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    FUNCTIONAL-IMAGING-BASED ABLATION MONITORING
    1.
    发明申请
    FUNCTIONAL-IMAGING-BASED ABLATION MONITORING 有权
    基于功能成像的ABIATION监测

    公开(公告)号：US20140088418A1

    公开(公告)日：2014-03-27

    申请号：US14007029

    申请日：2012-03-27

    申请人： Emil Radulescu ,  Sheng-Wen Huang ,  Ramon Erkamp ,  Ladislav Jankovic ,  Yan Shi ,  Khalid Shahzad

    发明人： Emil Radulescu ,  Sheng-Wen Huang ,  Ramon Erkamp ,  Ladislav Jankovic ,  Yan Shi ,  Khalid Shahzad

    IPC分类号： A61B5/00 ,  A61B18/18 ,  A61B18/14 ,  A61K49/00

    CPC分类号： A61B5/4836 ,  A61B5/0044 ,  A61B5/0059 ,  A61B5/0084 ,  A61B5/0095 ,  A61B5/6852 ,  A61B5/742 ,  A61B18/1492 ,  A61B18/18 ,  A61B2018/00577 ,  A61B2090/378 ,  A61B2576/00 ,  A61K49/0002

    摘要： Functional imaging for localization in biological tissue entails measuring a response in the tissue (240) to electromagnetic radiation. A catheter (200) for real-time monitoring of cardiac ablation is employed to distinguish a hemorrhage zone (232) from the sandwiching necrotic and healthy tissue, or to distinguish exogenous photoacoustic contrast agent from bordering native tissue. A pair of wavelengths is selected for differential absorption (244) of the radiation in, correspondingly, the hemorrhage zone or where the contrast agent exists, and relatively similar absorption elsewhere. Near infrared laser or LED light may be used photoacoustically to serially acquire (S310, S320) the two datasets to be compared, each representative of a time waveform. Alternatively, acquisition is for a pair of wavelength bands of microwave-induced thermoacoustic data. In either case, the members of the dataset pair are combined (110, 122) by subtraction or division to effect the piece-wise cancellation/enhancement for display (218) of the resulting signal in real time.

    摘要翻译： 用于在生物组织中定位的功能成像需要测量组织（240）中的电磁辐射的响应。 用于实时监测心脏消融的导管（200）用于区分出血区域（232）与夹心的坏死和健康组织，或区分外源光声造影剂与边界的天然组织。 选择一对波长用于相应地出血区域或存在造影剂的辐射的差异吸收（244）以及其他地方相对相似的吸收。 可以使用近红外激光器或LED光源来连续采集要比较的两个数据集（S310，S320），每个代表一个时间波形。 或者，采集是用于微波诱导的热声数据的一对波段。 在任一情况下，数据集对的成员通过减法或除法组合（110,122）以实现分段取消/增强以实时显示（218）所得到的信号。

    Apparatus, systems and methods for production and integration of compact illumination schemes
    4.
    发明授权
    Apparatus, systems and methods for production and integration of compact illumination schemes 有权
    用于生产和集成小型照明方案的设备，系统和方法

    公开(公告)号：US08677829B2

    公开(公告)日：2014-03-25

    申请号：US12738020

    申请日：2008-10-13

    申请人： Khalid Shahzad ,  Ladislav Jankovic

    发明人： Khalid Shahzad ,  Ladislav Jankovic

    IPC分类号： G01H9/00 ,  G02B27/14

    CPC分类号： G01N21/1702 ,  A61B5/0059 ,  A61B5/0095 ,  A61B5/02007 ,  A61B2562/146 ,  G01N21/255 ,  G01N2021/1782 ,  G01N2021/1785 ,  G01N2201/0221 ,  G01N2201/0636 ,  G01N2201/0666 ,  G01N2291/02466 ,  G01N2291/02475 ,  G01N2291/106 ,  G02B6/4203 ,  G02B27/283

    摘要： Apparatus, systems and methods are provided for production and integration of compact illumination schemes. More particularly, disclosed embodiments relate to apparatus/systems and methods for production of highly compact illumination schemes, whereby photoacoustic waves are induced in a target sample. Additionally, the disclosed apparatus/systems and methods are effective to produce compact and portable integrated transducer-illumination arrays. Apparatus disclosed generally include at least one lighting source and a beamsplitting assembly. Systems disclosed generally include one or more apparatus for the production of compact lighting schemes, an ultrasonic transducer assembly and means for coupling the one or more apparatus and US transducer assembly with a target sample.

    摘要翻译： 提供了用于紧凑照明方案的生产和集成的装置，系统和方法。 更具体地，所公开的实施例涉及用于生产高度紧凑的照明方案的装置/系统和方法，由此在目标样品中感应光声波。 此外，所公开的装置/系统和方法对于产生紧凑且便携的集成换能器照明阵列是有效的。 公开的装置通常包括至少一个照明源和分束组件。 公开的系统通常包括用于生产紧凑照明方案的一个或多个装置，超声换能器组件以及用于将一个或多个装置和US换能器组件与目标样品联接的装置。

    APPARATUS, SYSTEMS AND METHODS FOR PRODUCTION AND INTEGRATION OF COMPACT ILLUMINATION SCHEMES
    6.
    发明申请
    APPARATUS, SYSTEMS AND METHODS FOR PRODUCTION AND INTEGRATION OF COMPACT ILLUMINATION SCHEMES 有权
    装置，制造和集成紧凑照明方案的装置，系统和方法

    公开(公告)号：US20100229650A1

    公开(公告)日：2010-09-16

    申请号：US12738020

    申请日：2008-10-13

    申请人： Khalid Shahzad ,  Ladislav Jankovic

    发明人： Khalid Shahzad ,  Ladislav Jankovic

    IPC分类号： G01H9/00 ,  G02B27/14

    CPC分类号： G01N21/1702 ,  A61B5/0059 ,  A61B5/0095 ,  A61B5/02007 ,  A61B2562/146 ,  G01N21/255 ,  G01N2021/1782 ,  G01N2021/1785 ,  G01N2201/0221 ,  G01N2201/0636 ,  G01N2201/0666 ,  G01N2291/02466 ,  G01N2291/02475 ,  G01N2291/106 ,  G02B6/4203 ,  G02B27/283

    摘要： Apparatus, systems and methods are provided for production and integration of compact illumination schemes. More particularly, disclosed embodiments relate to apparatus/systems and methods for production of highly compact illumination schemes, whereby photoacoustic waves are induced in a target sample. Additionally, the disclosed apparatus/systems and methods are effective to produce compact and portable integrated transducer-illumination arrays. Apparatus disclosed generally include at least one lighting source and a beamsplitting assembly. Systems disclosed generally include one or more apparatus for the production of compact lighting schemes, an ultrasonic transducer assembly and means for coupling the one or more apparatus and US transducer assembly with a target sample.

    摘要翻译： 提供了用于紧凑照明方案的生产和集成的装置，系统和方法。 更具体地，所公开的实施例涉及用于生产高度紧凑的照明方案的装置/系统和方法，由此在目标样品中感应光声波。 此外，所公开的装置/系统和方法对于产生紧凑且便携的集成换能器照明阵列是有效的。 公开的装置通常包括至少一个照明源和分束组件。 公开的系统通常包括用于生产紧凑照明方案的一个或多个装置，超声换能器组件以及用于将一个或多个装置和US换能器组件与目标样品联接的装置。

    System and method for elimination of scattered side lobes created by integrator lenslet arrays
    7.
    发明授权
    System and method for elimination of scattered side lobes created by integrator lenslet arrays 失效
    用于消除由积分器小透镜阵列产生的散射旁瓣的系统和方法

    公开(公告)号：US06469834B1

    公开(公告)日：2002-10-22

    申请号：US09713847

    申请日：2000-11-16

    申请人： Khalid Shahzad ,  Jeffrey A. Shimizu ,  John Domm

    发明人： Khalid Shahzad ,  Jeffrey A. Shimizu ,  John Domm

    IPC分类号： G03B2710

    CPC分类号： G02B27/0927 ,  G02B3/0056 ,  G02B27/0961

    摘要： An optical illumination apparatus includes an illumination source, a pair of spaced integrator plates each having a plurality of lenslets, a conduit array, having a respective aperture corresponding to a plurality of the lenslets disposed there between, with non-reflective optically absorptive walls, and a relay optical structure for integrating light emitted from said second array of lenslets on a focal plane. The apparatus is employed by illuminating a first integrator plate having lenslets, subject to spatial intensity variations, segregating light from each respective lenslet with an elongated baffle, having a respective aperture for each of a plurality of respective lenslets, capturing light from each aperture with a second integrator plate having lenslets, and relaying the light to a focal plane, whereby light rays impinging on the walls of the elongated baffle are not transmitted through the aperture, thus substantially attenuating light rays having acute angles, to uniformly illuminate the focal plane.

    摘要翻译： 一种光学照明装置，包括照明源，一对隔开的积分器板，每个均具有多个小透镜，导管阵列具有与设置在其间的多个小透镜对应的相应孔径，与非反射光学吸收壁之间，以及 用于将从所述第二阵列的小透镜发射的光积分在焦平面上的中继光学结构。 通过照射具有小透镜的第一积分器板，经受空间强度变化，使用具有细长挡板的每个相应小透镜的光分离，具有用于多个相应小透镜中的每一个的相应光圈的装置， 第二积分器板具有小透镜，并且将光中继到焦平面，由此入射到细长挡板的壁上的光线不透过孔径，从而基本衰减具有锐角的光线，以均匀地照射焦平面。

    IMAGING SYSTEM FOR IMAGING A VISCOELASTIC MEDIUM
    8.
    发明申请
    IMAGING SYSTEM FOR IMAGING A VISCOELASTIC MEDIUM 审中-公开
    用于成像粘贴介质的成像系统

    公开(公告)号：US20120086789A1

    公开(公告)日：2012-04-12

    申请号：US13377936

    申请日：2010-06-15

    申请人： Khalid Shahzad ,  Ajay Anand ,  John Petruzzello ,  Shiwei Zhou ,  Jan Frederik Suijver

    发明人： Khalid Shahzad ,  Ajay Anand ,  John Petruzzello ,  Shiwei Zhou ,  Jan Frederik Suijver

    IPC分类号： H04N7/18

    CPC分类号： G10K11/30 ,  A61B5/0053 ,  A61B8/12 ,  A61B8/4281 ,  A61B8/445 ,  A61B18/1492 ,  A61B2090/378 ,  G01S15/8911

    摘要： An imaging system for imaging a viscoelastic medium is disclosed. The imaging system comprises a variable refractive lens (4) and a transducer system (5) for generating acoustic radiation. The imaging system is operated to alternate between first and second operating modes. While the variable refractive lens is operated to alternate between a first configuration and a second configuration, the transducer is operated to alternate between generating acoustic radiation for displacing the viscoelastic medium and acoustic radiation for imaging the displacement of the viscoelastic medium. In embodiments the variable refractive lens is a fluid focus lens. Moreover, in embodiments, the imaging system is integrated with a catheter-based interaction modality, such as a tissue ablation modality.

    摘要翻译： 公开了一种用于对粘弹性介质进行成像的成像系统。 成像系统包括可变折射透镜（4）和用于产生声辐射的换能器系统（5）。 操作成像系统以在第一和第二操作模式之间交替。 当可变折射透镜被操作以在第一配置和第二配置之间交替时，换能器被操作以在产生用于移动粘弹性介质的声辐射和用于成像粘弹介质的位移成像的声辐射之间交替。 在实施例中，可变折射透镜是流体聚焦透镜。 此外，在实施例中，成像系统与基于导管的相互作用模式（例如组织消融模态）整合。

    Achromatic apparatus for producing a wavelength-independent high contrast light signal
    9.
    发明授权
    Achromatic apparatus for producing a wavelength-independent high contrast light signal 失效
    用于产生与波长无关的高对比度光信号的消色差设备

    公开(公告)号：US06686975B2

    公开(公告)日：2004-02-03

    申请号：US09852871

    申请日：2001-05-10

    申请人： Duncan J. Anderson ,  Khalid Shahzad

    发明人： Duncan J. Anderson ,  Khalid Shahzad

    IPC分类号： G02F11335

    CPC分类号： G02F1/13363 ,  G02F2001/13355 ,  G02F2203/04 ,  G02F2413/02 ,  H04N5/7416

    摘要： An apparatus for improved contrast in projection optical systems consists of a polarizing beam splitter (PBS) in combination with two or more waveplates whose fast exes are aligned perpendicular to each other. The apparatus has an effective broadband frequency response that is better than that of the individual retarders acting alone, and through the selection of a birefringence factor and thickness of the individual retarders, wavelength dependencies are minimized.

    摘要翻译： 用于改善投影光学系统中的对比度的装置包括与两个或更多个波片相结合的偏振分束器（PBS），其中快速扫描线彼此垂直对准。 该装置具有比单独作用的单个缓速器更好的有效宽带频率响应，并且通过选择单个延迟器的双折射因子和厚度，波长依赖性被最小化。

    Image display system
    10.
    发明授权
    Image display system 失效

    公开(公告)号：US06669343B2

    公开(公告)日：2003-12-30

    申请号：US09867485

    申请日：2001-05-31

    申请人： Khalid Shahzad ,  Jeffrey A. Shimizu

    发明人： Khalid Shahzad ,  Jeffrey A. Shimizu

    IPC分类号： G03B2114

    CPC分类号： H04N9/3117

    摘要： An image display system utilizes primarily non-absorptive polarization components to polarize light illuminating an imaging device. The non-absorptive polarization components reduce cost and cooling requirements, increase durability, and permit the use of high powered light sources.