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公开(公告)号：US12091650B2
公开(公告)日：2024-09-17
申请号：US16286185
申请日：2019-02-26
Applicant: EMULATE, INC. , CEDARS-SINAI MEDICAL CENTER
Inventor： S. Jordan Kerns , Norman Wen , Carolina Lucchesi , Christopher David Hinojosa , Jacob Fraser , Geraldine Hamilton , Gad Vatine , Samuel Sances , Clive Svendsen , Daniel Levner , Dhruv Sareen
CPC classification number: C12M23/16 , B01L3/502715 , C12M25/02 , C12N5/0068 , C12N5/0619 , C12N5/0622 , C12N5/069 , B01L2200/0647 , B01L2300/0861 , C12N2502/081 , C12N2502/28 , C12N2506/02 , C12N2506/45 , C12N2531/00 , C12N2539/00
Abstract: The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems.
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公开(公告)号：US11733234B2
公开(公告)日：2023-08-22
申请号：US15648339
申请日：2017-07-12
Applicant: Emulate Inc.
Inventor： Daniel Levner , Kyung Jin Jang , Jacob Fraser , S. Jordan Kerns , Antonio Varone , Dongeun Huh
IPC: C12N5/00 , C12N5/02 , A61K38/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , G01N33/50 , C07K14/78 , C12N5/071 , C12M3/06 , C12M1/00 , C12M1/12 , C12N5/077
CPC classification number: G01N33/5032 , C07K2/00 , C07K14/78 , C12M23/16 , C12M23/20 , C12M25/02 , C12N5/0018 , C12N5/0068 , C12N5/067 , C12N5/0658 , G01N33/5014 , C12N2500/32 , C12N2521/00 , C12N2533/30 , C12N2533/50 , C12N2533/52 , C12N2533/54 , C12N2533/90 , C12N2535/10 , C12N2537/10 , G01N33/5044
Abstract: Compositions, devices and methods are described for improving adhesion, attachment, and/or differentiation of cells in a microfluidic device or chip. In one embodiment, one or more ECM proteins are covalently coupled to the surface of a microchannel of a microfluidic device. The microfluidic devices can be stored or used immediately for culture and/or support of living cells such as mammalian cells, and/or for simulating a function of a tissue, e.g., a liver tissue, muscle tissue, etc. Extended adhesion and viability with sustained function over time is observed.
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公开(公告)号：US20220282221A1
公开(公告)日：2022-09-08
申请号：US17678485
申请日：2022-02-23
Applicant: EMULATE, INC. , CEDARS-SINAI MEDICAL CENTER
Inventor： S. Jordan Kerns , Norman Wen , Carol Lucchesi , Christopher David Hinojosa , Jacob Fraser , Jefferson Puerta , Geraldine Hamilton , Robert Barrett , Clive Svendsen , Daniel Levner , Stephen R. Targan , Michael Workman , Dhruv Sareen , Uthra Rajamani , Magdalena Kasendra
Abstract: Organs-on-chips are microfluidic devices for culturing living cells in micrometer sized chambers in order to model physiological functions of tissues and organs. Engineered patterning and continuous fluid flow in these devices has allowed culturing of intestinal cells bearing physiologically relevant features and sustained exposure to bacteria while maintaining cellular viability, thereby allowing study of inflammatory bowl diseases. However, existing intestinal cells do not possess all physiologically relevant subtypes, do not possess the repertoire of genetic variations, or allow for study of other important cellular actors such as immune cells. Use of iPSC-derived epithelium, including IBD patient-specific cells, allows for superior disease modeling by capturing the multi-faceted nature of the disease.
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公开(公告)号：US10989721B2
公开(公告)日：2021-04-27
申请号：US15648162
申请日：2017-07-12
Applicant: Emulate Inc.
Inventor： Daniel Levner , Christopher David Hinojosa , Norman Wen , Jacob Fraser , Justin Nguyen , Riccardo Barrile , Geraldine Hamilton , Catherine Karalis , Hyoungshin Park , Antonio Varone , Andries Van der Meer , Monicah Otieno , David Conegliano
Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.
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公开(公告)号：US20180015462A1
公开(公告)日：2018-01-18
申请号：US15648085
申请日：2017-07-12
Applicant: Emulate Inc. , JANSSEN BIOTECH, Inc
Inventor： Daniel Levner , Christopher David Hinojosa , Norman Wen , Jacob Fraser , Justin Nguyen , Riccardo Barrile , Geraldine Hamilton , Catherine Karalis , Hyoung Shin Park , Antonio Varone , Andries Van der Meer , Monica Otieno , David Conegliano
CPC classification number: G01N33/86 , B01L3/5023 , B01L3/502707 , B01L3/502715 , B01L3/502746 , B01L3/502761 , B01L2200/02 , B01L2200/027 , B01L2200/0605 , B01L2200/0647 , B01L2200/16 , B01L2300/0809 , B01L2300/0816 , B01L2300/0867 , B01L2300/0883 , B01L2300/0887 , B01L2300/14 , B01L2300/16 , C12M23/16 , C12M29/00 , C12M29/04 , C12M29/10 , C12M35/08 , C12M41/46 , G01N33/54366 , G01N2500/10
Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.
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Patent Agency Ranking
公开(公告)号：US20170226478A1
公开(公告)日：2017-08-10
申请号：US15458185
申请日：2017-03-14
Applicant: EMULATE, INC. , CEDARS-SINAI MEDICAL CENTER
Inventor： Jordan Kerns , Norman Wen , Geraldine Hamilton , Christopher Hinojosa , Jacob Fraser , Catherine Karalis , Janna Nawroth , Dhruv Sareen , Anjoscha Kaus , Berhan Mandefro , Hyoung Shin Park , Ville Kujala
IPC: C12N5/0793 , B01L3/00 , C12N5/077
CPC classification number: C12N5/0619 , C12M23/16 , C12N5/0658 , C12N2502/083 , C12N2506/45 , C12N2531/00 , C12N2533/52
Abstract: The invention relates to culturing motor neuron cells together with skeletal muscle cells in a fluidic device under conditions whereby the interaction of these cells mimic the structure and function of the neuromuscular junction (NMJ) providing a NMJ-on-chip. Good viability, formation of myo-fibers and function of skeletal muscle cells on fluidic chips allow for measurements of muscle cell contractions. Embodiments of motor neurons co-cultures with contractile myo-fibers are contemplated for use with modeling diseases affecting NMJ's, e.g. Amyotrophic lateral sclerosis (ALS).
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公开(公告)号：US20240228954A1
公开(公告)日：2024-07-11
申请号：US18529198
申请日：2023-12-05
Applicant: EMULATE, Inc. , Cedars-Sinai Medical Center
Inventor： S. Jordan Kerns , Norman Wen , Carolina Lucchesi , Christopher David Hinojosa , Jacob Fraser , Geraldine Hamilton , Gad Vatine , Samuel Sances , Clive Svendsen , Daniel Levner , Dhruv Sareen
CPC classification number: C12N5/0619 , C12N5/0622 , C12N5/069 , C12N5/0692 , C12Q1/02 , B01L3/5027 , B01L2200/0647 , B01L2300/0861 , C12M23/16 , C12M25/02 , C12M35/08 , C12N5/0618 , C12N2502/081 , C12N2502/086 , C12N2502/28 , C12N2506/45 , C12N2531/00 , C12N2533/52 , C12N2533/54 , C12N2533/56 , C12N2535/10 , C12N2539/00
Abstract: The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems.
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公开(公告)号：US11952592B2
公开(公告)日：2024-04-09
申请号：US17678485
申请日：2022-02-23
Applicant: EMULATE, INC. , CEDARS-SINAI MEDICAL CENTER
Inventor： S. Jordan Kerns , Norman Wen , Carol Lucchesi , Christopher David Hinojosa , Jacob Fraser , Jefferson Puerta , Geraldine Hamilton , Robert Barrett , Clive Svendsen , Daniel Levner , Stephen R Targan , Michael Workman , Dhruv Sareen , Uthra Rajamani , Magdalena Kasendra
CPC classification number: C12N5/0679 , C12M21/08 , C12M23/16 , C12N5/0618 , C12N5/0696 , G01N33/5005 , C12N2501/11 , C12N2501/119 , C12N2501/13 , C12N2501/155 , C12N2501/16 , C12N2501/24 , C12N2501/25 , C12N2501/415 , C12N2501/998 , C12N2501/999 , C12N2506/45 , C12N2535/00
Abstract: Organs-on-chips are microfluidic devices for culturing living cells in micrometer sized chambers in order to model physiological functions of tissues and organs. Engineered patterning and continuous fluid flow in these devices has allowed culturing of intestinal cells bearing physiologically relevant features and sustained exposure to bacteria while maintaining cellular viability, thereby allowing study of inflammatory bowl diseases. However, existing intestinal cells do not possess all physiologically relevant subtypes, do not possess the repertoire of genetic variations, or allow for study of other important cellular actors such as immune cells. Use of iPSC-derived epithelium, including IBD patient-specific cells, allows for superior disease modeling by capturing the multi-faceted nature of the disease.
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公开(公告)号：US11519903B2
公开(公告)日：2022-12-06
申请号：US15648319
申请日：2017-07-12
Applicant: Emulate Inc.
Inventor： Daniel Levner , Kyung Jin Jang , Jacob Fraser , S. Jordan Kerns , Antonio Varone , Dongeun Huh
IPC: C12N5/00 , C12N5/02 , A61K38/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , G01N33/50 , C07K14/78 , C12N5/071 , C12M3/06 , C12M1/00 , C12M1/12 , C12N5/077
Abstract: Compositions, devices and methods are described for improving adhesion, attachment, and/or differentiation of cells in a microfluidic device or chip. In one embodiment, one or more ECM proteins are covalently coupled to the surface of a microchannel of a microfluidic device. The microfluidic devices can be stored or used immediately for culture and/or support of living cells such as mammalian cells, and/or for simulating a function of a tissue, e.g., a liver tissue, muscle tissue, etc. Extended adhesion and viability with sustained function over time is observed.
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公开(公告)号：US10908171B2
公开(公告)日：2021-02-02
申请号：US15648000
申请日：2017-07-12
Applicant: Emulate Inc.
Inventor： Daniel Levner , Christopher David Hinojosa , Norman Wen , Jacob Fraser , Justin Nguyen , Riccardo Barrile , Geraldine Hamilton , Catherine Karalis , Hyoungshin Park , Antonio Varone , Andries Van der Meer , Monicah Otieno , David Conegliano
Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.
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