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公开(公告)号：US20220387619A2
公开(公告)日：2022-12-08
申请号：US17395369
申请日：2021-08-05
IPC分类号： A61K47/69 , A61K41/00 , A61K39/12 , A61K47/64 , C07K1/13 , C07K14/025 , C07K16/08 , C07K16/32 , A61N5/06 , C12N7/00
摘要： The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules.
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公开(公告)号：US20090181997A1
公开(公告)日：2009-07-16
申请号：US12343245
申请日：2008-12-23
申请人： David GRAYZEL , Robert Ross , John MacDougall
发明人： David GRAYZEL , Robert Ross , John MacDougall
IPC分类号： A61K31/438
CPC分类号： A61K31/00 , A61K31/282 , A61K31/337 , A61K31/4355 , A61K31/7068 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： The invention is directed to use of hedgehog inhibitors in conjunction with chemotherapy in treating cancers, and preventing relapses thereby.
摘要翻译： 本发明涉及使用刺猬蛋白抑制剂与化疗联合治疗癌症，从而防止复发。
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公开(公告)号：US20060014153A1
公开(公告)日：2006-01-19
申请号：US10877346
申请日：2004-06-25
申请人： Valerie Gerlach , John MacDougall , Glennda Smithson , Isabelle Millet , David Stone , Erik Gunther , Karen Ellerman , William Grosse , John Alsobrook , Denise Lepley , Catherine Burgess , Muralidhara Padigaru , Ramesha Kekuda , Kimberly Spytek , Martin Leach , Richard Shimkets
发明人： Valerie Gerlach , John MacDougall , Glennda Smithson , Isabelle Millet , David Stone , Erik Gunther , Karen Ellerman , William Grosse , John Alsobrook , Denise Lepley , Catherine Burgess , Muralidhara Padigaru , Ramesha Kekuda , Kimberly Spytek , Martin Leach , Richard Shimkets
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：US08446572B2
公开(公告)日：2013-05-21
申请号：US10483759
申请日：2004-11-24
申请人： John MacDougall
发明人： John MacDougall
IPC分类号： G01C3/08
CPC分类号： G01J1/0228 , G01J1/0214 , G01J1/4228 , G01J3/0262 , G01J3/027 , G01J3/2803 , G01J3/44
摘要： Described herein is an improved sensing system (30) and its method of operation. The system (30) includes a camera (16) for viewing an external scene, the camera comprising one or more detector(s) and has a field of view (40) which overlaps with the path (32) of a pulsed laser (12). The laser path (32) and radiation from the scene viewed (40) share a beamsplitter (36) and a window (38). In order to substantially reduce back-scattered radiation from the laser path (32) affecting operation of the detector(s) of the camera (16), the detector(s) is (are) switched in accordance with the operation of the laser (12) to be “off” or non-receiving when the laser (12) is “on” or firing.
摘要翻译： 这里描述了改进的感测系统（30）及其操作方法。 所述系统（30）包括用于观看外部场景的相机（16），所述相机包括一个或多个检测器，并具有与脉冲激光器（12）的路径（32）重叠的视场（40） ）。 激光路径（32）和来自场景的辐射（40）共享分束器（36）和窗口（38）。 为了基本上减少影响照相机（16）的检测器的操作的来自激光路径（32）的反向散射的辐射，根据激光的操作来（...）切换检测器（ 12）当激光器（12）“接通”或点火时被“关闭”或不接收。
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公开(公告)号：US20060063200A1
公开(公告)日：2006-03-23
申请号：US11051724
申请日：2005-02-02
申请人： David Anderson , Jason Baumgartner , Ferenc Boldog , Stacie Casman , Shlomit Edinger , Esha Gangolli , Valerie Gerlach , Linda Gorman , Xiaojia Guo , Tord Hjalt , Ramesh Kekuda , Li Li , John MacDougall , Uriel Malyankar , Isabelle Millet , Muralidhara Padigaru , Meera Patturajan , Carol Pena , Luca Rastelli , Richard Shimkets , David Stone , Kimberly Spytek , Corine Vernet , Edward Voss , Bryan Zerhusen
发明人： David Anderson , Jason Baumgartner , Ferenc Boldog , Stacie Casman , Shlomit Edinger , Esha Gangolli , Valerie Gerlach , Linda Gorman , Xiaojia Guo , Tord Hjalt , Ramesh Kekuda , Li Li , John MacDougall , Uriel Malyankar , Isabelle Millet , Muralidhara Padigaru , Meera Patturajan , Carol Pena , Luca Rastelli , Richard Shimkets , David Stone , Kimberly Spytek , Corine Vernet , Edward Voss , Bryan Zerhusen
IPC分类号： G01N33/53 , C07H21/04 , C12P21/06 , C07K14/705 , C07K16/18
摘要： Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：US20060003323A1
公开(公告)日：2006-01-05
申请号：US10453372
申请日：2003-06-03
申请人： John Alsobrook , Enrique Alvarez , David Anderson , Ferenc Boldog , Stacie Casman , Elina Catterton , Andrei Chapoval , Julie Crabtree-Bokor , Shlomit Edinger , Karen Ellerman , Seth Ettenberg , Esha Gangolli , Valerie Gerlach , Linda Gorman , Erik Gunther , Xiaojia (Sasha) Guo , Vladimir Gusev , John Herrmann , Weizhen Ji , Ramesh Kekuda , Li Li , Xiaohong Liu , John MacDougall , Timothy Machlachlan , Uriel Malyankar , Amanda Mezick , Isabelle Millet , Vishnu Mishra , Muralidhara Padigaru , Meera Patturajan , Carol Pena , John Peyman , Debasish Raha , Luca Rastelli , Daniel Rieger , Mark Rothenberg , Paul Sciore , Suresh Shenoy , Richard Shimkets , Glennda Smithson , Kimberly Spytek , David Stone , Corine Vernet , Edward Voss , Mei Zhong , Hiahong Zhong
发明人： John Alsobrook , Enrique Alvarez , David Anderson , Ferenc Boldog , Stacie Casman , Elina Catterton , Andrei Chapoval , Julie Crabtree-Bokor , Shlomit Edinger , Karen Ellerman , Seth Ettenberg , Esha Gangolli , Valerie Gerlach , Linda Gorman , Erik Gunther , Xiaojia (Sasha) Guo , Vladimir Gusev , John Herrmann , Weizhen Ji , Ramesh Kekuda , Li Li , Xiaohong Liu , John MacDougall , Timothy Machlachlan , Uriel Malyankar , Amanda Mezick , Isabelle Millet , Vishnu Mishra , Muralidhara Padigaru , Meera Patturajan , Carol Pena , John Peyman , Debasish Raha , Luca Rastelli , Daniel Rieger , Mark Rothenberg , Paul Sciore , Suresh Shenoy , Richard Shimkets , Glennda Smithson , Kimberly Spytek , David Stone , Corine Vernet , Edward Voss , Mei Zhong , Hiahong Zhong
IPC分类号： C12Q1/68
CPC分类号： C07K14/47 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：US20050260713A1
公开(公告)日：2005-11-24
申请号：US11113424
申请日：2005-04-21
申请人： Esha Gangolli , Meera Patturajan , Corine Vernet , Uriel Malyankar , Ramesh Kekuda , David Stone , David Anderson , Richard Shimkets , Catherine Burgess , Bryan Zerhusen , Xiaohong Liu , Kimberly Spytek , Stacie Casman , Ference Boldog , Glennda Smithson , Li Li , Weizhen Ji , John MacDougall
发明人： Esha Gangolli , Meera Patturajan , Corine Vernet , Uriel Malyankar , Ramesh Kekuda , David Stone , David Anderson , Richard Shimkets , Catherine Burgess , Bryan Zerhusen , Xiaohong Liu , Kimberly Spytek , Stacie Casman , Ference Boldog , Glennda Smithson , Li Li , Weizhen Ji , John MacDougall
CPC分类号： C07K14/47 , A61K38/00 , G01N2500/04
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译： 本文公开了编码新型多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。
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8.发明申请公开(公告)号：US20050053930A1
公开(公告)日：2005-03-10
申请号：US10454246
申请日：2003-06-03
申请人： David Anderson , Ferenc Boldog , Catherine Burgess , Stacie Casman , Shlomit Edinger , Andrew Eisen , Karen Ellerman , Valerie Gerlach , Linda Gorman , Xiaojia Guo , Vladimir Gusev , Weizhen Ji , Li Li , John MacDougall , Uriel Malyankar , Isabelle Millet , Tatiana Ort , Muralidhara Padigaru , Sudhirdas Prayaga , Meera Patturajan , Carol Pena , John Peyman , Daniel Rieger , Mark Rothenberg , Paul Sciore , Suresh Shenoy , Glennda Smithson , Kimberly Spytek , David Stone , Raymond Taupier , Velizar Tchernev , Corine Vernet , Edward Voss , Bryan Zerhusen , Mei Zhong
发明人： David Anderson , Ferenc Boldog , Catherine Burgess , Stacie Casman , Shlomit Edinger , Andrew Eisen , Karen Ellerman , Valerie Gerlach , Linda Gorman , Xiaojia Guo , Vladimir Gusev , Weizhen Ji , Li Li , John MacDougall , Uriel Malyankar , Isabelle Millet , Tatiana Ort , Muralidhara Padigaru , Sudhirdas Prayaga , Meera Patturajan , Carol Pena , John Peyman , Daniel Rieger , Mark Rothenberg , Paul Sciore , Suresh Shenoy , Glennda Smithson , Kimberly Spytek , David Stone , Raymond Taupier , Velizar Tchernev , Corine Vernet , Edward Voss , Bryan Zerhusen , Mei Zhong
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译： 本文公开了编码新型多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体，以及多肽特异性的新型多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。
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公开(公告)号：US06600019B2
公开(公告)日：2003-07-29
申请号：US09755665
申请日：2001-01-04
申请人： Sudhirdas K. Prayaga , Kumud Majumder , Bruce Taillon , Steven Kurt Spaderna , Kimberly Spytek , John MacDougall
发明人： Sudhirdas K. Prayaga , Kumud Majumder , Bruce Taillon , Steven Kurt Spaderna , Kimberly Spytek , John MacDougall
IPC分类号： C07K1447
CPC分类号： C07K14/47 , A61K38/00 , A61K2039/505 , C07K14/8121 , C07K16/18 , C12N9/1205
摘要： The present invention provides novel isolated NOVX polynucleotides and polypeptides encoded by the NOVX polynucleotides. Also provided are the antibodies that immunospecifically bind to a NOVX polypeptide or any derivative, variant, mutant or fragment of the NOVX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the NOVX polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.
摘要翻译： 本发明提供新的分离的NOVX多核苷酸和由NOVX多核苷酸编码的多肽。 还提供免疫特异性结合NOVX多肽或NOVX多肽，多核苷酸或抗体的任何衍生物，变体，突变体或片段的抗体。 本发明还提供了其中使用NOVX多肽，多核苷酸和抗体来检测和治疗广泛的病理状态以及其它用途的方法。
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公开(公告)号：US4622905A
公开(公告)日：1986-11-18
申请号：US707796
申请日：1985-03-04
申请人： John MacDougall , John K. Pargeter
发明人： John MacDougall , John K. Pargeter
CPC分类号： C22B5/10 , C21B13/105 , C22B1/2406 , C22B23/021 , Y02P10/136
摘要： Discloses an improvement in furnacing objects on the top surface of an impervious rotating hearth in a directly fired rotary hearth furnace by the use of fuel burning with a luminous flame e.g., coal.
摘要翻译： 公开了通过使用用发光火焰例如煤燃烧的燃料在直接燃烧的转底炉中的不透水旋转炉床的顶面上提供物品的改进。
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