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公开(公告)号：US20170226478A1
公开(公告)日：2017-08-10
申请号：US15458185
申请日：2017-03-14
Applicant: EMULATE, INC. , CEDARS-SINAI MEDICAL CENTER
Inventor： Jordan Kerns , Norman Wen , Geraldine Hamilton , Christopher Hinojosa , Jacob Fraser , Catherine Karalis , Janna Nawroth , Dhruv Sareen , Anjoscha Kaus , Berhan Mandefro , Hyoung Shin Park , Ville Kujala
IPC: C12N5/0793 , B01L3/00 , C12N5/077
CPC classification number: C12N5/0619 , C12M23/16 , C12N5/0658 , C12N2502/083 , C12N2506/45 , C12N2531/00 , C12N2533/52
Abstract: The invention relates to culturing motor neuron cells together with skeletal muscle cells in a fluidic device under conditions whereby the interaction of these cells mimic the structure and function of the neuromuscular junction (NMJ) providing a NMJ-on-chip. Good viability, formation of myo-fibers and function of skeletal muscle cells on fluidic chips allow for measurements of muscle cell contractions. Embodiments of motor neurons co-cultures with contractile myo-fibers are contemplated for use with modeling diseases affecting NMJ's, e.g. Amyotrophic lateral sclerosis (ALS).
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公开(公告)号：US20180024120A1
公开(公告)日：2018-01-25
申请号：US15648352
申请日：2017-07-12
Applicant: Emulate Inc.
Inventor： Daniel Levner , Kyung Jin Jang , Jacob Fraser , Jordan Kerns , Antonio Varone , Dongeun Huh
CPC classification number: G01N33/5032 , C12M23/16 , C12M23/20 , C12M25/02 , C12N5/0018 , C12N5/0068 , C12N5/0658 , C12N5/067 , C12N2500/32 , C12N2521/00 , C12N2533/30 , C12N2533/50 , C12N2533/52 , C12N2533/54 , C12N2533/90 , C12N2535/10 , C12N2537/10 , G01N33/5014 , G01N33/5044
Abstract: Compositions, devices and methods are described for improving adhesion, attachment, and/or differentiation of cells in a microfluidic device or chip. In one embodiment, one or more ECM proteins are covalently coupled to the surface of a microchannel of a microfluidic device. The microfluidic devices can be stored or used immediately for culture and/or support of living cells such as mammalian cells, and/or for simulating a function of a tissue, e.g., a liver tissue, muscle tissue, etc. Extended adhesion and viability with sustained function over time is observed.
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公开(公告)号：US20180024117A1
公开(公告)日：2018-01-25
申请号：US15648293
申请日：2017-07-12
Applicant: Emulate Inc.
Inventor： Daniel Levner , Kyung Jin Jang , Jacob Frase , Jordan Kerns , Antonio Varone , Dongeun Huh
CPC classification number: G01N33/5032 , C12M23/16 , C12M23/20 , C12M25/02 , C12N5/0018 , C12N5/0068 , C12N5/0658 , C12N5/067 , C12N2500/32 , C12N2521/00 , C12N2533/30 , C12N2533/50 , C12N2533/52 , C12N2533/54 , C12N2533/90 , C12N2535/10 , C12N2537/10 , G01N33/5014 , G01N33/5044
Abstract: Compositions, devices and methods are described for improving adhesion, attachment, and/or differentiation of cells in a microfluidic device or chip. In one embodiment, one or more ECM proteins are covalently coupled to the surface of a microchannel of a microfluidic device. The microfluidic devices can be stored or used immediately for culture and/or support of living cells such as mammalian cells, and/or for simulating a function of a tissue, e.g., a liver tissue, muscle tissue, etc. Extended adhesion and viability with sustained function over time is observed.
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Patent Agency Ranking
公开(公告)号：US20180057788A1
公开(公告)日：2018-03-01
申请号：US15352289
申请日：2016-11-15
Applicant: EMULATE, INC. , CEDARS-SINAI MEDICAL CENTER
Inventor： Jordan Kerns , Norman Wen , Carol Lucchesi , Christopher Hinojosa , Jacob Fraser , Geraldine Hamilton , Gad Vatine , Sam Sances , Clive Svendsen , Daniel Levner , Dhruv Sareen
IPC: C12N5/00 , C12N5/0797 , B01L3/00
CPC classification number: C12N5/0068 , B01L3/502715 , B01L2300/044 , B01L2300/0858 , B01L2300/123 , C12M23/16 , C12M25/02 , C12N5/0623 , C12N5/069 , C12N2502/088 , C12N2531/00 , C12N2535/10 , C12N2539/00
Abstract: The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems.
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公开(公告)号：US20180024119A1
公开(公告)日：2018-01-25
申请号：US15648319
申请日：2017-07-12
Applicant: Emulate Inc.
Inventor： Daniel Levner , Kyung Jin Jang , Jacob Fraser , Jordan Kerns , Antonio Varone , Dongeun Huh
CPC classification number: G01N33/5032 , C12M23/16 , C12M23/20 , C12M25/02 , C12N5/0018 , C12N5/0068 , C12N5/0658 , C12N5/067 , C12N2500/32 , C12N2521/00 , C12N2533/30 , C12N2533/50 , C12N2533/52 , C12N2533/54 , C12N2533/90 , C12N2535/10 , C12N2537/10 , G01N33/5014 , G01N33/5044
Abstract: Compositions, devices and methods are described for improving adhesion, attachment, and/or differentiation of cells in a microfluidic device or chip. In one embodiment, one or more ECM proteins are covalently coupled to the surface of a microchannel of a microfluidic device. The microfluidic devices can be stored or used immediately for culture and/or support of living cells such as mammalian cells, and/or for simulating a function of a tissue, e.g., a liver tissue, muscle tissue, etc. Extended adhesion and viability with sustained function over time is observed.
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公开(公告)号：US20180024118A1
公开(公告)日：2018-01-25
申请号：US15648306
申请日：2017-07-12
Applicant: Emulate Inc.
Inventor： Daniel Levner , Kyung Jin Jang , Jacob Fraser , Jordan Kerns , Antonio Varone , Dongeun Huh
CPC classification number: G01N33/5032 , C12M23/16 , C12M23/20 , C12M25/02 , C12N5/0018 , C12N5/0068 , C12N5/0658 , C12N5/067 , C12N2500/32 , C12N2521/00 , C12N2533/30 , C12N2533/50 , C12N2533/52 , C12N2533/54 , C12N2533/90 , C12N2535/10 , C12N2537/10 , G01N33/5014 , G01N33/5044
Abstract: Compositions, devices and methods are described for improving adhesion, attachment, and/or differentiation of cells in a microfluidic device or chip. In one embodiment, one or more ECM proteins are covalently coupled to the surface of a microchannel of a microfluidic device. The microfluidic devices can be stored or used immediately for culture and/or support of living cells such as mammalian cells, and/or for simulating a function of a tissue, e.g., a liver tissue, muscle tissue, etc. Extended adhesion and viability with sustained function over time is observed.
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公开(公告)号：US20180024116A1
公开(公告)日：2018-01-25
申请号：US15648213
申请日：2017-07-12
Applicant: Emulate Inc.
Inventor： Daniel Levner , Kyung Jin Jang , Jacob Fraser , Jordan Kerns , Antonio Varone , Dongeun Huh
CPC classification number: G01N33/5032 , C12M23/16 , C12M23/20 , C12M25/02 , C12N5/0018 , C12N5/0068 , C12N5/0658 , C12N5/067 , C12N2500/32 , C12N2521/00 , C12N2533/30 , C12N2533/50 , C12N2533/52 , C12N2533/54 , C12N2533/90 , C12N2535/10 , C12N2537/10 , G01N33/5014 , G01N33/5044
Abstract: Compositions, devices and methods are described for improving adhesion, attachment, and/or differentiation of cells in a microfluidic device or chip. In one embodiment, one or more ECM proteins are covalently coupled to the surface of a microchannel of a microfluidic device. The microfluidic devices can be stored or used immediately for culture and/or support of living cells such as mammalian cells, and/or for simulating a function of a tissue, e.g., a liver tissue, muscle tissue, etc. Extended adhesion and viability with sustained function over time is observed.
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公开(公告)号：US20180023050A1
公开(公告)日：2018-01-25
申请号：US15648339
申请日：2017-07-12
Applicant: Emulate Inc.
Inventor： Daniel Levner , Kyung Jin Jang , Jacob Fraser , Jordan Kerns , Antonio Varone , Dongeun Huh
CPC classification number: G01N33/5032 , C12M23/16 , C12M23/20 , C12M25/02 , C12N5/0018 , C12N5/0068 , C12N5/0658 , C12N5/067 , C12N2500/32 , C12N2521/00 , C12N2533/30 , C12N2533/50 , C12N2533/52 , C12N2533/54 , C12N2533/90 , C12N2535/10 , C12N2537/10 , G01N33/5014 , G01N33/5044
Abstract: Compositions, devices and methods are described for improving adhesion, attachment, and/or differentiation of cells in a microfluidic device or chip. In one embodiment, one or more ECM proteins are covalently coupled to the surface of a microchannel of a microfluidic device. The microfluidic devices can be stored or used immediately for culture and/or support of living cells such as mammalian cells, and/or for simulating a function of a tissue, e.g., a liver tissue, muscle tissue, etc. Extended adhesion and viability with sustained function over time is observed.
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