example, a preliminary indication of an episode of cardiac ischemia is detected based on shifts in ST segment elevation within the IEGM. In response, the implanted device then records additional IEGM data for transmission to an external system. The external system analyzes the additional IEGM data to confirm the detection of cardiac ischemia using a more sophisticated analysis procedure exploiting additional detection parameters. In particular, the external system uses detection parameters capable of distinguishing hypoglycemia, hyperglycemia and hyperkalemia from cardiac ischemia, such as QTmax and QTend intervals. Alternatively, the more sophisticated analysis procedure may be performed by the device itself, if it is so equipped. Other examples described herein pertain instead to the detection of atrial fibrillation.

    摘要翻译： 描述了基于心脏电图（IEGM）信号来有效检测和区分心脏缺血，低血糖或高血糖的技术。 在一个实例中，基于IEGM内的ST段抬高的移动来检测心脏缺血发作的初步指示。 作为响应，植入的装置然后记录附加的IEGM数据以传输到外部系统。 外部系统使用更复杂的分析程序利用额外的检测参数来分析额外的IEGM数据，以确认心脏缺血的检测。 特别地，外部系统使用能够区分低血糖，高血糖和高血钾从心脏缺血的检测参数，例如QTmax和QTend间期。 或者，如果装置如此装备，则可以由装置本身执行更复杂的分析程序。 本文描述的其它实例代替心房颤动的检测。

    Systems and methods for assessing heart failure and controlling cardiac resynchronization therapy using hybrid impedance measurement configurations
    8.
    发明授权
    Systems and methods for assessing heart failure and controlling cardiac resynchronization therapy using hybrid impedance measurement configurations 有权
    用于评估心力衰竭并使用混合阻抗测量配置控制心脏再同步治疗的系统和方法

    公开(公告)号：US08750981B2

    公开(公告)日：2014-06-10

    申请号：US13217554

    申请日：2011-08-25

    申请人： Gene A. Bornzin ,  Xiaoyi Min ,  Laurence S. Sloman ,  Steve Koh

    发明人： Gene A. Bornzin ,  Xiaoyi Min ,  Laurence S. Sloman ,  Steve Koh

    IPC分类号： A61B5/05 ,  A61B5/053 ,  A61N1/36 ,  A61N1/368 ,  A61B5/0205

    CPC分类号： A61B5/053 ,  A61B5/0205 ,  A61B5/0538 ,  A61B5/686 ,  A61N1/36185 ,  A61N1/3627 ,  A61N1/3686

    摘要： Techniques are provided for use with an implantable medical device for detecting and assessing heart failure and for controlling cardiac resynchronization therapy (CRT) based on impedance signals obtained using hybrid impedance configurations. The hybrid configurations exploit right atrial (RA)-based impedance measurement vectors and/or left ventricular (LV)-based impedance measurement vectors. In one example, current is injected between the device case and a ring electrode in the right ventricle (RV) or RA. RA-based impedance values are measured along vectors between the device case and an RA electrode. LV-based impedance values are measured along vectors between the device case and one or more electrodes of the LV. Heart failure and other cardiac conditions are detected and tracked using the measured impedance values. CRT delay parameters are also optimized based impedance. In this manner, multiple hybrid impedance measurement configurations are exploited whereby different vectors are used to inject current and measure impedance.

    摘要翻译： 提供技术用于可植入医疗装置，用于基于使用混合阻抗配置获得的阻抗信号来检测和评估心力衰竭并用于控制心脏再同步治疗（CRT）。 混合配置利用基于右心房（RA）的阻抗测量向量和/或左心室（LV））的阻抗测量向量。 在一个示例中，电流注入到装置壳体和右心室（RV）或RA中的环形电极之间。 基于RA的阻抗值是沿器件壳体和RA电极之间的矢量测量的。 基于LV的阻抗值在器件壳体和LV的一个或多个电极之间的矢量上测量。 使用测量的阻抗值检测和跟踪心力衰竭和其他心脏状况。 CRT延迟参数也是基于阻抗的优化。 以这种方式，利用多个混合阻抗测量配置，由此使用不同的矢量来注入电流并测量阻抗。

    Implantable lead assembly having a plurality of inductors
    10.
    发明授权
    Implantable lead assembly having a plurality of inductors 有权
    具有多个电感器的可植入引线组件

    公开(公告)号：US08600520B2

    公开(公告)日：2013-12-03

    申请号：US13449897

    申请日：2012-04-18

    申请人： Phong D. Doan ,  Xiaoyi Min ,  Virote Indravudh

    发明人： Phong D. Doan ,  Xiaoyi Min ,  Virote Indravudh

    IPC分类号： A61N1/00

    CPC分类号： A61N1/05 ,  A61N1/086 ,  A61N1/3605 ,  A61N1/362 ,  H01F5/02 ,  H01F2005/025 ,  Y10T29/49002 ,  Y10T29/49071

    摘要： In accordance with an embodiment, an implantable lead assembly is provided comprised of an elongated body including a distal end, a proximal end having a header connector portion for coupling the elongated body with an implantable medical device, and an intermediate segment located between the distal and proximal ends. An intermediate electrode is disposed at the intermediate segment along the elongated body. A conductor is disposed in the elongated body and electrically coupled with the header connector portion and the intermediate electrode. The conductor wound within the intermediate segment to form first and second inductive coils that are axially separated from each other by an inter-coil gap, wherein the first and second inductive coils have different self-resonant frequencies.

    摘要翻译： 根据一个实施例，提供一种可植入引线组件，其包括细长主体，其包括远端，近端具有用于将细长主体与可植入医疗装置连接的插头连接器部分，以及位于远端和 近端 中间电极沿着细长体设置在中间部分。 导体设置在细长主体中并与插头连接器部分和中间电极电耦合。 导体缠绕在中间段内以形成通过线圈间隙彼此轴向分离的第一和第二感应线圈，其中第一和第二感应线圈具有不同的自谐振频率。