摘要:
The present invention is directed to novel 2-amino-3,4-dihydro-quinazoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of β-secretase, also known as β-site cleaving enzyme and BACE.
摘要:
A sensor array for nondestructively monitoring a structure to detect a critical event. The sensor array includes a plurality of discrete sensor nodes, each of the discrete sensor nodes producing an electrical signal in response to a structural event. In the preferred embodiment, the sensor nodes include a plurality of piezoceramic fibers arranged in a planar array in which the fibers are aligned substantially parallel to each other, each of the fibers having a plurality of polarized regions that are substantially oriented according to their polarity in either a series, parallel, or combined arrangement of series and parallel orientations, and an electrical interface connecting the plurality of polarized regions of each fiber in series with one another. A signal adder receives and combines the electrical signals from each of the discrete sensor nodes to form a single sensor array output signal. In the preferred embodiment, the electrical interface further includes at least one electrical bus substantially aligned with the fibers and a signal processing module for receiving and processing the single sensor output signal. The signal processing module is linked through the digital data bus to a central processing unit. The plurality of discrete sensor nodes may further be divided into discrete subgroups, each located at a different structural location to provide a degree of sensing and determining the location of the structural event. In the preferred embodiment, the discrete sensor nodes are electrically connected in series, thereby forming a continuous series connection between each of the discrete sensor nodes to improve the likelihood that a critical structural event will be detected.
摘要:
A method of forming a carbon nanotube array on a substrate is disclosed. One embodiment of the method comprises depositing a composite catalyst layer on the substrate, oxidizing the composite catalyst layer, reducing the oxidized composite catalyst layer, and growing the array on the composite catalyst layer. The composite catalyst layer may comprise a group VIII element and a non-catalytic element deposited onto the substrate from an alloy. In another embodiment, the composite catalyst layer comprises alternating layers of iron and a lanthanide, preferably gadolinium or lanthanum. The composite catalyst layer may be reused to grow multiple carbon nanotube arrays without additional processing of the substrate. The method may comprise bulk synthesis by forming carbon nanotubes on a plurality of particulate substrates having a composite catalyst layer comprising the group VIII element and the non-catalytic element. In another embodiment, the composite catalyst layer is deposited on both sides of the substrate.
摘要:
The present invention relates to certain novel compounds of Formula (I): and methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of prokineticin 1 or prokinetin 1 receptor mediated disorders.
摘要:
The present invention relates to certain novel compounds of Formula (I): and methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of prokineticin 1 or prokinetin 1 receptor mediated disorders.
摘要:
The invention is directed to compounds and methods of synthesizing hydroxyethlamino amides and their use in treatment of aspartyl protease mediated diseases and conditions.
摘要:
A method of forming a carbon nanotube array substrate is disclosed. One embodiment comprises depositing a composite catalyst layer on the substrate, oxidizing the composite catalyst layer, reducing the oxidized composite catalyst layer, and growing the array on the composite catalyst layer. The composite catalyst layer may comprise a group VIII element and a non-catalytic element deposited onto the substrate from an alloy. In another embodiment, the composite catalyst layer comprises alternating layers of iron and a lanthanide, preferably gadolinium or lanthanum. The composite catalyst layer may be reused to grow multiple carbon nanotube arrays without additional processing of the substrate. The method may comprise bulk synthesis by forming carbon nanotubes on a plurality of particulate substrates having a composite catalyst layer comprising the group VIII element and the non-catalytic element. In another embodiment, the composite catalyst layer is deposited on both sides of the substrate.
摘要:
The invention is directed to compounds and methods of synthesizing hydroxyethlamino amides and their use in treatment of aspartyl protease mediated diseases and conditions.
摘要:
The invention is directed to compounds and methods of synthesizing hydroxyethlamino amides and their use in treatment of aspartyl protease mediated diseases and conditions.
摘要:
Sensor assemblies for non-destructively monitoring a structure to detect a structural event include a plurality of sensor nodes configured to provide at least one sensor signal responsive to a structural event. A signal analyzer is configured to compare the sensor signal to a reference database of signal characteristics corresponding to respective structural events.