公开(公告)号：US11733234B2

公开(公告)日：2023-08-22

申请号：US15648339

申请日：2017-07-12

Applicant: Emulate Inc.

Inventor： Daniel Levner ,  Kyung Jin Jang ,  Jacob Fraser ,  S. Jordan Kerns ,  Antonio Varone ,  Dongeun Huh

IPC: C12N5/00 ,  C12N5/02 ,  A61K38/00 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07K7/00 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00 ,  G01N33/50 ,  C07K14/78 ,  C12N5/071 ,  C12M3/06 ,  C12M1/00 ,  C12M1/12 ,  C12N5/077

CPC classification number: G01N33/5032 ,  C07K2/00 ,  C07K14/78 ,  C12M23/16 ,  C12M23/20 ,  C12M25/02 ,  C12N5/0018 ,  C12N5/0068 ,  C12N5/067 ,  C12N5/0658 ,  G01N33/5014 ,  C12N2500/32 ,  C12N2521/00 ,  C12N2533/30 ,  C12N2533/50 ,  C12N2533/52 ,  C12N2533/54 ,  C12N2533/90 ,  C12N2535/10 ,  C12N2537/10 ,  G01N33/5044

Abstract: Compositions, devices and methods are described for improving adhesion, attachment, and/or differentiation of cells in a microfluidic device or chip. In one embodiment, one or more ECM proteins are covalently coupled to the surface of a microchannel of a microfluidic device. The microfluidic devices can be stored or used immediately for culture and/or support of living cells such as mammalian cells, and/or for simulating a function of a tissue, e.g., a liver tissue, muscle tissue, etc. Extended adhesion and viability with sustained function over time is observed.

公开(公告)号：US11506652B2

公开(公告)日：2022-11-22

申请号：US15648293

申请日：2017-07-12

Applicant: Emulate Inc.

Inventor： Daniel Levner ,  Kyung JIn Jang ,  Jacob Fraser ,  S. Jordan Kerns ,  Antonio Varone ,  Dongeun Huh

IPC: C12N5/00 ,  C12N5/02 ,  A61K38/00 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07K7/00 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00 ,  G01N33/50 ,  C07K14/78 ,  C12N5/071 ,  C12M3/06 ,  C12M1/00 ,  C12M1/12 ,  C12N5/077

Abstract: Compositions, devices and methods are described for improving adhesion, attachment, and/or differentiation of cells in a microfluidic device or chip. In one embodiment, one or more ECM proteins are covalently coupled to the surface of a microchannel of a microfluidic device. The microfluidic devices can be stored or used immediately for culture and/or support of living cells such as mammalian cells, and/or for simulating a function of a tissue, e.g., a liver tissue, muscle tissue, etc. Extended adhesion and viability with sustained function over time is observed.

公开(公告)号：US20180024120A1

公开(公告)日：2018-01-25

申请号：US15648352

申请日：2017-07-12

Applicant: Emulate Inc.

Inventor： Daniel Levner ,  Kyung Jin Jang ,  Jacob Fraser ,  Jordan Kerns ,  Antonio Varone ,  Dongeun Huh

IPC: G01N33/50 ,  C12N5/00

CPC classification number: G01N33/5032 ,  C12M23/16 ,  C12M23/20 ,  C12M25/02 ,  C12N5/0018 ,  C12N5/0068 ,  C12N5/0658 ,  C12N5/067 ,  C12N2500/32 ,  C12N2521/00 ,  C12N2533/30 ,  C12N2533/50 ,  C12N2533/52 ,  C12N2533/54 ,  C12N2533/90 ,  C12N2535/10 ,  C12N2537/10 ,  G01N33/5014 ,  G01N33/5044

Abstract: Compositions, devices and methods are described for improving adhesion, attachment, and/or differentiation of cells in a microfluidic device or chip. In one embodiment, one or more ECM proteins are covalently coupled to the surface of a microchannel of a microfluidic device. The microfluidic devices can be stored or used immediately for culture and/or support of living cells such as mammalian cells, and/or for simulating a function of a tissue, e.g., a liver tissue, muscle tissue, etc. Extended adhesion and viability with sustained function over time is observed.

公开(公告)号：US20180024117A1

公开(公告)日：2018-01-25

申请号：US15648293

申请日：2017-07-12

Applicant: Emulate Inc.

Inventor： Daniel Levner ,  Kyung Jin Jang ,  Jacob Frase ,  Jordan Kerns ,  Antonio Varone ,  Dongeun Huh

IPC: G01N33/50 ,  C12N5/071 ,  C12N5/00

CPC classification number: G01N33/5032 ,  C12M23/16 ,  C12M23/20 ,  C12M25/02 ,  C12N5/0018 ,  C12N5/0068 ,  C12N5/0658 ,  C12N5/067 ,  C12N2500/32 ,  C12N2521/00 ,  C12N2533/30 ,  C12N2533/50 ,  C12N2533/52 ,  C12N2533/54 ,  C12N2533/90 ,  C12N2535/10 ,  C12N2537/10 ,  G01N33/5014 ,  G01N33/5044

Abstract: Compositions, devices and methods are described for improving adhesion, attachment, and/or differentiation of cells in a microfluidic device or chip. In one embodiment, one or more ECM proteins are covalently coupled to the surface of a microchannel of a microfluidic device. The microfluidic devices can be stored or used immediately for culture and/or support of living cells such as mammalian cells, and/or for simulating a function of a tissue, e.g., a liver tissue, muscle tissue, etc. Extended adhesion and viability with sustained function over time is observed.

公开(公告)号：US11519903B2

公开(公告)日：2022-12-06

申请号：US15648319

申请日：2017-07-12

Applicant: Emulate Inc.

Inventor： Daniel Levner ,  Kyung Jin Jang ,  Jacob Fraser ,  S. Jordan Kerns ,  Antonio Varone ,  Dongeun Huh

IPC: C12N5/00 ,  C12N5/02 ,  A61K38/00 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07K7/00 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00 ,  G01N33/50 ,  C07K14/78 ,  C12N5/071 ,  C12M3/06 ,  C12M1/00 ,  C12M1/12 ,  C12N5/077

Abstract: Compositions, devices and methods are described for improving adhesion, attachment, and/or differentiation of cells in a microfluidic device or chip. In one embodiment, one or more ECM proteins are covalently coupled to the surface of a microchannel of a microfluidic device. The microfluidic devices can be stored or used immediately for culture and/or support of living cells such as mammalian cells, and/or for simulating a function of a tissue, e.g., a liver tissue, muscle tissue, etc. Extended adhesion and viability with sustained function over time is observed.

公开(公告)号：US11536714B2

公开(公告)日：2022-12-27

申请号：US15648213

申请日：2017-07-12

Applicant: Emulate Inc.

Inventor： Daniel Levner ,  Kyung Jin Jang ,  Jacob Fraser ,  S. Jordan Kerns ,  Antonio Varone ,  Dongeun Huh

IPC: C12N5/00 ,  C12N5/02 ,  A61K38/00 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07K7/00 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00 ,  G01N33/50 ,  C07K14/78 ,  C12N5/071 ,  C12M3/06 ,  C12M1/00 ,  C12M1/12 ,  C12N5/077

Abstract: Compositions, devices and methods are described for improving adhesion, attachment, and/or differentiation of cells in a microfluidic device or chip. In one embodiment, one or more ECM proteins are covalently coupled to the surface of a microchannel of a microfluidic device. The microfluidic devices can be stored or used immediately for culture and/or support of living cells such as mammalian cells, and/or for simulating a function of a tissue, e.g., a liver tissue, muscle tissue, etc. Extended adhesion and viability with sustained function over time is observed.

公开(公告)号：US11506653B2

公开(公告)日：2022-11-22

申请号：US15648352

申请日：2017-07-12

Applicant: Emulate Inc.

Inventor： Daniel Levner ,  Kyung Jin Jang ,  Jacob Fraser ,  S. Jordan Kerns ,  Antonio Varone ,  Dongeun Huh

IPC: C12N5/00 ,  C12N5/02 ,  A61K38/00 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07K7/00 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00 ,  G01N33/50 ,  C07K14/78 ,  C12N5/071 ,  C12M3/06 ,  C12M1/00 ,  C12M1/12 ,  C12N5/077

Abstract: Compositions, devices and methods are described for improving adhesion, attachment, and/or differentiation of cells in a microfluidic device or chip. In one embodiment, one or more ECM proteins are covalently coupled to the surface of a microchannel of a microfluidic device. The microfluidic devices can be stored or used immediately for culture and/or support of living cells such as mammalian cells, and/or for simulating a function of a tissue, e.g., a liver tissue, muscle tissue, etc. Extended adhesion and viability with sustained function over time is observed.

公开(公告)号：US20180024118A1

公开(公告)日：2018-01-25

申请号：US15648306

申请日：2017-07-12

Applicant: Emulate Inc.

Inventor： Daniel Levner ,  Kyung Jin Jang ,  Jacob Fraser ,  Jordan Kerns ,  Antonio Varone ,  Dongeun Huh

IPC: G01N33/50 ,  C12N5/071 ,  C12N5/00

CPC classification number: G01N33/5032 ,  C12M23/16 ,  C12M23/20 ,  C12M25/02 ,  C12N5/0018 ,  C12N5/0068 ,  C12N5/0658 ,  C12N5/067 ,  C12N2500/32 ,  C12N2521/00 ,  C12N2533/30 ,  C12N2533/50 ,  C12N2533/52 ,  C12N2533/54 ,  C12N2533/90 ,  C12N2535/10 ,  C12N2537/10 ,  G01N33/5014 ,  G01N33/5044

Abstract: Compositions, devices and methods are described for improving adhesion, attachment, and/or differentiation of cells in a microfluidic device or chip. In one embodiment, one or more ECM proteins are covalently coupled to the surface of a microchannel of a microfluidic device. The microfluidic devices can be stored or used immediately for culture and/or support of living cells such as mammalian cells, and/or for simulating a function of a tissue, e.g., a liver tissue, muscle tissue, etc. Extended adhesion and viability with sustained function over time is observed.

公开(公告)号：US20180024116A1

公开(公告)日：2018-01-25

申请号：US15648213

申请日：2017-07-12

Applicant: Emulate Inc.

Inventor： Daniel Levner ,  Kyung Jin Jang ,  Jacob Fraser ,  Jordan Kerns ,  Antonio Varone ,  Dongeun Huh

IPC: G01N33/50 ,  C12N5/071 ,  C12N5/00

CPC classification number: G01N33/5032 ,  C12M23/16 ,  C12M23/20 ,  C12M25/02 ,  C12N5/0018 ,  C12N5/0068 ,  C12N5/0658 ,  C12N5/067 ,  C12N2500/32 ,  C12N2521/00 ,  C12N2533/30 ,  C12N2533/50 ,  C12N2533/52 ,  C12N2533/54 ,  C12N2533/90 ,  C12N2535/10 ,  C12N2537/10 ,  G01N33/5014 ,  G01N33/5044

Abstract: Compositions, devices and methods are described for improving adhesion, attachment, and/or differentiation of cells in a microfluidic device or chip. In one embodiment, one or more ECM proteins are covalently coupled to the surface of a microchannel of a microfluidic device. The microfluidic devices can be stored or used immediately for culture and/or support of living cells such as mammalian cells, and/or for simulating a function of a tissue, e.g., a liver tissue, muscle tissue, etc. Extended adhesion and viability with sustained function over time is observed.

公开(公告)号：US20180023050A1

公开(公告)日：2018-01-25

申请号：US15648339

申请日：2017-07-12

Applicant: Emulate Inc.

Inventor： Daniel Levner ,  Kyung Jin Jang ,  Jacob Fraser ,  Jordan Kerns ,  Antonio Varone ,  Dongeun Huh

IPC: C12N5/00 ,  C12M1/00 ,  C12M1/12 ,  C12N5/077 ,  C12M3/06

CPC classification number: G01N33/5032 ,  C12M23/16 ,  C12M23/20 ,  C12M25/02 ,  C12N5/0018 ,  C12N5/0068 ,  C12N5/0658 ,  C12N5/067 ,  C12N2500/32 ,  C12N2521/00 ,  C12N2533/30 ,  C12N2533/50 ,  C12N2533/52 ,  C12N2533/54 ,  C12N2533/90 ,  C12N2535/10 ,  C12N2537/10 ,  G01N33/5014 ,  G01N33/5044

Abstract: Compositions, devices and methods are described for improving adhesion, attachment, and/or differentiation of cells in a microfluidic device or chip. In one embodiment, one or more ECM proteins are covalently coupled to the surface of a microchannel of a microfluidic device. The microfluidic devices can be stored or used immediately for culture and/or support of living cells such as mammalian cells, and/or for simulating a function of a tissue, e.g., a liver tissue, muscle tissue, etc. Extended adhesion and viability with sustained function over time is observed.